Renal Impairment

Nephrology
69
Pipeline Programs
30
Companies
50
Clinical Trials
3
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
62
0
2
0
0
5
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Small Molecule
1185%
Monoclonal Antibody
18%
RNA Therapeutic
18%
+ 54 programs with unclassified modality

On Market (3)

Approved therapies currently available

U
GABAPENTINApproved
gabapentin
Unknown Company
oral2010
Pfizer
NEURONTINApproved
gabapentin
Pfizer
oral2002
Amgen
XGEVAApproved
denosumab
Amgen
RANK Ligand Inhibitor [EPC]subcutaneous2010

Competitive Landscape

38 companies ranked by most advanced pipeline stage

Pfizer
PfizerNEW YORK, NY
5 programs
4
1
GabapentinPhase 41 trial
CP-690,550Phase 15 trials
ErtugliflozinPhase 1Small Molecule1 trial
PF-04965842Phase 11 trial
PF-07321332/ritonavirPhase 1Small Molecule1 trial
Active Trials
NCT01513902Completed26Est. Dec 2015
NCT01519089Completed95Est. Jan 2014
NCT01405118Completed24Est. Jul 2011
+6 more trials
Amgen
2 programs
2
1
XGEVA(Denosumab)Phase 1Monoclonal Antibody5 trials
OlpasiranPhase 11 trial
Active Trials
NCT04586660Active Not Recruiting36Est. Mar 2028
NCT04800367Active Not Recruiting30Est. Mar 2028
NCT03925532Completed30Est. Nov 2022
+3 more trials
Guerbet
GuerbetFrance - Villepinte
1 program
1
Ioversol 320 mgI/mLPhase 41 trial
Active Trials
NCT00793182Terminated6Est. Jun 2009
Takeda
TakedaTOKYO, Japan
3 programs
2
1
FebuxostatPhase 2Small Molecule1 trial
MobocertinibPhase 1Small Molecule4 trials
TAK-272Phase 11 trial
Active Trials
NCT04535557Approved For Marketing
NCT04056468Completed24Est. Feb 2022
NCT04056455Completed26Est. Apr 2022
+3 more trials
Oncopeptides
OncopeptidesSweden - Stockholm
1 program
1
MelflufenPhase 21 trial
Active Trials
NCT03639610TerminatedEst. Dec 2021
AstraZeneca
AstraZenecaCAMBRIDGE, United Kingdom
7 programs
7
AZD4144Phase 11 trial
AZD5462Phase 11 trial
AZD5672Phase 15 trials
AZD6140Phase 11 trial
AZD6234Phase 11 trial
+2 more programs
Active Trials
NCT06693765Completed41Est. Apr 2025
NCT06661733Completed16Est. Dec 2024
NCT00887770Completed64Est. Jul 2009
+8 more trials
M&
Merck & Co.RAHWAY, NJ
7 programs
7
BetrixabanPhase 11 trial
ErtugliflozinPhase 1Small Molecule
EvobrutinibPhase 1Small Molecule1 trial
MK-7145Phase 11 trial
MK-8527Phase 11 trial
+2 more programs
Active Trials
NCT00999336Completed32Est. Feb 2010
NCT03436394Completed31Est. Feb 2019
NCT01558674Terminated11Est. Dec 2014
+3 more trials
Novartis
NovartisBASEL, Switzerland
6 programs
6
AGO178CPhase 11 trial
AsciminibPhase 1Small Molecule1 trial
BAF312Phase 11 trial
ElinogrelPhase 11 trial
LCQ908Phase 11 trial
+1 more programs
Active Trials
NCT01459250Completed32
NCT03605277Completed14Est. Apr 2019
NCT01904214Completed16Est. Nov 2014
+3 more trials
E
3 programs
3
LemborexantPhase 11 trial
LenvatinibPhase 1Small Molecule1 trial
Lorcaserin 10mgPhase 11 trial
Active Trials
NCT03443063Completed16Est. Aug 2018
NCT02199379Completed26Est. Oct 2012
NCT00828438Completed40Est. Feb 2009
AbbVie
AbbVieNORTH CHICAGO, IL
2 programs
2
ABT-493Phase 15 trials
EmraclidinePhase 11 trial
Active Trials
NCT02738138Completed153Est. Jun 2017
NCT02441283Completed384Est. Oct 2019
NCT02442258Completed46Est. Dec 2015
+3 more trials
H
HutchmedChina - Hong Kong
2 programs
2
FruquintinibPhase 1Small Molecule1 trial
SurufatinibPhase 1Small Molecule1 trial
Active Trials
NCT05216354Completed24Est. Jun 2023
NCT04755088Completed16Est. Aug 2021
Sanofi
SanofiPARIS, France
2 programs
2
plerixaforPhase 15 trials
tolebrutinibPhase 1Small Molecule1 trial
Active Trials
NCT00720603No Longer Available
NCT05087212Completed53Est. Dec 2022
NCT04177810Completed25Est. May 2023
+3 more trials
Madrigal Pharmaceuticals
Madrigal PharmaceuticalsWEST CONSHOHOCKEN, PA
1 program
1
100 mg Resmetirom TabletPhase 11 trial
Active Trials
NCT06397872Completed28Est. Dec 2024
UP
1 program
1
20 mg HC-ERPhase 11 trial
Active Trials
NCT02244762Completed37Est. May 2011
Newron Pharmaceuticals
1 program
1
50mg safinamidePhase 11 trial
Active Trials
NCT01374113Completed
Alkermes
1 program
1
ALKS 5461Phase 11 trial
Active Trials
NCT02508506CompletedEst. Dec 2015
Antabio
AntabioFrance - Labège
1 program
1
ANT3310Phase 11 trial
Active Trials
NCT06527677CompletedEst. Jul 2025
Bayer
BayerLEVERKUSEN, Germany
1 program
1
BAY1101042Phase 11 trial
Active Trials
NCT03235076Completed36Est. Mar 2019
BioVersys
BioVersysSwitzerland - Basel
1 program
1
BV100Phase 11 trial
Active Trials
NCT05086107Completed48Est. Jan 2023
Insmed
InsmedBRIDGEWATER, NJ
1 program
1
BrensocatibPhase 11 trial
Active Trials
NCT05673603Completed28Est. Feb 2023
Chipscreen Biosciences
Chipscreen BiosciencesChina - Shenzhen
1 program
1
ChiglitazarPhase 11 trial
Active Trials
NCT05515458CompletedEst. Jul 2023
PTC Therapeutics
1 program
1
DeflazacortPhase 11 trial
Active Trials
NCT02286622Completed16Est. Feb 2015
Alumis
AlumisSOUTH SAN FRANCISCO, CA
1 program
1
ESK-001Phase 11 trial
Active Trials
NCT06962774Completed16Est. Aug 2025
argenx
argenxBelgium - Zwijnaarde
1 program
1
Efgartigimod IVPhase 11 trial
Active Trials
NCT05927415Completed33Est. Jun 2024
Galapagos
1 program
1
GLPG0634Phase 11 trial
Active Trials
NCT02084199Completed24Est. Jul 2014
Teva
TevaIsrael - Petach Tikva
1 program
1
Hydrocodone Bitartrate extended-release tabletPhase 11 trial
Active Trials
NCT01319266Completed55Est. Oct 2011
Ionis Pharmaceuticals
1 program
1
ISIS 681257Phase 11 trial
Active Trials
NCT03506854Completed16Est. Oct 2018
VP
1 program
1
IXPPhase 11 trial
Active Trials
NCT05865171Completed16Est. Jun 2024
MBX Biosciences
MBX BiosciencesCARMEL, IN
1 program
1
MBX 2109Phase 11 trial
Active Trials
NCT06496217Completed25Est. Sep 2025
Bausch Health
1 program
1
MethylnaltrexonePhase 11 trial
Active Trials
NCT01367509CompletedEst. Jun 2005

+8 more companies

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
2028
AmgenDenosumab
Sanofiplerixafor
AmgenDenosumab
AmgenDenosumab
Sanofiplerixafor
PfizerGabapentin
GuerbetIoversol 320 mgI/mL
AmgenDenosumab
AbbVieABT-493
AmgenDenosumab
AmgenDenosumab
AmgenDenosumab
Sanofiplerixafor
PfizerCP-690,550
AmgenDenosumab

Showing 15 of 50 trials with date data

Clinical Trials (50)

Total enrollment: 23,452 patients across 50 trials

Study of XGEVA® (Denosumab) in Chinese Adults and Skeletally Mature Adolescents With Giant Cell Tumor of the Bone

Start: Aug 2023Est. completion: Mar 202836 patients
Phase 4Active Not Recruiting

Mobilization of Stem Cells With AMD3100 (Plerixafor) in Combination With G-CSF in Multiple Myeloma Patients

Start: Oct 2021Est. completion: Dec 202253 patients
Phase 4Completed

Long-term Safety Follow-up of Subjects With Giant Cell Tumor of Bone Treated With Denosumab in Study 20062004

Start: Nov 2017Est. completion: Jul 202385 patients
Phase 4Completed

Treatment With Zoledronic Acid Subsequent to Denosumab in Osteoporosis

Start: Mar 2017Est. completion: Aug 202061 patients
Phase 4Completed

Stem Cell Harvesting Using GCSF Plus Plerxiafor, in First -Line, for Heavily Pre- Treated Pediatric Oncology Patients.

Start: Feb 2014Est. completion: Feb 202030 patients
Phase 4Unknown

A Post-Marketing Clinical Pharmacokinetics Study Of Gabapentin In Japanese Epileptic Subjects With Renal Impairment

Start: Mar 2010Est. completion: Apr 20101 patients
Phase 4Terminated
NCT00793182GuerbetIoversol 320 mgI/mL

Effects of Contrast Media on Subjects With Stable Reduced Renal Function Undergoing Contrast-Enhanced Computed Tomography

Start: Jan 2009Est. completion: Jun 20096 patients
Phase 4Terminated

Open-label Extension of Study 20130173 of Denosumab in Children and Young Adults With Osteogenesis Imperfecta

Start: Jul 2018Est. completion: Mar 202275 patients
Phase 3Terminated

A Study to Evaluate the Efficacy and Safety of Experimental Drugs ABT- 493/ABT-530 in Adults With Chronic Hepatitis C Virus Genotype 1-6 Infection and Human Immunodeficiency Virus -1 Coinfection (EXPEDITION-2)

Start: May 2016Est. completion: Jun 2017153 patients
Phase 3Completed

Multicenter,Single-arm Study to Evaluate Efficacy, Safety, & Pharmacokinetics of Denosumab in Children w/ OI

Start: Jun 2015Est. completion: Mar 2022153 patients
Phase 3Terminated

Survival imProvement in Lung cancEr iNduced by DenOsUmab theRapy

Start: Jan 2015Est. completion: Feb 2020595 patients
Phase 3Terminated

A Double-blind Study to Assess the Efficacy and Safety of Denosumab Produced by Two Different Processes in Postmenopausal Women With Osteoporosis

Start: May 2014Est. completion: Jul 2015394 patients
Phase 3Completed

Evaluation of Plerixafor Plus G-CSF to Mobilize and Collect 5×10^6CD34+ Cells/kg in Non-Hodgkin's Lymphoma (NHL) Patients for Autologous Transplantation

Start: Apr 2013Est. completion: Nov 2014100 patients
Phase 3Completed

A Long Term Study To Evaluate The Safety, Tolerability And Efficacy Of CP-690,550 In Patients With Moderate To Severe Plaque Psoriasis And/Or Psoriatic Arthritis

Start: Mar 2012Est. completion: Jan 201495 patients
Phase 3Completed

Open-Label Access Protocol of Denosumab for Subjects With Advanced Cancer

Start: Nov 2011Est. completion: Aug 2018129 patients
Phase 3Completed

Denosumab for Prolonging Bone Metastasis-Free Survival in Men With Hormone-Refractory Prostate Cancer

Start: Jan 2011Est. completion: Feb 201418 patients
Phase 3Completed

A Long Term Study To Evaluate The Safety And Tolerability Of CP-690,550 For Patients With Moderate To Severe Chronic Plaque Psoriasis

Start: Sep 2010Est. completion: Jun 20162,867 patients
Phase 3Terminated

A Study To Evaluate The Effects And Safety Of Treatment, Treatment Withdrawal, Followed By Re-Treatment With CP-690,550 In Subjects With Moderate To Severe Chronic Plaque Psoriasis

Start: Sep 2010Est. completion: Jan 2013666 patients
Phase 3Completed

Study to Evaluate the Safety and Efficacy of Denosumab and Actonel® in Post Menopausal Women Transitioned From Alendronate Therapy

Start: Sep 2009Est. completion: Mar 2012870 patients
Phase 3Completed

A Study to Evaluate the Safety and Efficacy of Denosumab and Ibandronate in Postmenopausal Women Sub-Optimally Treated With Daily or Weekly Bisphosphonates

Start: Jul 2009Est. completion: Jan 2012833 patients
Phase 3Completed

Extension Study to Evaluate Long Term Safety of Denosumab in Subjects Undergoing ADT for Non-Metastatic Prostate Cancer

Start: Feb 2009Est. completion: May 2012384 patients
Phase 3Completed

A Multi-centre, Open Label, Single-arm Study Intended to Further Investigate the Safety and Efficacy of Plerixafor as a Front-line Mobilisation Agent in Combination With G-CSF in Patients With Lymphoma or MM (Multiple Myeloma).

Start: Sep 2008Est. completion: Nov 2010118 patients
Phase 3Completed

Extension Study to Evaluate the Long Term Safety and Efficacy of Denosumab in the Treatment of Osteoporosis

Start: Aug 2007Est. completion: Jul 20154,550 patients
Phase 3Completed

A Multi-Center, Randomized, Open-Label Study to Assess the Immunogenicity and Safety of Denosumab in Pre-filled Syringe Compared to Vial in Subjects With Low Bone Mineral Density

Start: May 2007Est. completion: Mar 2009311 patients
Phase 3Completed

Long-Term Effectiveness And Safety Of CP-690,550 For The Treatment Of Rheumatoid Arthritis

Start: Feb 2007Est. completion: Oct 20174,488 patients
Phase 3Completed

Study of Denosumab vs. Zoledronic Acid to Treat Bone Metastases in Subjects With Advanced Cancer or Multiple Myeloma.

Start: Jun 2006Est. completion: Oct 20111,779 patients
Phase 3Completed

A Study Comparing Denosumab vs. Zoledronic Acid for the Treatment of Bone Metastases in Breast Cancer Subjects.

Start: Apr 2006Est. completion: Apr 20122,049 patients
Phase 3Completed

Mobilization of Stem Cells With AMD3100 (Plerixafor) in Multiple Myeloma Patients

Start: Jan 2005Est. completion: Jan 2008302 patients
Phase 3Completed

Mobilization of Stem Cells With AMD3100 (Plerixafor) in Non-Hodgkin's Lymphoma Patients

Start: Jan 2005Est. completion: Dec 2007298 patients
Phase 3Completed

A Study to Assess Resistance and Durability of Response to ABT-493 and/or ABT-530

Start: Jun 2015Est. completion: Oct 2019384 patients
Phase 2/3Completed

Romosozumab/Denosumab Study for Premenopausal IOP

Start: Mar 2021Est. completion: Mar 202830 patients
Phase 2Active Not Recruiting

Plerixafor and Cemiplimab in Metastatic Pancreatic Cancer

Start: Nov 2020Est. completion: May 202325 patients
Phase 2Completed

Denosumab in Treating Patients With Bone Loss Due to Donor Stem Cell Transplant

Start: Dec 2019Est. completion: Nov 202230 patients
Phase 2Completed

The Use of Steovess/Binosto After Denosumab Discontinuation to Prevent Increase in Bone Turnover

Start: Nov 2019Est. completion: Mar 202230 patients
Phase 2Completed

Denosumab for Smoldering Multiple Myeloma

Start: Apr 2019Est. completion: Jan 202520 patients
Phase 2Completed

Whole Brain Radiation Therapy With Standard Temozolomide Chemo-Radiotherapy and Plerixafor in Treating Patients With Glioblastoma

Start: Dec 2018Est. completion: Feb 202421 patients
Phase 2Completed

Denosumab + PD-1 in Subjects With Stage III/ IV Melanoma

Start: Sep 2018Est. completion: Aug 202325 patients
Phase 2Completed

PK of Melphalan During Treatment With Melflufen and Dexamethasone in Patients With RRMM and Impaired Renal Function

Start: Aug 2018Est. completion: Dec 2021
Phase 2Terminated

Denosumab in Subjects With Giant Cell Rich Tumors of Bone

Start: Jun 2018Est. completion: Jun 202360 patients
Phase 2Unknown

Denosumab and Pembrolizumab in Clear Cell Renal Carcinoma

Start: Dec 2017Est. completion: Jun 202359 patients
Phase 2Unknown

Denosumab in Treating Patients With ER and/or PR Positive, HER2 Negative Metastatic Breast Cancer With Bone Metastases and Detectable Circulating Tumor Cells

Start: Oct 2017Est. completion: Apr 20181 patients
Phase 2Terminated

Denosumab as an add-on Neoadjuvant Treatment (GeparX)

Start: Feb 2017Est. completion: Dec 2020780 patients
Phase 2Completed

A Study of Denosumab in Multiple Myeloma Patients With Renal Insufficiency

Start: Aug 2016Est. completion: Mar 202355 patients
Phase 2Completed

Study of the Impact of CD34+ Cell Dose on Absolute Lymphocyte Count Following High-Dose Therapy and Autologous Stem Cell Transplantation for Relapsed and Refractory Diffuse Large B-cell Lymphoma (DLBCL)

Start: Oct 2015Est. completion: Oct 202659 patients
Phase 2Active Not Recruiting

Plerixafor Plus Granulocyte Colony-Stimulating Factor For Mobilization And Collection Of Peripheral Hematopoietic Stem Cells In Japanese Participants With Non-Hodgkin Lymphoma

Start: Nov 2014Est. completion: Mar 201632 patients
Phase 2Completed

Plerixafor Plus Granulocyte Colony-stimulating Factor (G-CSF) For Mobilization And Collection Of Peripheral Hematopoietic Stem Cells In Japanese Participants With Multiple Myeloma

Start: Oct 2014Est. completion: Jul 201514 patients
Phase 2Completed

A Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of Co-administration of ABT-493 and ABT-530 With and Without Ribavirin in Subjects With HCV Genotype 1, 4, 5, and 6 Infection

Start: Aug 2014Est. completion: Feb 2016174 patients
Phase 2Completed

An Exploratory Safety Study to Investigate the Extent of Tumor Cell Mobilization (TCM) After Use of G-CSF Alone or G-CSF Plus Plerixafor in Multiple Myeloma (MM) Patients Who May be Poor Mobilizers of Stem Cells

Start: Jun 2013Est. completion: Sep 201623 patients
Phase 2Completed

A Phase II Study Evaluating the Safety and Efficacy of Subcutaneous Plerixafor

Start: May 2013Est. completion: Aug 2016127 patients
Phase 2Completed

Pilot Study to Evaluate the Impact of Denosumab on Disseminated Tumor Cells (DTC) in Patients With Early Stage Breast Cancer

Start: Nov 2012Est. completion: Jun 20164 patients
Phase 2Terminated

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

30 companies competing in this space