Vertex Pharmaceuticals ( VRTX )

N/A

Clinical Trials (1)

NCT06147778Performances and Safety of MuCopilot, a Digital Tool for the Unsupervised Objective Assessment of Cystic Fibrosis

N/A

Magnetic Resonance Imaging

N/A

Clinical Trials (1)

NCT04618185Gut Imaging for Function & Transit in CF - GIFT-CF 3

N/A

Connected Devices for 3 months

N/A

Clinical Trials (1)

NCT03304028MUCOviscidose EXacerbation Outils Connectés Education Thérapeutique

N/A

Energy Balance and Weight Gain With Ivacaftor Treatment

N/A

Clinical Trials (1)

NCT02141464Energy Balance and Weight Gain With Ivacaftor Treatment

N/A

Ivacaftor

N/A

Clinical Trials (1)

NCT03783286Ivacaftor Treatment in 4 Month to 2 Year Old CF Subjects

N/A

AVN944

Refractory Solid Tumors

N/A

Clinical Trials (1)

NCT00923728A Phase I Trial of AVN944, an IMPDH Inhibitor, in Adults With Advanced Stage Solid Tumors

N/A

Ophthalmologic examinations

N/A

Clinical Trials (1)

NCT01863238An Ocular Safety Study of Ivacaftor-Treated Pediatric Patients 11 Years of Age or Younger With Cystic Fibrosis

N/A

ivacaftor

N/A

Clinical Trials (1)

NCT02445053Observational Study of Outcomes in Cystic Fibrosis Patients With Selected Gating Mutations on a CFTR Allele (The VOCAL Study)

N/A

A Study to Confirm the Long-term Safety and Effectiveness of Kalydeco in Patients With Cystic Fibros

N/A

Clinical Trials (1)

NCT02722057A Study to Confirm the Long-term Safety and Effectiveness of Kalydeco in Patients With Cystic Fibrosis Who Have an R117H-CFTR Mutation, Including Pediatric Patients

N/A

VX-770

N/A

Clinical Trials (1)

NCT01381289VX-770 Expanded Access Program

N/A

Longitudinal Assessment of Exercise Capacity and Vascular Function in Patients With CF

N/A

Clinical Trials (1)

NCT03338595Longitudinal Assessment of Exercise Capacity and Vascular Function in Patients With CF

N/A

Questionnaires

N/A

Clinical Trials (1)

NCT03659214Impact of the Introduction of ORKAMBI on Anxiety, Depression, Quality of Life and Adherence of Adolescents and Young Adults

N/A

Gastrointestinal Study at Orkambi Therapy in CF Patients

Cystic Fibrosis in Children

N/A

Clinical Trials (1)

NCT03859531Gastrointestinal Study at Orkambi Therapy in CF Patients

N/A

Effect of Lumacaftor/Ivacaftor in Children With Cystic Fibrosis Homozygote for F508del on Small Airw

N/A

Clinical Trials (1)

NCT04138589Effect of Lumacaftor/Ivacaftor in Children With Cystic Fibrosis Homozygote for F508del on Small Airway Function

N/A

Natural History Study of Exocrine Pancreatic Function in Infants With Cystic Fibrosis (CF)

N/A

Clinical Trials (1)

NCT06506773Natural History Study of Exocrine Pancreatic Function in Infants With Cystic Fibrosis (CF)

N/A

telaprevir

N/A

Clinical Trials (1)

NCT00916474Virology Follow up Study in Subjects Previously Treated With Telaprevir

N/A

Rectal Biopsy

N/A

Clinical Trials (1)

NCT04254705Organoid Study R334W

N/A

Standard OGTT

N/A

Clinical Trials (1)

NCT03227094Simplification of CF-related Diabetes Screening at Home

N/A

Orkambi

N/A

Clinical Trials (1)

NCT03795363Orkambi Treatment in 2 to 5 Year Old Children With CF

N/A

tezacaftor/ivacaftor

Autosomal Dominant Polycystic Kidney Disease (ADPKD)

N/A

Clinical Trials (1)

NCT03278314Tezacaftor/Ivacaftor Combination Therapy Expanded Access Program for Patients 12 Years of Age and Older With Cystic Fibrosis

N/A

Polycystic Kidney Disease 1 (PKD1) Gene Variant Groups in Autosomal Dominant Polycystic Kidney Disea

N/A

Clinical Trials (1)

NCT06747572Polycystic Kidney Disease 1 (PKD1) Gene Variant Groups in Autosomal Dominant Polycystic Kidney Disease

N/A

ELX/TEZ/IVA

N/A

Clinical Trials (1)

NCT04702360ELX/TEZ/IVA Expanded Access Program for Cystic Fibrosis (CF) Patients With at Least One F508del Mutation

N/A

A Decentralized Study to Evaluate Physical Activity and Cough Frequency Using Wearable Technology in

N/A

Clinical Trials (1)

NCT04923464A Decentralized Study to Evaluate Physical Activity and Cough Frequency Using Wearable Technology in Cystic Fibrosis

N/A

ELX/TEZ/IVA

N/A

Clinical Trials (1)

NCT04058210VX-445/TEZ/IVA Expanded Access Program for Cystic Fibrosis (CF) Patients Heterozygous for F508del Mutation and a Minimal Function Mutation (F/MF Genotypes)

N/A

VX-973

PHASE_1

Clinical Trials (1)

NCT06615570A Phase 1 Dose Escalation Study of VX-973 in Healthy Participants

Phase 1

VX-121/TEZ/D-IVA

PHASE_1

Clinical Trials (1)

NCT05535959A Study to Evaluate the Relative Bioavailability of a Fixed-dose Combination Tablet of VX-121/Tezacaftor/Deutivacaftor

Phase 1

VX-993

In Development for Cystic Fibrosis

PHASE_1

Clinical Trials (1)

NCT06523595Evaluation of the Pharmacokinetic Drug-drug Interactions Between VX-993 and Metformin in Healthy Adults

Phase 1

Prednisone

Drug Interactions

PHASE_1

Clinical Trials (1)

NCT01886209Phase 1 PK Interaction Study Between VX-509 and Prednisone or Methylprednisolone in Healthy Male Subjects

Phase 1

VX-770

PHASE_1

Clinical Trials (1)

NCT01153542Study of VX-770 on Desipramine

Phase 1

VX-993

Alpha 1-Antitrypsin Deficiency

PHASE_1

Clinical Trials (1)

NCT06508762A Study to Evaluate the Relative Bioavailability and Food Effect of a New Tablet Formulation of VX-993

Phase 1

VX-634

PHASE_1

Clinical Trials (1)

NCT05579431A Phase 1, First-in-human Study of VX-634

Phase 1

telaprevir

PHASE_1

Clinical Trials (1)

NCT01038167A Study to Examine the Effects of Telaprevir on the Pharmacokinetics of Cyclosporine and Tacrolimus in Healthy Adults

Phase 1

VX-548

PHASE_1

Clinical Trials (1)

NCT05541471A Study to Evaluate the Pharmacokinetic Drug-drug Interactions Between VX-548, Midazolam, and Digoxin

Phase 1

VX-985 or matching placebo

Chronic Hepatitis C

PHASE_1

Clinical Trials (1)

NCT01144936Study of VX-985 in Subjects With Chronic Hepatitis C

Phase 1

Suzetrigine

PHASE_1

Clinical Trials (1)

NCT06336096A Study to Evaluate the Relative Bioavailability and Food Effect of a New Tablet Formulation and Strength of Suzetrigine

Phase 1

Telaprevir; Moxifloxacin; Placebo

PHASE_1

Clinical Trials (1)

NCT00973388VX-950-TiDP24-C136 - A Trial to Evaluate the Effect of Telaprevir (TVR) on the Results of Electrocardiograms (Electric Recording of the Heart) in Healthy Volunteers

Phase 1

Vanzacaftor

PHASE_1

Clinical Trials (1)

NCT05867147An Electrocardiogram Study to Evaluate the Effect of Vanzacaftor on the QT/QTc Interval in Healthy Participants

Phase 1

VX-548

PHASE_1

Clinical Trials (1)

NCT05455502A Study to Evaluate the Relative Bioavailability and Food Effect of a New Tablet Formulation of VX-548

Phase 1

VX-950

PHASE_1

Clinical Trials (1)

NCT00251199VX-950 and Peginterferon for Hepatitis C

Phase 1

lumacaftor

PHASE_1

Clinical Trials (1)

NCT01899105A Phase 1 Study to Investigate the Food Effect of Lumacaftor in Combination With Ivacaftor

Phase 1

Placebo

PHASE_1

Clinical Trials (1)

NCT05418712A Microneurography (MNG) Study of VX-150 in Healthy Participants

Phase 1

ALS-002158

Hepatitis C, Chronic

PHASE_1

Clinical Trials (1)

NCT01554085First in Human Study of ALS-002158; Single Dose, Food Effect in Healthy Volunteers; Multiple Doses in Chronic Hepatitis C Genotype 1

Phase 1

VX-548

PHASE_1

Clinical Trials (1)

NCT05560464Evaluation of the Pharmacokinetics and Safety of VX-548 in Participants With Mild or Moderate Hepatic Impairment

Phase 1

VX-809

PHASE_1

Clinical Trials (1)

NCT00966602Drug-Drug Interaction Study of VX-809 and VX-770 in Healthy Subjects

Phase 1

VX-509

Healthy

PHASE_1

Clinical Trials (1)

NCT00789126Single and Multiple Dose Escalation Study of VX-509 in Healthy Subjects

Phase 1

VCH 916

HCV Infection

PHASE_1

Clinical Trials (1)

NCT00623649Safety,Tolerability and Pharmacokinetics of Multiple Ascending Doses of VCH 916 in Subjects With Chronic Hep C Infection

Phase 1

VX-708

Acute Pain

PHASE_1

Clinical Trials (1)

NCT05347394A Phase 1 Dose Escalation Study of Oral VX-708 in Healthy Participants

Phase 1

Telaprevir

Healthy Participants

PHASE_1

Clinical Trials (1)

NCT00933283A Study to Investigate the Potential Interaction Between Telaprevir and Methadone, at Steady-State

Phase 1

MP-424