Spero Therapeutics

MA - CambridgeBiotechnology

Website LinkedIn Careers Page

Focus: Anti-infectives

Spero Therapeutics is a life sciences company focused on Anti-infectives.

Infectious Diseases

Profile data last refreshed Yesterday

Open Jobs

Data completeness

1/9 — Limited

Company HealthSolid

Pipeline

Mid-stage

2 Phase 3+

LOE Risk

Protected

No near-term cliffs

Hiring

0 open

Automated analysis based on publicly available data (FDA, SEC, ClinicalTrials.gov). May be incomplete or delayed. This score does not reflect insider knowledge and should not be used as the sole basis for investment or employment decisions.

Pipeline & Clinical Trials

SPR206

Healthy Volunteers

Phase 1

Clinical Trials (1)

NCT04868292Study to Assess the Intrapulmonary Pharmacokinetics of SPR206 in Healthy Volunteers

Phase 1

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Data Sources

Drug label: DailyMed / FDA
Clinical trials: ClinicalTrials.gov
Patent data: FDA Orange Book
Spending data: CMS Medicare

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.

TBP-PI-HBr

Healthy Volunteers

Phase 1

Clinical Trials (1)

NCT05856747A Study to Compare Two Bioanalytical Assays for Tebipenem

Phase 1

SPR741

Healthy Volunteers

Phase 1

Clinical Trials (1)

NCT03376529Phase 1 Study to Evaluate DDI, PK, Safety, Tolerability of SPR741

Phase 1

TBP-PI-HBr

Healthy Participants

Phase 1

Tebipenem Pivoxil Hydrobromide

Diabetes

Phase 1

Clinical Trials (1)

NCT04919954Tebipenem (SPR994) Tissue Penetration in Diabetic Patients With Wound Infections and Healthy Volunteers Via In Vivo Microdialysis

Phase 1

Tebipenem pivoxil hydrobromide

Healthy Volunteers

Phase 1

Clinical Trials (1)

NCT04368585Study to Examine the Effect of Antacid and Omeprazole on the Single-Dose Pharmacokinetics of Tebipenem Pivoxil Hydrobromide (TBPM-PI-HBr) in Healthy Adult Subjects

Phase 1

SPR720

Healthy Volunteer

Phase 1

Clinical Trials (1)

NCT05955586A Study to Assess the Intrapulmonary Pharmacokinetics (PK) of SPR719 by Comparing the Plasma, Epithelial Lining Fluid, and Alveolar Macrophage Concentrations Following the Oral Administration of Multiple Doses of SPR720 in Healthy Volunteers.

Phase 1

TBPM-PI-HBr

Healthy Volunteers

Phase 1

Clinical Trials (1)

NCT04710407Study to Assess the Intrapulmonary Pharmacokinetics of SPR859 by Comparing the Plasma, Epithelial Lining Fluid (ELF), and Alveolar Macrophages (AM) Concentrations Following the Oral Administration of Five Doses of SPR994 in Healthy, Nonsmoking Volunteers

Phase 1

TBPM-PI-HBr

Healthy Volunteers

Phase 1

Tebipenem tablet form

Relative Bioavailability

Phase 1

Clinical Trials (1)

NCT05296382Bioavailability of Tebipenem (SPR994) Crushed Tablet

Phase 1

Tebipenem pivoxil hydrobromide

Healthy Volunteers

Phase 1

Clinical Trials (1)

NCT04421885Bioequivalence Study Comparing Two Tablet Formulations of Tebipenem Pivoxil Hydrobromide (TBPM-PI-HBr) in Healthy Adult Subjects

Phase 1

SPR741

Healthy Volunteers

Phase 1

Clinical Trials (1)

NCT03022175A First in Human Study of the Safety and Tolerability of Single and Multiple Doses of SPR741 in Healthy Volunteers

Phase 1

Tebipenem pivoxil hydrobromide

Renal Impairment

Phase 1

Clinical Trials (1)

NCT04178577Phase 1 Study of PK and Safety of Tebipenem Pivoxil Hydrobromide (TBPM-PI-HBr) in Subjects With Various Degrees Of Renal Function

Phase 1

TBPM-PI-HBr

Healthy Volunteers

Phase 1

Clinical Trials (1)

NCT04625855Study of the Absorption, Metabolism, and Excretion of [14C]-Tebipenem Pivoxil Hydrobromide (TBPM-PI-HBr) Following a Single Oral Dose in Healthy Male Subjects

Phase 1

SPR206

Renal Impairment

Phase 1

Clinical Trials (1)

NCT04865393Phase 1 Study of PK and Safety of SPR206 in Subjects With Various Degrees Of Renal Function

Phase 1

Tebipenem Pivoxil Hydrobromide

TQT Study

Phase 1

Clinical Trials (1)

NCT04238195A Single-Dose, Randomized, Placebo- and Active-Control, Four-Way, Cross-Over Study for the Evaluation of the Effect of Tebipenem Pivoxil Hydrobromide (TBPM-PI-HBr) on the QT/QTc Intervals in Adult Healthy Subjects

Phase 1

SPR994

Healthy Volunteers

Phase 1

Clinical Trials (1)

NCT03395249Phase 1 Study of Safety, Tolerability and Pharmacokinetics of SPR994

Phase 1

SPR720

Healthy Volunteers

Phase 1

Clinical Trials (1)

NCT05966688A Study to Evaluate the Effect of Co-administration on the Pharmacokinetics of SPR720, Azithromycin, and Ethambutol in Healthy Participants

Phase 1

SPR206

Healthy Volunteers

Phase 1

Clinical Trials (1)

NCT03792308A First in Human Study of the Safety and Tolerability of Single and Multiple Doses of SPR206 in Healthy Volunteers

Phase 1

SPR720 for SAD

Healthy Volunteers

Phase 1

Clinical Trials (1)

NCT03796910A Study of the Safety, Tolerability, and Pharmacokinetics of SPR720 in Healthy Volunteers

Phase 1

Placebo

Nontuberculous Mycobacterial Pulmonary Disease (NTM-PD)

Phase 2

Clinical Trials (1)

NCT05496374A Study to Evaluate the Efficacy, Safety, Tolerability, and Pharmacokinetics of SPR720 as Compared With Placebo for the Treatment of Participants With Mycobacterium Avium Complex (MAC) Pulmonary Disease

Phase 2

SPR720

Mycobacterium Avium Complex

Phase 2

Clinical Trials (1)

NCT04553406Safety, Tolerability, Pharmacokinetics and Efficacy of SPR720 for the Treatment of Patients With Mycobacterium Avium Complex (MAC) Pulmonary Disease

Phase 2

TBPM-PI-HBr

Complicated Urinary Tract Infection

Phase 3

Clinical Trials (1)

NCT03788967Study to Assess the Efficacy, Safety and Pharmacokinetics of Orally Administered Tebipenem Pivoxil Hydrobromide (SPR994) Compared to Intravenous Ertapenem in Participants With Complicated Urinary Tract Infection (cUTI) or Acute Pyelonephritis (AP)

Phase 3

TBP-PI-HBr

Urinary Tract Infection

Phase 3