Kidney Failure, Chronic

Nephrology
17
Pipeline Programs
14
Companies
33
Clinical Trials
5
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
4
1
3
0
3
6
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Small Molecule
133%
Monoclonal Antibody
133%
Peptide
133%
+ 10 programs with unclassified modality

On Market (5)

Approved therapies currently available

Takeda
FOSRENOLApproved
lanthanum carbonate
Takeda
oral2004
U
LANTHANUM CARBONATEApproved
lanthanum carbonate
Unknown Company
oral2017
U
SAIZENApproved
somatropin
Unknown Company
injection1996
U
SEROSTIMApproved
somatropin
Unknown Company
injection1996
U
SEROSTIM LQApproved
somatropin
Unknown Company
subcutaneous1996

Competitive Landscape

12 companies ranked by most advanced pipeline stage

Abbott
AbbottABBOTT PARK, IL
2 programs
1
ZemplarPhase 45 trials
Correlations Between BNP & Dry Weight, and Between Troponin & Mortality, in Hemodialysis PatientsN/A1 trial
Active Trials
NCT00416013Unknown151Est. Dec 2010
NCT01368042Completed265Est. Jun 2013
NCT01401478Completed86Est. Jan 2013
+3 more trials
Takeda
TakedaTOKYO, Japan
1 program
1
1
FOSRENOL(Lanthanum carbonate)Phase 35 trials
Active Trials
NCT01696279Completed63Est. Nov 2018
NCT01130831Completed66Est. Jun 2012
NCT00925704Completed41Est. Jul 2009
+2 more trials
CorMedix
CorMedixPARSIPPANY, NJ
1 program
1
NeutrolinPhase 31 trial
Active Trials
NCT02651428Completed806Est. Oct 2018
Genentech
GenentechCA - Oceanside
1 program
1
somatropinPhase 31 trial
Active Trials
NCT00943995Completed3Est. Aug 2012
Allergy Therapeutics
Allergy TherapeuticsUK - West Sussex
1 program
1
AlemtuzumabPhase 2Monoclonal Antibody1 trial
Active Trials
NCT00240994CompletedEst. Nov 2009
Hansa Biopharma
Hansa BiopharmaSweden - Lund
1 program
1
IdeSPhase 21 trial
Active Trials
NCT02790437CompletedEst. Jul 2018
Novo Nordisk
Novo NordiskBAGSVAERD DENMARK, Denmark
1 program
1
LiraglutidePhase 2Peptide1 trial
Active Trials
NCT02284230Withdrawn0Est. Aug 2015
R
ResVerlogiXAB - Calgary
1 program
1
apabetalonePhase 1/21 trial
Active Trials
NCT03160430Not Yet Recruiting44Est. Nov 2026
Debiopharm
DebiopharmSwitzerland - Lausanne
1 program
1
AlisporivirPhase 1Small Molecule1 trial
Active Trials
NCT01975337CompletedEst. Feb 2014
Eli Lilly and Company
Eli Lilly and CompanyINDIANAPOLIS, IN
1 program
1
LY3113593Phase 11 trial
Active Trials
NCT02144285Completed64Est. Aug 2015
M&
Merck & Co.RAHWAY, NJ
1 program
1
MK-5684Phase 11 trial
Active Trials
NCT06814132Completed24Est. Oct 2025
United Therapeutics
United TherapeuticsMD - Silver Spring
1 program
1
UKidneyPhase 11 trial
Active Trials
NCT05340426Withdrawn0Est. Jun 2029

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
2028
2029
TakedaLanthanum carbonate
AbbottZemplar
TakedaLanthanum carbonate
AbbottZemplar
AbbottZemplar
CorMedixNeutrolin
Genentechsomatropin
TakedaLanthanum carbonate
TakedaLanthanum carbonate
AbbottZemplar
TakedaLanthanum carbonate
TakedaLanthanum carbonate
AbbottZemplar
Hansa BiopharmaIdeS
Novo NordiskLiraglutide

Showing 15 of 33 trials with date data

Clinical Trials (33)

Total enrollment: 8,819 patients across 33 trials

NCT00452478TakedaLanthanum carbonate

Conversion From Standard Phosphate Binder Therapy to Fosrenol® (Lanthanum Carbonate) in Chronic Kidney Disease Stage 5

Start: May 2007Est. completion: Dec 200768 patients
Phase 4Terminated
NCT00257920AbbottZemplar

A Study of Zemplar® Injection and Hectorol® Injection on Intestinal Absorption of Calcium in Chronic Kidney Disease

Start: Jun 200641 patients
Phase 4Completed
NCT00160121TakedaLanthanum carbonate

Efficacy and Safety of Fosrenol in Treating Elevated Serum Phosphate Levels in Adults With End Stage Renal Disease

Start: Jan 2005Est. completion: Dec 20052,500 patients
Phase 4Completed
NCT00073710AbbottZemplar

Study to Evaluate the Effects of Zemplar Injection and Calcijex on Intestinal Absorption of Calcium

Start: Sep 200430 patients
Phase 4Completed
NCT00091481AbbottZemplar

Study to Compare Initial Dosing Parameters of Zemplar in Stage V Chronic Kidney Disease Subjects on Hemodialysis

Start: Jun 2003201 patients
Phase 4Completed
NCT02651428CorMedixNeutrolin

Study Assessing Safety & Effectiveness of a Catheter Lock Solution in Dialysis Patients to Prevent Bloodstream Infection

Start: Dec 2015Est. completion: Oct 2018806 patients
Phase 3Completed
NCT00943995Genentechsomatropin

Three Times Weekly (TIW) Growth Hormone Therapy in Children on Hemodialysis

Start: Jul 2010Est. completion: Aug 20123 patients
Phase 3Completed
NCT00441545TakedaLanthanum carbonate

Head to Head Study Against Sevelamer Hydrochloride

Start: Jan 2007Est. completion: Jul 2008182 patients
Phase 3Completed
NCT00151918TakedaLanthanum carbonate

Efficacy and Safety of Lanthanum Carbonate and Sevelamer Hydrochloride in Patients Receiving Haemodialysis for End Stage Renal Disease

Start: Jan 2005Est. completion: Aug 200548 patients
Phase 3Completed
NCT00091975AbbottZemplar

Zemplar® Capsule in Reducing Serum Intact Parathyroid Hormone Levels in Chronic Kidney Disease Stage 5 Subjects on Hemodialysis or Peritoneal Dialysis

Start: Aug 200478 patients
Phase 3Completed
NCT00151931TakedaLanthanum carbonate

Efficacy and Tolerability of Treatment With Lanthanum Carbonate in Patients With End Stage Renal Disease Receiving Dialysis

Start: May 2004Est. completion: Jan 2006456 patients
Phase 3Completed
NCT00150540TakedaLanthanum carbonate

A Long Term Study of Lanthanum Carbonate in Patients Requiring Dialysis Who Have Ived Lanthanum Carbonate in Previous Studies Defined by the Protocol.

Start: Oct 2002Est. completion: Jun 200593 patients
Phase 3Completed
NCT01204528AbbottZemplar

Vitamin-D Receptor Activation (VDRA) in Chronic Kidney Disease

Start: Sep 2010Est. completion: Jul 201336 patients
Phase 2/3Completed
NCT02790437Hansa BiopharmaIdeS

A Phase II Study to Evaluate the Efficacy of IdeS to Desensitize Transplant Patients With a Positive Crossmatch Test

Start: Jun 2016Est. completion: Jul 2018
Phase 2Completed
NCT02284230Novo NordiskLiraglutide

The Effect of Liraglutide in Patients With Prediabetes and Kidney Failure

Start: Dec 2014Est. completion: Aug 20150
Phase 2Withdrawn
NCT01696279TakedaLanthanum carbonate

A Study to Assess the Pharmacokinetics of Lanthanum Carbonate, Investigate and Compare the Efficacy, Safety and Tolerability of Lanthanum Carbonate With Calcium Carbonate in Hyperphosphataemic Children and Adolescents With Chronic Kidney Disease on Dialysis

Start: Feb 2013Est. completion: Nov 201863 patients
Phase 2Completed
NCT00240994Allergy TherapeuticsAlemtuzumab

Safety in Immunomodulatory Functions of Alemtuzumab (Campath) in Pediatric Kidney Transplantation Recipients

Start: Jan 2005Est. completion: Nov 2009
Phase 2Completed
NCT03160430ResVerlogiXapabetalone

A Two-Part Phase 2a Study of RVX000222 in Patients With End-Stage Renal Disease Treated With Hemodialysis

Start: Nov 2024Est. completion: Nov 202644 patients
Phase 1/2Not Yet Recruiting
NCT06814132Merck & Co.MK-5684

A Study to Evaluate the Effect of MK-5684 in Male Participants With Severe Renal Impairment (RI) and With End-stage Renal Disease (ESRD) (MK-5684-010)

Start: Apr 2025Est. completion: Oct 202524 patients
Phase 1Completed
NCT05340426United TherapeuticsUKidney

Porcine Kidney Xenotransplantation in Patients With End-Stage Kidney Disease

Start: Jan 2024Est. completion: Jun 20290
Phase 1Withdrawn
NCT02144285Eli Lilly and CompanyLY3113593

A Study of LY3113593 in Healthy Participants and Participants With Chronic Kidney Disease Treated With Hemodialysis

Start: Jun 2014Est. completion: Aug 201564 patients
Phase 1Completed
NCT01975337DebiopharmAlisporivir

Pharmacokinetics and Safety of Alisporivir in Subjects With End Stage Renal Disease on Hemodialysis Compared to Healthy Subjects

Start: Aug 2013Est. completion: Feb 2014
Phase 1Completed
NCT00925704TakedaLanthanum carbonate

The Pharmacokinetics of Rocaltrol When Administered Alone or in Combination With Fosrenol or Renvela in Healthy Volunteers

Start: Jun 2009Est. completion: Jul 200941 patients
Phase 1Completed
NCT00875017TakedaLanthanum carbonate

Comparing Absorption of Dietary Phosphorus When Administering FOSRENOL® or RENVELA® in Healthy Adult Volunteers

Start: Apr 2009Est. completion: Jun 200931 patients
Phase 1Completed
NCT00880750TakedaLanthanum carbonate

Pharmacodynamic Study of Two Lanthanum Carbonate Formulations in Healthy Adults

Start: Jan 2009Est. completion: Jun 200972 patients
Phase 1Completed
NCT01368042AbbottZemplar

Quality of Life in Greek Hemodialysis Patients Receiving Zemplar Intravenous

Start: Aug 2011Est. completion: Jun 2013265 patients
N/ACompleted
NCT01401478AbbottZemplar

Observational Program of Zemplar in Patients With End Stage Chronic Kidney Disease and Parathyroid Disorder on Hemodialysis in the Russian Federation

Start: Jul 2011Est. completion: Jan 201386 patients
N/ACompleted
NCT01224782AbbottZemplar

Evaluation of Treatment With Zemplar Capsules in the Therapy of Secondary Hyperparathyroidism (SHPT)

Start: Oct 2010Est. completion: Aug 2013994 patients
N/ACompleted
NCT01130831TakedaLanthanum carbonate

Effect of Lanthanum Carbonate in Patients Previously Treated With Calcium-based Phosphate Binder Therapy

Start: Apr 2010Est. completion: Jun 201266 patients
N/ACompleted
NCT00557323TakedaLanthanum carbonate

Long-term Effect of Lanthanum Carbonate on Bone

Start: Mar 2007Est. completion: Aug 201034 patients
N/ACompleted
NCT01081665AbbottZemplar

Follow-up Patients With End Stage Renal Disease Receiving Zemplar to Prevent and Treat Secondary Hyperparathyroidism

Start: Dec 2006Est. completion: Feb 2011237 patients
N/ACompleted
NCT00567723TakedaLanthanum carbonate

Long Term Treatment of End Stage Renal Disease Patients With Lanthanum Carbonate (Fosrenol)

Start: Apr 2006Est. completion: Jun 20162,105 patients
N/ACompleted
NCT00416013AbbottCorrelations Between BNP & Dry Weight, and Between Troponin & Mortality, in Hemodialysis Patients

Correlations Between BNP & Dry Weight, and Between Troponin & Mortality, in Hemodialysis Patients

Start: Dec 2005Est. completion: Dec 2010151 patients
N/AUnknown

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Phase Legend

Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available

Key Insights

3 late-stage (Phase 3) programs — potential near-term approvals
14 companies competing in this space

Related Indications

Chronic Kidney Disease(86)Renal Impairment(67)End Stage Renal Disease(56)Kidney Transplantation(49)Renal Insufficiency(27)Chronic Kidney Diseases(25)Kidney Transplant(19)Diabetic Nephropathies(18)Kidney Diseases(17)Kidney Transplant Rejection(16)