Leo Pharma

Denmark - Ballerup

Pharmaceutical

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Focus: Small Molecules

Leo Pharma is a life sciences company focused on Small Molecules.

ImmunologyEndocrinology

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Products & Portfolio (10)

3 discontinued products not shown

ADBRY

tralokinumab-ldrm

Peak

mAbINJECTION · INJECTABLE

Interleukin-13 Antagonists

moderate-to-severe atopic dermatitis in adultsolder whose disease is not adequately controlled with topical prescription therapiesthose therapies are not advisable+1 more

Janus Kinase Inhibitors

CLINICAL PHARMACOLOGY In humans, the natural supply of vitamin D depends mainly on exposure to the ultraviolet rays of the sun for conversion of 7-dehydrocholesterol to vitamin D 3 (cholecalciferol) in the skin. Calcipotriene is a synthetic analog of vitamin D 3 . Clinical studies with radiolabelled Calcipotriene Ointment indicate that approximately 6% (± 3%, SD) of the applied dose of calcipotriene is absorbed systemically when the ointment is applied topically to psoriasis plaques, or 5% (± 2.6%, SD) when applied to normal skin, and much of the absorbed active is converted to inactive metabolites within 24 hours of application. Vitamin D and its metabolites are transported in the blood, bound to specific plasma proteins. The active form of the vitamin, 1,25-dihydroxy vitamin D 3 (calcitriol), is known to be recycled via the liver and excreted in the bile. Calcipotriene metabolism following systemic uptake is rapid, and occurs via a similar pathway to the natural hormone. The primary metabolites are much less potent than the parent compound. There is evidence that maternal 1,25-dihydroxy vitamin D 3 (calcitriol) may enter the fetal circulation, but it is not known whether it is excreted in human milk. The systemic disposition of calcipotriene is expected to be similar to that of the naturally occurring vitamin.

plaque psoriasis in adultspsoriasis

CLINICAL PHARMACOLOGY In humans, the natural supply of vitamin D depends mainly on exposure to the ultraviolet rays of the sun for conversion of 7-dehydrocholesterol to vitamin D 3 (cholecalciferol) in the skin. Calcipotriene is a synthetic analog of vitamin D 3 . Clinical studies with radiolabelled calcipotriene ointment indicate that approximately 6% (± 3%, SD) of the applied dose of calcipotriene is absorbed systemically when the ointment is applied topically to psoriasis plaques, or 5% (± 2.6%, SD) when applied to normal skin, and much of the absorbed active is converted to inactive metabolites within 24 hours of application. Systemic absorption of the cream has not been studied. Vitamin D and its metabolites are transported in the blood, bound to specific plasma proteins. The active form of the vitamin, 1,25-dihydroxy vitamin D 3 (calcitriol), is known to be recycled via the liver and excreted in the bile. Calcipotriene metabolism following systemic uptake is rapid, and occurs via a similar pathway to the natural hormone.

plaque psoriasispsoriasis

1996

ENSTILAR

calcipotriene and betamethasone dipropionate

Peak

TOPICAL · AEROSOL, FOAM

D3 analog and betamethasone dipropionate as a synthetic corticosteroid. However, while their pharmacologic and clinical effects are known, the exact mechanisms of their actions in the treatment of plaque psoriasis are unknown.

mechanism(s) by which azelaic acid interferes with the pathogenic events in rosacea are unknown.

TOPICAL · AEROSOL, FOAM

mechanism(s) by which azelaic acid interferes with the pathogenic events in rosacea are unknown.

calcipotriene and betamethasone dipropionate

calcipotriene and betamethasone dipropionate

LOE Approaching

TOPICAL · SUSPENSION

2008

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Interview Prep Quick Facts

Portfolio: 13 approved products

Top TAs: Immunology, Endocrinology

Portfolio Health

Launch1 (8%)

Peak3 (23%)

LOE Approaching9 (69%)

13 total products

Therapeutic Area Focus

Immunology

6 marketed

Endocrinology

2 marketed

Marketed

Pipeline