Chronic Kidney Disease

Nephrology
71
Pipeline Programs
30
Companies
50
Clinical Trials
3 recruiting
11
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
13
1
22
1
18
16
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Small Molecule
770%
Vaccine
110%
Peptide
110%
Monoclonal Antibody
110%
+ 65 programs with unclassified modality

On Market (11)

Approved therapies currently available

Boehringer Ingelheim
JARDIANCEApproved
empagliflozin
Boehringer Ingelheim
Sodium-Glucose Cotransporter 2 Inhibitor [EPC]oral2014
Bayer
KERENDIAApproved
finerenone
Bayer
Nonsteroidal Mineralocorticoid-Receptor Antagonist [EPC]oral2021
Novo Nordisk
NORDITROPINApproved
somatropin
Novo Nordisk
Recombinant Human Growth Hormone [EPC]injection2000
Novo Nordisk
NORDITROPIN FLEXPROApproved
somatropin
Novo Nordisk
Recombinant Human Growth Hormone [EPC]injection2000
Novo Nordisk
NORDITROPIN NORDIFLEXApproved
somatropin
Novo Nordisk
Recombinant Human Growth Hormone [EPC]injection2000
Sanofi
RENVELAApproved
sevelamer carbonate
Sanofi
oral2009
U
ROCALTROLApproved
calcitriol
Unknown Company
Vitamin D3 Analog [EPC]oral1978
U
SAIZENApproved
somatropin
Unknown Company
injection1996
U
SEROSTIMApproved
somatropin
Unknown Company
injection1996
U
SEROSTIM LQApproved
somatropin
Unknown Company
subcutaneous1996
U
SEVELAMER CARBONATEApproved
sevelamer carbonate
Unknown Company
oral2018

Competitive Landscape

30 companies ranked by most advanced pipeline stage

Novo Nordisk
9 programs
3
4
1
1
somatropinPhase 41 trial
somatropinPhase 31 trial
CagrilintidePhase 2Peptide1 trial
NNC0519-0130Phase 21 trial
ZiltivekimabPhase 2Monoclonal Antibody1 trial
+4 more programs
Active Trials
NCT02837237Completed11Est. Jun 2017
NCT05094934Terminated60Est. Aug 2022
NCT01502137Completed21Est. Nov 2005
+6 more trials
Bayer
BayerLEVERKUSEN, Germany
7 programs
2
1
3
1
FinerenonePhase 31 trial
FinerenonePhase 31 trial
FinerenonePhase 31 trial
runcaciguatPhase 21 trial
BAY3283142Phase 12 trials
+2 more programs
Active Trials
NCT05526157Completed50,000Est. Sep 2024
NCT06487845Completed24Est. Sep 2024
NCT06402721Completed24Est. Feb 2025
+5 more trials
Boehringer Ingelheim
Boehringer IngelheimINGELHEIM, Germany
6 programs
3
2
1
EmpagliflozinPhase 3Small Molecule1 trial
EmpagliflozinPhase 3Small Molecule1 trial
AvenciguatPhase 21 trial
VicadrostatPhase 2Small Molecule1 trial
collection of serum/capillary creatinine valuesPhase 21 trial
+1 more programs
Active Trials
NCT07063316Active Not Recruiting15,000Est. Sep 2026
NCT04736628Completed261Est. Sep 2023
NCT06926660Recruiting416Est. Aug 2026
+3 more trials
AbbVie
AbbVieNORTH CHICAGO, IL
4 programs
2
1
Viekira Pak ± ribavirinPhase 41 trial
AtrasentanPhase 22 trials
Atrasentan low dose groupPhase 2
Quality of Life in Greek Hemodialysis Patients Receiving Zemplar IntravenousN/A
Active Trials
NCT02118714Completed20Est. Jul 2018
NCT01858532Terminated5,107Est. Mar 2018
NCT02946034Completed10Est. Sep 2020
Sanofi
SanofiPARIS, France
2 programs
1
1
RENVELA(sevelamer carbonate)Phase 33 trials
CRICKET Study, Coronary Calcium Scores in Patients With Chronic Kidney DiseaseN/A1 trial
Active Trials
NCT00142636Withdrawn0Est. Sep 2005
NCT01191762Completed30Est. Apr 2013
NCT00853242Completed349Est. Aug 2009
+1 more trials
Genentech
2 programs
1
1
Recombinant Human Growth HormonePhase 41 trial
PirfenidonePhase 21 trial
Active Trials
NCT04258397Unknown200Est. Dec 2024
NCT00194961Terminated15Est. Dec 2007
Abbott
AbbottABBOTT PARK, IL
1 program
1
CalcitriolPhase 45 trials
Active Trials
NCT01506947Completed65Est. Apr 2016
NCT01134315Terminated61Est. May 2012
NCT00823303Completed110Est. Sep 2013
+2 more trials
Bristol Myers Squibb
1 program
1
pravastatinPhase 4Small Molecule1 trial
Active Trials
NCT00384618Terminated100Est. Aug 2005
Opko Health
Opko HealthMIAMI, FL
7 programs
2
1
1
3
CTAP101 30 μg capsulesPhase 31 trial
CTAP101 30 μg capsulesPhase 31 trial
CTAP101 CapsulesPhase 31 trial
Cohort 1 CTAP101 Capsules- 60µgPhase 2/31 trial
CTA018 InjectionPhase 21 trial
+2 more programs
Active Trials
NCT00888069CompletedEst. Dec 2009
NCT00792857CompletedEst. Oct 2009
NCT00742716CompletedEst. Jun 2010
+4 more trials
Amgen
AmgenTHOUSAND OAKS, CA
5 programs
1
1
2
Epoetin alfa DTPhase 32 trials
cinacalcet capsulePhase 31 trial
Cinacalcet hydrochloridePhase 21 trial
CinacalcetPhase 11 trial
Study to Evaluate the Prospective Payment SystemN/A1 trial
Active Trials
NCT01717989Completed2,248Est. Sep 2012
NCT01290029Completed14Est. Sep 2015
NCT01439867Terminated18Est. Jun 2016
+3 more trials
Astellas
AstellasChina - Shenyang
4 programs
4
ASP1585Phase 31 trial
ASP1585Phase 31 trial
RoxadustatPhase 3Small Molecule1 trial
roxadustatPhase 3Small Molecule1 trial
Active Trials
NCT01057407Completed110Est. Sep 2010
NCT01017276Completed35Est. Sep 2010
NCT05970172Recruiting100Est. Oct 2027
+1 more trials
Dynavax Technologies
Dynavax TechnologiesCA - Emeryville
2 programs
1
HEPLISAV-BPhase 31 trial
HEPLISAVN/A1 trial
Active Trials
NCT01282762Completed147Est. Aug 2013
NCT00985426Completed521Est. Jan 2012
MediBeacon
MediBeaconGermany - Mannheim
1 program
1
MB-102Phase 31 trial
Active Trials
NCT05425719Completed249Est. Feb 2023
AstraZeneca
AstraZenecaCAMBRIDGE, United Kingdom
5 programs
1
1
ZibotentanPhase 25 trials
AZD5718Phase 11 trial
Forxiga CKD Japan Post-Marketing Surveillance (PMS)N/A1 trial
OPTIMISE-CKD Drug UtilizationN/A1 trial
REVEAL-CKD: Prevalence and Consequences of Undiagnosed Chronic Kidney DiseaseN/A1 trial
Active Trials
NCT05306210Completed1,029Est. Oct 2024
NCT05932901Completed2,682,052Est. Sep 2023
NCT04847531Completed1,006,361Est. Nov 2023
+6 more trials
Eli Lilly and Company
Eli Lilly and CompanyINDIANAPOLIS, IN
2 programs
1
1
LY2623091Phase 21 trial
LY3113593Phase 11 trial
Active Trials
NCT02604160Completed7Est. Jun 2016
NCT01427972Completed42Est. Mar 2013
OD
2 programs
1
1
epoetin alfaPhase 2
epoetin alfaPhase 1
Atom Therapeutics
Atom TherapeuticsChina - Suzhou
1 program
1
ABP-671 plus febuxostat Group 1Phase 21 trial
Active Trials
NCT07323095Not Yet RecruitingEst. Jan 2028
Hansa Biopharma
Hansa BiopharmaSweden - Lund
1 program
1
IdeSPhase 21 trial
Active Trials
NCT02224820CompletedEst. Feb 2015
Mineralys Therapeutics
1 program
1
Lorundrostat 25mg+SGLT2i QD, Washout, Placebo+SGLT2i QDPhase 21 trial
Active Trials
NCT06150924Completed60Est. Apr 2025
Pfizer
PfizerNEW YORK, NY
1 program
1
OpenPhase 25 trials
Active Trials
NCT00002077Completed
NCT00002040Completed
NCT00002090Completed
+2 more trials
Akebia Therapeutics
Akebia TherapeuticsCAMBRIDGE, MA
1 program
1
VadadustatPhase 2Small Molecule1 trial
Active Trials
NCT04707573CompletedEst. Sep 2010
J&
Johnson & JohnsonNEW BRUNSWICK, NJ
1 program
1
epoetin alfaPhase 21 trial
Active Trials
NCT00212875Completed267Est. Feb 2007
Novartis
NovartisBASEL, Switzerland
1 program
1
SBR759Phase 1/23 trials
Active Trials
NCT00704678Completed203
NCT00704483Completed321
NCT00750295Completed60Est. Jan 2008
Biogen
BiogenCAMBRIDGE, MA
1 program
1
20 mg bardoxolone methylPhase 11 trial
Active Trials
NCT01500798Terminated18Est. Oct 2013
DiaMedica Therapeutics
DiaMedica TherapeuticsMINNEAPOLIS, MN
1 program
1
DM199Phase 11 trial
Active Trials
NCT03795389CompletedEst. Jul 2019
M&
Merck & Co.RAHWAY, NJ
2 programs
Human Papillomavirus VaccineN/AVaccine1 trial
Mechanisms of Chronic Kidney Disease (CKD)-Induced Foam Cell FormationN/A1 trial
Active Trials
NCT00767897Completed72Est. Dec 2018
NCT01671605Completed103Est. Apr 2015
Pulse Biosciences
Pulse BiosciencesCA - Hayward
1 program
Control FoodN/A1 trial
Active Trials
NCT01842087CompletedEst. Nov 2010
Providence Therapeutics
1 program
Medication Information Transfer InterventionN/A1 trial
Active Trials
NCT01459770CompletedEst. Apr 2016
Regeneron
RegeneronTARRYTOWN, NY
1 program
University of Michigan "Nephrology Research BioBank"N/A1 trial
Active Trials
NCT00381121Recruiting420Est. Aug 2030
Takeda
TakedaTOKYO, Japan
1 program
Uric Acid and Long-term Outcomes in Chronic Kidney DiseaseN/A1 trial
Active Trials
NCT01158911Completed838

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
2028
2029
GenentechRecombinant Human Growth Hormone
PfizerOpen
AbbVieViekira Pak ± ribavirin
PfizerOpen
PfizerOpen
AbbottCalcitriol
PfizerOpen
PfizerOpen
PfizerOpen
PfizerOpen
AbbottCalcitriol
AbbottCalcitriol
AbbottCalcitriol
PfizerOpen
PfizerOpen

Showing 15 of 50 trials with date data

Clinical Trials (50)

Total enrollment: 30,574 patients across 50 trials

NCT00194961GenentechRecombinant Human Growth Hormone

Effect of Growth Hormone on Leptin, Cytokines and Body Composition of Children With Growth Failure Due to Chronic Kidney Disease

Est. completion: Dec 200715 patients
Phase 4Terminated

A Randomized, Open-label, Multi-center Phase IV Study Evaluating Palbociclib Plus Endocrine Treatment Versus a Chemotherapy-based Treatment Strategy in Patients With Hormone Receptor Positive / HER2 Negative Breast Cancer in a Real World Setting (GBG 93 - PADMA Study).

Start: Mar 2018Est. completion: Aug 2024130 patients
Phase 4Completed
NCT02946034AbbVieViekira Pak ± ribavirin

Viekira Pak or Mavyret Treatment for Patient With Chronic Kidney Disease and Hepatitis C

Start: Feb 2017Est. completion: Sep 202010 patients
Phase 4Completed

A Study of Apixaban in Patients With Atrial Fibrillation, Not Caused by a Heart Valve Problem, Who Are at Risk for Thrombosis (Blood Clots) Due to Having Had a Recent Coronary Event, Such as a Heart Attack or a Procedure to Open the Vessels of the Heart

Start: Jun 2015Est. completion: Nov 20184,614 patients
Phase 4Completed

Open-Label, Safety Study Evaluating the Use of Dexmedetomidine in Pediatric Subjects Undergoing Procedure-Type Sedation

Start: Oct 2012Est. completion: Jan 201491 patients
Phase 4Completed

A Pilot Clinical Study Evaluating the Effect of Parathyroid Hormone (PTH) Lowering On Erythropoietin Consumption in Calcitriol-Resistant Patients

Start: May 2012Est. completion: Apr 201665 patients
Phase 4Completed

Open-Label Drug Interaction Study Evaluating Desvenlafaxine Succinate Sustained Release (DVS SR) 100mg On The Pharmacokinetics Of Tamoxifen When Coadministered To Healthy Post-Menopausal Female Subjects

Start: Aug 2010Est. completion: Oct 201030 patients
Phase 4Completed

Open Label Study To Evaluate The Long-Term Safety Profiles Of Caduet In Japanese Patients

Start: Aug 2010Est. completion: Feb 2012159 patients
Phase 4Completed

Value of the LightCycler® SeptiFast Test MGRADE for the Pathogen Detection in Neutropenic Hematological Patients

Start: May 2010Est. completion: Sep 2012150 patients
Phase 4Completed

Local, Open-Label, Extension Trial Of The Efficacy And Safety Of Fesoterodine In Elderly Patients With Overactive Bladder

Start: May 2010Est. completion: Jan 201231 patients
Phase 4Completed

Paricalcitol Versus Calcitriol for Efficacy and Safety in Stage 3/4 Chronic Kidney Disease (CKD) With Secondary Hyperparathyroidism (SHPT)

Start: Feb 2009Est. completion: Sep 2013110 patients
Phase 4Completed

Efficacy and Safety of Paricalcitol on the Treatment of Secondary Hyperparathyroidism in Calcitriol Resistant Dialysis Subjects

Start: Jan 2009Est. completion: Jun 200913 patients
Phase 4Terminated

Vitamin D and Coronary Calcification Study

Start: Sep 2008Est. completion: Oct 201344 patients
Phase 4Completed

This Is An Open-Label, Non-Comparative Study Designed To Evaluate A Short Course Of IV Anidulafungin, Followed Optionally By Oral Voriconazole, For The Treatment Of Candidemia And Invasive Candidiasis

Start: Feb 2008Est. completion: Oct 200954 patients
Phase 4Completed

An Open Label Pharmacokinetic Study Of Gabapentin In Japanese Subjects With Renal Impairment Including Hemodialysis

Start: Oct 2007Est. completion: Dec 20078 patients
Phase 4Terminated

A Multicenter, Open Label, To Evaluate The Efficacy And Satisfaction Of Patrex® In Men With Erectile Dysfunction.

Start: Jun 2007Est. completion: Feb 2008117 patients
Phase 4Completed

Open Label Comparative Study On Celecoxib Efficacy And Safety Vs Non-Selective NSAID In Acute Pain Due To Ankle Sprain

Start: May 2007Est. completion: Apr 2008278 patients
Phase 4Completed

Pregabalin In Partial Seizures (PREPS): An Open-Label, Multicenter Add On Therapy Trial

Start: Mar 2007Est. completion: Aug 2009136 patients
Phase 4Terminated

Open Label Non-comparative Clinical Trial of Tigecycline in Patients With Catheter Infection

Start: Jan 2007Est. completion: May 200810 patients
Phase 4Completed

An Open Label Trial to Investigate Macugen for the Preservation of Visual Function in Subjects With Neovascular AMD

Start: Jul 2006Est. completion: Aug 2009288 patients
Phase 4Terminated

Open Label Comparative Study Of De Novo Renal Allograft Recipients Receiving CSA + MMF + Corticosteroids Versus CSA + Rapamune + Corticosteroids

Start: Apr 2006Est. completion: Mar 2008245 patients
Phase 4Completed

Pregabalin for Abdominal Pain From Adhesions

Start: Mar 2006Est. completion: Aug 200818 patients
Phase 4Terminated

An Open Label Study To Evaluate The Safety and Kinetics of Nelfinavir in Subjects With HIV and Hepatitis C

Start: Oct 2005Est. completion: Dec 200612 patients
Phase 4Completed

Pregabalin In Partial Seizures: An Open-Label, International, Multicenter Add-On Therapy Trial.

Start: Nov 2004Est. completion: May 2006540 patients
Phase 4Completed

An Open-Label Multicentre Long-Term Extension Study of Etanercept for Ankylosing Spondylitis

Start: Apr 2004Est. completion: Jul 200770 patients
Phase 4Completed

A Study to Assess the Efficacy of 3 Months of Latanoprost Treatment in Reducing the Intraocular Pressure in Patients With Ocular Hypertension or Open-angle Glaucoma

Start: Dec 2003Est. completion: Feb 2005600 patients
Phase 4Completed

12 Week Open, Non-Comparative Switch Study Of Oral Ziprazidone In Previously Treated Schizophrenic Patients

Start: Nov 2003Est. completion: Feb 2005150 patients
Phase 4Terminated

A Randomized, Open-Label, Crossover, Multicenter, Single Dose Comparator Study Evaluating Onset Of Penile Rigidity In Men With Erectile Dysfunction Who Are Treated With Sildenafil And Tadalafil

Start: Jun 2003Est. completion: Nov 200356 patients
Phase 4Completed

A Study to Determine if Antibiotics Prevent Infection in the Pancreas of Patients Where Part of the Pancreas Has Died

Start: Feb 2003Est. completion: Dec 2004240 patients
Phase 4Completed

Multicenter, Open, Randomized Comparative Trial To Compare The Efficacy Of Azithromycin Versus Amoxicillin In Children With Strep Throat

Start: Dec 2002Est. completion: Jul 2003360 patients
Phase 4Completed

Evaluation of Pancreatic Tissue Penetration of Meronem® in the Prophylaxis of Septic Complications in Severe Pancreatitis

Start: Feb 2002Est. completion: May 20076 patients
Phase 4Completed

Pharmacoeconomic Analysis of First Line Meropenem Versus Standard Antibiotic Treatment in Seriously Infected Secondary Nosocomial Sepsis Syndrome Patients.

Start: Jan 2002Est. completion: Jun 2006160 patients
Phase 4Completed

Anti-Oxidant Therapy In Chronic Renal Insufficiency (ATIC) Study

Start: May 2001Est. completion: Aug 2005100 patients
Phase 4Terminated

Growth Hormone Treatment in Infants Aged 1 to 2 Years With Chronic Renal Insufficiency (CRI) and Growth Retardation.

Start: Jan 1998Est. completion: Dec 200516 patients
Phase 4Completed

A Study to Find Out How EMPAgliflozin is Tolerated and if it Helps Children and Adolescents With Chronic KIDNEY Disease (EMPA-KIDNEY® Kids)

Start: Dec 2025Est. completion: Jun 2029120 patients
Phase 3Recruiting

A Study to Learn How Well the Study Treatment Finerenone Works and How Safe it is in People With Long-term Decrease in the Kidneys' Ability to Work Properly (Chronic Kidney Disease) Together With Type 1 Diabetes

Start: Feb 2024Est. completion: Sep 2025241 patients
Phase 3Completed

A Study of Roxadustat to Treat Anemia in Children and Teenagers With Chronic Kidney Disease

Start: Jan 2024Est. completion: Oct 2027100 patients
Phase 3Recruiting

Pharmacokinetics and Safety of MB-102 (Relmapirazin) and the MediBeacon Transdermal GFR Measurement System in Evaluation of Kidney Function in Normal and Renal Compromised Subjects

Start: Jun 2022Est. completion: Feb 2023249 patients
Phase 3Completed

A Study to Learn More About How Well the Study Treatment Finerenone Works, How Safe it is, How it Moves Into, Through, and Out of the Body, and the Effects it Has on the Body When Taken With an ACE Inhibitor or Angiotensin Receptor Blocker in Children With Chronic Kidney Disease and Proteinuria

Start: Mar 2022Est. completion: Aug 2027219 patients
Phase 3Recruiting

Open-Label Extension of Voxelotor

Start: Nov 2019Est. completion: Nov 2024162 patients
Phase 3Terminated

EMPA-KIDNEY (The Study of Heart and Kidney Protection With Empagliflozin)

Start: Jan 2019Est. completion: Jul 20246,609 patients
Phase 3Completed

A Study to Determine the Efficacy, Safety and Tolerability of Aztreonam-Avibactam (ATM-AVI) ± Metronidazole (MTZ) Versus Meropenem (MER) ± Colistin (COL) for the Treatment of Serious Infections Due to Gram Negative Bacteria.

Start: Apr 2018Est. completion: Feb 2023422 patients
Phase 3Completed

A Study of Intermittent Oral Dosing of ASP1517 in ESA-untreated Chronic Kidney Disease Patients With Anemia

Start: Jan 2017Est. completion: Aug 2018100 patients
Phase 3Completed

Efficacy and Safety of Finerenone in Subjects With Type 2 Diabetes Mellitus and Diabetic Kidney Disease

Start: Sep 2015Est. completion: Apr 20205,734 patients
Phase 3Completed

Open-label Long-term Extension Study of Fesoterodine in Japanese Subjects With Neurogenic Detrusor Overactivity.

Start: Jun 2015Est. completion: Apr 202012 patients
Phase 3Completed

Safety and Efficacy Study of Enzalutamide Plus Leuprolide in Patients With Nonmetastatic Prostate Cancer (EMBARK)

Start: Dec 2014Est. completion: Sep 20261,068 patients
Phase 3Active Not Recruiting

A Multicenter Phase 3, Open-Label Study of Bosutinib Versus Imatinib in Adult Patients With Newly Diagnosed Chronic Phase Chronic Myelogenous Leukemia

Start: Jul 2014Est. completion: Apr 2020536 patients
Phase 3Completed

Study Of Diabetic Nephropathy With Atrasentan

Start: May 2013Est. completion: Mar 20185,107 patients
Phase 3Terminated
NCT02282813Opko HealthCTAP101 Capsules

Extension Study of CTAP101-CL-3001 or CTAP101-CL-3002

Start: Apr 2013Est. completion: May 2015
Phase 3Completed

A Study Comparing Ceftazidime-Avibactam Versus Meropenem in Hospitalized Adults With Nosocomial Pneumonia

Start: Apr 2013Est. completion: Jan 2016969 patients
Phase 3Completed

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

18 late-stage (Phase 3) programs — potential near-term approvals
3 actively recruiting trials targeting 30,574 patients
30 companies competing in this space