Acute Kidney Injury

Nephrology
9
Pipeline Programs
14
Companies
10
Clinical Trials
1 recruiting
1
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
1
0
6
0
1
1
Early DiscoveryClinical DevelopmentMarket

On Market (1)

Approved therapies currently available

U
DEFERIPRONEApproved
deferiprone
Unknown Company
Iron Chelator [EPC]oral2025

Competitive Landscape

10 companies ranked by most advanced pipeline stage

CorMedix
CorMedixPARSIPPANY, NJ
1 program
1
deferipronePhase 31 trial
Active Trials
NCT01391520Withdrawn0Est. Jun 2013
MediBeacon
MediBeaconGermany - Mannheim
2 programs
1
MB-102-- single dose of 4 µmol/kgPhase 21 trial
Brilliance device sensorN/A1 trial
Active Trials
NCT03810833Completed12Est. Sep 2019
NCT02772276Completed234Est. Aug 2021
AbbVie
AbbVieNORTH CHICAGO, IL
1 program
1
ABT-719Phase 22 trials
Active Trials
NCT01897519Terminated56Est. May 2014
NCT01777165Completed240Est. Mar 2014
Stuart Therapeutics
1 program
1
Amino Acid infusionPhase 2
Mereo BioPharma
Mereo BioPharmaUK - London
1 program
1
BCT197 Part APhase 2
Genentech
GenentechCA - Oceanside
1 program
1
GDC-8264Phase 21 trial
Active Trials
NCT06602453Recruiting404Est. Mar 2026
AM-Pharma
AM-PharmaNetherlands - Utrecht
1 program
1
recAPPhase 21 trial
Active Trials
NCT02182440CompletedEst. Sep 2017
Renibus Therapeutics
Renibus TherapeuticsTX - Southlake
1 program
1
FeS and SnPPPhase 11 trial
Active Trials
NCT03630029WithdrawnEst. Mar 2019
Mozarc Medical
Mozarc MedicalMN - Minneapolis
1 program
CARPEDIEMN/A1 trial
Active Trials
NCT05161078Enrolling By InvitationEst. Dec 2031
Abbott
AbbottABBOTT PARK, IL
1 program
Rapid Evaluation of Acute Kidney Injury With NGAL in Acutely Ill Patients in the ICUN/A1 trial
Active Trials
NCT01294228Completed1,001Est. Dec 2014

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
2028
2029
2030
2031
CorMedixdeferiprone
GenentechGDC-8264
MediBeaconMB-102-- single dose of 4 µmol/kg
AM-PharmarecAP
AbbVieABT-719
AbbVieABT-719
Renibus TherapeuticsFeS and SnPP
Mozarc MedicalCARPEDIEM
MediBeaconBrilliance device sensor
AbbottRapid Evaluation of Acute Kidney Injury With NGAL in Acutely Ill Patients in the ICU

Clinical Trials (10)

Total enrollment: 1,947 patients across 10 trials

NCT01391520CorMedixdeferiprone

Efficacy and Safety of Deferiprone in Patients With Chronic Kidney Disease Undergoing a Cardiac Catheterization and Receiving Contrast Agent

Start: Jan 2012Est. completion: Jun 20130
Phase 3Withdrawn
NCT06602453GenentechGDC-8264

A Study to Evaluate the Efficacy and Safety of GDC-8264 in Preventing Cardiac Surgery-Associated Acute Kidney Injury (AKI) and Major Adverse Kidney Events (MAKE)

Start: Jan 2025Est. completion: Mar 2026404 patients
Phase 2Recruiting
NCT02772276MediBeaconMB-102-- single dose of 4 µmol/kg

Pharmacokinetics of MB-102 and Use of the Non-invasive Optical Renal Function Monitor (ORFM) Device in Subjects With Normal and Impaired Renal Function and a Range of Skin Color Types

Start: May 2016Est. completion: Aug 2021234 patients
Phase 2Completed
NCT02182440AM-PharmarecAP

A Safety, Tolerability, Efficacy and QoL Study of Human recAP in the Treatment of Patients With SA-AKI

Start: Dec 2014Est. completion: Sep 2017
Phase 2Completed
NCT01897519AbbVieABT-719

A Safety and Efficacy Trial of Multiple Dosing Regimens of ABT-719 for the Prevention of Acute Kidney Injury in Subjects Undergoing High Risk Surgery

Start: May 2013Est. completion: May 201456 patients
Phase 2Terminated
NCT01777165AbbVieABT-719

A Safety and Efficacy Trial of Multiple Dosing Regimens of ABT-719 for the Prevention of Acute Kidney Injury in Subjects Undergoing High Risk Cardiac Surgery

Start: Feb 2013Est. completion: Mar 2014240 patients
Phase 2Completed
NCT03630029Renibus TherapeuticsFeS and SnPP

RBT-1 Phase 1b Clinical Trial in Healthy Volunteers and Subjects With CKD

Start: Sep 2018Est. completion: Mar 2019
Phase 1Withdrawn
NCT05161078Mozarc MedicalCARPEDIEM

Improving Continuous Renal Replacement Therapy Outcomes in Neonates and Infants Through Interdisciplinary Collaboration

Start: Dec 2021Est. completion: Dec 2031
N/AEnrolling By Invitation
NCT03810833MediBeaconBrilliance device sensor

Tolerability and Background Fluorescence of the MediBeacon Transdermal GFR Measurement System

Start: Sep 2019Est. completion: Sep 201912 patients
N/ACompleted
NCT01294228AbbottRapid Evaluation of Acute Kidney Injury With NGAL in Acutely Ill Patients in the ICU

Rapid Evaluation of Acute Kidney Injury With NGAL in Acutely Ill Patients in the ICU

Start: Mar 2011Est. completion: Dec 20141,001 patients
N/ACompleted

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Phase Legend

Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available

Key Insights

1 late-stage (Phase 3) programs — potential near-term approvals
1 actively recruiting trials targeting 1,947 patients
14 companies competing in this space

Related Indications

Chronic Kidney Disease(86)Renal Impairment(67)End Stage Renal Disease(56)Kidney Transplantation(49)Renal Insufficiency(27)Chronic Kidney Diseases(25)Kidney Transplant(19)Diabetic Nephropathies(18)Kidney Diseases(17)Kidney Transplant Rejection(16)