Leiomyosarcoma

Oncology
8
Pipeline Programs
7
Companies
8
Clinical Trials
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
3
0
4
1
0
0
Early DiscoveryClinical DevelopmentMarket

Competitive Landscape

7 companies ranked by most advanced pipeline stage

PTC Therapeutics
2 programs
1
1
UnesbulinPhase 2/31 trial
UnesbulinPhase 11 trial
Active Trials
NCT03761095Completed41Est. Feb 2024
NCT05269355Terminated359Est. Jul 2024
Recordati
RecordatiFrance - Saint-Victor
1 program
1
Dinutuximab Beta, Zoledronic acid, Interleukin-2Phase 21 trial
Active Trials
NCT05080790Completed7Est. Jan 2025
Philogen
PhilogenItaly - Monteriggioni
1 program
1
DoxorubicinPhase 21 trial
Active Trials
NCT03420014Unknown114Est. Dec 2025
Pfizer
PfizerNEW YORK, NY
1 program
1
OntorpaceptPhase 21 trial
Active Trials
NCT04996004Terminated76Est. Dec 2023
Bristol Myers Squibb
1 program
1
RucaparibPhase 21 trial
Active Trials
NCT04624178Active Not Recruiting20Est. Nov 2026
Highlight Therapeutics
Highlight TherapeuticsSpain - Valencia
1 program
1
Definitive Surgical ResectionPhase 11 trial
Active Trials
NCT04420975Active Not Recruiting14Est. Jan 2028
Heidelberg Pharma
Heidelberg PharmaGermany - Ladenburg
1 program
1
Gemcitabine + TrabectedinPhase 11 trial
Active Trials
NCT01426633Completed5Est. Dec 2014

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
2028
PTC TherapeuticsUnesbulin
RecordatiDinutuximab Beta, Zoledronic acid, Interleukin-2
PfizerOntorpacept
Bristol Myers SquibbRucaparib
PhilogenDoxorubicin
Highlight TherapeuticsDefinitive Surgical Resection
PTC TherapeuticsUnesbulin
Heidelberg PharmaGemcitabine + Trabectedin

Clinical Trials (8)

Total enrollment: 636 patients across 8 trials

NCT05269355PTC TherapeuticsUnesbulin

A Study of Unesbulin in Participants With Advanced Leiomyosarcoma (LMS)

Start: May 2022Est. completion: Jul 2024359 patients
Phase 2/3Terminated
NCT05080790RecordatiDinutuximab Beta, Zoledronic acid, Interleukin-2

Treatment With Dinutuximab Beta, Zoledronic Acid and Low-dose Interleukin (IL-2) in Patients With Leiomyosarcoma

Start: Nov 2021Est. completion: Jan 20257 patients
Phase 2Completed
NCT04996004PfizerOntorpacept

A Study to Learn About the Study Medicine (Called Ontorpacept or TTI-621) Given Alone and in Combination With Doxorubicin in People With Leiomyosarcoma

Start: Jun 2021Est. completion: Dec 202376 patients
Phase 2Terminated
NCT04624178Bristol Myers SquibbRucaparib

A Study of Rucaparib and Nivolumab in People With Leiomyosarcoma

Start: Nov 2020Est. completion: Nov 202620 patients
Phase 2Active Not Recruiting
NCT03420014PhilogenDoxorubicin

Treatment of Metastatic Soft Tissue Sarcoma (STS) Patients (FIBROSARC USA)

Start: Dec 2018Est. completion: Dec 2025114 patients
Phase 2Unknown
NCT04420975Highlight TherapeuticsDefinitive Surgical Resection

Nivolumab and BO-112 Before Surgery for the Treatment of Resectable Soft Tissue Sarcoma

Start: Oct 2020Est. completion: Jan 202814 patients
Phase 1Active Not Recruiting
NCT03761095PTC TherapeuticsUnesbulin

A Study of Unesbulin (PTC596) in Combination With Dacarbazine in Participants With Advanced Leiomyosarcoma (LMS)

Start: Mar 2019Est. completion: Feb 202441 patients
Phase 1Completed
NCT01426633Heidelberg PharmaGemcitabine + Trabectedin

Combination Therapy of Gemcitabine and Trabectedin in L-sarcomas

Start: Nov 2011Est. completion: Dec 20145 patients
Phase 1Completed

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Phase Legend

Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available

Key Insights

7 companies competing in this space

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