Solid Tumor

Oncology
144
Pipeline Programs
30
Companies
50
Clinical Trials
10 recruiting
4
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
87
37
15
0
0
5
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Monoclonal Antibody
844%
Small Molecule
739%
ADC
211%
Cell Therapy
16%
+ 123 programs with unclassified modality

On Market (4)

Approved therapies currently available

U
BILDYOSApproved
denosumab
Unknown Company
RANK Ligand Inhibitor [EPC]injection2025
U
BILPREVDAApproved
denosumab
Unknown Company
RANK Ligand Inhibitor [EPC]injection2025
Amgen
PROLIAApproved
denosumab
Amgen
RANK Ligand Inhibitor [EPC]subcutaneous2010
Amgen
XGEVAApproved
denosumab
Amgen
RANK Ligand Inhibitor [EPC]subcutaneous2010

Competitive Landscape

77 companies ranked by most advanced pipeline stage

Amgen
1 program
1
denosumabPhase 4Monoclonal Antibody1 trial
Active Trials
NCT02101164Withdrawn0Est. Nov 2014
GS
Gilead SciencesFOSTER CITY, CA
8 programs
3
1
4
MagrolimabPhase 2Monoclonal Antibody1 trial
MagrolimabPhase 2Monoclonal Antibody
Sacituzumab Govitecan-hziyPhase 2ADC1 trial
Sacituzumab Govitecan-hziyPhase 2ADC
MagrolimabPhase 1/2Monoclonal Antibody5 trials
+3 more programs
Active Trials
NCT05840224Active Not Recruiting182Est. Jul 2026
NCT02216409Completed88Est. Dec 2018
NCT05627466No Longer Available
+6 more trials
Novartis
3 programs
1
1
1
BGJ398Phase 21 trial
68Ga-FAP-2286Phase 1/21 trial
INCB028060Phase 11 trial
Active Trials
NCT01072266Completed45Est. Jan 2013
NCT04939610Recruiting222Est. Jun 2028
NCT02160041Terminated84Est. Apr 2018
PharmaEssentia
2 programs
1
1
OraxolPhase 21 trial
HM30181 methanesulfonate monohydrate plus oral paclitaxel capsulesPhase 11 trial
Active Trials
NCT04035473CompletedEst. Mar 2019
NCT04180384CompletedEst. Jun 2021
Ipsen
IpsenChina - Tianjin
2 programs
1
1
TazemetostatPhase 2Small Molecule1 trial
IPN60090Phase 11 trial
Active Trials
NCT03894540Terminated22Est. Dec 2020
NCT05023655Recruiting40Est. Jan 2028
Eli Lilly and Company
Eli Lilly and CompanyINDIANAPOLIS, IN
2 programs
1
1
CetuximabPhase 2Monoclonal Antibody1 trial
LY3435151Phase 11 trial
Active Trials
NCT04099277Terminated2Est. Mar 2020
NCT01063075Completed34Est. Oct 2015
Pfizer
PfizerNEW YORK, NY
2 programs
1
1
LGX818Phase 21 trial
TalazoparibPhase 11 trial
Active Trials
NCT03042910Completed38Est. Jun 2017
NCT01981187Terminated12Est. Oct 2015
Genesis Therapeutics
1
1
Technetium [99mTc]-H7ND injectionPhase 21 trial
Technetium [99mTc]-H7ND injectionPhase 11 trial
Active Trials
NCT06443710CompletedEst. Nov 2024
NCT07107633RecruitingEst. Sep 2025
Bayer
2 programs
1
1
BAY 1000394Phase 21 trial
TopotecanPhase 11 trial
Active Trials
NCT01683149Completed13Est. Jan 2016
NCT02656849Withdrawn0Est. May 2023
CytomX Therapeutics
CytomX TherapeuticsSOUTH SAN FRANCISCO, CA
2 programs
1
1
CX-072Phase 21 trial
CX-072Phase 1/21 trial
Active Trials
NCT03013491TerminatedEst. Oct 2020
NCT03993379TerminatedEst. May 2020
Debiopharm
DebiopharmSwitzerland - Lausanne
2 programs
1
1
Debio 1347Phase 21 trial
Debio 1143Phase 1/21 trial
Active Trials
NCT04122625CompletedEst. Apr 2022
NCT03834220TerminatedEst. Jan 2022
Tempus
1 program
1
NiraparibPhase 21 trial
Active Trials
NCT05169437Terminated22Est. Aug 2024
J&
1
TrabectedinPhase 21 trial
Active Trials
NCT00786838Completed76Est. Dec 2009
M&
9 programs
8
1
INBRX-106 - Hexavalent OX40 agonist antibodyPhase 1/21 trial
ARQ 092Phase 11 trial
ARQ 736Phase 11 trial
DalotuzumabPhase 1Monoclonal Antibody1 trial
EMD525797Phase 11 trial
+4 more programs
Active Trials
NCT01473095Completed120Est. Aug 2017
NCT01225536Completed24Est. Mar 2013
NCT00701103Completed80Est. Dec 2009
+6 more trials
Bristol Myers Squibb
3
1
CM-24 and Nivolumab - Dose EscalationPhase 1/21 trial
ATG-017Phase 11 trial
HuMax-IL8Phase 11 trial
SAR302503Phase 15 trials
TocilizumabN/AMonoclonal Antibody1 trial
Active Trials
NCT03601611Completed20Est. Jan 2020
NCT04305249Terminated36Est. May 2024
NCT02536469Completed15Est. Nov 2016
+6 more trials
E
5 programs
4
1
Farletuzumab ecteribulinPhase 1/21 trial
E7050Phase 11 trial
E7389-LFPhase 11 trial
MORAb-004Phase 11 trial
lenvatinibPhase 1Small Molecule1 trial
Active Trials
NCT01428141Completed18Est. Jul 2013
NCT03207672Active Not Recruiting140Est. Mar 2027
NCT01773434Completed46Est. Oct 2016
+2 more trials
H
4 programs
2
2
HMPL-453Phase 1/21 trial
Surufatinib in combination with GemcitabinePhase 1/21 trial
EpitinibPhase 1Small Molecule1 trial
HMPL-453Phase 11 trial
Active Trials
NCT02590952Completed108Est. Apr 2019
NCT02966171Terminated14Est. Aug 2018
NCT05173142Unknown141Est. Aug 2025
+1 more trials
Adagene
AdageneJIANGSU, China
3 programs
2
1
ADG106 injectionPhase 1/21 trial
ADG106Phase 11 trial
ADG116Phase 11 trial
Active Trials
NCT03802955Completed62Est. Nov 2021
NCT04111445Terminated1Est. Apr 2021
NCT04775680Terminated25Est. Feb 2023
Alligator Bioscience
2
1
ALG.APV-527Phase 1/21 trial
ATOR-1015Phase 11 trial
ATOR-1017Phase 11 trial
Active Trials
NCT03782467CompletedEst. Mar 2021
NCT04144842CompletedEst. Mar 2023
NCT05934539UnknownEst. Dec 2025
Roche
3 programs
2
1
ipatasertibPhase 1/2Small Molecule1 trial
CapecitabinePhase 11 trial
RXDX-107Phase 11 trial
Active Trials
NCT02494596Completed19Est. Sep 2005
NCT02548390Terminated70Est. Sep 2016
NCT03673787Active Not Recruiting87Est. Mar 2026
Qilu Pharmaceutical
1
2
QLC1101+QL1203Phase 1/21 trial
QLS31905Phase 1/21 trial
QLF31907Phase 11 trial
Active Trials
NCT05150405UnknownEst. Jun 2024
NCT06949761Not Yet RecruitingEst. Jun 2027
NCT06041035UnknownEst. Oct 2025
InxMed
3 programs
3
D-1553Phase 1/21 trial
D1553Phase 1/21 trial
IN10018Phase 1/21 trial
Active Trials
NCT05379946Active Not Recruiting92Est. Dec 2025
NCT06166836Recruiting140Est. Dec 2028
NCT05982522Not Yet Recruiting72Est. Dec 2026
Biohaven
BiohavenNEW HAVEN, CT
2 programs
1
1
BHV-1510Phase 1/21 trial
BHV-1530Phase 11 trial
Active Trials
NCT06874335RecruitingEst. Mar 2029
NCT06384807RecruitingEst. Feb 2028
InnoCare
InnoCareChina - Beijing
2 programs
1
1
ICP-192Phase 1/21 trial
ICP-105Phase 11 trial
Active Trials
NCT03642834Completed21Est. Mar 2021
NCT03758664Unknown56Est. Dec 2024
Laekna Therapeutics
1
1
AfuresertibPhase 1/2Small Molecule1 trial
LAE005 + Afuresertib + Nab-PaclitaxelPhase 11 trial
Active Trials
NCT05390710CompletedEst. Dec 2023
NCT05383482CompletedEst. Jul 2024
Aptevo Therapeutics
1 program
1
ALG.APV-527Phase 1/2
Precision BioSciences
1 program
1
CEA CAR-T cellsPhase 1/2Cell Therapy1 trial
Active Trials
NCT04348643Unknown40Est. Apr 2024
Corbus Pharmaceuticals
1
CRB-601 monoclonal antibodyPhase 1/21 trial
Active Trials
NCT06603844Recruiting156Est. Dec 2026
BP
1
Derazantinib low dose rangePhase 1/2
Philogen
1 program
1
F16IL2 in combination with paclitaxelPhase 1/21 trial
Active Trials
NCT01134250Completed48Est. Apr 2014

+47 more companies

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
2028
2029
2030
2031
Amgendenosumab
Gilead SciencesMagrolimab
Bristol Myers SquibbSAR302503
Genesis TherapeuticsTechnetium [99mTc]-H7ND injection
Gilead SciencesMagrolimab
Gilead SciencesMagrolimab
Gilead SciencesMagrolimab
TempusNiraparib
IpsenTazemetostat
Gilead SciencesMagrolimab
Gilead SciencesSacituzumab Govitecan-hziy
Gilead SciencesMagrolimab
CytomX TherapeuticsCX-072
DebiopharmDebio 1347
BayerBAY 1000394

Showing 15 of 50 trials with date data

Clinical Trials (50)

Total enrollment: 3,300 patients across 50 trials

Evaluate Time Associated With the Preparation & Administration of Denosumab/Pamidronate in Patients With Solid Tumors and Metastatic Bone Disease

Start: Nov 2014Est. completion: Nov 20140
Phase 4Withdrawn

Magrolimab + Azacitidine Versus Azacitidine + Placebo in Untreated Participants With Myelodysplastic Syndrome (MDS)

Start: Sep 2020Est. completion: Sep 2023539 patients
Phase 3Terminated

Phase III Study of SAR302503 in Intermediate-2 and High Risk Patients With Myelofibrosis

Start: Dec 2011Est. completion: Jun 2014289 patients
Phase 3Completed
NCT07107633Genesis TherapeuticsTechnetium [99mTc]-H7ND injection

A Phase II Clinical Study to Evaluate the Efficacy and Safety of Technetium [99mtc]-H7ND Injection in the Diagnosis of Peritoneal Metastasis of Gastrointestinal Malignant Tumor.

Start: Mar 2025Est. completion: Sep 2025
Phase 2Recruiting

Magrolimab Plus Intensive Chemotherapy in Newly Diagnosed AML or HR-MDS

Start: Mar 2024Est. completion: Aug 20290
Phase 2Withdrawn

Phase II Trial of Magrolimab and Cetuximab With Pembrolizumab or Docetaxel for Recurrent/Metastatic Head Neck Squamous Cell Carcinoma

Start: Nov 2023Est. completion: Aug 20244 patients
Phase 2Terminated

Study of Magrolimab Given Together With FOLFIRI/Bevacizumab (BEV) in Participants With Previously Treated Advanced Inoperable Metastatic Colorectal Cancer (mCRC)

Start: Jul 2022Est. completion: Jun 202477 patients
Phase 2Terminated

Niraparib in the Treatment of Patients With Advanced PALB2 Mutated Tumors

Start: Mar 2022Est. completion: Aug 202422 patients
Phase 2Terminated
NCT05023655IpsenTazemetostat

Phase II Study of Tazemetostat in Solid Tumors Harboring an ARID1A Mutation

Start: Jan 2022Est. completion: Jan 202840 patients
Phase 2Recruiting

Study of Magrolimab Combinations in Patients With Relapsed/Refractory Multiple Myeloma

Start: Nov 2021Est. completion: Apr 202436 patients
Phase 2Terminated
NCT05119907Gilead SciencesSacituzumab Govitecan-hziy

Study of Sacituzumab Govitecan in Patients With Solid Tumor

Start: Oct 2021Est. completion: Oct 202653 patients
Phase 2Active Not Recruiting

Study of Magrolimab in Patients With Solid Tumors

Start: Oct 2021Est. completion: Oct 2024106 patients
Phase 2Terminated

PROCLAIM: CX-072-002: Study of PD-L1 Probody Therapeutic CX-072 in Combination With Other Anticancer Therapy in Adults With Solid Tumors

Start: Nov 2019Est. completion: May 2020
Phase 2Terminated

Basket Trial in Solid Tumors Harboring a Fusion of FGFR1, FGFR2 or FGFR3- (FUZE Clinical Trial)

Start: Mar 2019Est. completion: Jan 2022
Phase 2Terminated
NCT02656849BayerBAY 1000394

BAY 1000394 for MCL-1-, MYC-, and CCNE1-Amplified Tumors

Start: Feb 2016Est. completion: May 20230
Phase 2Withdrawn

A Safety Study of Oraxol (HM30181 + Oral Paclitaxel) in Cancer Patients

Start: Sep 2015Est. completion: Jun 2021
Phase 2Completed

BGJ398 for Patients With Tumors With FGFR Genetic Alterations

Start: Jul 2014Est. completion: Apr 201884 patients
Phase 2Terminated

LGX818 for Patients With BRAFV600 Mutated Tumors

Start: Jan 2014Est. completion: Oct 201512 patients
Phase 2Terminated

Phase 2 Study in Japanese Patients With Intermediate-2 or High Risk Primary Myelofibrosis, Post-Polycythemia Vera Myelofibrosis, Post-Essential Thrombocythemia Myelofibrosis With Splenomegaly

Start: Nov 2012Est. completion: Mar 20148 patients
Phase 2Completed

Phase II, Open Label, Single Arm Study of SAR302503 In Myelofibrosis Patients Previously Treated With Ruxolitinib

Start: Apr 2012Est. completion: Apr 201497 patients
Phase 2Completed

Study With SAR302503 in Patients With Polycythemia Vera or Essential Thrombocythemia

Start: Oct 2011Est. completion: May 201481 patients
Phase 2Completed

Phase 2 Study of SAR302503 in Patients With Myelofibrosis

Start: Aug 2011Est. completion: Apr 201430 patients
Phase 2Completed

A Study in Advanced Solid Tumors

Start: Jun 2010Est. completion: Oct 201534 patients
Phase 2Completed

A Study to Assess the Potential Effects of a Single-Dose Administration of Trabectedin on the QT Intervals of the Electrocardiogram

Start: Oct 2008Est. completion: Dec 200976 patients
Phase 2Completed

Phase 1/2 Study to Evaluate TH9619 in the Treatment of Advanced Solid Tumors

Start: Aug 2025Est. completion: Dec 2026
Phase 1/2Recruiting

IN10018 Combination Therapy in Previously-treated Solid Tumors

Start: Aug 2025Est. completion: Dec 202672 patients
Phase 1/2Not Yet Recruiting

A Clinical Study to Evaluate the Safety, Tolerability, and Efficacy of QLC1101 in Combination With Other Therapies in the Treatment of Patients With Advanced Solid Tumors Harboring a KRAS G12D Mutation

Start: Jun 2025Est. completion: Jun 2027
Phase 1/2Not Yet Recruiting
NCT06603844Corbus PharmaceuticalsCRB-601 monoclonal antibody

First-in-human Study of CRB-601-01 to Treat Patients With Advanced Solid Tumor.

Start: Dec 2024Est. completion: Dec 2026156 patients
Phase 1/2Recruiting

FIH Trial of VERT-002 in Patients With Locally Advanced or Metastatic Solid Tumors With MET Alterations

Start: Oct 2024Est. completion: Oct 2032140 patients
Phase 1/2Recruiting

A Phase 1/2 Study of BHV-1510 (Previously PBI-410) in Advanced Solid Tumors

Start: Apr 2024Est. completion: Feb 2028
Phase 1/2Recruiting

A Dose Escalation and Expansion Study of [177Lu]Lu-SN201 in Participants With Advanced Cancer

Start: Dec 2023Est. completion: Dec 2027
Phase 1/2Recruiting

A Study of QLS31905 Combination Chemotherapy as First-Line Treatment in Patients With Advanced Solid Tumors

Start: Oct 2023Est. completion: Oct 2025
Phase 1/2Unknown

A Study of OMX-0407 in Patients With Previously Treated Solid Tumours That Can't be Removed Surgically

Start: Mar 2023Est. completion: Jun 2026
Phase 1/2Active Not Recruiting

ALG.APV-527 First-in-human Study

Start: Dec 2022Est. completion: Dec 2025
Phase 1/2Unknown

a Study to Evaluate the Safety and Efficacy of D-1553 Combined With IN10018 in KRAS G12C Mutant Solid Tumors

Start: Oct 2022Est. completion: Dec 2028140 patients
Phase 1/2Recruiting

Study to Evaluate D-1553 in Combination With IN10018 in Subjects With Solid Tumors

Start: Oct 2022Est. completion: Dec 202592 patients
Phase 1/2Active Not Recruiting

Afuresertib +Sintilimab+Chemotherapy in Patients With Selected Solid Tumors That Resistance to Prior Anti-PD-1/PD-L1

Start: Jul 2022Est. completion: Jul 2024
Phase 1/2Completed

HMPL-453 (FGFR Inhibitor) in Combination With Chemotherapy or Anti-PD-1 Antibody in Advanced Solid Tumors

Start: Jan 2022Est. completion: Aug 2025141 patients
Phase 1/2Unknown
NCT05093322HutchmedSurufatinib in combination with Gemcitabine

A Study of Surufatinib in Combination With Gemcitabine in Pediatric, Adolescent, and Young Adult Patients With Recurrent or Refractory Solid Tumors

Start: Nov 2021Est. completion: Apr 202313 patients
Phase 1/2Completed

A Study of NDI 1150-101 in Patients With Solid Tumors

Start: Nov 2021Est. completion: May 2025
Phase 1/2Active Not Recruiting
NCT04939610Novartis68Ga-FAP-2286

A Study of 177Lu-FAP-2286 in Advanced Solid Tumors

Start: Jul 2021Est. completion: Jun 2028222 patients
Phase 1/2Recruiting

JAB-3312 Based Combination Therapy in Adult Patients With Advanced Solid Tumors

Start: Mar 2021Est. completion: Dec 202358 patients
Phase 1/2Completed
NCT04731467Bristol Myers SquibbCM-24 and Nivolumab - Dose Escalation

A Study of CM24 in Combination with Nivolumab in Adults with Advanced Solid Tumors

Start: Mar 2021Est. completion: Sep 202479 patients
Phase 1/2Completed
NCT04775680AdageneADG106 injection

Study of ADG106 In Combination With PD-1 Antibody In Advanced or Metastatic Solid Tumors and/or Non Hodgkin Lymphoma

Start: Mar 2021Est. completion: Feb 202325 patients
Phase 1/2Terminated
NCT04300556EisaiFarletuzumab ecteribulin

A Study to Evaluate the Safety, Tolerability, and Efficacy of MORAb-202 (Herein Referred to as Farletuzumab Ecteribulin), a Folate Receptor Alpha (FRα)-Targeting Antibody-drug Conjugate (ADC) in Participants With Selected Tumor Types

Start: Aug 2020Est. completion: Aug 2030182 patients
Phase 1/2Recruiting

Safety and Efficacy of CEA-Targeted CAR-T Therapy for Relapsed/Refractory CEA+ Cancer

Start: Feb 2020Est. completion: Apr 202440 patients
Phase 1/2Unknown
NCT04198766Merck & Co.INBRX-106 - Hexavalent OX40 agonist antibody

Study of INBRX-106 and INBRX-106 in Combination With Pembrolizumab (Keytruda®) in Subjects With Locally Advanced or Metastatic Solid Tumors (Hexavalent OX40 Agonist)

Start: Dec 2019Est. completion: May 2027296 patients
Phase 1/2Active Not Recruiting

Study to Assess Safety and Efficacy of the Second Mitochondrial-derived Activator of Caspases (SMAC) Mimetic Debio 1143

Start: Apr 2019Est. completion: Apr 2022
Phase 1/2Completed
NCT03647163VyriadVSV-IFNβ-NIS

Ph I/II Trial of Systemic VSV-IFNβ-NIS in Combination With Checkpoint Inhibitor Therapy in Patients With Select Solid Tumors

Start: Apr 2019Est. completion: Sep 2025
Phase 1/2Active Not Recruiting

Clinical Study of ICP-192 in Solid Tumors Patients

Start: Dec 2018Est. completion: Dec 202456 patients
Phase 1/2Unknown

Related Jobs in Oncology

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

10 actively recruiting trials targeting 3,300 patients
30 companies competing in this space