Colorectal Cancer
Pipeline by Development Stage
Drug Modality Breakdown
Colorectal Cancer is a $334M Part D market in peak maturity, dominated by two oral small molecules capturing 88% of spend.
Key Trends
- LONSURF (trifluridine/tipiracil) and STIVARGA (regorafenib) duopoly reflects late-stage disease focus
- Bevacizumab biosimilars (MVASI, ZIRABEV, ALYMSYS) fragmenting VEGF-directed segment despite originators' LOE approach
- High clinical trial load (1,372 trials) signals active pipeline development beyond current standard-of-care agents
Career Verdict
Colorectal cancer is a stable, well-established market suitable for commercial and medical affairs roles, but with limited innovation upside—early-career professionals should consider oncology subsegments with stronger growth signals.
AI-generated market analysis based on FDA, CMS, ClinicalTrials.gov, and hiring data
Market Leaders
| # | Product | Company | Revenue | Share | Stage | Trend | LOE |
|---|---|---|---|---|---|---|---|
| 1 | LONSURF (trifluridine and tipiracil) | Taiho Oncology | $176M | 53% | PEAK | Stable | 10.4yr |
| 2 | STIVARGA (regorafenib) | Bayer | $111M | 33% | PEAK | Stable | 5.8yr |
| 3 | MVASI (bevacizumab-awwb) | Amgen | $13M | 4% | PEAK | Stable | |
| 4 | AVASTIN (bevacizumab) | Roche | $12M | 4% | LOE_APPROACHING | Declining | |
| 5 | ZIRABEV (bevacizumab-bvzr) | Pfizer | $9M | 3% | PEAK | Stable |
Drug Class Breakdown
market standard, stable
multi-mechanism, stable
biosimilar fragmentation
legacy, declining
Career Outlook
StableColorectal cancer is a mature, well-capitalized market with predictable revenue, stable competitor positions, and ongoing clinical trial activity supporting R&D and operations employment. The dominance of two oral agents and lack of imminent blockbuster approvals limit upside, but the indication's established treatment guidelines and high patient volume (third-leading cancer) ensure consistent commercial demand. Career progression is most attractive in commercial leadership, medical affairs strategy, and clinical operations roles within large diversified oncology portfolios.
Breaking In
Entry-level professionals should target commercial (sales rep) or clinical operations roles at large oncology employers (J&J, Takeda, Roche) to build established-market acumen; colorectal cancer's stability makes it ideal for learning sales execution without pipeline uncertainty.
For Experienced Professionals
Experienced professionals should pursue medical affairs, product strategy, or clinical development roles to drive lifecycle extensions (combination trials, new patient populations) or transition to emerging oncology areas; staying too long in a mature, duopolistic segment risks skill stagnation.
In-Demand Skills
Best For
Hiring Landscape
Colorectal cancer specialization spans 8,589 jobs across 15 companies, but hiring is concentrated in large, diversified oncology employers (Johnson & Johnson, Takeda, AbbVie, AstraZeneca) rather than pure colorectal-focused boutiques. Commercial roles dominate (1,675 jobs, $225K avg), followed by engineering (710 jobs, outlier $2.375M avg) and medical affairs (264 jobs, $302K avg), indicating strong demand for sales, medical science liaisons, and technical product specialists.
Top Hiring Companies
By Department
Commercial and medical affairs roles offer stable, well-paid positions with large employers, but engineering outlier suggests demand for specialized manufacturing/analytics roles; hiring is steady rather than explosive.
On Market (6)
Approved therapies currently available
Competitive Landscape
162 companies ranked by most advanced pipeline stage
+132 more companies
Trial Timeline
Clinical trial activity over time
Showing 15 of 49 trials with date data
Clinical Trials (50)
Total enrollment: 27,853 patients across 50 trials
Anti-EGFR Agents in Patients With Right-sided Advanced Colorectal Cancer With Wild-type RAS and AREG/EREG High Status
A Trial to Evaluate the Safety and Activity of Fruquintinib in Minority Populations With Advanced, Previously Treated Colorectal Cancer
Dacomitinib for Treatment of Patients in India With Metastatic Non Small Cell Lung Cancer With EGFR Activating Mutations
Two Low Volume Regimens for Colorectal Cancer Screening Colonoscopy
Phase IV Panitumumab Study in Indian Subjects With Metastatic Colorectal Cancer
Radial Reload Laparoscopic LAR Case Series
A Study of Bevacizumab Plus 5-Flurouracil (5-FU) Based Doublet Chemotherapy as Neoadjuvant Therapy for Participants With Previously Untreated Unresectable Liver-Only Metastases From Colorectal Cancer
A Multi-centre Study Comparing the Polyp Detection Rate of Two Different Types of Bowel Preparation: a 2-litre Solution (MOVIPREP®) Versus a Hyperosmotic and Stimulant Combined Low Volume Bowel Preparation (Sodium Picosulfate and Magnesium Citrate)
A Study of The Safety Profile of First-line Avastin (Bevacizumab) in Combination With Paclitaxel in Patients With Locally Recurrent or Metastatic Her2-negative Breast Cancer (AVATAX)
PRIMADOS Study:A Study of Avastin (Bevacizumab) Plus Docetaxel for First Line Treatment of Patients With Metastatic Breast Cancer
A Study of Avastin (Bevacizumab) in Combination With Platinum-Containing Chemotherapy in Patients With Advanced or Recurrent Non-Squamous Cell Lung Cancer.
An Expanded Access Program of Pegfilgrastim (Neulastim) in Participants With Non-Hodgkin's Lymphoma (NHL)
Toxicity/Benefit Ratio Optimization of Chemotherapy in Colorectal Cancer (CRC) Patients by Determination of Individual Genotypic Determinants
Xeloda Vs Monitoring in Advanced Colorectal Cancer Responsive to Chemotherapy
Study of Zoldonrasib (RMC-9805) Plus Daraxonrasib (RMC-6236) Versus Gemcitabine and Nab-Paclitaxel as First-Line Treatment in Metastatic KRAS G12D-Mutated Pancreatic Adenocarcinoma
Personalizing Chemotherapy Selection After Surgery for Patients With Stage III Colorectal Cancer Using a Blood Test
A Study of Tucidinostat in Combination With Sintilimab and Bevacizumab in MSS/pMMR Colorectal Cancer Patients
A Study of Tucatinib With Trastuzumab and mFOLFOX6 Versus Standard of Care Treatment in First-line HER2+ Metastatic Colorectal Cancer
Study of XL092 + Atezolizumab vs Regorafenib in Participants With Metastatic Colorectal Cancer
Efficacy of HIPEC in Patients With Colorectal Cancer at High Risk of Peritoneal Carcinomatosis
A Two-Arm Study to Evaluate the Pharmacokinetics, Efficacy, and Safety of Subcutaneous Administration of the Fixed-Dose Combination of Pertuzumab and Trastuzumab in Combination With Chemotherapy in Chinese Participants With HER2-Positive Early Breast Cancer
RAMucirumab in Combination Wth TAS102 vs. TAS102 Alone in Chemotherapy Refractory Metastatic Colorectal Cancer Patients
Preventive Treatment of OxaLiplatin Induced peripherAl neuRopathy in Adjuvant Colorectal Cancer
Preventive Treatment of Oxaliplatin Induced Peripheral Neuropathy in Metastatic Colorectal Cancer (POLAR-M)
Study to Evaluate the Efficacy of FOLFOX + Panitumumab Followed by FOLFIRI + Bevacizumab (Sequence 1) Versus FOLFOX + Bevacizumab Followed by FOLFIRI + Panitumumab (Sequence 2) in Untreated Patients With Wild-type RAS Metastatic, Primary Left-sided, Unresectable Colorectal Cancer
Panitumumab and RAS, Diagnostically-useful Gene Mutation for mCRC
A Phase III Trial Evaluating Fruquintinib Efficacy and Safety in 3+ Line Colorectal Cancer Patients （FRESCO)
Multicenter Randomized Parallel Group Phase III Study Comparing the Bowel Cleansing Efficacy, Safety and Tolerability of NER1006 Versus a Sodium Picosulfate and Magnesium Salt Solution Using Day Before-Only Dosing Regimen in Adults.
Multicenter Randomized Parallel Group Phase III Study Comparing the Bowel Cleansing Efficacy, Safety and Tolerability of NER1006 Versus MOVIPREP® Using 2-Day Split-Dosing and 1-Day Morning Split-Dosing Regimen in Adults.
A Study of Participant Satisfaction and Safety With Subcutaneously Administered Trastuzumab (Herceptin) in Participants With Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Early Breast Cancer
Neoadjuvant Chemotherapy in HER2 Positive Breast Cancer, TRAIN-2
S-1 Versus Capecitabine in the First Line Treatment of MCC Patients.
Study of Trifluridine/Tipiracil (TAS-102) in Patients With Metastatic Colorectal Cancer in Asia
The Safety and Efficacy of Methylene Blue MMX® Modified Release Tablets Administered to Subjects Undergoing Screening or Surveillance Colonoscopy
Study of Prophylactic Topical Dapsone 5% Gel Versus Moisturizer for Cetuximab-induced Papulopustular (Acneiform) Rash in Patients With mCRC or HNSCC Without Previous or Concurrent RT
Study of TAS-102 in Patients With Metastatic Colorectal Cancer Refractory to Standard Chemotherapies
A Study of Herceptin (Trastuzumab) in Combination With Cisplatin/Capecitabine Chemotherapy in Participants With Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Metastatic Gastric or Gastro-Esophageal Junction Cancer
A Study of Avastin (Bevacizumab) in Combination With mFOLFOX6 in Treatment-Naïve Patients With Metastatic Colorectal Cancer With or Without K-RAS Mutations, and Comparison to Cetuximab
Study of Imprime PGG® in Combination With Cetuximab in Subjects With Recurrent or Progressive KRAS Wild Type Colorectal Cancer
A Study of Avastin (Bevacizumab) in Combination With Chemotherapy in Patients With Breast Cancer Progressing After First-Line Therapy With Avastin and Chemotherapy (TANIA)
Standard Therapy With or Without Surgery and Mitomycin C in Treating Patients With Advanced Limited Peritoneal Dissemination of Colon Cancer
Capecitabine (NX) Versus Docetaxel Plus Capecitabine (TX) as 1-line Chemotherapy on Metastatic Breast Cancer (MBC)
Oxaliplatin, Leucovorin Calcium, and Fluorouracil With or Without Celecoxib in Treating Patients With Stage III Colon Cancer Previously Treated With Surgery
AURELIA: A Study of Avastin (Bevacizumab) Added to Chemotherapy in Patients With Platinum-resistant Ovarian Cancer
AVAPERL1 Study: A Study of Avastin (Bevacizumab) With or Without Pemetrexed as Maintenance Therapy After Avastin in First Line in Patients With Non-Squamous Non-Small Cell Lung Cancer
A Study of Avastin (Bevacizumab) + Xeloda (Capecitabine)as Maintenance Therapy in Patients With HER2-Negative Metastatic Breast Cancer
Laparoscopic-Assisted Resection or Open Resection in Treating Patients With Rectal Cancer
BETH Study: Treatment of HER2 Positive Breast Cancer With Chemotherapy Plus Trastuzumab vs Chemotherapy Plus Trastuzumab Plus Bevacizumab
Tegafur-Uracil and Leucovorin or S-1 in Treating Patients With Stage III Colon Cancer That Has Been Completely Removed by Surgery
A Study of Avastin (Bevacizumab) and Xeloda (Capecitabine) as Maintenance Treatment in Patients With Metastatic Colorectal Cancer
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Key Insights
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.