Solid Tumours

Oncology
15
Pipeline Programs
11
Companies
20
Clinical Trials
7 recruiting
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
11
1
3
0
0
0
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Small Molecule
2100%
+ 14 programs with unclassified modality

Competitive Landscape

11 companies ranked by most advanced pipeline stage

Boehringer Ingelheim
Boehringer IngelheimINGELHEIM, Germany
3 programs
1
2
BrigimadlinPhase 21 trial
ZongertinibPhase 2Small Molecule1 trial
BI 3810944Phase 11 trial
Active Trials
NCT07224425Recruiting69Est. Oct 2029
NCT06619509Active Not Recruiting90Est. Dec 2030
NCT06581432Recruiting430Est. Dec 2028
Novartis
NovartisBASEL, Switzerland
1 program
1
PazopanibPhase 2Small Molecule1 trial
Active Trials
NCT01956669Completed57Est. Nov 2019
Bristol Myers Squibb
1 program
1
BMS-986517Phase 1/21 trial
Active Trials
NCT07160725Recruiting315Est. Aug 2028
AstraZeneca
AstraZenecaCAMBRIDGE, United Kingdom
4 programs
4
AZD1152Phase 11 trial
CYP1A2Phase 12 trials
Pharmacokinetic samplingPhase 14 trials
Treatment A - AZD1775 administered under fasted conditionsPhase 11 trial
Active Trials
NCT00497679Terminated45Est. Jul 2007
NCT03333824Completed33Est. Jan 2019
NCT00824057Completed24Est. Mar 2009
+5 more trials
AB
AP BiosciencesTaiwan - Taipei
1 program
1
AP601Phase 11 trial
Active Trials
NCT07165067RecruitingEst. Jan 2028
Debiopharm
DebiopharmSwitzerland - Lausanne
1 program
1
Debio1347Phase 11 trial
Active Trials
NCT01948297TerminatedEst. Jun 2020
Precision BioSciences
1 program
1
OKN4395Phase 11 trial
Active Trials
NCT06789172Recruiting166Est. Sep 2028
United Therapeutics
United TherapeuticsMD - Silver Spring
1 program
1
ONX-0801Phase 11 trial
Active Trials
NCT02360345Completed111Est. Mar 2021
Race Oncology
Race OncologyAustralia - Sydney
1 program
1
RC220Phase 11 trial
Active Trials
NCT06815575RecruitingEst. Jan 2029
CP
Chugai PharmaJapan - Tokyo
1 program
1
VS-6766Phase 11 trial
Active Trials
NCT02407509Completed104Est. Oct 2025
Roche
RocheSTAVANGER NORWAY, Norway
1 program
A Worldwide Cancer Registry Enrolling Participants Profiled With a Next-Generation Sequencing TestN/A1 trial
Active Trials
NCT04529122Recruiting15,000Est. Dec 2027

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
2028
2029
2030
Boehringer IngelheimBrigimadlin
Boehringer IngelheimZongertinib
NovartisPazopanib
Bristol Myers SquibbBMS-986517
Boehringer IngelheimBI 3810944
AP BiosciencesAP601
Race OncologyRC220
Precision BioSciencesOKN4395
AstraZenecaCYP1A2
AstraZenecaTreatment A - AZD1775 administered under fasted conditions
AstraZenecaPharmacokinetic sampling
AstraZenecaPharmacokinetic sampling
AstraZenecaPharmacokinetic sampling
AstraZenecaPharmacokinetic sampling
United TherapeuticsONX-0801

Showing 15 of 20 trials with date data

Clinical Trials (20)

Total enrollment: 16,778 patients across 20 trials

NCT06619509Boehringer IngelheimBrigimadlin

A Study to Test Long-term Treatment With Brigimadlin in People With Solid Tumours Who Took Part in a Previous Study With This Medicine

Start: Dec 2024Est. completion: Dec 203090 patients
Phase 2Active Not Recruiting
NCT06581432Boehringer IngelheimZongertinib

Beamion PANTUMOR-1: A Study to Test Whether Zongertinib Helps People With Advanced Cancers With HER2 Alterations

Start: Oct 2024Est. completion: Dec 2028430 patients
Phase 2Recruiting
NCT01956669NovartisPazopanib

Pazopanib Paediatric Phase II Trial Children's Oncology Group (COG) in Solid Tumors

Start: Oct 2014Est. completion: Nov 201957 patients
Phase 2Completed
NCT07160725Bristol Myers SquibbBMS-986517

A Phase 1/2a, First-in-human, Study of BMS-986517 in Participants With Advanced Solid Tumors

Start: Oct 2025Est. completion: Aug 2028315 patients
Phase 1/2Recruiting
NCT07224425Boehringer IngelheimBI 3810944

A Study in People With Advanced Cancer (Solid Tumours) to Test Different Doses of BI 3810944 and to Find Out Whether it Helps

Start: Feb 2026Est. completion: Oct 202969 patients
Phase 1Recruiting
NCT07165067AP BiosciencesAP601

A Study of AP601 in Patients With Locally Unresectable Advanced or Metastatic Solid Tumors

Start: Jan 2026Est. completion: Jan 2028
Phase 1Recruiting
NCT06815575Race OncologyRC220

A Safety and Pharmacokinetics Study of RC220 Combined With Doxorubicin in Adult Participants With Solid Tumours.

Start: Apr 2025Est. completion: Jan 2029
Phase 1Recruiting
NCT06789172Precision BioSciencesOKN4395

A Phase 1, First-in-human Study of OKN4395 and Pembrolizumab in Patients With Solid Tumors

Start: Jan 2025Est. completion: Sep 2028166 patients
Phase 1Recruiting
NCT03333824AstraZenecaCYP1A2

Effects of AZD1775 on the PK Substrates for CYP3A, CYP2C19, CYP1A2 and on QT Interval in Patients With Advanced Cancer

Start: Dec 2017Est. completion: Jan 201933 patients
Phase 1Completed
NCT03315091AstraZenecaTreatment A - AZD1775 administered under fasted conditions

Phase I Study to Assess the Effect of Food on AZD1775 Pharmacokinetics in Patients With Advanced Solid Tumours

Start: Sep 2017Est. completion: Apr 201831 patients
Phase 1Completed
NCT02161770AstraZenecaPharmacokinetic sampling

Study to Assess the Blood Levels and Safety of AZD9291 in Patients With Advanced Solid Tumours and Normal Liver Function or Mild or Moderate Liver Impairment

Start: Dec 2014Est. completion: Aug 201730 patients
Phase 1Completed
NCT02197234AstraZenecaPharmacokinetic sampling

Study to Assess the Effect of AZD9291 on the Blood Levels of Simvastatin in Patients With EGFRm+ NSCLC

Start: Dec 2014Est. completion: Jun 202452 patients
Phase 1Completed
NCT02224053AstraZenecaPharmacokinetic sampling

Drug-Drug Interaction Study With AZD9291 and Omeprazole in Healthy Volunteers

Start: Sep 2014Est. completion: Jan 2015136 patients
Phase 1Completed
NCT01900028AstraZenecaPharmacokinetic sampling

To Assess the Effect of Itraconazole (a CYP3A4 Inhibitor) on the Pharmacokinetics of Olaparib, and the Effect of Olaparib on QT Interval Following Oral Dosing of a Tablet Formulation to Patients With Advanced Solid Tumours

Start: Oct 2013Est. completion: Sep 201685 patients
Phase 1Completed
NCT02360345United TherapeuticsONX-0801

Phase I Trial of ONX-0801 Once Weekly or Alternate Weekly

Start: Sep 2013Est. completion: Mar 2021111 patients
Phase 1Completed
NCT01948297DebiopharmDebio1347

Debio 1347-101 Phase I Trial in Advanced Solid Tumours With Fibroblast Growth Factor Receptor (FGFR) Alterations

Start: Aug 2013Est. completion: Jun 2020
Phase 1Terminated
NCT02407509Chugai PharmaVS-6766

Phase I Trial of VS-6766 Alone and in Combination With Everolimus

Start: Jun 2013Est. completion: Oct 2025104 patients
Phase 1Completed
NCT00824057AstraZenecaCYP1A2

Effect of Multiple Doses of AZD6280 on the Pharmacokinetics of Midazolam (CYP3A4) and Caffeine (CYP1A2)

Start: Jan 2009Est. completion: Mar 200924 patients
Phase 1Completed
NCT00497679AstraZenecaAZD1152

AZD1152 in Patients With Advanced Solid Malignancies-Study 3

Start: Aug 2006Est. completion: Jul 200745 patients
Phase 1Terminated
NCT04529122RocheA Worldwide Cancer Registry Enrolling Participants Profiled With a Next-Generation Sequencing Test

A Worldwide Cancer Registry Enrolling Participants Profiled With a Next-Generation Sequencing Test

Start: Aug 2020Est. completion: Dec 202715,000 patients
N/ARecruiting

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Phase Legend

Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available

Key Insights

7 actively recruiting trials targeting 16,778 patients
11 companies competing in this space

Related Indications

Breast Cancer(530)Non-small Cell Lung Cancer(373)Prostate Cancer(371)Multiple Myeloma(244)Advanced Solid Tumors(221)Acute Myeloid Leukemia(204)Cancer(187)Neoplasms(173)Colorectal Cancer(166)Advanced Solid Tumor(165)