Metastatic Pancreatic Adenocarcinoma

Oncology
9
Pipeline Programs
9
Companies
7
Clinical Trials
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
5
3
1
0
0
0
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Monoclonal Antibody
3100%
+ 6 programs with unclassified modality

Competitive Landscape

9 companies ranked by most advanced pipeline stage

BioLineRx
BioLineRxIsrael - Modi’in
1 program
1
BL-8040Phase 2
Vaccinex
VaccinexROCHESTER, NY
1 program
1
Avelumab and PepinemabPhase 1/2Monoclonal Antibody1 trial
Active Trials
NCT05102721Active Not RecruitingEst. Dec 2028
Pfizer
PfizerNEW YORK, NY
1 program
1
MEK162Phase 1/21 trial
Active Trials
NCT01562899Terminated77Est. Apr 2015
Scandion Oncology
Scandion OncologyDenmark - Copenhagen
1 program
1
SCO-101Phase 1/21 trial
Active Trials
NCT04652206Unknown18Est. May 2022
GS
Gilead SciencesFOSTER CITY, CA
1 program
1
90Y-hPAM4Phase 11 trial
Active Trials
NCT01510561Withdrawn0Est. Sep 2015
Ipsen
IpsenChina - Tianjin
1 program
1
Irinotecan liposome injectionPhase 11 trial
Active Trials
NCT05383352Completed177Est. Apr 2025
Dynavax Technologies
Dynavax TechnologiesCA - Emeryville
1 program
1
NivolumabPhase 1Monoclonal Antibody
Celldex Therapeutics
1 program
1
odetiglucanPhase 11 trial
Active Trials
NCT05484011Terminated5Est. Mar 2024
Astellas
AstellasChina - Shenyang
1 program
1
zolbetuximabPhase 1Monoclonal Antibody1 trial
Active Trials
NCT06396091Active Not Recruiting12Est. Jul 2026

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
2028
VaccinexAvelumab and Pepinemab
Scandion OncologySCO-101
PfizerMEK162
Astellaszolbetuximab
Celldex Therapeuticsodetiglucan
IpsenIrinotecan liposome injection
Gilead Sciences90Y-hPAM4

Clinical Trials (7)

Total enrollment: 289 patients across 7 trials

NCT05102721VaccinexAvelumab and Pepinemab

Trial of Immunotherapy With Avelumab and Pepinemab As Second Line For Patients With Metastatic Pancreatic Adenocarcinoma

Start: Dec 2022Est. completion: Dec 2028
Phase 1/2Active Not Recruiting
NCT04652206Scandion OncologySCO-101

Clinical Trial to Investigate Safety, Tolerability and MTD for SCO-101 in Combination With Gemcitabine and Nab-paclitaxel in Inoperable Pancreatic Cancer Patients.

Start: Oct 2020Est. completion: May 202218 patients
Phase 1/2Unknown
NCT01562899PfizerMEK162

A Study of MEK162 and AMG 479 in Patients With Selected Solid Tumors

Start: Aug 2012Est. completion: Apr 201577 patients
Phase 1/2Terminated
NCT06396091Astellaszolbetuximab

A Study of Zolbetuximab With Chemotherapy in Adults With Pancreatic Cancer

Start: Sep 2025Est. completion: Jul 202612 patients
Phase 1Active Not Recruiting
NCT05484011Celldex Therapeuticsodetiglucan

A Maintenance Therapy Study of Odetiglucan With CDX-1140 in Patients With Metastatic Pancreatic Ductal Adenocarcinoma

Start: Dec 2022Est. completion: Mar 20245 patients
Phase 1Terminated
NCT05383352IpsenIrinotecan liposome injection

A Study to Compare Onivyde Manufactured at Two Different Production Sites in Adult Participants With Advanced Cancer in the Pancreas

Start: May 2022Est. completion: Apr 2025177 patients
Phase 1Completed
NCT01510561Gilead Sciences90Y-hPAM4

A Study of Fractionated 90Y-hPAM4 Plus Gemcitabine in Pancreatic Cancer Patients Receiving at Least 2 Prior Therapies.

Start: Mar 2012Est. completion: Sep 20150
Phase 1Withdrawn

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Phase Legend

Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available

Key Insights

9 companies competing in this space

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