Mesothelioma

Oncology
10
Pipeline Programs
9
Companies
9
Clinical Trials
2 recruiting
1
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
3
1
4
1
0
1
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Small Molecule
267%
ADC
133%
+ 6 programs with unclassified modality

On Market (1)

Approved therapies currently available

Boehringer Ingelheim
OFEVApproved
nintedanib
Boehringer Ingelheim
oral2014

Competitive Landscape

9 companies ranked by most advanced pipeline stage

Boehringer Ingelheim
Boehringer IngelheimINGELHEIM, Germany
1 program
1
1
NintedanibPhase 2/3Small Molecule1 trial
Active Trials
NCT01907100Terminated545Est. Aug 2018
Eli Lilly and Company
Eli Lilly and CompanyINDIANAPOLIS, IN
1 program
1
PemetrexedPhase 21 trial
Active Trials
NCT00061477Completed48Est. Sep 2006
GS
Gilead SciencesFOSTER CITY, CA
1 program
1
Sacituzumab govitecan-hziyPhase 2ADC1 trial
Active Trials
NCT06477419Recruiting33Est. Jun 2029
Bayer
BayerLEVERKUSEN, Germany
1 program
1
SorafenibPhase 2Small Molecule1 trial
Active Trials
NCT00794859Unknown54
Pierre Fabre
Pierre FabreFrance - Aignan
1 program
1
VinorelbinePhase 21 trial
Active Trials
NCT02139904CompletedEst. Mar 2021
Genentech
GenentechCA - Oceanside
1 program
1
Carboplatin, Bevacizumab and PemetrexedPhase 1/21 trial
Active Trials
NCT00604461Terminated13Est. Jan 2011
ProgenaBiome
ProgenaBiomeCA - Ventura
1 program
1
Fecal Microbiota TransplantPhase 11 trial
Active Trials
NCT04056026CompletedEst. Dec 2018
Novartis
NovartisBASEL, Switzerland
1 program
1
IAG933Phase 11 trial
Active Trials
NCT04857372Active Not Recruiting137Est. Sep 2026
Bristol Myers Squibb
1 program
1
MRTX1719Phase 11 trial
Active Trials
NCT05245500Recruiting336Est. Dec 2027

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
2028
2029
Boehringer IngelheimNintedanib
Gilead SciencesSacituzumab govitecan-hziy
Pierre FabreVinorelbine
BayerSorafenib
Eli Lilly and CompanyPemetrexed
GenentechCarboplatin, Bevacizumab and Pemetrexed
Bristol Myers SquibbMRTX1719
NovartisIAG933
ProgenaBiomeFecal Microbiota Transplant

Clinical Trials (9)

Total enrollment: 1,166 patients across 9 trials

NCT01907100Boehringer IngelheimNintedanib

Nintedanib (BIBF 1120) in Mesothelioma

Start: Sep 2013Est. completion: Aug 2018545 patients
Phase 2/3Terminated
NCT06477419Gilead SciencesSacituzumab govitecan-hziy

A Study of Sacituzumab Govitecan in People With Mesothelioma

Start: Jun 2024Est. completion: Jun 202933 patients
Phase 2Recruiting
NCT02139904Pierre FabreVinorelbine

Vinorelbine in Mesothelioma

Start: Mar 2016Est. completion: Mar 2021
Phase 2Completed
NCT00794859BayerSorafenib

Sorafenib in Previously Treated Malignant Mesothelioma

Start: Oct 200854 patients
Phase 2Unknown
NCT00061477Eli Lilly and CompanyPemetrexed

Pemetrexed Plus Gemcitabine as Front-Line Chemotherapy for Patients With Malignant Pleural or Peritoneal Mesothelioma

Start: Dec 2002Est. completion: Sep 200648 patients
Phase 2Completed
NCT00604461GenentechCarboplatin, Bevacizumab and Pemetrexed

Carboplatin, Bevacizumab and Pemetrexed in the First-Line Treatment of Patients With Malignant Pleural Mesothelioma (MPM)

Start: Oct 2007Est. completion: Jan 201113 patients
Phase 1/2Terminated
NCT05245500Bristol Myers SquibbMRTX1719

Phase 1 Study of MRTX1719 in Solid Tumors With MTAP Deletion

Start: Jun 2022Est. completion: Dec 2027336 patients
Phase 1Recruiting
NCT04857372NovartisIAG933

A Phase I Study of IAG933 in Patients With Advanced Mesothelioma and Other Solid Tumors

Start: Oct 2021Est. completion: Sep 2026137 patients
Phase 1Active Not Recruiting
NCT04056026ProgenaBiomeFecal Microbiota Transplant

A Single Dose FMT Infusion as an Adjunct to Keytruda for Metastatic Mesothelioma

Start: Sep 2018Est. completion: Dec 2018
Phase 1Completed

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Phase Legend

Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available

Key Insights

2 actively recruiting trials targeting 1,166 patients
9 companies competing in this space

Related Indications

Breast Cancer(530)Non-small Cell Lung Cancer(373)Prostate Cancer(371)Multiple Myeloma(244)Advanced Solid Tumors(221)Acute Myeloid Leukemia(204)Cancer(187)Neoplasms(173)Colorectal Cancer(166)Advanced Solid Tumor(165)