Glioma

Oncology
22
Pipeline Programs
21
Companies
50
Clinical Trials
3 recruiting
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
9
4
9
0
0
0
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Small Molecule
250%
Vaccine
125%
Monoclonal Antibody
125%
+ 22 programs with unclassified modality

Competitive Landscape

18 companies ranked by most advanced pipeline stage

Jazz Pharmaceuticals
Jazz PharmaceuticalsCA - Palo Alto
4 programs
1
DordavipronePhase 21 trial
ONC201N/A1 trial
ONC201N/A1 trial
ONC201N/A1 trial
Active Trials
NCT05392374No Longer Available
NCT03134131No Longer Available
NCT04617002Approved For Marketing
+1 more trials
E
EisaiChina - Liaoning
3 programs
3
LenvatinibPhase 2Small Molecule1 trial
TemozolomidePhase 21 trial
Temozolomide and BevacizumabPhase 2Monoclonal Antibody1 trial
Active Trials
NCT01137604Completed151Est. Oct 2014
NCT00660283Unknown20Est. Dec 2010
NCT00660621Unknown40Est. Dec 2010
M&
Merck & Co.RAHWAY, NJ
2 programs
1
temozolomidePhase 25 trials
Development of Magnetic Resonance Spectroscopy (MRS) Biomarkers of Tumor Metabolism (MK-0000-145)N/A1 trial
Active Trials
NCT01138813Completed8Est. Feb 2010
NCT01450826Completed136Est. Apr 2017
NCT01517776TerminatedEst. Apr 2014
+3 more trials
Boehringer Ingelheim
Boehringer IngelheimINGELHEIM, Germany
2 programs
1
1
BIBW 2992Phase 21 trial
BI 764532Phase 11 trial
Active Trials
NCT05916313Active Not Recruiting18Est. Jun 2026
NCT00727506Completed151Est. May 2016
Cellectar Biosciences
Cellectar BiosciencesFLORHAM PARK, NJ
1 program
1
I-131-CLR1404 InjectionPhase 21 trial
Active Trials
NCT01778088WithdrawnEst. Jan 2015
Pfizer
PfizerNEW YORK, NY
1 program
1
IrinotecanPhase 21 trial
Active Trials
NCT00404495Completed83Est. Dec 2011
Philogen
PhilogenItaly - Monteriggioni
1 program
1
L19TNFPhase 21 trial
Active Trials
NCT07120984Not Yet Recruiting52Est. Jan 2029
Plus Therapeutics
2 programs
1
1
Rhenium Liposome TreatmentPhase 1/21 trial
Retreatment Rhenium LiposomePhase 11 trial
Active Trials
NCT05460507Recruiting40Est. Mar 2028
NCT01906385Recruiting55Est. Dec 2025
Aveta Biomics
Aveta BiomicsMA - Bedford
1 program
1
APG-157Phase 1/21 trial
Active Trials
NCT06011109RecruitingEst. Jan 2026
Laminar Pharmaceuticals
Laminar PharmaceuticalsSpain - Palma de Mallorca
1 program
1
LAM561Phase 1/21 trial
Active Trials
NCT01792310CompletedEst. Sep 2016
Eli Lilly and Company
Eli Lilly and CompanyINDIANAPOLIS, IN
1 program
1
LY2157299Phase 1/21 trial
Active Trials
NCT01220271Completed75Est. Nov 2016
Bayer
BayerLEVERKUSEN, Germany
1 program
1
BAY 2402234Phase 11 trial
Active Trials
NCT05061251Withdrawn0Est. Dec 2023
DS
Daiichi SankyoChina - Shanghai
1 program
1
DS-1001bPhase 11 trial
Active Trials
NCT03030066Active Not Recruiting47Est. Aug 2026
Heidelberg Pharma
Heidelberg PharmaGermany - Ladenburg
1 program
1
IDH1 peptide vaccinePhase 1Vaccine1 trial
Active Trials
NCT02454634Completed39Est. Sep 2017
Celldex Therapeutics
1 program
1
IMA950Phase 11 trial
Active Trials
NCT02924038Terminated14Est. Dec 2022
BridgeBio Pharma
BridgeBio PharmaCA - Palo Alto
1 program
1
InfigratinibPhase 1Small Molecule1 trial
Active Trials
NCT04424966Terminated7Est. Feb 2024
Biogen
BiogenCAMBRIDGE, MA
1 program
1
RTA 744Phase 11 trial
Active Trials
NCT00526812Completed54
Roche
RocheSTAVANGER NORWAY, Norway
1 program
1
capecitabine [Xeloda]Phase 11 trial
Active Trials
NCT00532948Completed24Est. Oct 2010

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
2028
2029
Merck & Co.temozolomide
Merck & Co.temozolomide
Merck & Co.temozolomide
Merck & Co.temozolomide
PhilogenL19TNF
Jazz PharmaceuticalsDordaviprone
Merck & Co.temozolomide
Cellectar BiosciencesI-131-CLR1404 Injection
Merck & Co.temozolomide
EisaiLenvatinib
Merck & Co.temozolomide
EisaiTemozolomide
Merck & Co.temozolomide
Boehringer IngelheimBIBW 2992
EisaiTemozolomide and Bevacizumab

Showing 15 of 47 trials with date data

Clinical Trials (50)

Total enrollment: 6,060 patients across 50 trials

Standard Temodal (Temozolomide) Regimen Versus Standard Regimen Plus Early Postsurgery Temodal for Newly Diagnosed Glioblastoma Multiforme (Study P05572)

Start: Jun 2008Est. completion: Sep 201199 patients
Phase 4Completed

Cilengitide, Temozolomide, and Radiation Therapy in Treating Patients With Newly Diagnosed Glioblastoma and Methylated Gene Promoter Status

Start: Sep 2008Est. completion: Aug 2013545 patients
Phase 3Completed

Efficacy and Safety of Temodal vs Semustine in Subjects With Recurrent Glioblastoma or Anaplastic Astrocytoma (Study P03644)

Start: Mar 2005Est. completion: Feb 2006151 patients
Phase 3Completed

Temozolomide Versus Dacarbazine in Stage IV Metastatic Melanoma (Study P03267)

Start: Oct 2004Est. completion: Dec 2007859 patients
Phase 3Completed

A Study to Evaluate the Safety and Efficacy of L19TNF With Alkylating Chemotherapy for Patients With Recurrent IDH-mutant Astrocytoma or Oligodendroglioma

Start: Jan 2026Est. completion: Jan 202952 patients
Phase 2Not Yet Recruiting

ONC201 in Adults With Recurrent H3 K27M-mutant Glioma

Start: Oct 2017Est. completion: Jul 202373 patients
Phase 2Terminated

Emend and Ondansetron Compared to Ondansetron Alone to Prevent CINV in Glioma Patients Receiving Temozolomide

Start: Jun 2014Est. completion: Apr 2017136 patients
Phase 2Completed
NCT01778088Cellectar BiosciencesI-131-CLR1404 Injection

Open-Label Study of I-131-CLR1404 in Subjects With Recurrent Glioma

Start: May 2014Est. completion: Jan 2015
Phase 2Withdrawn

Cilengitide and Metronomic Temozolomide for Relapsed or Refractory High Grade Gliomas or Diffuse Intrinsic Pontine Gliomas in Children and Adolescents

Start: Jan 2012Est. completion: Apr 2014
Phase 2Terminated

A Study in Subjects With Recurrent Malignant Glioma

Start: Nov 2010Est. completion: Oct 2014151 patients
Phase 2Completed

Temozolomide and Procarbazine With Cilengitide for Patients With Glioblastoma Multiforme Without Methylation of the MGMT Promoter Gene

Start: Nov 2009Est. completion: Jan 201448 patients
Phase 2Unknown
NCT00660283EisaiTemozolomide

A Phase II Study of Gliadel, Concomitant Temozolomide and Radiation, Followed By Dose Dense Therapy With Temozolomide For Newly Diagnosed Malignant High Grade Glioma

Start: Jan 2009Est. completion: Dec 201020 patients
Phase 2Unknown

Temozolomide as a Prophylaxis Against Brain Recurrence in Participants With Metastatic Breast Cancer (P05225 AM2)

Start: Oct 2008Est. completion: Jun 20106 patients
Phase 2Terminated

BIBW 2992 (Afatinib) With or Without Daily Temozolomide in the Treatment of Patients With Recurrent Malignant Glioma

Start: Jul 2008Est. completion: May 2016151 patients
Phase 2Completed
NCT00660621EisaiTemozolomide and Bevacizumab

A Phase II Study Of Gliadel, Concomitant Temozolomide And Radiation, Followed By Dose Dense Therapy With Temozolomide Plus Bevacizumab For Newly Diagnosed Malignant High Grade Glioma

Start: Apr 2008Est. completion: Dec 201040 patients
Phase 2Unknown

Study of Maintenance Temozolomide Versus Observation in Stable or Responding Stage III/IV Non-Small Cell Lung Cancer Patients (Study P05146)

Start: Mar 2008Est. completion: Jan 201153 patients
Phase 2Terminated

Combination of Irinotecan and Temozolomide in Children With Brain Tumors.

Start: Apr 2007Est. completion: Dec 201183 patients
Phase 2Completed

Phase 2 Study of Temozolomide in Pre-Selected Advanced Aerodigestive Tract Cancers (Study P04273AM2)(TERMINATED)

Start: Jan 2007Est. completion: Jun 200986 patients
Phase 2Terminated

Low-dose Temozolomide for 2 Weeks on Brain Tumor Enzyme in Patients With Gliomas (P04602 AM1) (Completed)

Start: Sep 2006Est. completion: Feb 201140 patients
Phase 2Completed

The Effects of Continuous 28-day (28/28) Temozolomide Chemotherapy in Subjects With Recurrent Malignant Glioma Who Have Failed the Conventional 5-day (5/28) Treatment (P04601)

Start: Jun 2006Est. completion: Sep 2009120 patients
Phase 2Completed

Temozolomide Phase II Clinical Study in Patients With Newly Diagnosed Glioblastoma Multiforme (Study P04661)(COMPLETED)

Start: Sep 2005Est. completion: Oct 200730 patients
Phase 2Completed

Safety and Tolerability of Low-Dose Temozolomide During Whole Brain Radiation in Patients With Cerebral Metastases From Non-Small-Cell Lung Cancer (Study P04071)(TERMINATED)

Start: Mar 2005Est. completion: Jan 200835 patients
Phase 2Terminated

Temozolomide for Treatment of Brain Metastases From Non-Small Cell Lung Cancer (Study P03247)

Start: Mar 2004Est. completion: Mar 200695 patients
Phase 2Completed

SCH 52365 Phase II Clinical Study: A Study on the Efficacy and Safety of Monotherapy With SCH 52365 in Patients With First Relapsed Anaplastic Astrocytoma (Study P03745)

Start: May 2003Est. completion: Jun 200532 patients
Phase 2Completed

Study of Temozolomide in the Treatment of Brain Metastasis From Non-small-cell Lung Cancer (Study P02143)

Start: Jun 2001Est. completion: Jan 200324 patients
Phase 2Terminated

Study to Evaluate the Efficacy and Safety of Temozolomide in Subjects With Brain Metastases of Either Malignant Melanoma, Breast, or Non-small Cell Lung Cancer (P02064)

Start: Dec 2000Est. completion: Oct 2006162 patients
Phase 2Completed

Treatment of Patients With Recurrent High-Grade Glioma With APG-157 and Bevacizumab

Start: Dec 2023Est. completion: Jan 2026
Phase 1/2Recruiting
NCT01906385Plus TherapeuticsRhenium Liposome Treatment

Maximum Tolerated Dose, Safety, and Efficacy of Rhenium Nanoliposomes in Recurrent Glioma (ReSPECT)

Start: Jun 2015Est. completion: Dec 202555 patients
Phase 1/2Recruiting

A Phase 1/2A Study of LAM561 in Adult Patients With Advanced Solid Tumours

Start: May 2013Est. completion: Sep 2016
Phase 1/2Completed

A Study Combining LY2157299 With Temozolomide-based Radiochemotherapy in Patients With Newly Diagnosed Malignant Glioma

Start: Apr 2011Est. completion: Nov 201675 patients
Phase 1/2Completed

Suberoylanilide Hydroxamic Acid (SAHA), Bevacizumab, Daily Temozolomide for Recurrent Malignant Gliomas

Start: Oct 2009Est. completion: Apr 201348 patients
Phase 1/2Completed
NCT05460507Plus TherapeuticsRetreatment Rhenium Liposome

Safety & Efficacy/Tolerability of Rhenium-186 NanoLiposomes (186RNL) for Patients Who Received a Prior 186RNL Treatment

Start: Dec 2024Est. completion: Mar 202840 patients
Phase 1Recruiting

A Study to Test How Well Different Doses of BI 764532 Are Tolerated by People With a Tumour in the Brain That is Positive for DLL3

Start: Jan 2024Est. completion: Jun 202618 patients
Phase 1Active Not Recruiting
NCT05061251BayerBAY 2402234

Surgical Window of Opportunity Study of Orally Administered BAY 2402234 in Recurrent Glioma

Start: Dec 2021Est. completion: Dec 20230
Phase 1Withdrawn

Infigratinib in Recurrent High-Grade Glioma Patients

Start: Jul 2020Est. completion: Feb 20247 patients
Phase 1Terminated

A Study of Varlilumab and IMA950 Vaccine Plus Poly-ICLC in Patients With WHO Grade II Low-Grade Glioma (LGG)

Start: Apr 2017Est. completion: Dec 202214 patients
Phase 1Terminated

Study of DS-1001b in Patients With Gene IDH1-Mutated Gliomas

Start: Jan 2017Est. completion: Aug 202647 patients
Phase 1Active Not Recruiting
NCT02454634Heidelberg PharmaIDH1 peptide vaccine

Phase I Trial of IDH1 Peptide Vaccine in IDH1R132H-mutated Grade III-IV Gliomas

Start: Jun 2015Est. completion: Sep 201739 patients
Phase 1Completed

Study of the Safety and Efficacy of MK-4827 Given With Temozolomide in Participants With Advanced Cancer (MK-4827-014 AM1)

Start: Feb 2011Est. completion: May 201219 patients
Phase 1Completed

Evaluate Safety/Tolerability Intra-Arterial Temozolomide in Patients w/Extremity Melanoma by Isolated Limb Infusion

Start: Jul 2010Est. completion: Jun 201429 patients
Phase 1Completed

A Study of Robatumumab (SCH 717454, MK-7454) in Combination With Different Treatment Regimens in Pediatric Participants With Advanced Solid Tumors (P05883, MK-7454-006)

Start: Nov 2009Est. completion: Dec 20104 patients
Phase 1Terminated
NCT00532948Rochecapecitabine [Xeloda]

A Study of Xeloda (Capecitabine) Plus Radiation Therapy in Children With Newly Diagnosed Gliomas

Start: May 2007Est. completion: Oct 201024 patients
Phase 1Completed

A Safety Study of RTA 744 in Patients With Recurrent High-Grade Gliomas

Start: Nov 200554 patients
Phase 1Completed

Expanded Access Use of ONC201 in a Patient With Diffuse Intrinsic Pontine Gliomas

N/ANo Longer Available

Expanded Access to ONC201 for Patients With H3 K27M-mutant and/or Midline High Grade Gliomas

N/ANo Longer Available

Intermediate-size Expanded Access to ONC201 for Patients With H3 K27M-mutant and/or Midline Gliomas

N/AApproved For Marketing

Ovarian Aging in Low Grade Glioma (LGG) Treated With Temozolomide

Start: Oct 2011Est. completion: Nov 20132 patients
N/ATerminated
NCT01138813Merck & Co.Development of Magnetic Resonance Spectroscopy (MRS) Biomarkers of Tumor Metabolism (MK-0000-145)

Development of Magnetic Resonance Spectroscopy (MRS) Biomarkers of Tumor Metabolism (MK-0000-145)

Start: Mar 2009Est. completion: Feb 20108 patients
N/ACompleted

Temodal (Temozolomide) Post Marketing Surveillance Protocol (Study P05557AM2)

Start: Mar 2008Est. completion: Sep 2011682 patients
N/ACompleted

Temozolomide All-Case-Registered Surveillance (Designated Drug Use Investigation)(Study P05062)

Start: Sep 2006Est. completion: Jul 20161,804 patients
N/ACompleted

Related Jobs in Oncology

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

3 actively recruiting trials targeting 6,060 patients
21 companies competing in this space