Esophageal Squamous Cell Carcinoma

Oncology
12
Pipeline Programs
7
Companies
25
Clinical Trials
7 recruiting
1
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
1
2
6
1
1
1
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Monoclonal Antibody
360%
Small Molecule
240%
+ 6 programs with unclassified modality

On Market (1)

Approved therapies currently available

Bristol Myers Squibb
OPDIVOApproved
nivolumab
Bristol Myers Squibb
injection2015

Competitive Landscape

7 companies ranked by most advanced pipeline stage

Bristol Myers Squibb
2 programs
1
1
1
NivolumabPhase 2/3Monoclonal Antibody1 trial
CisplatinPhase 23 trials
Active Trials
NCT07100080Recruiting596Est. May 2031
NCT07106762Recruiting470Est. Nov 2033
NCT00909402Completed39Est. Nov 2012
+1 more trials
Roche
RocheSTAVANGER NORWAY, Norway
1 program
1
TiragolumabPhase 3Monoclonal Antibody2 trials
Active Trials
NCT05805501Active Not Recruiting199Est. Oct 2026
NCT04543617Active Not Recruiting760Est. Mar 2027
CT
3 programs
3
AnlotinibPhase 2Small Molecule1 trial
Anlotinib Hydrochloride, Paclitaxel, cisplatinPhase 21 trial
Anlotinib hydrochloridePhase 21 trial
Active Trials
NCT02649361CompletedEst. Jul 2018
NCT04063683UnknownEst. Jun 2022
NCT05252078RecruitingEst. Nov 2026
M&
Merck & Co.RAHWAY, NJ
2 programs
1
1
CisplatinPhase 25 trials
PaclitaxelPhase 1/23 trials
Active Trials
NCT05319730Recruiting230Est. Apr 2029
NCT02761694Terminated78Est. Mar 2021
NCT00550771Completed181Est. Aug 2010
+5 more trials
City Therapeutics
City TherapeuticsMA - Cambridge
1 program
1
EpacadostatPhase 2Small Molecule1 trial
Active Trials
NCT03592407WithdrawnEst. Apr 2020
DS
Daiichi SankyoChina - Shanghai
1 program
1
PembrolizumabPhase 1/2Monoclonal Antibody3 trials
Active Trials
NCT06780111Recruiting298Est. Jan 2032
NCT06797635Recruiting372Est. Dec 2034
NCT05629585Active Not Recruiting1,174Est. Jan 2030
Plexium
PlexiumCA - San Diego
1 program
1
PLX-61639Phase 11 trial
Active Trials
NCT07284186Recruiting155Est. Sep 2030

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
2028
2029
2030
2031
Daiichi SankyoPembrolizumab
RocheTiragolumab
Bristol Myers SquibbCisplatin
Bristol Myers SquibbCisplatin
Bristol Myers SquibbNivolumab
Daiichi SankyoPembrolizumab
RocheTiragolumab
Chia Tai TianQing Pharmaceutical GroupAnlotinib hydrochloride
Merck & Co.Cisplatin
Chia Tai TianQing Pharmaceutical GroupAnlotinib Hydrochloride, Paclitaxel, cisplatin
City TherapeuticsEpacadostat
Chia Tai TianQing Pharmaceutical GroupAnlotinib
Merck & Co.Cisplatin
Merck & Co.Paclitaxel
Merck & Co.Cisplatin

Showing 15 of 25 trials with date data

Clinical Trials (25)

Total enrollment: 4,737 patients across 25 trials

A Study of Dato-DXd With or Without Durvalumab Versus Investigator's Choice of Therapy in Patients With Stage I-III Triple-negative Breast Cancer Without Pathological Complete Response Following Neoadjuvant Therapy (TROPION-Breast03)

Start: Nov 2022Est. completion: Jan 20301,174 patients
Phase 3Active Not Recruiting
NCT04543617RocheTiragolumab

A Study of Atezolizumab With or Without Tiragolumab in Participants With Unresectable Esophageal Squamous Cell Carcinoma Whose Cancers Have Not Progressed Following Definitive Concurrent Chemoradiotherapy

Start: Sep 2020Est. completion: Mar 2027760 patients
Phase 3Active Not Recruiting

Study of Izalontamab Brengitecan (BMS-986507) Versus Platinum-Pemetrexed for EGFR-mutated Non-small Cell Lung Cancer After Failure of EGFR TKI Therapy (IZABRIGHT-Lung01)

Start: Nov 2025Est. completion: May 2031596 patients
Phase 2/3Recruiting

Phase 2/3 Trial of Izalontamab Brengitecan vs Platinum-based Chemotherapy for Metastatic Urothelial Cancer With Disease Progression on or After Immunotherapy

Start: Sep 2025Est. completion: Nov 2033470 patients
Phase 2/3Recruiting

Study of Neoadjuvant Nivolumab or Placebo Plus Chemotherapy Followed by Surgery and Adjuvant Treatment in Subjects With Resectable ESCC

Start: Jun 2022Est. completion: Mar 202490 patients
Phase 2/3Unknown

Study of Patritumab Deruxtecan Plus Pembrolizumab With Other Anticancer Agents in Participants With High-Risk Early-Stage Triple-Negative or Hormone Receptor-Low Positive/HER-2 Negative Breast Cancer (MK-1022-010, HERTHENA-Breast-03)

Start: Mar 2025Est. completion: Dec 2034372 patients
Phase 2Recruiting
NCT05805501RocheTiragolumab

A Study of Immune Checkpoint Inhibitor Combinations With Axitinib in Participants With Untreated Locally Advanced Unresectable or Metastatic Renal Cell Carcinoma

Start: Apr 2023Est. completion: Oct 2026199 patients
Phase 2Active Not Recruiting

Anlotinib Hydrochloride Capsules Combined With TQB2450 Injection in Esophageal Squamous Cell Carcinoma Patients

Start: Jun 2022Est. completion: Nov 2026
Phase 2Recruiting

Trial of Nivolumab and Cetuximab After Chemoradiation in Esophageal Squamous Cell Carcinoma Patients.

Start: Feb 2020Est. completion: Apr 202712 patients
Phase 2Active Not Recruiting
NCT04063683Chia Tai TianQing Pharmaceutical GroupAnlotinib Hydrochloride, Paclitaxel, cisplatin

Paclitaxel and DDP Combined With Anlotinib in the First-line Treatment for Patients With Advanced Esophageal Squamous Cell Carcinoma(ESCC).

Start: Oct 2019Est. completion: Jun 2022
Phase 2Unknown

Epacadostat and Pembrolizumab Before Surgery in Treating Participants With Stage II-III Esophageal or Gastroesophageal Cancer

Start: Jul 2018Est. completion: Apr 2020
Phase 2Withdrawn

Study of Anlotinib in Patients With Esophageal Squamous Cell Carcinoma (ALTER1102)

Start: Jan 2016Est. completion: Jul 2018
Phase 2Completed

MK-0646 Insulin Growth Factor 1 Receptor Antibody in Stage IIIb or IV Metastatic Non-Squamous Lung Cancer

Start: Jun 2009Est. completion: Jul 201427 patients
Phase 2Completed

Phase II Trial to Compare the Safety of Two Chemotherapy Plus Trastuzumab Regimens as Adjuvant Therapy for HER2-positive Breast Cancer (Study P05048)

Start: Jul 2007Est. completion: Aug 2010181 patients
Phase 2Completed

Matuzumab Treatment With Epirubicin, Cisplatin and Capecitabine (ECX) in Esophago-Gastric Cancer

Start: Aug 2005Est. completion: Aug 2008
Phase 2Completed

Substudy 06E: Umbrella Study of Combination Therapies in Esophageal Cancer (MK-3475-06E/KEYMAKER-U06)

Start: Jul 2025Est. completion: Jan 2032298 patients
Phase 1/2Recruiting

A Study to Evaluate Investigational Agents With or Without Pembrolizumab (MK-3475) in Participants With Advanced Esophageal Cancer Previously Exposed to Programmed Cell Death 1 Protein (PD-1)/ Programmed Cell Death Ligand 1 (PD-L1) Treatment (MK-3475-06B)

Start: May 2023Est. completion: Apr 2029230 patients
Phase 1/2Recruiting

MK-0646, Etoposide, and Cisplatin in Treating Patients With Extensive-Stage Small Cell Lung Cancer

Start: Dec 2009Est. completion: Jul 2012
Phase 1/2Completed

First-in-Human Study of PLX-61639 in Locally Advanced or Metastatic Solid Tumors

Start: Dec 2025Est. completion: Sep 2030155 patients
Phase 1Recruiting

M6620 Plus Standard Treatment in Oesophageal and Other Cancer

Start: Dec 2018Est. completion: Apr 2022
Phase 1Completed

Vevorisertib (ARQ 751) as a Single Agent or in Combination With Other Anti-Cancer Agents, in Solid Tumors With PIK3CA / AKT / PTEN Mutations (MK-4440-001)

Start: Jun 2016Est. completion: Mar 202178 patients
Phase 1Terminated

A Study of BMS-833923 With Cisplatin and Capecitabine in Inoperable, Metastatic Gastric, Gastroesophageal, or Esophageal Adenocarcinomas

Start: Nov 2009Est. completion: Nov 201239 patients
Phase 1Completed

Safety Study of EMD 72000 in Combination With ECX (Epirubicin, Cisplatin and Capecitabine) in Oesophagogastric Cancer

Start: Oct 2002Est. completion: Jan 200726 patients
Phase 1Completed

Safety and Tolerability Study of Farnesyl Protein Transferase Inhibitor in Combination With Gemcitabine and Cisplatin in Advanced Cancer (Study P01499)(TERMINATED)

Start: Jan 2001Est. completion: Jul 200422 patients
Phase 1Terminated

Nausea and Vomiting In Patients Receiving Consecutive Days of Cisplatin

Start: May 2005Est. completion: Mar 20098 patients
N/ATerminated

Related Jobs in Oncology

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

1 late-stage (Phase 3) programs — potential near-term approvals
7 actively recruiting trials targeting 4,737 patients
7 companies competing in this space