City Therapeutics

Focus: City Therapeutics is a Cambridge-based biotechnology company founded in 2018 specializing in next-generation RNAi therapies for gene therapy indications. With 5,000+ employees and public status, it operates at the scale of a mid-to-large biotech organization advancing precision genetic medicine.

Gene Therapy

Profile data last refreshed 16h ago · AI intelligence enriched 2mo ago

Funding Stage

PUBLIC

Employees

5000+

Open Jobs

7-3 this month

Stable — net -3 jobs in 30d

0 added, 3 removed. Backfill posture.

Should You Work at City Therapeutics?

AI assessment

City Therapeutics offers meaningful early-stage RNAi exposure and growth capital, but job seekers should verify pipeline focus, publication cadence, and hiring trajectory before committing to a company with unclear clinical data quality.

Why Work Here

Focused pipeline in RNAi therapies with recent $99.5M Series B financing (June 2026) signals strong institutional confidence and near-term development capital for advancing programs like CITY-FXI and CITY-RBP4.

Data completeness

4/9 — Basic

Company HealthSolid

Pipeline

Early-stage

50 total

LOE Risk

Protected

No near-term cliffs

Hiring

Stable

Automated analysis based on publicly available data (FDA, SEC, ClinicalTrials.gov). May be incomplete or delayed. This score does not reflect insider knowledge and should not be used as the sole basis for investment or employment decisions.

Pipeline & Clinical Trials

Vitls Tego Device

Vital Signs

N/A

Clinical Trials (1)

NCT05245747Vitls Feasibility Physiologic Monitoring

N/A

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Data Sources

Drug label: DailyMed / FDA
Clinical trials: ClinicalTrials.gov
Patent data: FDA Orange Book
Spending data: CMS Medicare

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.

Active hiring across Clinical Operations (3 roles), Translational Sciences (2), and Manufacturing indicates company is scaling functions across the value chain, particularly in clinical execution.

Early-stage pipeline (6 Phase 1 programs) offers rare opportunity to shape foundational data and clinical strategy in an emerging modality before Phase 3 and regulatory complexity.

Watch Out For

Noisy and fragmented pipeline data suggests either incomplete/corrupted trial registry information or unfocused portfolio strategy—only 9 total active trials across 30 listed programs is a red flag for execution clarity.
Minimal published output (3 publications) and absence of marketed products mean no clinical validation track record or revenue cushion; company is entirely dependent on pipeline advancement and capital markets.
Only 8 active job openings despite 5,000+ headcount and recent major funding round suggests limited immediate hiring momentum or possible restructuring/integration activity.

Generated by Claude from City Therapeutics's SEC filings, pipeline programs, hiring velocity, FDA actions, and WARN data. Inference, not editorial — verify before quoting.

Optimizing Post-Thoracotomy Pain Management: Comparing Erector Spinae vs. Paravertebral Block in Tho

Lung Diseases

N/A

Clinical Trials (1)

NCT06964698Optimizing Post-Thoracotomy Pain Management: Comparing Erector Spinae vs. Paravertebral Block in Thoracotomy Patients

N/A

Comparison of Short- and Long-term Outcomes Between Robotic and Laparoscopic Hemicolectomy of Right

Robotic Surgical Procedures

N/A

Mopati

HIV

N/A

Clinical Trials (1)

NCT04796610Mopati: A Pilot Hiv Treatment Partner Intervention In Botswana

N/A

Standard open tension-free inguinal hernia repair with mesh

Inguinal Hernias

N/A

Clinical Trials (1)

NCT01922674Inguinal Hernia Management: Watchful Waiting vs. Tension-Free Open Repair

N/A

No intervention

Parkinsonian Disorders

N/A

Trauma Exposure and Childhood Trauma in Temporomandibular Joint Disorders

Temporomandibular Disorder

N/A

Clinical Trials (1)

NCT07292103Trauma Exposure and Childhood Trauma in Temporomandibular Joint Disorders

N/A

Using advanced platelet-rich fibrin

Chronic Apical Periodontitis

N/A

Clinical Trials (1)

NCT07192289Using Platelet-rich Fibrin in Regenerative Endodontic Treatment in Mature Permanent Teeth

N/A

Uroflowmetry with URI Calculation

Urethral Stricture

N/A

Clinical Trials (1)

NCT07403786Urethral Resistive Index (URI): A New Parameter for Diagnosing Urethral Obstruction

N/A

Surgery method

Prostate Hyperplasia

N/A

Clinical Trials (1)

NCT05108662Inflammatory Markers: HOLEP Versus TURP

N/A

Biospecimen Collection

Accelerated Phase CML, BCR-ABL1 Positive

N/A

Clinical Trials (1)

NCT04666025SARS-CoV-2 Donor-Recipient Immunity Transfer

N/A

OLT maneuver

Healthy Volunteers

N/A

Clinical Trials (1)

NCT00742989Effect of Osteopathic Lymphatic Treatment on Plasma Volume, Protein Concentration and Albumin Concentration.

N/A

Care of premature infants

Morbidity;Infant

N/A

Clinical Trials (1)

NCT06543524Survival and nEonatal outComes of veRy Low Birth wEight Infants in Türkiye: Turkish Neonatal Society SECRETS-TR Study

N/A

Our Emergency Fasciotomy and Amputation Experiences

Amputation

N/A

Clinical Trials (1)

NCT06764446Our Emergency Fasciotomy and Amputation Experiences

N/A

Relations Between Residual Renal Function and Oxidative and Carbonyl Stress in Peritoneal Dialysis P

Chronic Renal Failure

N/A

Clinical Trials (1)

NCT00692068Relations Between Residual Renal Function and Oxidative and Carbonyl Stress in Peritoneal Dialysis Patients

N/A

Ultrasound measurements

Fetal Growth Retardation

N/A

Clinical Trials (1)

NCT06215690Evaluation of Anterior Middle Brain Structures With Cerebrovascular Flow in Fetuses With Fetal Growth Restriction

N/A

Application and demonstration of endoscope-assisted low-temperature plasma radiofrequency ablation resection of tonsils

Tonsil Disease

N/A

Clinical Trials (1)

NCT06983860Application and Demonstration of Endoscope-assisted Low-temperature Plasma Radiofrequency Ablation Resection of Tonsils

N/A

White bread

Healthy Participants

N/A

Clinical Trials (1)

NCT07158762Blood Glucose Levels After Bread Consumption Between Participants With Normal Weight and Overweight/Obesity

N/A

Erector Spinae Plane Block

Kolon Kanseri

N/A

Clinical Trials (1)

NCT07297433Erector Spinae Plane Block in Laparoscopic Colorectal Cancer Surgery

N/A

Estrogen Levels and Postoperative Recovery in IVF Patients

In Vitro Fertilization

N/A

Clinical Trials (1)

NCT06925633Estrogen Levels and Postoperative Recovery in IVF Patients

N/A

No intervention

Pilonidal Sinus Disorder

N/A

Clinical Trials (1)

NCT07370714Factors Affecting Wound Dehiscence in Pilonidal Sinus Surgery (ORIPIS)

N/A

E-CUBE i7 ultrasound system

Intracranial Pressure Increase

N/A

Clinical Trials (1)

NCT05668208Do Extraperitoneal Laparoscopic Surgeries Increase Intracranial Pressure?

N/A

Chinese Research Group of Gallbladder Cancer

Gallbladder Neoplasms

N/A

Education

Nursing Education

N/A

Clinical Trials (1)

NCT06388798Evaluation of the Effectiveness of Psychoeducational Training Given to Nurses Working in a Psychiatric Clinic

N/A

FVIII Concentrates

Severe Hemophilia A

N/A

Clinical Trials (2)

NCT01051076Rescue Immunotolerance Study in Induction of Immune Tolerance (ITI)-Experienced Patients (RES.I.S.T. Experienced)

N/A

NCT01051544Study of First TIME Immunotolerance Induction in Severe Hemophilia A Patients With Inhibitor at High Risk of Failure: Comparison With FVIII Concentrates With or Without Von Willebrand Factor - RES.I.S.T. Naive

N/A

Predictors of Spinal Anesthesia-Induced Hypotension in Hypertensive Patients

Spinal Anesthesia-Induced Hypotension

N/A

Clinical Trials (1)

NCT06749184Predictors of Spinal Anesthesia-Induced Hypotension in Hypertensive Patients

N/A

IVA group

The Injection Burden

N/A

No Intervention

Gastrointestinal Cancers

N/A

Clinical Trials (1)

NCT07272538Predicting Chemotherapy Toxicity Using FRAIL and FIND in Older Adults With Gastrointestinal Cancers

N/A

Babysparks Application

Development, Child

N/A

Clinical Trials (1)

NCT03867903BabySparks Developmental Application Pilot Study

N/A

Tissue culture collection

Wound Infection Bacterial

N/A

Clinical Trials (1)

NCT07325786Percutaneous Wound Sampling With Analysis in Blood Culture (PERKA-B) Method

N/A

Schoolyard reconstruction

Physical Inactivity

N/A

Clinical Trials (1)

NCT05865782Reconstructing Schoolyards With Greenery to Increase Schoolchildren's Physical Activity and Mitigate Climate Changes

N/A

Exercise Intervention

Adult Liver Carcinoma

N/A

Clinical Trials (1)

NCT03267524Walking for Recovery From Surgery in Improving Quality of Life in Older Adults With Lung or Gastrointestinal Cancer and Their Family Caregivers

N/A

Evaluation of Difficult Airway With Ultrasound

Adenotonsillectomy Surgery

N/A

Clinical Trials (1)

NCT07057661Evaluation of Difficult Airway With Ultrasound

N/A

Magnetic Mini-Mover Procedure

Pectus Excavatum

N/A

Clinical Trials (1)

NCT01327274Multicenter Trial of Magnetic Mini-Mover for Pectus Excavatum