Brain Metastases, Adult

Oncology
2
Pipeline Programs
4
Companies
5
Clinical Trials
2 recruiting
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
0
0
2
0
0
0
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

ADC
1100%
+ 3 programs with unclassified modality

Competitive Landscape

2 companies ranked by most advanced pipeline stage

Varian Medical Systems
3 programs
1
Targeting All Brain MetastasesPhase 21 trial
Noona® applicationN/A1 trial
Stereotactic radiosurgeryN/A1 trial
Active Trials
NCT04567251TerminatedEst. May 2024
NCT02886572CompletedEst. Apr 2021
NCT05050929RecruitingEst. Dec 2027
DS
Daiichi SankyoChina - Shanghai
1 program
1
Patritumab deruxtecanPhase 2ADC2 trials
Active Trials
NCT05620914Withdrawn0Est. Apr 2027
NCT06941272Recruiting50Est. Dec 2030

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
2028
2029
2030
Daiichi SankyoPatritumab deruxtecan
Varian Medical SystemsTargeting All Brain Metastases
Daiichi SankyoPatritumab deruxtecan
Varian Medical SystemsNoona® application
Varian Medical SystemsStereotactic radiosurgery

Clinical Trials (5)

Total enrollment: 50 patients across 5 trials

NCT05620914Daiichi SankyoPatritumab deruxtecan

A Window of Opportunity Study of Patritumab Deruxtecan in Patients With Brain Metastases

Start: Jul 2025Est. completion: Apr 20270
Phase 2Withdrawn
NCT05050929Varian Medical SystemsTargeting All Brain Metastases

RAPid SimPLE Targeted Radiation Treatment for Brain Metastases

Start: Jul 2022Est. completion: Dec 2027
Phase 2Recruiting
NCT06941272Daiichi SankyoPatritumab deruxtecan

A Study of Patritumab Deruxtecan in Pediatric Participants With Relapsed or Refractory Solid Tumors (MK-9999-01C/LIGHTBEAM-U01)

Start: May 2025Est. completion: Dec 203050 patients
Phase 1/2Recruiting
NCT04567251Varian Medical SystemsNoona® application

Survivorship Study of Cancer Patients Who Received Cranial Radiation Therapy

Start: Dec 2021Est. completion: May 2024
N/ATerminated
NCT02886572Varian Medical SystemsStereotactic radiosurgery

SIMT Stereotactic Radiosurgery Outcomes Study

Start: Jan 2017Est. completion: Apr 2021
N/ACompleted

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Phase Legend

Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available

Key Insights

2 actively recruiting trials targeting 50 patients
4 companies competing in this space

Related Indications

Breast Cancer(530)Non-small Cell Lung Cancer(373)Prostate Cancer(371)Multiple Myeloma(244)Advanced Solid Tumors(221)Acute Myeloid Leukemia(204)Cancer(187)Neoplasms(173)Colorectal Cancer(166)Advanced Solid Tumor(165)