Pulmonary Hypertension

Cardiovascular
49
Pipeline Programs
19
Companies
50
Clinical Trials
7 recruiting
10
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
3
0
12
5
17
12
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Small Molecule
2100%
+ 48 programs with unclassified modality

On Market (10)

Approved therapies currently available

Eli Lilly and Company
ADCIRCAApproved
tadalafil
Eli Lilly and Company
Phosphodiesterase 5 Inhibitor [EPC]oral2009
U
ASPRUZYO SPRINKLEApproved
ranolazine
Unknown Company
Anti-anginal [EPC]oral2022
U
CHEWTADZYApproved
tadalafil
Unknown Company
oral2024
Eli Lilly and Company
CIALISApproved
tadalafil
Eli Lilly and Company
Phosphodiesterase 5 Inhibitor [EPC]oral2003
GS
LETAIRISApproved
ambrisentan
Gilead Sciences
Endothelin Receptor Antagonist [EPC]oral2007
U
LIQREVApproved
sildenafil citrate
Unknown Company
oral2023
U
RANOLAZINEApproved
ranolazine
Unknown Company
Anti-anginal [EPC]oral2019
U
SILDENAFIL CITRATEApproved
sildenafil citrate
Unknown Company
oral2021
U
TADLIQApproved
tadalafil
Unknown Company
Phosphodiesterase 5 Inhibitor [EPC]oral2022
U
VYBRIQUEApproved
sildenafil citrate
Unknown Company
oral2025

Competitive Landscape

18 companies ranked by most advanced pipeline stage

United Therapeutics
United TherapeuticsMD - Silver Spring
20 programs
1
5
3
9
1
treprostinil sodiumPhase 41 trial
Inhaled treprostinilPhase 31 trial
Inhaled treprostinil solutionPhase 31 trial
Inhaled treprostinil solutionPhase 31 trial
Oral treprostinilPhase 31 trial
+15 more programs
Active Trials
NCT06911632Active Not Recruiting1,000Est. Jul 2028
NCT07116681Not Yet Recruiting8Est. Jul 2027
NCT03012646Withdrawn0Est. Apr 2019
+17 more trials
GS
Gilead SciencesFOSTER CITY, CA
8 programs
2
3
1
RanolazinePhase 41 trial
AmbrisentanPhase 3
AmbrisentanPhase 31 trial
AmbrisentanPhase 31 trial
BSF 208075Phase 2
+3 more programs
Active Trials
NCT01961232Active Not Recruiting100Est. Jun 2027
NCT00046319Completed60Est. Jun 2003
NCT00380068Completed224Est. May 2009
+2 more trials
Eli Lilly and Company
Eli Lilly and CompanyINDIANAPOLIS, IN
1 program
1
1
TadalafilPhase 2/3
Insmed
InsmedBRIDGEWATER, NJ
4 programs
1
1
2
Treprostinil Palmitil Inhalation PowderPhase 31 trial
Treprostinil Palmitil Inhalation PowderPhase 31 trial
Treprostinil Palmitil Inhalation PowderPhase 2/31 trial
Treprostinil PalmitilPhase 21 trial
Active Trials
NCT05176951Completed39Est. Mar 2024
NCT05649722Active Not Recruiting31Est. Mar 2026
NCT07179380Recruiting344Est. Dec 2028
+1 more trials
Pfizer
PfizerNEW YORK, NY
2 programs
1
1
Sildenafil citratePhase 35 trials
PF-07868489Phase 21 trial
Active Trials
NCT07073820Recruiting36Est. Jan 2029
NCT03356353Unknown24Est. Jan 2022
NCT01365585Completed227Est. Oct 2011
+3 more trials
Biogen
BiogenCAMBRIDGE, MA
1 program
1
Bardoxolone methylPhase 31 trial
Active Trials
NCT03068130Terminated261Est. Sep 2020
Tenax Therapeutics
Tenax TherapeuticsCHAPEL HILL, NC
1 program
1
TNX-103Phase 31 trial
Active Trials
NCT05983250RecruitingEst. Oct 2028
Alliance Pharmaceuticals
1 program
1
EmpagliflozinPhase 2Small Molecule1 trial
Active Trials
NCT06570473Recruiting30Est. Dec 2026
Function Therapeutics
Function TherapeuticsWI - Milwaukee
1 program
1
EmpagliflozinPhase 2Small Molecule
Pulse Biosciences
Pulse BiosciencesCA - Hayward
1 program
1
Inhaled NO delivered via INOpulse DS-C DevicePhase 21 trial
Active Trials
NCT01728220CompletedEst. Jul 2014
35Pharma
35PharmaQC - Montreal
1 program
1
HS235Phase 11 trial
Active Trials
NCT07123779Not Yet Recruiting40Est. Sep 2028
M&
Merck & Co.RAHWAY, NJ
1 program
1
MK-8892Phase 11 trial
Active Trials
NCT02078557Terminated4Est. Sep 2014
Bayer
BayerLEVERKUSEN, Germany
3 programs
Exhaled Breath Olfactory SignatureN/A1 trial
Latin American Pulmonary Hypertension RegistryN/A1 trial
Pulmonary Index of Microcirculatory ResistanceN/A1 trial
Active Trials
NCT02782026Completed273Est. Sep 2018
NCT02570737Unknown500Est. Apr 2019
NCT05812976Completed22Est. Apr 2025
Tempus
TempusIL - Chicago
1 program
ECG-based AI Device - Results Returned to InvestigatorN/A
LP
Lee's PharmaceuticalChina - Guangzhou
1 program
Inhaled nitric oxideN/A1 trial
Active Trials
NCT07099144Recruiting120Est. Dec 2026
Heidelberg Pharma
Heidelberg PharmaGermany - Ladenburg
1 program
PVRI GoDeep Global Deep Phenotyping Meta-Registry for Pulmonary HypertensionN/A1 trial
Active Trials
NCT05329714Recruiting40,000Est. Jan 2055
Abbott
AbbottABBOTT PARK, IL
1 program
Pulmonary Index of Microcirculatory ResistanceN/A1 trial
Active Trials
NCT05843461Completed30Est. Jul 2024
Eko Devices
Eko DevicesCA - Emeryville
1 program
Use of Eko DUO stethoscopeN/A1 trial
Active Trials
NCT05873387Recruiting2,420Est. Dec 2026

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
2028
2029
2030
2031
Gilead SciencesRanolazine
United Therapeuticstreprostinil sodium
PfizerSildenafil citrate
PfizerSildenafil citrate
PfizerSildenafil citrate
InsmedTreprostinil Palmitil Inhalation Powder
InsmedTreprostinil Palmitil Inhalation Powder
Tenax TherapeuticsTNX-103
United TherapeuticsInhaled treprostinil solution
United TherapeuticsInhaled treprostinil solution
PfizerSildenafil citrate
United TherapeuticsOral treprostinil
BiogenBardoxolone methyl
United TherapeuticsUT-15C SR
United TherapeuticsUT-15C 1 mg

Showing 15 of 50 trials with date data

Clinical Trials (50)

Total enrollment: 49,218 patients across 50 trials

Study of Ranolazine in the Treatment of Pulmonary Hypertension Associated With Diastolic Left Ventricular Dysfunction

Start: Jul 2011Est. completion: May 201410 patients
Phase 4Completed

Safety, Efficacy and Treatment Satisfaction in Patients With PAH Rapidly Switched From Epoprostenol to Remodulin

Start: Sep 2006Est. completion: Jan 200810 patients
Phase 4Completed
NCT00159900PfizerSildenafil citrate

Quality of Erection Study

Start: May 2005Est. completion: Jan 2006300 patients
Phase 4Completed
NCT00151463PfizerSildenafil citrate

QEQ Treatment Responsiveness Evaluation Study

Start: Jan 2005100 patients
Phase 4Completed
NCT00479908PfizerSildenafil citrate

Blood Pressure Interaction Between Sildenafil and Sublingual Glyceryl Trinitrate (GTN) in Men With Angina

Start: Jan 2004Est. completion: Sep 200520 patients
Phase 4Completed
NCT07234032InsmedTreprostinil Palmitil Inhalation Powder

An Open-Label Extension Study of Treprostinil Palmitil Inhalation Powder (TPIP) in Participants With Pulmonary Hypertension Associated With Interstitial Lung Disease (PH-ILD)

Start: Apr 2026Est. completion: Jan 2031344 patients
Phase 3Not Yet Recruiting
NCT07179380InsmedTreprostinil Palmitil Inhalation Powder

Efficacy and Safety Study of Treprostinil Palmitil Inhalation Powder (TPIP) in Participants With Pulmonary Hypertension Associated With Interstitial Lung Disease (PH-ILD)

Start: Jan 2026Est. completion: Dec 2028344 patients
Phase 3Recruiting

LEVosimendan to Improve Exercise Limitation in Patients With PH-HFpEF

Start: Jan 2024Est. completion: Oct 2028
Phase 3Recruiting
NCT03794583United TherapeuticsInhaled treprostinil solution

Inhaled Treprostinil in Participants With Pulmonary Hypertension Due to Chronic Obstructive Pulmonary Disease (PH-COPD)

Start: Dec 2018Est. completion: Nov 202241 patients
Phase 3Terminated
NCT03496623United TherapeuticsInhaled treprostinil solution

A Phase 3 Adaptive Study to Evaluate the Safety and Efficacy of Inhaled Treprostinil in Participants With Pulmonary Hypertension (PH) Due to Chronic Obstructive Pulmonary Disease (COPD)

Start: May 2018Est. completion: Oct 2022188 patients
Phase 3Terminated
NCT03356353PfizerSildenafil citrate

Sildenafil for the Prevention of Right Heart Failure Following LVAD Implantation

Start: Mar 2018Est. completion: Jan 202224 patients
Phase 3Unknown

Oral Treprostinil in Subjects With Pulmonary Hypertension Associated With Heart Failure With Preserved Ejection Fraction

Start: Aug 2017Est. completion: Dec 201984 patients
Phase 3Terminated
NCT03068130BiogenBardoxolone methyl

Extended Access Program to Assess Long-term Safety of Bardoxolone Methyl in Patients With Pulmonary Hypertension RANGER

Start: Apr 2017Est. completion: Sep 2020261 patients
Phase 3Terminated

Efficacy and Safety of Oral UT-15C Tablets to Treat Pulmonary Arterial Hypertension

Start: Jun 2009Est. completion: Jul 2011310 patients
Phase 3Completed

FREEDOM DR: Oral Treprostinil in Combination With an Endothelin Receptor Antagonist (ERA) and/or a Phosphodiesterase-5 (PDE-5) Inhibitor or as Monotherapy for the Treatment of Pulmonary Arterial Hypertension (PAH)

Start: Dec 2008Est. completion: Jan 20090
Phase 3Withdrawn

Study of Ambrisentan in Participants With Pulmonary Hypertension

Start: Nov 2008Est. completion: Sep 2019140 patients
Phase 3Completed

FREEDOM - M: Oral Treprostinil as Monotherapy for the Treatment of Pulmonary Arterial Hypertension (PAH)

Start: Oct 2006Est. completion: Apr 2011349 patients
Phase 3Completed

FREEDOM-C: Oral Treprostinil in Combination With an Endothelin Receptor Antagonist (ERA) and/or a Phosphodiesterase-5 (PDE-5) Inhibitor for the Treatment of Pulmonary Arterial Hypertension (PAH)

Start: Oct 2006Est. completion: Dec 2010354 patients
Phase 3Completed

Safety and Efficacy Study of Ambrisentan in Subjects With Pulmonary Hypertension

Start: Aug 2006Est. completion: May 2009224 patients
Phase 3Completed
NCT00147199United TherapeuticsInhaled treprostinil

Clinical Investigation Into Inhaled Treprostinil Sodium in Patients With Severe Pulmonary Arterial Hypertension (PAH)

Start: Jun 2005Est. completion: Oct 2007235 patients
Phase 3Completed
NCT00159874PfizerSildenafil citrate

A Long Term Extension Study Evaluating Safety Of Sildenafil Citrate When Used To Treat Pulmonary Arterial Hypertension (PAH) In Children

Start: Jan 2004Est. completion: Dec 2012234 patients
Phase 3Completed
NCT00159861PfizerSildenafil citrate

The Efficacy and Safety of Sildenafil Citrate Used in Combination With Intravenous Epoprostenol in PAH

Start: Jul 2003Est. completion: Jan 2006267 patients
Phase 3Completed

Phase III Randomized Study of UT-15 in Patients With Primary Pulmonary Hypertension

Start: Oct 1998Est. completion: Sep 2000
Phase 3Completed
NCT05649722InsmedTreprostinil Palmitil Inhalation Powder

An Extension Study of Treprostinil Palmitil Inhalation Powder (TPIP) for Pulmonary Hypertension Associated With Interstitial Lung Disease (PH-ILD)

Start: May 2023Est. completion: Mar 202631 patients
Phase 2/3Active Not Recruiting
NCT02630316United TherapeuticsInhaled Treprostinil

Safety and Efficacy of Inhaled Treprostinil in Adult PH With ILD Including CPFE

Start: Feb 2017Est. completion: Dec 2019326 patients
Phase 2/3Completed
NCT02633293United TherapeuticsInhaled Treprostinil

An Open Label Extension Study to Evaluate Inhaled Treprostinil in Adult PH With ILD Including CPFE

Start: Sep 2016Est. completion: Aug 2021243 patients
Phase 2/3Terminated

Tadalafil for Sarcoidosis Associated Pulmonary Hypertension

Start: Mar 2011Est. completion: Oct 201312 patients
Phase 2/3Completed

A Study to Learn About the Study Medicine (Called PF-07868489) in People With Pulmonary Arterial Hypertension Who Have Previously Participated in a Clinical Study With PF-07868489

Start: Nov 2025Est. completion: Jan 202936 patients
Phase 2Recruiting

Feasibility Trial for a Right Ventricular Failure Platform Trial

Start: Jul 2025Est. completion: Dec 202630 patients
Phase 2Recruiting
NCT05176951InsmedTreprostinil Palmitil

A Study to Evaluate the Safety and Tolerability of Treprostinil Palmitil Inhalation Powder in Participants With Pulmonary Hypertension Associated With Interstitial Lung Disease

Start: Dec 2022Est. completion: Mar 202439 patients
Phase 2Completed
NCT03012646United TherapeuticsInhaled Treprostinil

Safety and Tolerability of Inhaled Treprostinil in Adult PH Due to COPD

Start: Apr 2017Est. completion: Apr 20190
Phase 2Withdrawn

Oral Treprostinil in Subjects With Pulmonary Hypertension Associated With Pulmonary Fibrosis

Start: Feb 2016Est. completion: Jul 20180
Phase 2Withdrawn
NCT01728220Pulse BiosciencesInhaled NO delivered via INOpulse DS-C Device

Two-Part Dose-Confirming Study of Pulsed Inhaled Nitric Oxide in Subjects With WHO Group 3 Pulmonary Hypertension Associated With COPD

Start: Dec 2012Est. completion: Jul 2014
Phase 2Completed

Qutenza®-Remodulin® in Pulmonary Arterial Hypertension Patients

Start: Aug 2011Est. completion: Jul 201211 patients
Phase 2Completed

The Qutenza Patch as Treatment for Disabling Treprostinil (Remodulin) Infusion Site Pain

Start: Nov 2010Est. completion: Apr 20126 patients
Phase 2Completed

A Dose Response Study of UT-15C SR in Patients With Exercise-Induced Pulmonary Hypertension

Start: Apr 2010Est. completion: Jan 201350 patients
Phase 2Completed
NCT00141310PfizerSildenafil citrate

Sildenafil Citrate for the Treatment of Established Pre-Eclampsia

Start: Sep 2004Est. completion: Apr 200676 patients
Phase 2Terminated

Study of BSF 208075 Evaluating Exercise Capacity in Patients With Pulmonary Arterial Hypertension

Start: Sep 2002Est. completion: Jun 200360 patients
Phase 2Completed
NCT07116681United TherapeuticsInhaled treprostinil

Effects of Inhaled Treprostinil on Exercise Performance in Exercise Induced Pulmonary Hypertension

Start: Oct 2025Est. completion: Jul 20278 patients
Phase 1Not Yet Recruiting

Study of HS235 in Obese Patients With Pulmonary Hypertension and Heart Failure With Preserved Ejection Fraction (HFpEF)

Start: Sep 2025Est. completion: Sep 202840 patients
Phase 1Not Yet Recruiting

A Multiple Dose Titration Study of MK-8892 in Participants With Pulmonary Hypertension and Left Heart Disease (MK-8892-007)

Start: May 2014Est. completion: Sep 20144 patients
Phase 1Terminated
NCT01247805PfizerSildenafil citrate

A Pivotal Bioequivalence Study Between The Sildenafil Powder For Oral Suspension (10 Mg/Ml) And The Sildenafil 10 Mg Immediate Release (IR) Tablet Relative To The Revatio 20 Mg IR Tablet In Healthy Volunteers Under Fasting Conditions

Start: Jan 2011Est. completion: Feb 201142 patients
Phase 1Completed
NCT06911632United TherapeuticsECG-based AI Device - Results Returned to Investigator

Multi-site Study of the Clinical Impact of an AI-assisted Approach to Referring Patients With Interstitial Lung Disease for Diagnostic Evaluation of Pulmonary Hypertension

Start: Jul 2025Est. completion: Jul 20281,000 patients
N/AActive Not Recruiting

Inhaled Nitric Oxide for the Treatment of Neonatal Hypoxic Respiratory Failure With Pulmonary Hypertension

Start: Dec 2024Est. completion: Dec 2026120 patients
N/ARecruiting
NCT05873387Eko DevicesUse of Eko DUO stethoscope

Development of an Algorithm to Detect Pulmonary Hypertension Using an Electronic Stethoscope

Start: Jul 2023Est. completion: Dec 20262,420 patients
N/ARecruiting
NCT05812976BayerPulmonary Index of Microcirculatory Resistance

Novel Index (PIMR) in PAH

Start: Feb 2023Est. completion: Apr 202522 patients
N/ACompleted
NCT05843461AbbottPulmonary Index of Microcirculatory Resistance

PIMR and Pulmonary Vascular Disease

Start: Jan 2023Est. completion: Jul 202430 patients
N/ACompleted
NCT05329714Heidelberg PharmaPVRI GoDeep Global Deep Phenotyping Meta-Registry for Pulmonary Hypertension

PVRI GoDeep Global Deep Phenotyping Meta-Registry for Pulmonary Hypertension

Start: Jan 2020Est. completion: Jan 205540,000 patients
N/ARecruiting
NCT02782026BayerExhaled Breath Olfactory Signature

Exhaled Breath Olfactory Signature of Pulmonary Arterial Hypertension

Start: Mar 2016Est. completion: Sep 2018273 patients
N/ACompleted
NCT02570737BayerLatin American Pulmonary Hypertension Registry

Latin American Pulmonary Hypertension Registry

Start: Apr 2014Est. completion: Apr 2019500 patients
N/AUnknown

Related Jobs in Cardiovascular

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

17 late-stage (Phase 3) programs — potential near-term approvals
7 actively recruiting trials targeting 49,218 patients
19 companies competing in this space