Atrial Fibrillation

Cardiovascular
86
Pipeline Programs
30
Companies
50
Clinical Trials
1 recruiting
16
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
2
1
18
1
20
44
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Small Molecule
6100%
+ 221 programs with unclassified modality

On Market (16)

Approved therapies currently available

U
APIXABANApproved
apixaban
Unknown Company
Factor Xa Inhibitor [EPC]oral2025
Sanofi
AVALIDEApproved
irbesartan and hydrochlorothiazide
Sanofi
Thiazide Diuretic [EPC]oral1997
Sanofi
AVAPROApproved
irbesartan
Sanofi
Angiotensin 2 Receptor Blocker [EPC]oral1997
U
DRONEDARONEApproved
dronedarone
Unknown Company
oral
U
EDOXABANApproved
edoxaban
Unknown Company
oral
Bristol Myers Squibb
ELIQUISApproved
apixaban
Bristol Myers Squibb
oral2012
Bristol Myers Squibb
ELIQUIS SPRINKLEApproved
apixaban
Bristol Myers Squibb
oral2025
AstraZeneca
FARXIGAApproved
dapagliflozin
AstraZeneca
oral2014
U
IRBESARTANApproved
irbesartan
Unknown Company
Angiotensin 2 Receptor Blocker [EPC]oral2012
Sanofi
MULTAQApproved
dronedarone
Sanofi
Antiarrhythmic [EPC]oral2009
U
PANTOPRAZOLE SODIUMApproved
pantoprazole
Unknown Company
oral2016
Boehringer Ingelheim
PRADAXAApproved
dabigatran etexilate mesylate
Boehringer Ingelheim
oral2010
U
RIVAROXABANApproved
rivaroxaban
Unknown Company
Factor Xa Inhibitor [EPC]oral2025
DS
SAVAYSAApproved
edoxaban tosylate
Daiichi Sankyo
oral2015
U
WARFARIN SODIUMApproved
warfarin
Unknown Company
oral2011
J&
XARELTOApproved
rivaroxaban
Johnson & Johnson
oral2011

Competitive Landscape

33 companies ranked by most advanced pipeline stage

Boehringer Ingelheim
Boehringer IngelheimINGELHEIM, Germany
52 programs
3
4
11
DabigatranPhase 41 trial
DabigatranPhase 41 trial
Dabigatran Etexilate Oral CapsulePhase 41 trial
DabigatranetexilatePhase 41 trial
Pradaxa, dabigatran etexilatePhase 41 trial
+47 more programs
Active Trials
NCT02006524Completed3,269Est. Dec 2014
NCT01847560Completed333,664Est. Nov 2017
NCT02785354Completed103,101Est. Apr 2016
+48 more trials
Abbott
AbbottABBOTT PARK, IL
24 programs
2
early standardised rhythm controlPhase 41 trial
pacemaker implantationPhase 42 trials
AMPLATZER Cardiac PlugN/A2 trials
AMPLATZER™ LAA OccluderN/A1 trial
ASSERT Insertable Cardiac MonitorN/A1 trial
+19 more programs
Active Trials
NCT01118299Completed97Est. Dec 2018
NCT01786486Completed204Est. Jan 2014
NCT02964208Completed520Est. Aug 2022
+24 more trials
Rhythm Pharmaceuticals
22 programs
3
Medtronic AT500Phase 41 trial
Pacemaker Medtronic EnRhythmPhase 41 trial
early standardised rhythm controlPhase 4
AFib detection with wearable smart watchN/A1 trial
Arctic Front Cardiac Cryoablation SystemN/A1 trial
+17 more programs
Active Trials
NCT04499807Terminated16Est. Mar 2021
NCT00889681Completed81Est. Oct 2013
NCT02222818Completed71Est. Jan 2016
+14 more trials
Bristol Myers Squibb
21 programs
1
3
2
ApixabanPhase 4
Zio®XT MonitorPhase 41 trial
IrbesartanPhase 3Small Molecule
IrbesartanPhase 3Small Molecule
clopidogrelPhase 3
+16 more programs
Active Trials
NCT05890274Active Not Recruiting120Est. Feb 2026
NCT05810896Active Not Recruiting300Est. Jun 2026
NCT03583008Completed112Est. Mar 2019
+16 more trials
Pfizer
16 programs
3
2
ApixabanPhase 41 trial
ApixabanPhase 41 trial
ApixabanPhase 31 trial
ApixabanPhase 31 trial
amiodaronePhase 31 trial
+11 more programs
Active Trials
NCT05038228Active Not Recruiting1Est. Apr 2026
NCT03572972Completed64,684Est. Dec 2018
NCT04681482Completed107,383Est. Nov 2020
+11 more trials
DS
16 programs
2
4
1
OAC alonePhase 41 trial
EdoxabanPhase 31 trial
EdoxabanPhase 31 trial
EdoxabanPhase 31 trial
Edoxaban-based RegimenPhase 31 trial
+11 more programs
Active Trials
NCT02339493Completed458Est. Sep 2018
NCT05898165Active Not Recruiting1,955Est. Feb 2026
NCT05804747Completed1,204Est. Jul 2025
+15 more trials
Biotronik
BiotronikGermany - Berlin
12 programs
2
Home Monitoring Guided OACPhase 41 trial
RivaroxabanPhase 4
BIOMONITOR IIIN/A1 trial
ICD with DX systemN/A1 trial
Implantable ECG holter deviceN/A1 trial
+7 more programs
Active Trials
NCT03850327Completed48Est. Oct 2019
NCT02186704Completed450Est. Jul 2018
NCT05860894Recruiting150Est. Dec 2026
+7 more trials
Sanofi
10 programs
1
3
4
DRONEDARONEPhase 41 trial
DronedaronePhase 41 trial
DronedaronePhase 41 trial
early standardised rhythm controlPhase 4
AVALIDE(Irbesartan)Phase 3Small Molecule1 trial
+5 more programs
Active Trials
NCT00995748Completed2,674Est. Oct 2011
NCT05279833Completed87,810Est. Mar 2022
NCT00232310Completed150Est. Apr 2006
+6 more trials
AstraZeneca
2 programs
1
1
dapagliflozinPhase 4Small Molecule1 trial
AZD7009, no generic name availablePhase 21 trial
Active Trials
NCT00255281Completed160Est. May 2006
NCT04792190Completed25Est. Jun 2023
J&
Johnson & JohnsonNEW BRUNSWICK, NJ
1 program
1
RivaroxabanN/A1 trial
Active Trials
NCT04249401Completed134,897Est. Sep 2023
Stuart Therapeutics
1 program
1
IrbesartanPhase 3Small Molecule
Astellas
AstellasChina - Shenyang
1 program
1
RSD1235Phase 34 trials
Active Trials
NCT00281554Completed254Est. Jan 2007
NCT00125320Completed190Est. Feb 2007
NCT00476112Completed60Est. Sep 2004
+1 more trials
Stereotaxis
StereotaxisST.LOUIS, MO
1 program
1
Vdrive Lasso navigationPhase 31 trial
Active Trials
NCT01656772Completed120Est. Dec 2013
Bayer
20 programs
2
1
Rivaroxaban 10 mg qdPhase 2/31 trial
CapadenosonPhase 21 trial
XareltoPhase 22 trials
12-point-ECGN/A1 trial
AF screeningN/A1 trial
+15 more programs
Active Trials
NCT02875106Completed165Est. May 2019
NCT02534532Withdrawn0Est. Apr 2016
NCT02687854Completed18,591Est. Mar 2016
+16 more trials
GS
Gilead SciencesFOSTER CITY, CA
3 programs
3
RanolazinePhase 21 trial
TecadenosonPhase 2
TecadenosonPhase 21 trial
Active Trials
NCT01522651Completed134Est. Mar 2014
NCT00713401Completed21Est. Jul 2008
Novartis
NovartisBASEL, Switzerland
2 programs
2
MAA868Phase 22 trials
PKN605Phase 21 trial
Active Trials
NCT03398434Withdrawn0Est. Jan 2020
NCT03393481Withdrawn0Est. Apr 2020
NCT07217067Recruiting165Est. Sep 2027
Pierre Fabre
Pierre FabreFrance - Aignan
1 program
1
1g of F373280Phase 21 trial
Active Trials
NCT01831856Completed135Est. Jun 2017
Knight Therapeutics
Knight TherapeuticsQC - Montréal
1 program
1
Amiodarone HydrochloridePhase 21 trial
Active Trials
NCT06067438Recruiting90Est. Aug 2026
OMEICOS Therapeutics
OMEICOS TherapeuticsGermany - Berlin
1 program
1
OMT-28Phase 21 trial
Active Trials
NCT03906799CompletedEst. Mar 2020
Spectrum Dynamics
Spectrum DynamicsFL - Sarasota
1 program
1
Cardiac CTPhase 1/21 trial
Active Trials
NCT02914860Unknown60Est. Jun 2017
Helios Cardio
Helios CardioMA - Weston
1 program
1
CardiaMend in Combination with AmiodaronePhase 11 trial
Active Trials
NCT06063538Recruiting63Est. Jun 2027
Thryv Therapeutics
Thryv TherapeuticsQC - Montreal
1 program
1
THRV-1268Phase 11 trial
Active Trials
NCT06507839CompletedEst. Nov 2024
City Therapeutics
City TherapeuticsMA - Cambridge
4 programs
Intravenous caffeineN/A1 trial
Left Atrial Appendage OcclusionN/A1 trial
Unipolar Polarity Switch LeftN/A1 trial
Venous ClosureN/A1 trial
Active Trials
NCT05464940Not Yet Recruiting100Est. Jun 2026
NCT06075628Recruiting100Est. Dec 2025
NCT05464537Terminated8Est. Nov 2024
+1 more trials
Heidelberg Pharma
Heidelberg PharmaGermany - Ladenburg
3 programs
International Registry on Cardioversion of Atrial Fibrillation (MK-6621-051)N/A1 trial
Pulmonary vein isolationN/A2 trials
Subcutaneously implanted event recorderN/A1 trial
Active Trials
NCT01119716Completed4,658Est. Feb 2013
NCT05603611Unknown40Est. Dec 2022
NCT01448265Completed40Est. Jul 2013
+1 more trials
Laminar Pharmaceuticals
Laminar PharmaceuticalsSpain - Palma de Mallorca
2 programs
Left Atrial Appendage ClosureN/A1 trial
Left Atrial Appendage ClosureN/A1 trial
Active Trials
NCT05224375CompletedEst. Feb 2024
NCT04807283UnknownEst. Dec 2023
Circle Pharma
1 program
Dynamic fluoroscopyN/A1 trial
Active Trials
NCT07462910Not Yet Recruiting250Est. May 2027
Impulse Dynamics
Impulse DynamicsNY - Pearl River
1 program
Impulse Dynamics Optimizer DeviceN/A1 trial
Active Trials
NCT05704426TerminatedEst. Jul 2023
M&
Merck & Co.RAHWAY, NJ
1 program
International Registry on Cardioversion of Atrial Fibrillation (MK-6621-051)N/A
Siemens Healthineers
Siemens HealthineersGermany - Forchheim
1 program
Intervention groupN/A
Hamilton medical
Hamilton medicalSwitzerland - Bonaduz
1 program
Left Posterior PericardiotomyN/A1 trial
Active Trials
NCT06486636RecruitingEst. Sep 2031

+3 more companies

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
BayerRivaroxaban
AstraZenecadapagliflozin
BayerRivaroxaban
BayerRivaroxaban
BayerRivaroxaban
BayerRivaroxaban
Bristol Myers SquibbZio®XT Monitor
Daiichi SankyoEdoxaban
Boehringer IngelheimDabigatran Etexilate Oral Capsule
Boehringer Ingelheimdabigatran etexilate
Boehringer IngelheimDabigatran
Bristol Myers SquibbWarfarin
Daiichi SankyoEdoxaban
Boehringer IngelheimDabigatranetexilate
Boehringer IngelheimDabigatran

Showing 15 of 50 trials with date data

Clinical Trials (50)

Total enrollment: 48,538 patients across 50 trials

NCT05797376BayerRivaroxaban

Effects of aSPIrin Versus Aspirin Plus Low-dose RIvaroxaban on Carotid aTherosclerotic Plaque Inflammation

Start: Aug 2021Est. completion: Dec 202492 patients
Phase 4Completed

Use of Dapagliflozin to Reduce Burden of Atrial Fibrillation in Patients Undergoing Catheter Ablation of Symptomatic Atrial Fibrillation

Start: Jul 2021Est. completion: Jun 202325 patients
Phase 4Completed
NCT06986369BayerRivaroxaban

Effects of Rivaroxaban on Vascular FMD in Patients With Stable Atherosclerotic Vascular Diseases

Start: May 2021Est. completion: Mar 2024140 patients
Phase 4Completed
NCT04853719BayerRivaroxaban

Rivaroxaban 2.5 mg BID and Aspirin for Intermittent Claudication in PAD Patients

Start: Apr 2021Est. completion: Nov 202288 patients
Phase 4Completed
NCT04263038BayerRivaroxaban

Clinical Surveillance vs. Anticoagulation for Low-risk Patients With Isolated Subsegmental Pulmonary Embolism

Start: May 2020Est. completion: May 2026276 patients
Phase 4Recruiting
NCT04073316BayerRivaroxaban

AntiCoagulants and COGnition

Start: Feb 2020Est. completion: Feb 202348 patients
Phase 4Unknown

A Study to Determine if Identification of Undiagnosed Atrial Fibrillation in People at Least 70 Years of Age Reduces the Risk of Stroke

Start: Dec 2019Est. completion: Jun 202311,931 patients
Phase 4Completed

Resolution of Thrombi in Left Atrial Appendage With Edoxaban

Start: May 2019Est. completion: Aug 202436 patients
Phase 4Completed
NCT03539055Boehringer IngelheimDabigatran Etexilate Oral Capsule

Efficacy of Short Term Dabigatran Etexilate Followed by Aspirin Monotherapy After LAA (Left Atrial Appendage) Device Closure (the DEA-LAA Study).

Start: Sep 2018Est. completion: Feb 2024100 patients
Phase 4Completed

Evaluation of Abbreviated Versus Conventional Course of Dabigatran Etexilate Before Electric Cardioversion in Patients With Atrial Fibrillation (RE-SOUND Study)

Start: Dec 2017Est. completion: Dec 2020400 patients
Phase 4Unknown

Dabigatran Versus Conventional Treatment for Prevention of Silent Cerebral Infarct in Atrial Fibrillation Associated With Valvular Disease

Start: Dec 2016Est. completion: Oct 2020120 patients
Phase 4Completed

Trial to Evaluate Anticoagulation Therapy in Hemodialysis Patients With Atrial Fibrillation

Start: Dec 2016Est. completion: Aug 2019154 patients
Phase 4Completed

Edoxaban in Patients With Coronary Artery Disease on Dual Antiplatelet Therapy With Aspirin and Clopidogrel

Start: Mar 2016Est. completion: Mar 201880 patients
Phase 4Completed

Left Atrial Thrombus Reduction - Effect of Dabigatran Versus Phenprocoumon

Start: Oct 201540 patients
Phase 4Unknown

Prevention of Silent Cerebral Thromboembolism by Oral Anticoagulation With Dabigatran After Pulmonary Vein Isolation for Atrial Fibrillation

Start: Aug 2015Est. completion: Sep 2020200 patients
Phase 4Completed

Apixaban for the Reduction of Thrombo-Embolism in Patients With Device-Detected Sub-Clinical Atrial Fibrillation

Start: May 2015Est. completion: Nov 20234,012 patients
Phase 4Completed

Uninterrupted Dabigatran Etexilate in Comparison to Uninterrupted Warfarin in Pulmonary Vein Ablation (RE-CIRCUIT)

Start: Apr 2015Est. completion: Nov 2016678 patients
Phase 4Completed

Apixaban for Secondary Prevention of Thromboembolism Among Patients With AntiphosPholipid Syndrome

Start: Dec 2014Est. completion: Mar 202248 patients
Phase 4Completed

Cognitive Impairment Related to Atrial Fibrillation Prevention Trial

Start: Nov 2014Est. completion: Mar 2021200 patients
Phase 4Completed
NCT02116036BayerRivaroxaban

Rivaroxaban for Antiphospholipid Antibody Syndrome

Start: Sep 2014Est. completion: Sep 201781 patients
Phase 4Completed

Study Of The Blood Thinner, Apixaban, For Patients Who Have An Abnormal Heart Rhythm (Atrial Fibrillation) And Expected To Have Treatment To Put Them Back Into A Normal Heart Rhythm (Cardioversion)

Start: Jul 2014Est. completion: Feb 20171,500 patients
Phase 4Completed

Optimizing Antithrombotic Care in Patients With AtriaL fibrillatiON and Coronary stEnt (OAC-ALONE) Study

Start: Nov 2013Est. completion: May 2018690 patients
Phase 4Completed
NCT01976507Boehringer Ingelheimdabigatran etexilate mesylate

Use of Dabigatran Etexilate to Prevent Stroke and Thromboembolism

Start: Oct 2013Est. completion: Dec 2016101 patients
Phase 4Completed
NCT01896297Boehringer IngelheimPradaxa, dabigatran etexilate

Pradaxa Study in Non-valvular Atrial Fibrillation Patients With Severely Impaired Renal Function

Start: Jul 2013Est. completion: Oct 201563 patients
Phase 4Completed
NCT02066662BayerRivaroxaban

Rivaroxaban Compared to Vitamin K Antagonist Upon Development of Cardiovascular Calcification

Start: Jul 2013Est. completion: Mar 2020192 patients
Phase 4Completed

A Prospective, Open Label Study Evaluating Two Management Strategies on Gastrointestinal Symptoms in Patients Newly on Treatment With Pradaxa for the Prevention of Stroke and Systemic Embolism With Non-valvular Atrial Fibrillation

Start: Dec 2011Est. completion: Jul 20141,067 patients
Phase 4Completed
NCT01448265Heidelberg PharmaPulmonary vein isolation

Real-Time Assessment of Cryoballoon Pulmonary Vein Isolation Using a Novel Circular Mapping Catheter

Start: Sep 2011Est. completion: Jul 201340 patients
Phase 4Completed

DAPPAR AF Dabigatran for Peri Procedural Anticoagulation During Radiofrequency Ablation of Atrial Fibrillation

Start: Jul 2011Est. completion: Jun 201750 patients
Phase 4Completed
NCT01288352Abbottearly standardised rhythm control

Early Treatment of Atrial Fibrillation for Stroke Prevention Trial

Start: Jul 2011Est. completion: May 20202,789 patients
Phase 4Completed

Pharmacokinetics and Optimal Timing of Dronedarone Initiation Following Long-term Amiodarone in Patients With Paroxysmal or Persistent Atrial Fibrillation

Start: Oct 2010Est. completion: Apr 2012154 patients
Phase 4Completed

Optimal Timing of Dronedarone Initiation After Conversion in Patients With Persistent Atrial Fibrillation

Start: Sep 2010Est. completion: Dec 2011402 patients
Phase 4Completed

Effect of Addition of Dronedarone to Standard Rate Control Therapy on Ventricular Rate During Persistent Atrial Fibrillation (AFRODITE)

Start: Apr 2010Est. completion: Sep 2011183 patients
Phase 4Completed
NCT00559988BiotronikHome Monitoring Guided OAC

Combined Use of BIOTRONIK Home Monitoring and Predefined Anticoagulation to Reduce Stroke Risk

Start: Feb 2008Est. completion: Jun 20132,718 patients
Phase 4Terminated
NCT00512915Abbottpacemaker implantation

Avoid FFS - Use of the Atrial Pacemaker Lead 1699 With Very Short Tip Ring Spacing to Avoid Far Field Sensing

Start: Dec 2006Est. completion: Aug 2008204 patients
Phase 4Completed
NCT00262119Rhythm PharmaceuticalsPacemaker Medtronic EnRhythm

MINERVA: MINimizE Right Ventricular Pacing to Prevent Atrial Fibrillation and Heart Failure

Start: Feb 2006Est. completion: Apr 20131,300 patients
Phase 4Completed

LEAF - Low Energy In Atrial Fibrillation

Start: Aug 2000Est. completion: Nov 2003237 patients
Phase 4Completed
NCT03969953BayerRivaroxaban

Treatment of Cardiovascular Disease With Low Dose Rivaroxaban in Advanced Chronic Kidney Disease

Start: Dec 2020Est. completion: Dec 20252,000 patients
Phase 3Active Not Recruiting
NCT04324463BayerRivaroxaban

Anti-Coronavirus Therapies to Prevent Progression of Coronavirus Disease 2019 (COVID-19) Trial

Start: Apr 2020Est. completion: Dec 20226,667 patients
Phase 3Completed

Trial of Apixaban vs Warfarin in Reducing Rate of Cognitive Decline, Silent Cerebral Infarcts and Cerebral Microbleeds in Patients With Atrial Fibrillation

Start: Dec 2018Est. completion: Dec 202034 patients
Phase 3Terminated

Edoxaban for Prevention of Blood Vessels Being Blocked by Clots (Thrombotic Events) in Children at Risk Because of Cardiac Disease

Start: May 2018Est. completion: Dec 2021168 patients
Phase 3Completed

Compare Apixaban and Vitamin-K Antagonists in Patients With Atrial Fibrillation (AF) and End-Stage Kidney Disease (ESKD)

Start: Jun 2017Est. completion: Jul 2022108 patients
Phase 3Completed
NCT02943785Daiichi SankyoEdoxaban-based Regimen

Edoxaban Compared to Standard Care After Heart Valve Replacement Using a Catheter in Patients With Atrial Fibrillation (ENVISAGE-TAVI AF)

Start: Mar 2017Est. completion: Feb 20211,426 patients
Phase 3Completed

Edoxaban Treatment Versus Vitamin K Antagonist (VKA) in Patients With Atrial Fibrillation (AF) Undergoing Catheter Ablation

Start: Mar 2017Est. completion: Sep 2018632 patients
Phase 3Completed

Edoxaban Treatment Versus Vitamin K Antagonist in Patients With Atrial Fibrillation Undergoing Percutaneous Coronary Intervention

Start: Feb 2017Est. completion: Jun 20191,506 patients
Phase 3Completed
NCT02746185BayerRivaroxaban

Cancer Associated Thrombosis, a Pilot Treatment Study Using Rivaroxaban

Start: Sep 2016Est. completion: Apr 2018159 patients
Phase 3Completed
NCT02833948BayerRivaroxaban

Comparison of a Rivaroxaban-based Strategy With an Antiplatelet-based Strategy Following Successful TAVR for the Prevention of Leaflet Thickening and Reduced Leaflet Motion as Evaluated by Four-dimensional, Volume-rendered Computed Tomography (4DCT)

Start: May 2016Est. completion: Mar 2019231 patients
Phase 3Completed
NCT02401594BayerRivaroxaban

PROphylaxis in NOn Major Orthopaedic Surgery

Start: Dec 2015Est. completion: Apr 20183,608 patients
Phase 3Terminated
NCT02403596BayerRivaroxaban

Blood-sparing During Hip Prosthesis Surgery With Exacyl® in Patients Treated With Rivaroxaban

Start: Oct 2015Est. completion: Aug 2017231 patients
Phase 3Completed

Apixaban for Early Prevention of Recurrent Embolic Stroke and Hemorrhagic Transformation

Start: Apr 2015Est. completion: Jun 201991 patients
Phase 3Completed
NCT02387229BayerRivaroxaban

Blinded Randomized Trial of Anticoagulation to Prevent Ischemic Stroke and Neurocognitive Impairment in AF

Start: Mar 2015Est. completion: May 20241,238 patients
Phase 3Terminated

Related Jobs in Cardiovascular

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

20 late-stage (Phase 3) programs — potential near-term approvals
1 actively recruiting trials targeting 48,538 patients
30 companies competing in this space