Congestive Heart Failure

Cardiovascular
9
Pipeline Programs
14
Companies
4
Clinical Trials
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
2
1
3
0
1
2
Early DiscoveryClinical DevelopmentMarket

Competitive Landscape

13 companies ranked by most advanced pipeline stage

Biotronik
BiotronikGermany - Berlin
6 programs
1
2
Corox OTW Steroid Left Ventricular LeadPhase 41 trial
Kronos LV-T, Lumax HF-TPhase 41 trial
Optimized interventricular delay biventricular pacingPhase 21 trial
CRT Therapy - LV Lead RegistryN/A1 trial
PHR MessagingN/A1 trial
+1 more programs
Active Trials
NCT00810264Completed2,499Est. Nov 2018
NCT02682251Completed10Est. Oct 2019
NCT05971225Recruiting450Est. Apr 2027
+3 more trials
Sanofi
SanofiPARIS, France
1 program
1
SR121463BPhase 31 trial
Active Trials
NCT00274326Completed150Est. Jul 2007
AskBio
AskBioNC - Durham
2 programs
1
1
AB-1002Phase 21 trial
3 x 10e13vg AB-1002Phase 11 trial
Active Trials
NCT04179643Active Not Recruiting17Est. Sep 2026
NCT05598333Active Not Recruiting150Est. Dec 2030
Amgen
AmgenTHOUSAND OAKS, CA
1 program
1
Darbepoetin AlfaPhase 21 trial
Active Trials
NCT00086086Completed150
J&
Johnson & JohnsonNEW BRUNSWICK, NJ
2 programs
1
telehomecarePhase 1/21 trial
Tailored Healthmedia programs on EHR Patient PortalN/A1 trial
Active Trials
NCT00147706Completed6,000Est. Aug 2006
NCT00261664Completed290Est. Jul 2005
Bayer
BayerLEVERKUSEN, Germany
1 program
1
PecavaptanPhase 11 trial
Active Trials
NCT05599997Completed32Est. May 2021
Abbott
AbbottABBOTT PARK, IL
3 programs
CRT AlgorithmN/A1 trial
EnSite NavX SystemN/A1 trial
SyncAV programmed ONN/A1 trial
Active Trials
NCT02803775Completed92Est. Feb 2019
NCT01615835Completed16Est. Oct 2007
NCT04100148Active Not Recruiting1,686Est. Jun 2026
Rhythm Pharmaceuticals
3 programs
CRT-P ImplantN/A1 trial
Cardiac Compass with OptiVol Fluid Status MonitoringN/A1 trial
Fluid Status MonitoringN/A1 trial
Active Trials
NCT01735916Terminated44Est. Mar 2014
NCT00510198Terminated120Est. Apr 2009
NCT00289276Completed156
Boehringer Ingelheim
Boehringer IngelheimINGELHEIM, Germany
1 program
BodyPortN/A1 trial
Active Trials
NCT04394754Completed182Est. Dec 2021
Heidelberg Pharma
Heidelberg PharmaGermany - Ladenburg
1 program
New Echocardiographic Parameters for Prediction of Response to Cardiac Resynchronization TherapyN/A1 trial
Active Trials
NCT02375399Terminated15Est. Sep 2015
Verona Pharma
Verona PharmaUK - London
1 program
Telemonitoring for patients with Congestive Heart FailureN/A1 trial
Active Trials
NCT01513993CompletedEst. May 2014
NK
Nihon KohdenNEW YORK, NY
1 program
ezCVP measurementN/A1 trial
Active Trials
NCT05441696Enrolling By InvitationEst. Sep 2026
Zoll
ZollCA - San Jose
1 program
uCorN/A1 trial
Active Trials
NCT02700191WithdrawnEst. Dec 2016

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
2028
2029
2030
BiotronikKronos LV-T, Lumax HF-T
BiotronikCorox OTW Steroid Left Ventricular Lead
SanofiSR121463B
AskBioAB-1002

Clinical Trials (4)

Total enrollment: 587 patients across 4 trials

NCT00395642BiotronikKronos LV-T, Lumax HF-T

TRIAGE-CRT Telemonitoring in Patients With CHF and Indication of CRT-D

Start: Nov 2006Est. completion: Jan 200866 patients
Phase 4Completed
NCT00396136BiotronikCorox OTW Steroid Left Ventricular Lead

COSMO Post Approval Registry: Corox OTW Steroid LV Lead Monitoring

Start: Oct 2006Est. completion: Dec 2011221 patients
Phase 4Completed
NCT00274326SanofiSR121463B

DILIPO (DILutIonal HyPOnatremia)

Start: May 2005Est. completion: Jul 2007150 patients
Phase 3Completed
NCT05598333AskBioAB-1002

Phosphatase Inhibition by Intracoronary Gene Therapy in Subjects With Non-Ischemic NYHA Class III Heart Failure

Start: Oct 2023Est. completion: Dec 2030150 patients
Phase 2Active Not Recruiting

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Phase Legend

Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available

Key Insights

1 late-stage (Phase 3) programs — potential near-term approvals
14 companies competing in this space

Related Indications

Heart Failure(334)Hypertension(333)Coronary Artery Disease(295)Atrial Fibrillation(288)Pulmonary Arterial Hypertension(103)Acute Coronary Syndrome(62)Pulmonary Hypertension(55)Essential Hypertension(32)Coronary Heart Disease(28)Aortic Valve Stenosis(27)