Acute Leukemia

Oncology
9
Pipeline Programs
10
Companies
9
Clinical Trials
1 recruiting
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
4
2
1
0
2
0
Early DiscoveryClinical DevelopmentMarket

Competitive Landscape

8 companies ranked by most advanced pipeline stage

Roche
RocheSTAVANGER NORWAY, Norway
1 program
1
Bone marrow transplantationPhase 3
Amgen
AmgenTHOUSAND OAKS, CA
1 program
1
Bone marrow transplantationPhase 31 trial
Active Trials
NCT01020175Completed350Est. Dec 2002
Sanofi
SanofiPARIS, France
1 program
1
CyclophosphamidePhase 21 trial
Active Trials
NCT04202835Active Not Recruiting80Est. Feb 2026
Ossium Health
Ossium HealthIN - Indianapolis
3 programs
2
1
Ossium HPC Marrow, Bone Marrow TransplantPhase 1/21 trial
CyclophosphamidePhase 11 trial
Interferon gammaPhase 11 trial
Active Trials
NCT05170828Withdrawn0Est. Nov 2024
NCT04328714TerminatedEst. Jul 2022
NCT05589896Recruiting12Est. Mar 2027
MEDIPOST
MEDIPOSTKorea - Gyeonggi
1 program
1
Human umbilical cord blood-derived mesenchymal stem cellsPhase 1/21 trial
Active Trials
NCT00823316CompletedEst. Feb 2010
VP
1 program
1
AVN-944 capsules for oral administrationPhase 11 trial
Active Trials
NCT00273936Completed72
Eli Lilly and Company
Eli Lilly and CompanyINDIANAPOLIS, IN
1 program
1
LY2523355Phase 11 trial
Active Trials
NCT01214655Terminated33Est. Feb 2011
Alliance Pharmaceuticals
1 program
biologic sample preservation procedureN/A1 trial
Active Trials
NCT00899223Active Not Recruiting1,500

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
AmgenBone marrow transplantation
SanofiCyclophosphamide
Ossium HealthOssium HPC Marrow, Bone Marrow Transplant
MEDIPOSTHuman umbilical cord blood-derived mesenchymal stem cells
Ossium HealthCyclophosphamide
Ossium HealthInterferon gamma
Eli Lilly and CompanyLY2523355
Vertex PharmaceuticalsAVN-944 capsules for oral administration
Alliance Pharmaceuticalsbiologic sample preservation procedure

Clinical Trials (9)

Total enrollment: 2,047 patients across 9 trials

NCT01020175AmgenBone marrow transplantation

Peripheral Blood (PB) Versus Bone Marrow (BM) in Allogeneic Stem Cell Transplantation

Start: Jan 1995Est. completion: Dec 2002350 patients
Phase 3Completed
NCT04202835SanofiCyclophosphamide

ATG Plus PTCy vs ATG for CGVHD Prophylaxis

Start: Oct 2020Est. completion: Feb 202680 patients
Phase 2Active Not Recruiting
NCT05589896Ossium HealthOssium HPC Marrow, Bone Marrow Transplant

A First-in-Human Study of HLA-Partially to Fully Matched Allogenic Cryopreserved Deceased Donor Bone Marrow Transplantation for Patients With Hematologic Malignancies

Start: Aug 2024Est. completion: Mar 202712 patients
Phase 1/2Recruiting
NCT00823316MEDIPOSTHuman umbilical cord blood-derived mesenchymal stem cells

Safety and Efficacy Study of Umbilical Cord Blood-Drived Mesenchymal Stem Cells to Promote Engraftment of Unrelated Hematopoietic Stem Cell Transplantation

Start: Aug 2008Est. completion: Feb 2010
Phase 1/2Completed
NCT05170828Ossium HealthCyclophosphamide

Cryopreserved MMUD BM With PTCy for Hematologic Malignancies

Start: Sep 2022Est. completion: Nov 20240
Phase 1Withdrawn
NCT04328714Ossium HealthInterferon gamma

Interferon γ-Primed Mesenchymal Stromal Cells as Prophylaxis for Acute Graft v Host Disease

Start: Dec 2021Est. completion: Jul 2022
Phase 1Terminated
NCT01214655Eli Lilly and CompanyLY2523355

A Study for Patients With Acute Leukemia

Start: Jun 2008Est. completion: Feb 201133 patients
Phase 1Terminated
NCT00273936Vertex PharmaceuticalsAVN-944 capsules for oral administration

Trial of AVN-944 in Patients With Advanced Hematologic Malignancies

Start: Jan 200672 patients
Phase 1Completed
NCT00899223Alliance Pharmaceuticalsbiologic sample preservation procedure

Collecting and Storing Blood, Bone Marrow, and Other Samples From Patients With Acute Leukemia, Chronic Leukemia, or Myelodysplastic Syndromes

Start: May 19961,500 patients
N/AActive Not Recruiting

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Phase Legend

Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available

Key Insights

2 late-stage (Phase 3) programs — potential near-term approvals
1 actively recruiting trials targeting 2,047 patients
10 companies competing in this space

Related Indications

Breast Cancer(530)Non-small Cell Lung Cancer(373)Prostate Cancer(371)Multiple Myeloma(244)Advanced Solid Tumors(221)Acute Myeloid Leukemia(204)Cancer(187)Neoplasms(173)Colorectal Cancer(166)Advanced Solid Tumor(165)