NDAORALTABLETPriority Review
Approved
Jan 2025
Lifecycle
Growth
Competitive Pressure
0/100
Clinical Trials
18
Data completeness
7/8 — Comprehensive
Priority Review
JOURNAVX (suzetrigine) by Vertex Pharmaceuticals is sodium channel antagonists [moa]. Approved for sodium channel blocker [epc]. First approved in 2025.
Drug data last refreshed 13h ago · AI intelligence enriched 1w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
JOURNAVX (suzetrigine) is an oral small-molecule sodium channel antagonist approved by the FDA on January 30, 2025, for the treatment of pain conditions. It works by blocking sodium channels to reduce neuronal excitability and pain signal transmission. The drug represents Vertex Pharmaceuticals' entry into the pain management market with a novel mechanism.
Growth14.2 years to LOE
Early-stage growth trajectory with no direct competitors currently present, positioning the brand team to establish market share and build institutional infrastructure.
Mechanism of Action
Sodium Channel Antagonists
Pharmacologic Class:
Sodium Channel Blocker
Indications
Indication data is being enriched from DailyMed and FDA labeling. Check back soon for approved therapeutic uses.
Clinical Trials (18)
Suzetrigine for Opioid-Sparing Postoperative Analgesia Following Transvaginal Pelvic Reconstructive Surgery
Started Nov 2026
120 enrolled
Pelvic Organ Prolapse (POP)Stress Urinary Incontinence (SUI)Postoperative Pain
Suzetrigine for Postoperative Pain After Total Ankle Replacement
Started Oct 2026
28 enrolled
Ankle OsteoarthritisPostoperative PainAcute Pain
Suzetrigine Versus Usual-care Opioids for Postop Pain in Sports
Started Sep 2026
140 enrolled
Postoperative Pain Management
Assessing Suzetrigine for Pain Reduction Following Ureteroscopic Surgery
Started Aug 2026
100 enrolled
Opioid Consumption, PostoperativeMultimodal AnalgesiaUreteroscopy+2 more
Role of Suzetrigine as a Part of a Multimodal Regimen to Reduce Pain and Opioid Use After Total Knee Arthroplasty
Started Jul 2026
75 enrolled
Knee ArthritisKnee Osteoarthritis
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.