Discovery Process Chemistry Scale-Up Research Scientist

Job Description

The Discovery Process Chemistry Research Scientist will work as part of the Scale-up group in Medicinal Chemistry to synthesize compounds on a range of scales from multigrams to hundreds of grams for biological evaluation. Performs experimental troubleshooting and synthetic route development with the ability to execute complex experimental procedures. Completes work in a resourceful, self-sufficient and timely manner and is able to design alternative approaches to achieve desired outcomes. Keeps up to date with current scientific literature and technologies relevant to their field of technical expertise. This is an onsite position at our San Diego research site.

Key Duties and Responsibilities:

• Design and undertake experimental synthetic work as part of the scale-up group to deliver material for internal customers working on 10s grams to 100s grams scale.
• Personally deliver material and independently develop and optimize processes.
• Work within the Scale-up group to enable rapid delivery of material, problem solve and share knowledge.
• Collates and interprets complex data systematically, and organizes results into a cohesive body of conclusions or recommendations to guide Project decisions and new research activities.
• Exercises solid judgment to prioritize studies, considering feasibility and Project impact.
• Performs advanced and/or complex experimental troubleshooting.
• Scours relevant scientific literature and routinely incorporates new insights into research activities.
• Identifies, prioritizes and introduces relevant emerging technologies in their field of expertise to advance the existing technology platforms and create/maintain a competitive advantage.
• Explores the feasibility of applying new scientific principles/concepts or implements and validates novel experimental approaches and technologies to achieve project goals.
• Contributes significantly to patent and/or publication preparation.
• Independently prepares study presentations and presents experimental conclusions.

Knowledge and Skills:

• Experience of working in a large-scale, synthetic laboratory to deliver complex organic compounds
• Display a flexible approach and be comfortable working on a variety of scales
• Experience using ≥ 5L glassware
• Strong interpersonal skills and a team player
• Some experience and understanding of process safety and hazard assessment. A diligent approach to all safety matters.
• Very strong synthetic chemistry knowledge and mechanistic understanding

Education and Experience Level

• PhD or post-doc with 0 - 3 years of experience in a relevant area of research, or the equivalent industrial experience
• BS and 6+ years of experience
• MS and 3 years of experience, or

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Pay Range:

$104,000 - $156,000

Disclosure Statement:

Flex Designation:

On-Site Designated

Flex Eligibility Status:

In this On-Site designated role, you will work five days per week on-site with ad hoc flexibility.  

Note: The Flex status for this position is subject to Vertex’s Policy on Flex @ Vertex Program and may be changed at any time.

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Company Information

Vertex is a global biotechnology company that invests in scientific innovation.

Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com