NDAORALTABLETPriority Review
Approved
Dec 2024
Lifecycle
Growth
Competitive Pressure
0/100
Clinical Trials
1
Data completeness
6/8 — Strong
Priority Review
ALYFTREK (vanzacaftor, tezacaftor, and deutivacaftor) by Vertex Pharmaceuticals is chloride channel activation potentiators [moa]. Approved for cystic fibrosis transmembrane conductance regulator potentiator [epc]. First approved in 2024.
Drug data last refreshed 3h ago · AI intelligence enriched 1w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
ALYFTREK is a triple-combination oral tablet containing vanzacaftor, tezacaftor, and deutivacaftor approved December 2024 for cystic fibrosis. It works by activating the cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel to restore protein function. This represents an advancement in Vertex's CFTR potentiator portfolio targeting CF patients with specific CFTR mutations.
Growth16.3 years to LOE
Early-stage growth product with zero competitive pressure creates opportunity for commercial team building and market expansion initiatives.
Mechanism of Action
Chloride Channel Activation Potentiators
Pharmacologic Class:
Cystic Fibrosis Transmembrane Conductance Regulator Potentiator
Indications
Indication data is being enriched from DailyMed and FDA labeling. Check back soon for approved therapeutic uses.
Clinical Trials (1)
Study of Ivacaftor in Cystic Fibrosis Subjects Aged 12 Years and Older Homozygous for the F508del-CFTR Mutation
Started Sep 2009
140 enrolled
Cystic Fibrosis
Career Relevance
ALYFTREK generates 233 linked pharma career opportunities across R&D, regulatory, and data science functions, reflecting active investment in a newly launched product. Leadership roles (Director, Executive Director) predominate, signaling cross-functional team expansion and strategic positioning within Vertex's CF franchise.
Director
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.