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Drug Interactions

14
Pipeline Programs
10
Companies
38
Clinical Trials
1 recruiting
1
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
12
0
0
0
0
2
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Small Molecule
267%
RNA Therapeutic
133%
+ 13 programs with unclassified modality

On Market (1)

Approved therapies currently available

Aurinia Pharmaceuticals
LUPKYNISApproved
voclosporin
Aurinia Pharmaceuticals
Calcineurin Inhibitor Immunosuppressant [EPC]oral2021
20M Part D

Competitive Landscape

10 companies ranked by most advanced pipeline stage

Aurinia Pharmaceuticals
1 program
1
1
LUPKYNIS(voclosporin)Phase 1
Sandoz
SandozAustria - Kundl
1 program
1
Inclisiran sodium 300 mgPhase 4RNA Therapeutic1 trial
Active Trials
NCT06865885Recruiting100Est. Dec 2026
Bayer
BayerLEVERKUSEN, Germany
4 programs
4
BAY1902607Phase 11 trial
BAY86-9766Phase 12 trials
RosuvastatinPhase 1Small Molecule1 trial
SorafenibPhase 1Small Molecule1 trial
Active Trials
NCT03789890Completed14Est. May 2019
NCT01925638Completed18Est. Dec 2013
NCT01392521Completed64Est. Apr 2014
+2 more trials
Lexicon Pharmaceuticals
Lexicon PharmaceuticalsNJ - Bridgewater
3 programs
3
FexofenadinePhase 11 trial
Telotristat etipratePhase 11 trial
Telotristat etipratePhase 11 trial
Active Trials
NCT02157558Completed24
NCT02195635Completed24
NCT02147808Completed24
ViiV Healthcare
ViiV HealthcareNC - Durham
2 programs
2
CaffeinePhase 1
GSK525762 Besylate TabletsPhase 1
Gebro Pharma
Gebro PharmaAustria - Fieberbrunn
1 program
1
SPhase 11 trial
Active Trials
NCT00442585Completed72Est. Oct 2007
Abbott
AbbottABBOTT PARK, IL
1 program
1
Vicodin® CRPhase 11 trial
Active Trials
NCT00429468Completed25
Colorado Therapeutics
Colorado TherapeuticsCO - Louisville
1 program
OxycodoneN/A1 trial
Active Trials
NCT01859715Completed502Est. Feb 2013
Merck & Co.
Merck & Co.RAHWAY, NJ
1 program
DaptomycinPHASE_15 trials
Active Trials
NCT02097953Completed12Est. Jul 2016
NCT01922011Completed149Est. Dec 2016
NCT01728376Completed82Est. Jan 2016
+2 more trials
Vertex Pharmaceuticals
1 program
PrednisonePHASE_11 trial
Active Trials
NCT01886209Completed28Est. Aug 2013

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
SandozInclisiran sodium 300 mg
Merck & Co.Daptomycin
Merck & Co.Daptomycin
Merck & Co.Daptomycin
Merck & Co.Daptomycin
Merck & Co.Daptomycin
Merck & Co.Daptomycin
Merck & Co.Daptomycin
Merck & Co.Daptomycin
Merck & Co.Daptomycin
Merck & Co.Daptomycin
Merck & Co.Daptomycin
Merck & Co.Daptomycin
Merck & Co.Daptomycin
Merck & Co.Daptomycin

Showing 15 of 38 trials with date data

Clinical Trials (38)

Total enrollment: 2,692 patients across 38 trials

NCT06865885SandozInclisiran sodium 300 mg

LDL-C Optimization Using Inclisiran in Patients in Which Drug-Drug Interactions Limit LDL Lowering

Start: Apr 2025Est. completion: Dec 2026100 patients
Phase 4Recruiting

Safety & Efficacy of Daptomycin Versus Standard of Care (SOC) in 1 - 17 Year Olds With Staphylococcus Aureus Bacteremia (MK-3009-005)

Start: Nov 2012Est. completion: Jan 201682 patients
Phase 4Completed

Daptomycin Versus Vancomycin in Participants With Skin Infections Due to MRSA

Start: Sep 2011Est. completion: Oct 2012250 patients
Phase 4Completed

Vancomycin Versus Daptomycin for the Treatment of Methicillin-resistant Staphylococcus Aureus Bacteremia Due to Isolates With High Vancomycin Minimum Inhibitory Concentrations (MICs)

Start: Jun 2011Est. completion: Jan 201211 patients
Phase 4Terminated

Daptomycin Use for Antimicrobial Prophylaxis in Methicillin Resistant Staphylococcus Aureus (MRSA) Colonized Adult Patients Undergoing Primary Elective Hip, Knee, or Shoulder Arthroplasty

Start: Oct 2010Est. completion: Mar 201428 patients
Phase 4Terminated

Study Comparing Cubicin With Vancomycin in Treatment of Participants With Complicated Skin and Skin Structure Infections in a Home Infusion Setting

Start: Jul 2010Est. completion: Nov 201180 patients
Phase 4Terminated

Study of Daptomycin Safety and Efficacy for Complicated Skin and Skin Structure Infections (cSSSI) and Bacteremia in Renal Impairment

Start: Apr 2010Est. completion: Jun 201292 patients
Phase 4Terminated

Safety and Efficacy Study of Daptomycin in Pediatric Participants (1 to 17 Years-old) With Skin and Skin Structure Infections

Start: Jul 2008Est. completion: Oct 2013396 patients
Phase 4Completed

A Pilot Study of Daptomycin for Antimicrobial Prophylaxis

Start: Jan 2008Est. completion: Sep 200811 patients
Phase 4Terminated

Study Comparing CUBICIN® (Daptomycin for Injection) With Vancomycin in Cellulitis or Erysipelas

Start: Feb 2006Est. completion: Aug 200680 patients
Phase 4Completed

Cubicin(R) for Complicated Post-surgical Wound Infections

Start: Jun 2004Est. completion: Mar 200569 patients
Phase 4Terminated

Safety and Efficacy Study of Daptomycin Compared to Active Comparator in Pediatric Participants With Acute Hematogenous Osteomyelitis (AHO) (MK-3009-006)

Start: Sep 2013Est. completion: Dec 2016149 patients
Phase 3Completed

A Study of MK-3009 in Japanese Patients With Skin or Blood Stream Infections Caused by Methicillin-resistant Staphylococcus Aureus (MK-3009-002)

Start: Sep 2008Est. completion: Feb 2010122 patients
Phase 3Completed

Daptomycin for the Treatment of Infections Due to Gram-Positive Bacteria

Start: Dec 2002Est. completion: Jan 200475 patients
Phase 3Terminated

Daptomycin in the Treatment of Subjects With Infective Endocarditis or Bacteremia Due to S. Aureus

Start: Mar 2002Est. completion: Feb 2005
Phase 3Completed

Study of Cidecin™ (Daptomycin) to Rocephin® (Ceftriaxone) in the Treatment of Moderate to Severe Community-Acquired Acute Bacterial Pneumonia Due to S. Pneumoniae

Start: Jul 2001Est. completion: Feb 2002
Phase 3Completed

Comparative Study of Cidecin™ (Daptomycin) to Rocephin® (Ceftriaxone) in the Treatment of Moderate to Severe Community-Acquired Acute Bacterial Pneumonia

Start: Oct 2000Est. completion: Sep 2001
Phase 3Completed

Study of Daptomycin in Subjects Undergoing Surgery for Osteomyelitis Associated With an Infected Prosthetic Caused by Staphylococci

Start: Jun 2007Est. completion: Jun 201075 patients
Phase 2Completed

Catheter Related - Gram Positive Bloodstream Infections

Start: Mar 2007Est. completion: Sep 201230 patients
Phase 2Completed

Phase 2 Safety and Efficacy Study of Daptomycin in Complicated Skin and Skin Structure Infections

Start: Jan 2007Est. completion: Sep 2007100 patients
Phase 2Completed

Daptomycin in the Treatment of Catheter-Related Staphylococcus Aureus

Start: May 2006Est. completion: Sep 201211 patients
Phase 2Completed
NCT04252300BayerRosuvastatin

Study to Learn the Effect of Drug BAY1817080 on the Way the Body Absorbs, Distributes and Excretes Another Drug Rosuvastatin in Healthy Adult Participants

Start: Mar 2020Est. completion: Dec 202014 patients
Phase 1Completed

Study to Learn More About the Effect of Itraconazole (ITZ) Given Repeatedly by Mouth on the Way How the Study Drug BAY1902607 Given One Time by Mouth Acts in the Human Body of Healthy Male Participants

Start: Jan 2019Est. completion: May 201914 patients
Phase 1Completed

Sorafenib Drug Drug Interaction Study in Healthy Male Subjects

Start: Feb 2015Est. completion: Sep 201525 patients
Phase 1Completed

Phase 1, Open-label, Drug-drug Interaction Study With Octreotide Acetate Injection and Telotristat Etiprate in Healthy Subjects

Start: Jul 201424 patients
Phase 1Completed

An Open-Label Drug-Drug Interaction Study of Telotristat Etiprate and Fexofenadine in Healthy Subjects

Start: Jul 201424 patients
Phase 1Completed

A Open-Label Drug-Drug Interaction Study of Telotristat Etiprate and Midazolam in Healthy Subjects

Start: May 201424 patients
Phase 1Completed

Influence of Rifampin Co-Administration on the Pharmacokinetic Profile of Daptomycin

Start: May 2014Est. completion: Jul 201612 patients
Phase 1Completed

Effect of Ketoconazole on the Pharmacokinetics of Refametinib

Start: Sep 2013Est. completion: Dec 201318 patients
Phase 1Completed

Phase 1 PK Interaction Study Between VX-509 and Prednisone or Methylprednisolone in Healthy Male Subjects

Start: Jun 2013Est. completion: Aug 201328 patients
Phase 1Completed

Phase Ib Study of PI3(Phosphoinositol 3)-Kinase Inhibitor Copanlisib With MEK (Mitogen-activated Protein Kinase) Inhibitor Refametinib (BAY86-9766) in Patients With Advanced Cancer

Start: Jul 2011Est. completion: Apr 201464 patients
Phase 1Completed

Study to Evaluate Daptomycin Given During Dialysis and After Dialysis

Start: Apr 2009Est. completion: Jul 200916 patients
Phase 1Completed

PK and Safety Evaluation of Daptomycin in Children Ages 2-6 With Proven or Suspected Gram-positive Infections

Start: Jun 2008Est. completion: Nov 200824 patients
Phase 1Completed

Safety Study to Evaluate Daptomycin in Non-infected Adults Who Are Either on Hemodialysis or Continuous Ambulatory Peritoneal Dialysis (MK-3009-021)

Start: Aug 2007Est. completion: May 200812 patients
Phase 1Completed
NCT00429468AbbottVicodin® CR

A Study to Evaluate the Interaction Between Vicodin® CR and Ethanol in Healthy Male and Female Moderate Alcohol Drinkers

Start: Jan 200725 patients
Phase 1Completed

S(+)-Ibuprofen Effects on Asprin Treated Volunteers

Start: Sep 2006Est. completion: Oct 200772 patients
Phase 1Completed

Study of Single Dose Daptomycin in Pediatric Patients With Gram-positive Infection for Which They Are Receiving Standard Antibiotics

Start: Aug 2005Est. completion: Aug 200633 patients
Phase 1Completed

Emergency Department (ED) Drug Interaction in Emergency Department Patients

Start: Jun 2012Est. completion: Feb 2013502 patients
N/ACompleted

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

1 actively recruiting trials targeting 2,692 patients
10 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.