Drug Interactions

4
Pipeline Programs
4
Companies
37
Clinical Trials
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
4
0
0
0
0
0
Early DiscoveryClinical DevelopmentMarket

Competitive Landscape

4 companies ranked by most advanced pipeline stage

Bayer
BayerLEVERKUSEN, Germany
1 program
1
BAY1902607Phase 11 trial
Active Trials
NCT03789890Completed14Est. May 2019
M&
Merck & Co.RAHWAY, NJ
1 program
1
DaptomycinPhase 15 trials
Active Trials
NCT04983901Completed100Est. Oct 2023
NCT03643952Completed18Est. Apr 2020
NCT02097953Completed12Est. Jul 2016
+2 more trials
VP
1 program
1
PrednisonePhase 11 trial
Active Trials
NCT01886209Completed28Est. Aug 2013
Abbott
AbbottABBOTT PARK, IL
1 program
1
Vicodin® CRPhase 11 trial
Active Trials
NCT00429468Completed25

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
Merck & Co.Daptomycin
Merck & Co.Daptomycin
Merck & Co.Daptomycin
Merck & Co.Daptomycin
Merck & Co.Daptomycin
Merck & Co.Daptomycin
Merck & Co.Daptomycin
Merck & Co.Daptomycin
Merck & Co.Daptomycin
Merck & Co.Daptomycin
Merck & Co.Daptomycin
Merck & Co.Daptomycin
Merck & Co.Daptomycin
Merck & Co.Daptomycin
Merck & Co.Daptomycin

Showing 15 of 37 trials with date data

Clinical Trials (37)

Total enrollment: 2,056 patients across 37 trials

Safety & Efficacy of Daptomycin Versus Standard of Care (SOC) in 1 - 17 Year Olds With Staphylococcus Aureus Bacteremia (MK-3009-005)

Start: Nov 2012Est. completion: Jan 201682 patients
Phase 4Completed

Daptomycin Versus Vancomycin in Participants With Skin Infections Due to MRSA

Start: Sep 2011Est. completion: Oct 2012250 patients
Phase 4Completed

Vancomycin Versus Daptomycin for the Treatment of Methicillin-resistant Staphylococcus Aureus Bacteremia Due to Isolates With High Vancomycin Minimum Inhibitory Concentrations (MICs)

Start: Jun 2011Est. completion: Jan 201211 patients
Phase 4Terminated

Daptomycin Use for Antimicrobial Prophylaxis in Methicillin Resistant Staphylococcus Aureus (MRSA) Colonized Adult Patients Undergoing Primary Elective Hip, Knee, or Shoulder Arthroplasty

Start: Oct 2010Est. completion: Mar 201428 patients
Phase 4Terminated

Outpatient Treatment of Gram Positive Wound Infections in the Diabetic Foot: A Pharmaco-economic Comparison of Daptomycin vs. Vancomycin Based Regimens

Start: Aug 2010Est. completion: Aug 20126 patients
Phase 4Terminated

Study Comparing Cubicin With Vancomycin in Treatment of Participants With Complicated Skin and Skin Structure Infections in a Home Infusion Setting

Start: Jul 2010Est. completion: Nov 201180 patients
Phase 4Terminated

Study of Daptomycin Safety and Efficacy for Complicated Skin and Skin Structure Infections (cSSSI) and Bacteremia in Renal Impairment

Start: Apr 2010Est. completion: Jun 201292 patients
Phase 4Terminated

Safety and Efficacy Study of Daptomycin in Pediatric Participants (1 to 17 Years-old) With Skin and Skin Structure Infections

Start: Jul 2008Est. completion: Oct 2013396 patients
Phase 4Completed

A Pilot Study of Daptomycin for Antimicrobial Prophylaxis

Start: Jan 2008Est. completion: Sep 200811 patients
Phase 4Terminated

Pharmacokinetics of Daptomycin in Critically Ill Patients Receiving Continuous Venovenous Hemodialysis (CVVHD)

Start: Feb 2007Est. completion: Apr 20098 patients
Phase 4Completed

Study Comparing CUBICIN® (Daptomycin for Injection) With Vancomycin in Cellulitis or Erysipelas

Start: Feb 2006Est. completion: Aug 200680 patients
Phase 4Completed

Cubicin(R) for Complicated Post-surgical Wound Infections

Start: Jun 2004Est. completion: Mar 200569 patients
Phase 4Terminated

Safety and Efficacy Study of Daptomycin Compared to Active Comparator in Pediatric Participants With Acute Hematogenous Osteomyelitis (AHO) (MK-3009-006)

Start: Sep 2013Est. completion: Dec 2016149 patients
Phase 3Completed

A Study of MK-3009 in Japanese Patients With Skin or Blood Stream Infections Caused by Methicillin-resistant Staphylococcus Aureus (MK-3009-002)

Start: Sep 2008Est. completion: Feb 2010122 patients
Phase 3Completed

Pharmacokinetics of Daptomycin During Cardiopulmonary Bypass Surgery

Start: Jul 2008Est. completion: Oct 201030 patients
Phase 3Completed

Daptomycin for the Treatment of Infections Due to Gram-Positive Bacteria

Start: Dec 2002Est. completion: Jan 200475 patients
Phase 3Terminated

Daptomycin in the Treatment of Subjects With Infective Endocarditis or Bacteremia Due to S. Aureus

Start: Mar 2002Est. completion: Feb 2005
Phase 3Completed

Study of Cidecin™ (Daptomycin) to Rocephin® (Ceftriaxone) in the Treatment of Moderate to Severe Community-Acquired Acute Bacterial Pneumonia Due to S. Pneumoniae

Start: Jul 2001Est. completion: Feb 2002
Phase 3Completed

Comparative Study of Cidecin™ (Daptomycin) to Rocephin® (Ceftriaxone) in the Treatment of Moderate to Severe Community-Acquired Acute Bacterial Pneumonia

Start: Oct 2000Est. completion: Sep 2001
Phase 3Completed

PHASE II SINGLE-CENTER, RANDOMIZED, OPEN-LABEL, PROSPECTIVE, STUDY TO DETERMINE THE IMPACT OF SERIAL PROCALCITONIN

Start: Sep 2021Est. completion: Oct 2023100 patients
Phase 2Completed

Safety, Efficacy, and Pharmacokinetics (PK) of Daptomycin (MK-3009) in Japanese Pediatric Subjects With Complicated Skin and Soft Tissue Infections (cSSTI) and Bacteremia (MK-3009-029)

Start: Dec 2018Est. completion: Apr 202018 patients
Phase 2Completed

Phase 2 Study of Safety, Efficacy, and Pharmacokinetics of Higher Doses of Daptomycin and Vancomycin in MRSA Bacteremia

Start: Sep 2008Est. completion: Oct 201038 patients
Phase 2Terminated

Study of Daptomycin in Subjects Undergoing Surgery for Osteomyelitis Associated With an Infected Prosthetic Caused by Staphylococci

Start: Jun 2007Est. completion: Jun 201075 patients
Phase 2Completed

Catheter Related - Gram Positive Bloodstream Infections

Start: Mar 2007Est. completion: Sep 201230 patients
Phase 2Completed

Phase 2 Safety and Efficacy Study of Daptomycin in Complicated Skin and Skin Structure Infections

Start: Jan 2007Est. completion: Sep 2007100 patients
Phase 2Completed

Daptomycin in the Treatment of Catheter-Related Staphylococcus Aureus

Start: May 2006Est. completion: Sep 201211 patients
Phase 2Completed

Study to Learn More About the Effect of Itraconazole (ITZ) Given Repeatedly by Mouth on the Way How the Study Drug BAY1902607 Given One Time by Mouth Acts in the Human Body of Healthy Male Participants

Start: Jan 2019Est. completion: May 201914 patients
Phase 1Completed

Influence of Rifampin Co-Administration on the Pharmacokinetic Profile of Daptomycin

Start: May 2014Est. completion: Jul 201612 patients
Phase 1Completed

Phase 1 PK Interaction Study Between VX-509 and Prednisone or Methylprednisolone in Healthy Male Subjects

Start: Jun 2013Est. completion: Aug 201328 patients
Phase 1Completed

Pharmacokinetics (PK) and Safety Evaluation of Daptomycin in Children Ages 3-24 Months With Proven or Suspected Gram-positive Infections or Peri-Operative Subjects Receiving Prophylactic Antibiotics

Start: Jan 2010Est. completion: Mar 201223 patients
Phase 1Completed

Study to Evaluate Daptomycin Given During Dialysis and After Dialysis

Start: Apr 2009Est. completion: Jul 200916 patients
Phase 1Completed

PK and Safety Evaluation of Daptomycin in Children Ages 2-6 With Proven or Suspected Gram-positive Infections

Start: Jun 2008Est. completion: Nov 200824 patients
Phase 1Completed

Safety Study to Evaluate Daptomycin in Non-infected Adults Who Are Either on Hemodialysis or Continuous Ambulatory Peritoneal Dialysis (MK-3009-021)

Start: Aug 2007Est. completion: May 200812 patients
Phase 1Completed
NCT00429468AbbottVicodin® CR

A Study to Evaluate the Interaction Between Vicodin® CR and Ethanol in Healthy Male and Female Moderate Alcohol Drinkers

Start: Jan 200725 patients
Phase 1Completed

Study of Single Dose Daptomycin in Pediatric Patients With Gram-positive Infection for Which They Are Receiving Standard Antibiotics

Start: Aug 2005Est. completion: Aug 200633 patients
Phase 1Completed

Cerebrospinal Fluid Pharmacokinetics of Daptomycin

Start: May 2010Est. completion: May 20112 patients
N/ATerminated

Study of the Pharmacokinetics of Daptomycin in Children With Renal Disease

Start: Nov 2009Est. completion: Apr 20146 patients
N/ACompleted

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

4 companies competing in this space