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HCV Infection

26
Pipeline Programs
12
Companies
50
Clinical Trials
1
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
12
0
11
0
0
3
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Small Molecule
10100%
+ 37 programs with unclassified modality

On Market (1)

Approved therapies currently available

Gilead Sciences
HARVONIApproved
ledipasvir and sofosbuvir
Gilead Sciences
Hepatitis C Virus NS5A Inhibitor [EPC]oral2014
55M Part D

Competitive Landscape

12 companies ranked by most advanced pipeline stage

Gilead Sciences
Gilead SciencesFOSTER CITY, CA
13 programs
1
SovaldiN/A1 trial
SovaldiN/A
GS-5885PHASE_12 trials
SOF/VEL/VOXPHASE_11 trial
VoxilaprevirPHASE_1Small Molecule1 trial
+8 more programs
Active Trials
NCT02783976Completed25Est. Jun 2018
NCT01384383Terminated248Est. Jun 2013
NCT01193478Completed71Est. Dec 2011
+12 more trials
Sharp Therapeutics
Sharp TherapeuticsPA - Pittsburgh
4 programs
2
1
Glecaprevir/pibrentasvirPhase 4Small Molecule
BoceprevirPhase 2Small Molecule
EBR/GZR FDC TabletPhase 2
HCV serologyN/A
MSD
MSDIreland - Ballydine
4 programs
2
1
Glecaprevir/pibrentasvirPhase 4Small Molecule
BoceprevirPhase 2Small Molecule
EBR/GZR FDC TabletPhase 2
HCV serologyN/A
Kite Pharma
Kite PharmaCA - El Segundo
11 programs
4
6
GS-9256Phase 2
GS-9450Phase 2
GS-9450Phase 2
LDV/SOFPhase 2
LDV/SOFPhase 2
+6 more programs
AstraZeneca
AstraZenecaCAMBRIDGE, United Kingdom
1 program
1
ACH-0137171Phase 21 trial
Active Trials
NCT00401947Terminated30Est. Mar 2007
Abbott
AbbottABBOTT PARK, IL
5 programs
5
ABT-072Phase 12 trials
ABT-267Phase 14 trials
ABT-333Phase 11 trial
ABT-333Phase 15 trials
ABT-333 TabletPhase 11 trial
Active Trials
NCT01221298Completed11Est. Apr 2012
NCT00890318Completed32
NCT01685203Completed316Est. Feb 2015
+10 more trials
AbbVie
AbbVieNORTH CHICAGO, IL
2 programs
2
ABT-333Phase 11 trial
ABT-450Phase 11 trial
Active Trials
NCT00696904Completed133
NCT00850044Completed87
Inovio Pharmaceuticals
1 program
1
GLS-6150Phase 11 trial
Active Trials
NCT03674125Completed32Est. May 2020
Merck & Co.
Merck & Co.RAHWAY, NJ
3 programs
HCV serologyN/A1 trial
BoceprevirPHASE_2Small Molecule1 trial
Glecaprevir/pibrentasvirPHASE_4Small Molecule1 trial
Active Trials
NCT03461250Unknown293Est. Aug 2018
NCT01463956Completed58Est. Jan 2015
NCT04235049Withdrawn0Est. Oct 2024
Genentech
GenentechCA - Oceanside
1 program
MMF Influence on HCV Viral Evolution After Liver TransplantationN/A
Roche
RocheSTAVANGER NORWAY, Norway
1 program
MMF Influence on HCV Viral Evolution After Liver TransplantationN/A1 trial
Active Trials
NCT00170131Completed17Est. Jul 2007
Vertex Pharmaceuticals
1 program
VCH 916PHASE_11 trial
Active Trials
NCT00623649Completed42Est. Oct 2008

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
Merck & Co.Glecaprevir/pibrentasvir
Gilead SciencesSOF
Gilead SciencesSOF
Gilead SciencesSOF
Gilead SciencesSOF
Gilead SciencesSOF
AbbottABT-333
Gilead SciencesSOF
Gilead SciencesSOF
AbbottABT-333
AbbottABT-333
Gilead SciencesSOF
Gilead SciencesSOF
Gilead SciencesSOF
Gilead SciencesSOF

Showing 15 of 50 trials with date data

Clinical Trials (50)

Total enrollment: 7,612 patients across 50 trials

NCT04235049Merck & Co.Glecaprevir/pibrentasvir

Elimination of HCV Through Linkage and In Prison Treatment of Incarcerated Populations (ECLIPSE)

Start: Oct 2021Est. completion: Oct 20240
Phase 4Withdrawn

Hepatitis C Virus(HCV) Heart and Lung Study

Start: Dec 2016Est. completion: Jul 201915 patients
Phase 4Completed

Therapy With Ledipasvir/Sofosbuvir in Patients With Genotype 1 HCV Infection Receiving Opiate Substitution Therapy

Start: Sep 2015Est. completion: Sep 201640 patients
Phase 4Unknown

Effects of Harvoni in Patients With Decompensated Cirrhosis Due to Hepatitis C Genotype 1 Infection

Start: Jan 2016Est. completion: Jun 201814 patients
Phase 3Completed

Efficacy and Safety of Sofosbuvir Plus Ribavirin in Adults With Chronic HCV Infection

Start: Dec 2013Est. completion: Nov 2016687 patients
Phase 3Completed

SOF (Sovaldi®) +RBV for 16 or 24 Weeks and SOF+RBV+Peg-IFN for 12 Weeks in Adults With Genotype 2 or 3 Chronic HCV Infection

Start: Sep 2013Est. completion: Jul 2016601 patients
Phase 3Completed

A Follow up Study Designed to Obtain Long Term Data on Participants Who Either Achieved a Sustained Virologic Response or Did Not Achieve a Sustained Virologic Response in an AbbVie Sponsored Hepatitis C Study

Start: Jun 2013Est. completion: Oct 2016478 patients
Phase 3Completed

Efficacy and Safety of Sofosbuvir Plus Ribavirin in Japanese Adults With Chronic Genotype 2 HCV Infection

Start: Feb 2013Est. completion: Jun 2014153 patients
Phase 3Completed

A Phase 3, Open-label Study to Investigate the Efficacy and Safety of Sofosbuvir Plus Ribavirin in Chronic Genotype 1, 2, 3 and 4 Hepatitis C Virus (HCV) and Human Immunodeficiency Virus (HIV) Co-infected Adults

Start: Jan 2013Est. completion: Jul 2014275 patients
Phase 3Completed

A Study to Evaluate the Safety and Efficacy of ABT-450/Ritonavir/ABT-267; (ABT-267 Also Known as Ombitasvir) and ABT-333 (Also Known as Dasabuvir) Coadministered With Ribavirin (RBV) in Hepatitis C Virus (HCV) Genotype 1-infected Adults With Compensated Cirrhosis

Start: Oct 2012Est. completion: Sep 2014381 patients
Phase 3Completed

A Study to Evaluate the Safety and Effect of the Experimental Drugs ABT-450/Ritonavir/ABT-267 (ABT-450/r/ABT-267) and ABT-333 in Subjects With Chronic Hepatitis C

Start: Aug 2012Est. completion: Oct 2014187 patients
Phase 3Completed

Efficacy and Safety of Sofosbuvir Plus Ribavirin in Chronic Genotype 1, 2 and 3 Hepatitis C Virus (HCV) and Human Immunodeficiency Virus (HIV) Co-infected Adults

Start: Jul 2012Est. completion: Feb 2014224 patients
Phase 3Completed

Phase 3 Study of Sofosbuvir and Ribavirin

Start: Dec 2011Est. completion: Apr 2013527 patients
Phase 3Completed

Ledipasvir/Sofosbuvir for Hepatitis B Virus Infection

Start: Feb 2018Est. completion: Jun 202121 patients
Phase 2Completed

Sofosbuvir Plus Ribavirin, or Ledipasvir/Sofosbuvir in Adults With HCV Infection and Renal Insufficiency

Start: Oct 2013Est. completion: Oct 201738 patients
Phase 2Completed

Efficacy and Safety of Sofosbuvir/Ledipasvir Fixed-Dose Combination ± Ribavirin in Cirrhotic Subjects With Chronic Genotype 1 HCV Infection

Start: Oct 2013Est. completion: Nov 2014155 patients
Phase 2Completed

Safety and Efficacy of Sofosbuvir + Velpatasvir With or Without Ribavirin in Treatment-Naive Adults With Chronic HCV Infection

Start: Apr 2013Est. completion: Aug 2014379 patients
Phase 2Completed

Sofosbuvir Plus Ribavirin in Treatment-Naive and Treatment-Experienced Egyptian Adults With Chronic Genotype 4 Hepatitis C Virus (HCV) Infection

Start: Oct 2012Est. completion: Feb 201460 patients
Phase 2Completed

A Study to Evaluate the Safety and Effect of Co-administration of ABT-450 With Ritonavir (ABT-450/r) and ABT-267 in Adults With Chronic Hepatitis C Virus Infection

Start: Aug 2012Est. completion: Feb 2015316 patients
Phase 2Completed

A Study to Evaluate ABT-450 With Ritonavir (ABT-450/r) and ABT-267 in Japanese Adults With Chronic Hepatitis C Virus Infection

Start: Jul 2012Est. completion: May 2014110 patients
Phase 2Completed

Sofosbuvir and Ribavirin in Patients With Chronic HCV With Cirrhosis and Portal Hypertension With or Without Liver Decompensation

Start: Jul 2012Est. completion: Oct 201550 patients
Phase 2Completed

Study to Assess the Safety, Tolerability, Pharmacokinetics and Antiviral Activity of ABT-267 in HCV Infected Subjects

Start: Feb 2012Est. completion: Jun 201312 patients
Phase 2Completed

Efficacy of PegInterferon-Ribavirin-Boceprevir Therapy in Patients Infected With G1 HCV With Cirrhosis, Awaiting Liver Transplantation

Start: Jan 2012Est. completion: Jan 201558 patients
Phase 2Completed

ABT-450 With Ritonavir and ABT-267 and/or ABT-333 With and Without Ribavirin in Genotype 1 Hepatitis C Virus Infected Patients

Start: Oct 2011Est. completion: Sep 2013580 patients
Phase 2Completed

A Study to Evaluate Paritaprevir With Ritonavir (ABT-450/r) When Given Together With Ombitasvir and With and Without Ribavirin (RBV) in Treatment-Naïve Participants With Genotype 1, 2 or 3 Chronic Hepatitis C Virus (HCV)

Start: Sep 2011Est. completion: May 201361 patients
Phase 2Completed

GS-5885, GS-9451 With Peginterferon Alfa 2a (PEG) and Ribavirin in Treatment-Naïve Subjects With Chronic Genotype 1 Hep C Virus Infection and IL28B CC Genotype

Start: Aug 2011Est. completion: Jun 2013248 patients
Phase 2Terminated

Sofosbuvir With Pegylated Interferon and Ribavirin Hepatitis C Virus (HCV) Genotypes 1,4,5,6

Start: Mar 2011Est. completion: Aug 2012332 patients
Phase 2Completed

A Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of ABT-450 With Ritonavir (ABT-450/r) When Given Together With ABT-333 and Ribavirin (RBV) in Treatment-Naïve and Non-responder Subjects With Genotype 1 Chronic Hepatitis C Virus (HCV) Infection

Start: Feb 2011Est. completion: Oct 201250 patients
Phase 2Completed

A Pilot Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Antiviral Activity of ABT-450 With Ritonavir (ABT-450/r) Dosed in Combination With ABT-072 and Ribavirin (RBV)

Start: Oct 2010Est. completion: Apr 201211 patients
Phase 2Completed

A Randomized Study to Evaluate the Safety, Tolerability and Antiviral Activity of ABT-450, ABT-333 and ABT-072

Start: Mar 2010Est. completion: Jan 201274 patients
Phase 2Completed

Efficacy and Safety Study of GS-9256 and GS-9190 Alone and in Combination With Ribavirin for 28 Days in Patients With Chronic Hepatitis C Virus Infection

Start: Feb 2010Est. completion: Jan 201246 patients
Phase 2Completed

Efficacy and Safety Study of GS-9450 Treatment for 6 Months in Patients With Chronic Hepatitis C Virus Infection

Start: May 2009Est. completion: Jul 2010307 patients
Phase 2Terminated

Evaluation of the Safety, Tolerability, Pharmacokinetics, and Activity of GS-9450 in Subjects With Chronic HCV

Start: Apr 2008Est. completion: Mar 200933 patients
Phase 2Completed

A Study to Investigate the Safety, Tolerability, Pharmacokinetics, and Antiviral Activity of ACH-0137171 in Participants With Chronic Hepatitis C Infection

Start: Nov 2006Est. completion: Mar 200730 patients
Phase 2Terminated

Part A: Drug Interaction Study of Sofosbuvir and Antiretroviral Therapy (ART) Combinations in HIV and Hepatitis C Virus (HCV) Co-infected Patients. Part B: Efficacy and Safety of Sofosbuvir for 12 Weeks in HIV/HCV Co-infected Patients.

Start: Mar 2012Est. completion: Nov 201352 patients
Phase 1/2Completed

Evaluation of Safety, Tolerability, and Immunogenicity Study of GLS-6150 in Healthy Volunteers and in Persons Previously Treated for Hepatitis C Virus Infection

Start: Sep 2018Est. completion: May 202032 patients
Phase 1Completed

Study of Hepatitis C Treatment During Pregnancy

Start: Sep 2016Est. completion: Feb 20209 patients
Phase 1Completed

Study to Evaluate Effect of Sofosbuvir/Velpatasvir/GS-9857 Fixed-Dose Combination on the Pharmacokinetics of a Representative Hormonal Contraceptive Medication, Norgestimate/Ethinyl Estradiol

Start: Oct 2015Est. completion: Mar 201615 patients
Phase 1Completed

Pharmacokinetics of Voxilaprevir in Adults With Normal Renal Function and Severe Renal Impairment

Start: May 2015Est. completion: Sep 201520 patients
Phase 1Completed

Pharmacokinetics of Voxilaprevir in Adults With Normal Hepatic Function and Moderate or Severe Hepatic Impairment

Start: Mar 2015Est. completion: Mar 201633 patients
Phase 1Completed

A Multiple Ascending Dose Study of GS 5885 in Previously Untreated Subjects With Genotype 1 Chronic Hepatitis C

Start: Aug 2010Est. completion: Dec 201171 patients
Phase 1Completed

Study of ABT-267 in Both Healthy Volunteers and Hepatitis C Virus (HCV) Genotype 1 Infected Subjects

Start: Aug 2010Est. completion: Jan 2012137 patients
Phase 1Completed

A Study to Assess the Safety, Tolerability, and Pharmacokinetics of Multiple Ascending Doses of the ABT-333 Tablet

Start: May 200924 patients
Phase 1Completed

A Study in Healthy Adult Subjects to Evaluate the Safety, Tolerability, and Pharmacokinetic Profiles of Multiple Doses of ABT-072 Used to Treat Hepatitis C

Start: Apr 200932 patients
Phase 1Completed
NCT00895102AbbottABT-333 Tablet

Bioavailability of ABT-333 Tablet Versus First in Human (FIH) Capsule Formulation and Safety, Tolerability and PK Study of Single Doses of ABT-333 in Healthy Volunteers

Start: Apr 200934 patients
Phase 1Completed

Safety, Tolerability and PK Study of Single Doses of ABT-450 With and Without Ritonavir to Treat Hepatitis C Virus (HCV) Genotype 1

Start: Feb 200987 patients
Phase 1Completed

A Study in Healthy Adult Subjects to Evaluate the Safety, Tolerability, and Pharmacokinetics of Multiple Doses of ABT-333

Start: Oct 200845 patients
Phase 1Completed

Study of ABT-333 in Both Healthy Volunteers and Hepatitis C Virus (HCV) + Genotype 1 Infected Subjects

Start: Jun 2008133 patients
Phase 1Completed

Safety,Tolerability and Pharmacokinetics of Multiple Ascending Doses of VCH 916 in Subjects With Chronic Hep C Infection

Start: Nov 2007Est. completion: Oct 200842 patients
Phase 1Completed

Chronic Hepatitis C in Chronic Hemodialysis Recipients - An Observational Study

Start: Apr 2018Est. completion: Aug 2018293 patients
N/AUnknown

Phase Legend

Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available

Key Insights

12 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.

HCV Infection | Pipeline & Competitive Landscape | Formulate