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HCV Infection

26
Pipeline Programs
12
Companies
50
Clinical Trials
1
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
12
0
11
0
0
3
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Small Molecule
10100%
+ 37 programs with unclassified modality

On Market (1)

Approved therapies currently available

Gilead Sciences
HARVONIApproved
ledipasvir and sofosbuvir
Gilead Sciences
Hepatitis C Virus NS5A Inhibitor [EPC]oral2014
55M Part D

Competitive Landscape

12 companies ranked by most advanced pipeline stage

Gilead Sciences
Gilead SciencesFOSTER CITY, CA
13 programs
1
SovaldiN/A1 trial
SovaldiN/A
GS-5885PHASE_12 trials
SOF/VEL/VOXPHASE_11 trial
VoxilaprevirPHASE_1Small Molecule1 trial
+8 more programs
Active Trials
NCT02783976Completed25Est. Jun 2018
NCT01384383Terminated248Est. Jun 2013
NCT01193478Completed71Est. Dec 2011
+12 more trials
Sharp Therapeutics
Sharp TherapeuticsPA - Pittsburgh
4 programs
2
1
Glecaprevir/pibrentasvirPhase 4Small Molecule
BoceprevirPhase 2Small Molecule
EBR/GZR FDC TabletPhase 2
HCV serologyN/A
MSD
MSDIreland - Ballydine
4 programs
2
1
Glecaprevir/pibrentasvirPhase 4Small Molecule1 trial
BoceprevirPhase 2Small Molecule1 trial
EBR/GZR FDC TabletPhase 21 trial
HCV serologyN/A1 trial
Active Trials
NCT03461250Unknown293Est. Aug 2018
NCT01463956Completed58Est. Jan 2015
NCT03379506Completed57Est. Jul 2020
+1 more trials
Kite Pharma
Kite PharmaCA - El Segundo
11 programs
4
6
GS-9256Phase 2
GS-9450Phase 2
GS-9450Phase 2
LDV/SOFPhase 2
LDV/SOFPhase 2
+6 more programs
AstraZeneca
AstraZenecaCAMBRIDGE, United Kingdom
1 program
1
ACH-0137171Phase 21 trial
Active Trials
NCT00401947Terminated30Est. Mar 2007
Abbott
AbbottABBOTT PARK, IL
5 programs
5
ABT-072Phase 12 trials
ABT-267Phase 14 trials
ABT-333Phase 15 trials
ABT-333Phase 11 trial
ABT-333 TabletPhase 11 trial
Active Trials
NCT01221298Completed11Est. Apr 2012
NCT00890318Completed32
NCT01685203Completed316Est. Feb 2015
+10 more trials
AbbVie
AbbVieNORTH CHICAGO, IL
2 programs
2
ABT-333Phase 11 trial
ABT-450Phase 11 trial
Active Trials
NCT00696904Completed133
NCT00850044Completed87
Inovio Pharmaceuticals
1 program
1
GLS-6150Phase 11 trial
Active Trials
NCT03674125Completed32Est. May 2020
Merck & Co.
Merck & Co.RAHWAY, NJ
3 programs
HCV serologyN/A
BoceprevirPHASE_2Small Molecule
Glecaprevir/pibrentasvirPHASE_4Small Molecule
Roche
RocheSTAVANGER NORWAY, Norway
1 program
MMF Influence on HCV Viral Evolution After Liver TransplantationN/A
Genentech
GenentechCA - Oceanside
1 program
MMF Influence on HCV Viral Evolution After Liver TransplantationN/A1 trial
Active Trials
NCT00170131Completed17Est. Jul 2007
Vertex Pharmaceuticals
1 program
VCH 916PHASE_11 trial
Active Trials
NCT00623649Completed42Est. Oct 2008

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
MSDGlecaprevir/pibrentasvir
Gilead SciencesSOF
Gilead SciencesSOF
Gilead SciencesSOF
Gilead SciencesSOF
Gilead SciencesSOF
Gilead SciencesSOF
Gilead SciencesSOF
Gilead SciencesSOF
Gilead SciencesSOF
Gilead SciencesSOF
Gilead SciencesSOF
Gilead SciencesSOF
Gilead SciencesSOF
Gilead SciencesSOF

Showing 15 of 50 trials with date data

Clinical Trials (50)

Total enrollment: 9,476 patients across 50 trials

NCT04235049MSDGlecaprevir/pibrentasvir

Elimination of HCV Through Linkage and In Prison Treatment of Incarcerated Populations (ECLIPSE)

Start: Oct 2021Est. completion: Oct 20240
Phase 4Withdrawn

The No One Waits Study: Acceptability and Feasibility of Community-based Point-of-diagnosis HCV Treatment Study

Start: Jul 2020Est. completion: Dec 202287 patients
Phase 4Completed

Hepatitis C Virus(HCV) Heart and Lung Study

Start: Dec 2016Est. completion: Jul 201915 patients
Phase 4Completed

Study to Investigate the Efficacy and Safety of Ledipasvir/Sofosbuvir Fixed-Dose Combination for 12 Weeks in Subjects With Chronic Genotype 1 and 4 HCV Infection With Autoimmune Disease

Start: Feb 2016Est. completion: May 201740 patients
Phase 4Unknown

Therapy With Ledipasvir/Sofosbuvir in Patients With Genotype 1 HCV Infection Receiving Opiate Substitution Therapy

Start: Sep 2015Est. completion: Sep 201640 patients
Phase 4Unknown

Study to Investigate the Efficacy and Safety of Sofosbuvir/Velpatasvir Fixed-Dose Combination for 12 Weeks in Adults With Chronic HCV Infection and Compensated Cirrhosis

Start: Oct 2019Est. completion: Jun 202137 patients
Phase 3Completed

Safety And Efficacy of Sofosbuvir/Velpatasvir/Voxilaprevir Fixed-Dose Combination for 12 Weeks in Adults Who Participated in a Prior Gilead-Sponsored HCV Treatment Study

Start: Apr 2017Est. completion: Mar 201831 patients
Phase 3Completed

Efficacy and Safety of Sofosbuvir/Velpatasvir ± Ribavirin for 12 Weeks in Adults With Chronic HCV Infection and Decompensated Cirrhosis

Start: Dec 2016Est. completion: May 2018102 patients
Phase 3Completed

Efficacy and Safety of Sofosbuvir/Velpatasvir Fixed Dose Combination for 12 Weeks in Participants With Chronic HCV

Start: Apr 2016Est. completion: Mar 2018375 patients
Phase 3Completed

Ledipasvir/Sofosbuvir Fixed-Dose Combination for 12 Weeks in Participants With Chronic Genotype 2 HCV Infection

Start: Apr 2016Est. completion: May 2017239 patients
Phase 3Completed

Efficacy and Safety of Sofosbuvir/Velpatasvir Fixed-Dose Combination in Participants With Chronic Hepatitis C Virus Infection

Start: Apr 2016Est. completion: Sep 2017119 patients
Phase 3Completed

Effects of Harvoni in Patients With Decompensated Cirrhosis Due to Hepatitis C Genotype 1 Infection

Start: Jan 2016Est. completion: Jun 201814 patients
Phase 3Completed

Safety and Efficacy of SOF/VEL/VOX FDC for 12 Weeks and SOF/VEL for 12 Weeks in DAA-Experienced Adults With Chronic HCV Infection Who Have Not Received an NS5A Inhibitor

Start: Dec 2015Est. completion: Jan 2017333 patients
Phase 3Completed

Safety and Efficacy of SOF/VEL/VOX FDC for 8 Weeks and SOF/VEL for 12 Weeks in Adults Chronic Genotype 3 HCV Infection and Cirrhosis

Start: Dec 2015Est. completion: Jan 2017220 patients
Phase 3Completed

Safety and Efficacy of Ledipasvir/Sofosbuvir Fixed-Dose Combination in Adults With Chronic HCV and HBV Coinfection

Start: Dec 2015Est. completion: Nov 2018111 patients
Phase 3Completed

Safety and Efficacy of Sofosbuvir/Velpatasvir/Voxilaprevir in Adults With Chronic HCV Infection Who Have Previously Received Treatment With Direct-Acting Antiviral Therapy

Start: Nov 2015Est. completion: Jun 2017416 patients
Phase 3Completed

Safety and Efficacy of Ledipasvir/Sofosbuvir Fixed Dose Combination, With or Without Ribavirin, in Egyptian Adults With Chronic Genotype 4 HCV Infection

Start: Sep 2015Est. completion: Feb 2017255 patients
Phase 3Completed

Safety and Efficacy of Ledipasvir/Sofosbuvir in Adults With Chronic HCV Infection

Start: Jun 2015Est. completion: Jun 2016153 patients
Phase 3Completed

Sofosbuvir/Velpatasvir Fixed-Dose Combination in Adults With Chronic HCV Infection

Start: Feb 2015Est. completion: Jun 2016111 patients
Phase 3Completed

Efficacy and Safety of Sofosbuvir Plus Ribavirin in Adults With Chronic HCV Infection

Start: Dec 2013Est. completion: Nov 2016687 patients
Phase 3Completed

Efficacy and Safety of Sofosbuvir/Ledipasvir ± Ribavirin in Japanese Participants With Chronic Genotype 1 HCV Infection

Start: Oct 2013Est. completion: Aug 2014341 patients
Phase 3Completed

SOF (Sovaldi®) +RBV for 16 or 24 Weeks and SOF+RBV+Peg-IFN for 12 Weeks in Adults With Genotype 2 or 3 Chronic HCV Infection

Start: Sep 2013Est. completion: Jul 2016601 patients
Phase 3Completed

A Follow up Study Designed to Obtain Long Term Data on Participants Who Either Achieved a Sustained Virologic Response or Did Not Achieve a Sustained Virologic Response in an AbbVie Sponsored Hepatitis C Study

Start: Jun 2013Est. completion: Oct 2016478 patients
Phase 3Completed

Efficacy and Safety of Sofosbuvir Plus Ribavirin in Japanese Adults With Chronic Genotype 2 HCV Infection

Start: Feb 2013Est. completion: Jun 2014153 patients
Phase 3Completed

A Phase 3, Open-label Study to Investigate the Efficacy and Safety of Sofosbuvir Plus Ribavirin in Chronic Genotype 1, 2, 3 and 4 Hepatitis C Virus (HCV) and Human Immunodeficiency Virus (HIV) Co-infected Adults

Start: Jan 2013Est. completion: Jul 2014275 patients
Phase 3Completed

A Study to Evaluate the Safety and Efficacy of ABT-450/Ritonavir/ABT-267; (ABT-267 Also Known as Ombitasvir) and ABT-333 (Also Known as Dasabuvir) Coadministered With Ribavirin (RBV) in Hepatitis C Virus (HCV) Genotype 1-infected Adults With Compensated Cirrhosis

Start: Oct 2012Est. completion: Sep 2014381 patients
Phase 3Completed

Sofosbuvir and Ribavirin in Treatment-Naive and Treatment-Experienced Subjects With Chronic Genotype 2 or 3 HCV Infection

Start: Sep 2012Est. completion: Jan 2014421 patients
Phase 3Completed

A Study to Evaluate the Safety and Effect of the Experimental Drugs ABT-450/Ritonavir/ABT-267 (ABT-450/r/ABT-267) and ABT-333 in Subjects With Chronic Hepatitis C

Start: Aug 2012Est. completion: Oct 2014187 patients
Phase 3Completed

Efficacy and Safety of Sofosbuvir Plus Ribavirin in Chronic Genotype 1, 2 and 3 Hepatitis C Virus (HCV) and Human Immunodeficiency Virus (HIV) Co-infected Adults

Start: Jul 2012Est. completion: Feb 2014224 patients
Phase 3Completed

Phase 3 Study of Sofosbuvir and Ribavirin

Start: Dec 2011Est. completion: Apr 2013527 patients
Phase 3Completed

Ledipasvir/Sofosbuvir for Hepatitis B Virus Infection

Start: Feb 2018Est. completion: Jun 202121 patients
Phase 2Completed
NCT03379506MSDEBR/GZR FDC Tablet

Elbasvir (EBR)/Grazoprevir (GZR) in Pediatric Participants With Chronic Hepatitis C Infection (MK-5172-079)

Start: Jan 2018Est. completion: Jul 202057 patients
Phase 2Completed

Sofosbuvir/Velpatasvir in Adults With Chronic Hepatitis C Virus Infection Who Are on Dialysis for End Stage Renal Disease

Start: Mar 2017Est. completion: Nov 201859 patients
Phase 2Completed

Efficacy and Safety of Ledipasvir/Sofosbuvir Fixed Dose Combination in the Treatment of Hepatitis C Virus (HCV) Infection in Pediatric Participants Undergoing Cancer Chemotherapy

Start: Aug 2016Est. completion: Feb 201919 patients
Phase 2Completed

Efficacy and Safety of Sofosbuvir/Velpatasvir Fixed-Dose Combination (FDC) and Sofosbuvir/Velpatasvir FDC and Ribavirin in Participants With Chronic Genotype 3 HCV Infection and Cirrhosis

Start: Jul 2016Est. completion: Oct 2017204 patients
Phase 2Completed

Sofosbuvir/Velpatasvir Fixed-Dose Combination in HCV-Infected Adults Who Are Undergoing Liver Transplantation

Start: Jun 2016Est. completion: Jan 20189 patients
Phase 2Completed

Safety, Tolerability and Efficacy of Sofosbuvir, Velpatasvir, and Voxilaprevir in Subjects With Previous DAA Experience

Start: May 2016Est. completion: Oct 201877 patients
Phase 2Completed

Ledipasvir/Sofosbuvir Fixed-Dose Combination for 12 or 24 Weeks in Genotype 1 or 4 HCV Infected Adults With Sickle Cell Disease

Start: Mar 2015Est. completion: Apr 201610 patients
Phase 2Completed

Safety and Efficacy of Voxilaprevir Plus Sofosbuvir/Velpatasvir Fixed Dose Combination in Adults With Chronic Genotype 1 HCV Infection

Start: Feb 2015Est. completion: Apr 2016205 patients
Phase 2Completed

Efficacy And Safety Of Sofosbuvir/Velpatasvir Fixed Dose Combination With Ribavirin in Chronic HCV Infected Adults Who Participated in a Prior Gilead Sponsored HCV Treatment Study

Start: Dec 2014Est. completion: Sep 201669 patients
Phase 2Completed

Safety and Efficacy of Ledipasvir/Sofosbuvir Fixed Dose Combination +/- Ribavirin in Adolescents and Children With Chronic HCV-Infection

Start: Nov 2014Est. completion: Aug 2018226 patients
Phase 2Completed

Ledipasvir/Sofosbuvir Fixed-Dose Combination ± Ribavirin in Participants With Chronic Genotype 1 HCV Who Participated in a Prior Gilead-Sponsored HCV Treatment Study

Start: Jul 2014Est. completion: Nov 2015100 patients
Phase 2Completed

Sofosbuvir Plus Ribavirin, or Ledipasvir/Sofosbuvir in Adults With HCV Infection and Renal Insufficiency

Start: Oct 2013Est. completion: Oct 201738 patients
Phase 2Completed

Efficacy and Safety of Sofosbuvir/Ledipasvir Fixed-Dose Combination ± Ribavirin in Cirrhotic Subjects With Chronic Genotype 1 HCV Infection

Start: Oct 2013Est. completion: Nov 2014155 patients
Phase 2Completed

Ledipasvir/Sofosbuvir Fixed-Dose Combination + Ribavirin in Subjects With Chronic HCV With Advanced Liver Disease or Post-Liver Transplant

Start: Sep 2013Est. completion: Mar 2015339 patients
Phase 2Completed

Safety and Efficacy of Sofosbuvir + Velpatasvir With or Without Ribavirin in Treatment-Naive Adults With Chronic HCV Infection

Start: Apr 2013Est. completion: Aug 2014379 patients
Phase 2Completed

Sofosbuvir Plus Ribavirin in Treatment-Naive and Treatment-Experienced Egyptian Adults With Chronic Genotype 4 Hepatitis C Virus (HCV) Infection

Start: Oct 2012Est. completion: Feb 201460 patients
Phase 2Completed

A Study to Evaluate the Safety and Effect of Co-administration of ABT-450 With Ritonavir (ABT-450/r) and ABT-267 in Adults With Chronic Hepatitis C Virus Infection

Start: Aug 2012Est. completion: Feb 2015316 patients
Phase 2Completed

Sofosbuvir and Ribavirin in Patients With Chronic HCV With Cirrhosis and Portal Hypertension With or Without Liver Decompensation

Start: Jul 2012Est. completion: Oct 201550 patients
Phase 2Completed

A Study to Evaluate ABT-450 With Ritonavir (ABT-450/r) and ABT-267 in Japanese Adults With Chronic Hepatitis C Virus Infection

Start: Jul 2012Est. completion: May 2014110 patients
Phase 2Completed

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

12 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.