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HCV Infection

26
Pipeline Programs
12
Companies
37
Clinical Trials
1
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
12
0
11
0
0
3
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Small Molecule
10100%
+ 37 programs with unclassified modality

On Market (1)

Approved therapies currently available

Gilead Sciences
HARVONIApproved
ledipasvir and sofosbuvir
Gilead Sciences
Hepatitis C Virus NS5A Inhibitor [EPC]oral2014
55M Part D

Competitive Landscape

12 companies ranked by most advanced pipeline stage

Gilead Sciences
Gilead SciencesFOSTER CITY, CA
13 programs
1
SovaldiN/A
SovaldiN/A
GS-5885PHASE_1
SOF/VEL/VOXPHASE_1
VoxilaprevirPHASE_1Small Molecule
+8 more programs
MSD
MSDIreland - Ballydine
4 programs
2
1
Glecaprevir/pibrentasvirPhase 4Small Molecule
BoceprevirPhase 2Small Molecule
EBR/GZR FDC TabletPhase 2
HCV serologyN/A
Sharp Therapeutics
Sharp TherapeuticsPA - Pittsburgh
4 programs
2
1
Glecaprevir/pibrentasvirPhase 4Small Molecule1 trial
BoceprevirPhase 2Small Molecule1 trial
EBR/GZR FDC TabletPhase 21 trial
HCV serologyN/A1 trial
Active Trials
NCT03461250Unknown293Est. Aug 2018
NCT01463956Completed58Est. Jan 2015
NCT03379506Completed57Est. Jul 2020
+1 more trials
Kite Pharma
Kite PharmaCA - El Segundo
11 programs
4
6
GS-9256Phase 21 trial
GS-9450Phase 21 trial
GS-9450Phase 21 trial
LDV/SOFPhase 21 trial
LDV/SOFPhase 21 trial
+6 more programs
Active Trials
NCT02783976Completed25Est. Jun 2018
NCT01193478Completed71Est. Dec 2011
NCT02533427Completed15Est. Mar 2016
+8 more trials
AstraZeneca
AstraZenecaCAMBRIDGE, United Kingdom
1 program
1
ACH-0137171Phase 21 trial
Active Trials
NCT00401947Terminated30Est. Mar 2007
Abbott
AbbottABBOTT PARK, IL
5 programs
5
ABT-072Phase 12 trials
ABT-267Phase 14 trials
ABT-333Phase 15 trials
ABT-333Phase 11 trial
ABT-333 TabletPhase 11 trial
Active Trials
NCT01221298Completed11Est. Apr 2012
NCT00890318Completed32
NCT01685203Completed316Est. Feb 2015
+10 more trials
AbbVie
AbbVieNORTH CHICAGO, IL
2 programs
2
ABT-333Phase 11 trial
ABT-450Phase 11 trial
Active Trials
NCT00696904Completed133
NCT00850044Completed87
Inovio Pharmaceuticals
1 program
1
GLS-6150Phase 11 trial
Active Trials
NCT03674125Completed32Est. May 2020
Merck & Co.
Merck & Co.RAHWAY, NJ
3 programs
HCV serologyN/A
BoceprevirPHASE_2Small Molecule
Glecaprevir/pibrentasvirPHASE_4Small Molecule
Genentech
GenentechCA - Oceanside
1 program
MMF Influence on HCV Viral Evolution After Liver TransplantationN/A1 trial
Active Trials
NCT00170131Completed17Est. Jul 2007
Roche
RocheSTAVANGER NORWAY, Norway
1 program
MMF Influence on HCV Viral Evolution After Liver TransplantationN/A
Vertex Pharmaceuticals
1 program
VCH 916PHASE_11 trial
Active Trials
NCT00623649Completed42Est. Oct 2008

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
Sharp TherapeuticsGlecaprevir/pibrentasvir
AbbottABT-333
AbbottABT-333
AbbottABT-333
Sharp TherapeuticsEBR/GZR FDC Tablet
Kite PharmaLDV/SOF
Kite PharmaSOF
Kite PharmaLDV/SOF
AbbottABT-267
AbbottABT-267
AbbottABT-333
Sharp TherapeuticsBoceprevir
AbbottABT-333
AbbottABT-267
AbbottABT-333

Showing 15 of 37 trials with date data

Clinical Trials (37)

Total enrollment: 4,124 patients across 37 trials

NCT04235049Sharp TherapeuticsGlecaprevir/pibrentasvir

Elimination of HCV Through Linkage and In Prison Treatment of Incarcerated Populations (ECLIPSE)

Start: Oct 2021Est. completion: Oct 20240
Phase 4Withdrawn

A Follow up Study Designed to Obtain Long Term Data on Participants Who Either Achieved a Sustained Virologic Response or Did Not Achieve a Sustained Virologic Response in an AbbVie Sponsored Hepatitis C Study

Start: Jun 2013Est. completion: Oct 2016478 patients
Phase 3Completed

A Study to Evaluate the Safety and Efficacy of ABT-450/Ritonavir/ABT-267; (ABT-267 Also Known as Ombitasvir) and ABT-333 (Also Known as Dasabuvir) Coadministered With Ribavirin (RBV) in Hepatitis C Virus (HCV) Genotype 1-infected Adults With Compensated Cirrhosis

Start: Oct 2012Est. completion: Sep 2014381 patients
Phase 3Completed

A Study to Evaluate the Safety and Effect of the Experimental Drugs ABT-450/Ritonavir/ABT-267 (ABT-450/r/ABT-267) and ABT-333 in Subjects With Chronic Hepatitis C

Start: Aug 2012Est. completion: Oct 2014187 patients
Phase 3Completed

Elbasvir (EBR)/Grazoprevir (GZR) in Pediatric Participants With Chronic Hepatitis C Infection (MK-5172-079)

Start: Jan 2018Est. completion: Jul 202057 patients
Phase 2Completed

Ledipasvir/Sofosbuvir Fixed-Dose Combination ± Ribavirin in Participants With Chronic Genotype 1 HCV Who Participated in a Prior Gilead-Sponsored HCV Treatment Study

Start: Jul 2014Est. completion: Nov 2015100 patients
Phase 2Completed

Sofosbuvir Plus Ribavirin, or Ledipasvir/Sofosbuvir in Adults With HCV Infection and Renal Insufficiency

Start: Oct 2013Est. completion: Oct 201738 patients
Phase 2Completed

Efficacy and Safety of Sofosbuvir/Ledipasvir Fixed-Dose Combination ± Ribavirin in Cirrhotic Subjects With Chronic Genotype 1 HCV Infection

Start: Oct 2013Est. completion: Nov 2014155 patients
Phase 2Completed

A Study to Evaluate the Safety and Effect of Co-administration of ABT-450 With Ritonavir (ABT-450/r) and ABT-267 in Adults With Chronic Hepatitis C Virus Infection

Start: Aug 2012Est. completion: Feb 2015316 patients
Phase 2Completed

A Study to Evaluate ABT-450 With Ritonavir (ABT-450/r) and ABT-267 in Japanese Adults With Chronic Hepatitis C Virus Infection

Start: Jul 2012Est. completion: May 2014110 patients
Phase 2Completed

Study to Assess the Safety, Tolerability, Pharmacokinetics and Antiviral Activity of ABT-267 in HCV Infected Subjects

Start: Feb 2012Est. completion: Jun 201312 patients
Phase 2Completed

Efficacy of PegInterferon-Ribavirin-Boceprevir Therapy in Patients Infected With G1 HCV With Cirrhosis, Awaiting Liver Transplantation

Start: Jan 2012Est. completion: Jan 201558 patients
Phase 2Completed

ABT-450 With Ritonavir and ABT-267 and/or ABT-333 With and Without Ribavirin in Genotype 1 Hepatitis C Virus Infected Patients

Start: Oct 2011Est. completion: Sep 2013580 patients
Phase 2Completed

A Study to Evaluate Paritaprevir With Ritonavir (ABT-450/r) When Given Together With Ombitasvir and With and Without Ribavirin (RBV) in Treatment-Naïve Participants With Genotype 1, 2 or 3 Chronic Hepatitis C Virus (HCV)

Start: Sep 2011Est. completion: May 201361 patients
Phase 2Completed

A Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of ABT-450 With Ritonavir (ABT-450/r) When Given Together With ABT-333 and Ribavirin (RBV) in Treatment-Naïve and Non-responder Subjects With Genotype 1 Chronic Hepatitis C Virus (HCV) Infection

Start: Feb 2011Est. completion: Oct 201250 patients
Phase 2Completed

A Pilot Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Antiviral Activity of ABT-450 With Ritonavir (ABT-450/r) Dosed in Combination With ABT-072 and Ribavirin (RBV)

Start: Oct 2010Est. completion: Apr 201211 patients
Phase 2Completed

A Randomized Study to Evaluate the Safety, Tolerability and Antiviral Activity of ABT-450, ABT-333 and ABT-072

Start: Mar 2010Est. completion: Jan 201274 patients
Phase 2Completed

Efficacy and Safety Study of GS-9256 and GS-9190 Alone and in Combination With Ribavirin for 28 Days in Patients With Chronic Hepatitis C Virus Infection

Start: Feb 2010Est. completion: Jan 201246 patients
Phase 2Completed

Efficacy and Safety Study of GS-9450 Treatment for 6 Months in Patients With Chronic Hepatitis C Virus Infection

Start: May 2009Est. completion: Jul 2010307 patients
Phase 2Terminated

Evaluation of the Safety, Tolerability, Pharmacokinetics, and Activity of GS-9450 in Subjects With Chronic HCV

Start: Apr 2008Est. completion: Mar 200933 patients
Phase 2Completed

A Study to Investigate the Safety, Tolerability, Pharmacokinetics, and Antiviral Activity of ACH-0137171 in Participants With Chronic Hepatitis C Infection

Start: Nov 2006Est. completion: Mar 200730 patients
Phase 2Terminated

Evaluation of Safety, Tolerability, and Immunogenicity Study of GLS-6150 in Healthy Volunteers and in Persons Previously Treated for Hepatitis C Virus Infection

Start: Sep 2018Est. completion: May 202032 patients
Phase 1Completed

Study to Evaluate Effect of Sofosbuvir/Velpatasvir/GS-9857 Fixed-Dose Combination on the Pharmacokinetics of a Representative Hormonal Contraceptive Medication, Norgestimate/Ethinyl Estradiol

Start: Oct 2015Est. completion: Mar 201615 patients
Phase 1Completed

Pharmacokinetics of Voxilaprevir in Adults With Normal Renal Function and Severe Renal Impairment

Start: May 2015Est. completion: Sep 201520 patients
Phase 1Completed

Pharmacokinetics of Voxilaprevir in Adults With Normal Hepatic Function and Moderate or Severe Hepatic Impairment

Start: Mar 2015Est. completion: Mar 201633 patients
Phase 1Completed

A Multiple Ascending Dose Study of GS 5885 in Previously Untreated Subjects With Genotype 1 Chronic Hepatitis C

Start: Aug 2010Est. completion: Dec 201171 patients
Phase 1Completed

Study of ABT-267 in Both Healthy Volunteers and Hepatitis C Virus (HCV) Genotype 1 Infected Subjects

Start: Aug 2010Est. completion: Jan 2012137 patients
Phase 1Completed

A Study to Assess the Safety, Tolerability, and Pharmacokinetics of Multiple Ascending Doses of the ABT-333 Tablet

Start: May 200924 patients
Phase 1Completed
NCT00895102AbbottABT-333 Tablet

Bioavailability of ABT-333 Tablet Versus First in Human (FIH) Capsule Formulation and Safety, Tolerability and PK Study of Single Doses of ABT-333 in Healthy Volunteers

Start: Apr 200934 patients
Phase 1Completed

A Study in Healthy Adult Subjects to Evaluate the Safety, Tolerability, and Pharmacokinetic Profiles of Multiple Doses of ABT-072 Used to Treat Hepatitis C

Start: Apr 200932 patients
Phase 1Completed

Safety, Tolerability and PK Study of Single Doses of ABT-450 With and Without Ritonavir to Treat Hepatitis C Virus (HCV) Genotype 1

Start: Feb 200987 patients
Phase 1Completed

A Study in Healthy Adult Subjects to Evaluate the Safety, Tolerability, and Pharmacokinetics of Multiple Doses of ABT-333

Start: Oct 200845 patients
Phase 1Completed

Study of ABT-333 in Both Healthy Volunteers and Hepatitis C Virus (HCV) + Genotype 1 Infected Subjects

Start: Jun 2008133 patients
Phase 1Completed

Safety,Tolerability and Pharmacokinetics of Multiple Ascending Doses of VCH 916 in Subjects With Chronic Hep C Infection

Start: Nov 2007Est. completion: Oct 200842 patients
Phase 1Completed

Chronic Hepatitis C in Chronic Hemodialysis Recipients - An Observational Study

Start: Apr 2018Est. completion: Aug 2018293 patients
N/AUnknown

Sovaldi-based Regimens in Patients in Mexico With Chronic Hepatitis C Virus Infection in Clinical Practice

Start: Oct 2016Est. completion: Jun 201825 patients
N/ACompleted
NCT00170131GenentechMMF Influence on HCV Viral Evolution After Liver Transplantation

MMF Influence on HCV Viral Evolution After Liver Transplantation

Start: Sep 2002Est. completion: Jul 200717 patients
N/ACompleted

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

12 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.