HCV Infection

18
Pipeline Programs
6
Companies
25
Clinical Trials
1
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
8
0
8
0
0
2
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Small Molecule
4100%
+ 17 programs with unclassified modality

On Market (1)

Approved therapies currently available

GS
HARVONIApproved
ledipasvir and sofosbuvir
Gilead Sciences
Hepatitis C Virus NS5A Inhibitor [EPC]oral2014

Competitive Landscape

6 companies ranked by most advanced pipeline stage

GS
Gilead SciencesFOSTER CITY, CA
13 programs
4
7
1
GS-9256Phase 21 trial
GS-9256Phase 2
GS-9450Phase 22 trials
LDV/SOFPhase 21 trial
LDV/SOFPhase 2
+8 more programs
Active Trials
NCT02783976Completed25Est. Jun 2018
NCT01193478Completed71Est. Dec 2011
NCT02533427Completed15Est. Mar 2016
+7 more trials
M&
Merck & Co.RAHWAY, NJ
3 programs
1
1
Glecaprevir/pibrentasvirPhase 4Small Molecule1 trial
BoceprevirPhase 2Small Molecule1 trial
HCV serologyN/A1 trial
Active Trials
NCT03461250Unknown293Est. Aug 2018
NCT01463956Completed58Est. Jan 2015
NCT04235049Withdrawn0Est. Oct 2024
Abbott
AbbottABBOTT PARK, IL
2 programs
2
ABT-267Phase 15 trials
ABT-450Phase 11 trial
Active Trials
NCT01773070Completed478Est. Oct 2016
NCT01609933Completed32Est. May 2017
NCT01704755Completed381Est. Sep 2014
+3 more trials
AbbVie
AbbVieNORTH CHICAGO, IL
1 program
1
ABT-450Phase 11 trial
Active Trials
NCT00850044Completed87
VP
1 program
1
VCH 916Phase 11 trial
Active Trials
NCT00623649Completed42Est. Oct 2008
Roche
RocheSTAVANGER NORWAY, Norway
1 program
MMF Influence on HCV Viral Evolution After Liver TransplantationN/A1 trial
Active Trials
NCT00170131Completed17Est. Jul 2007

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
Merck & Co.Glecaprevir/pibrentasvir
AbbottABT-267
AbbottABT-267
AbbottABT-267
Gilead SciencesSOF
Gilead SciencesLDV/SOF
AbbottABT-267
AbbottABT-267
Merck & Co.Boceprevir
AbbottABT-267
AbbottABT-267
Gilead SciencesGS-9256
Gilead SciencesGS-9450
Gilead SciencesGS-9450
Gilead SciencesSOF/VEL/VOX

Showing 15 of 25 trials with date data

Clinical Trials (25)

Total enrollment: 3,214 patients across 25 trials

NCT04235049Merck & Co.Glecaprevir/pibrentasvir

Elimination of HCV Through Linkage and In Prison Treatment of Incarcerated Populations (ECLIPSE)

Start: Oct 2021Est. completion: Oct 20240
Phase 4Withdrawn

A Follow up Study Designed to Obtain Long Term Data on Participants Who Either Achieved a Sustained Virologic Response or Did Not Achieve a Sustained Virologic Response in an AbbVie Sponsored Hepatitis C Study

Start: Jun 2013Est. completion: Oct 2016478 patients
Phase 3Completed

A Study to Evaluate the Safety and Efficacy of ABT-450/Ritonavir/ABT-267; (ABT-267 Also Known as Ombitasvir) and ABT-333 (Also Known as Dasabuvir) Coadministered With Ribavirin (RBV) in Hepatitis C Virus (HCV) Genotype 1-infected Adults With Compensated Cirrhosis

Start: Oct 2012Est. completion: Sep 2014381 patients
Phase 3Completed

A Study to Evaluate the Safety and Effect of the Experimental Drugs ABT-450/Ritonavir/ABT-267 (ABT-450/r/ABT-267) and ABT-333 in Subjects With Chronic Hepatitis C

Start: Aug 2012Est. completion: Oct 2014187 patients
Phase 3Completed

Sofosbuvir Plus Ribavirin, or Ledipasvir/Sofosbuvir in Adults With HCV Infection and Renal Insufficiency

Start: Oct 2013Est. completion: Oct 201738 patients
Phase 2Completed

Efficacy and Safety of Sofosbuvir/Ledipasvir Fixed-Dose Combination ± Ribavirin in Cirrhotic Subjects With Chronic Genotype 1 HCV Infection

Start: Oct 2013Est. completion: Nov 2014155 patients
Phase 2Completed

A Study to Evaluate the Safety and Effect of Treatment With Experimental Antiviral Drugs in Combination With Peginterferon Alpha-2a and Ribavirin in People With Hepatitis C Virus Who Did Not Respond to Treatment in a Previous AbbVie/Abbott Combination Study

Start: Dec 2012Est. completion: May 201732 patients
Phase 2Completed

A Study to Evaluate ABT-450 With Ritonavir (ABT-450/r) and ABT-267 in Japanese Adults With Chronic Hepatitis C Virus Infection

Start: Jul 2012Est. completion: May 2014110 patients
Phase 2Completed

Efficacy of PegInterferon-Ribavirin-Boceprevir Therapy in Patients Infected With G1 HCV With Cirrhosis, Awaiting Liver Transplantation

Start: Jan 2012Est. completion: Jan 201558 patients
Phase 2Completed

ABT-450 With Ritonavir and ABT-267 and/or ABT-333 With and Without Ribavirin in Genotype 1 Hepatitis C Virus Infected Patients

Start: Oct 2011Est. completion: Sep 2013580 patients
Phase 2Completed

A Study to Evaluate Paritaprevir With Ritonavir (ABT-450/r) When Given Together With Ombitasvir and With and Without Ribavirin (RBV) in Treatment-Naïve Participants With Genotype 1, 2 or 3 Chronic Hepatitis C Virus (HCV)

Start: Sep 2011Est. completion: May 201361 patients
Phase 2Completed

Efficacy and Safety Study of GS-9256 and GS-9190 Alone and in Combination With Ribavirin for 28 Days in Patients With Chronic Hepatitis C Virus Infection

Start: Feb 2010Est. completion: Jan 201246 patients
Phase 2Completed

Efficacy and Safety Study of GS-9450 Treatment for 6 Months in Patients With Chronic Hepatitis C Virus Infection

Start: May 2009Est. completion: Jul 2010307 patients
Phase 2Terminated

Evaluation of the Safety, Tolerability, Pharmacokinetics, and Activity of GS-9450 in Subjects With Chronic HCV

Start: Apr 2008Est. completion: Mar 200933 patients
Phase 2Completed

Study to Evaluate Effect of Sofosbuvir/Velpatasvir/GS-9857 Fixed-Dose Combination on the Pharmacokinetics of a Representative Hormonal Contraceptive Medication, Norgestimate/Ethinyl Estradiol

Start: Oct 2015Est. completion: Mar 201615 patients
Phase 1Completed

Pharmacokinetics of Voxilaprevir in Adults With Normal Renal Function and Severe Renal Impairment

Start: May 2015Est. completion: Sep 201520 patients
Phase 1Completed

Pharmacokinetics of Voxilaprevir in Adults With Normal Hepatic Function and Moderate or Severe Hepatic Impairment

Start: Mar 2015Est. completion: Mar 201633 patients
Phase 1Completed

Study of ABT-267 in Both Healthy Volunteers and Hepatitis C Virus (HCV) Genotype 1 Infected Subjects

Start: Aug 2010Est. completion: Jan 2012137 patients
Phase 1Completed

A Multiple Ascending Dose Study of GS 5885 in Previously Untreated Subjects With Genotype 1 Chronic Hepatitis C

Start: Aug 2010Est. completion: Dec 201171 patients
Phase 1Completed

Study in Healthy Adults to Evaluate Effect of Food on Pharmacokinetics, Safety and Tolerability of ABT-450 With Ritonavir

Start: May 20098 patients
Phase 1Completed

Safety, Tolerability and PK Study of Single Doses of ABT-450 With and Without Ritonavir to Treat Hepatitis C Virus (HCV) Genotype 1

Start: Feb 200987 patients
Phase 1Completed

Safety,Tolerability and Pharmacokinetics of Multiple Ascending Doses of VCH 916 in Subjects With Chronic Hep C Infection

Start: Nov 2007Est. completion: Oct 200842 patients
Phase 1Completed

Chronic Hepatitis C in Chronic Hemodialysis Recipients - An Observational Study

Start: Apr 2018Est. completion: Aug 2018293 patients
N/AUnknown

Sovaldi-based Regimens in Patients in Mexico With Chronic Hepatitis C Virus Infection in Clinical Practice

Start: Oct 2016Est. completion: Jun 201825 patients
N/ACompleted
NCT00170131RocheMMF Influence on HCV Viral Evolution After Liver Transplantation

MMF Influence on HCV Viral Evolution After Liver Transplantation

Start: Sep 2002Est. completion: Jul 200717 patients
N/ACompleted

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

6 companies competing in this space