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Nasolabial Folds

5
Pipeline Programs
5
Companies
12
Clinical Trials
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
0
0
0
1
0
4
Early DiscoveryClinical DevelopmentMarket

Competitive Landscape

5 companies ranked by most advanced pipeline stage

Galderma
GaldermaTX - Dallas
6 programs
3
Emervel ClassicPhase 41 trial
Emervel Classic and/or Deep Treatment GroupPhase 41 trial
tetracaine 7% / lidocaine 7% creamPhase 41 trial
RestylaneN/A1 trial
Sculptra Aesthetic 8mlN/A1 trial
+1 more programs
Active Trials
NCT02179736Completed114Est. Jan 2016
NCT03780244Completed80Est. Feb 2020
NCT04225273Completed38Est. Jan 2021
+3 more trials
AbbVie
AbbVieNORTH CHICAGO, IL
2 programs
1
1
Hyaluronic acid gelPhase 41 trial
No-Treatment ControlPhase 2/31 trial
Active Trials
NCT06018987Completed61Est. Feb 2025
NCT00850889Completed32Est. Nov 2008
Q Therapeutics
Q TherapeuticsUT - Salt Lake City
2 programs
Perlane and Perlane-LN/A1 trial
Restylane and Restylane-LN/A1 trial
Active Trials
NCT00823069CompletedEst. Apr 2009
NCT00797459CompletedEst. Mar 2009
JETEMA
JETEMAKorea - Gangwon
1 program
Hyaluronic AcidN/A1 trial
Active Trials
NCT06699147Completed238Est. May 2023
Croma-Pharma
Croma-PharmaAustria - Leobendorf
1 program
Princess® VOLUMEN/A1 trial
Active Trials
NCT01798498Completed48Est. Jun 2014

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
GaldermaEmervel Classic and/or Deep Treatment Group
GaldermaEmervel Classic
AbbVieHyaluronic acid gel
Galdermatetracaine 7% / lidocaine 7% cream
AbbVieNo-Treatment Control
JETEMAHyaluronic Acid
GaldermaSculptra Aesthetic, Lidocaine HCL
GaldermaSculptra Aesthetic 8ml
GaldermaRestylane
Croma-PharmaPrincess® VOLUME
Q TherapeuticsPerlane and Perlane-L
Q TherapeuticsRestylane and Restylane-L

Clinical Trials (12)

Total enrollment: 712 patients across 12 trials

NCT02718040GaldermaEmervel Classic and/or Deep Treatment Group

Emervel for the Correction of Lower Face Wrinkles & Folds

Start: Apr 2016Est. completion: Aug 201630 patients
Phase 4Completed
NCT02672644GaldermaEmervel Classic

Non-comparative Evaluation of Facial Expressions Following Lower Face Correction Using Emervel Classic and Emervel Deep

Start: Mar 2016Est. completion: May 201620 patients
Phase 4Completed
NCT00850889AbbVieHyaluronic acid gel

Juvederm Ultra With Lidocaine Compared With Restylane for the Correction of Nasolabial Folds

Start: Nov 2008Est. completion: Nov 200832 patients
Phase 4Completed
NCT00716443Galdermatetracaine 7% / lidocaine 7% cream

Evaluate Efficacy, Safety & Subject Satisfaction of Pain Management With Pliaglis® Cream for Dermal Filler Injections

Start: Jul 2008Est. completion: Sep 200851 patients
Phase 4Terminated
NCT06018987AbbVieNo-Treatment Control

A Study to Assess Adverse Events and Effectiveness of HAC 20L Injections in Adult Participants for the Treatment of Nasolabial Folds

Start: Sep 2023Est. completion: Feb 202561 patients
Phase 2/3Completed
NCT06699147JETEMAHyaluronic Acid

Evaluate the Post-marketing Efficacy and Safety of Eptq S and Eptq Lidocaine S

Start: Sep 2022Est. completion: May 2023238 patients
N/ACompleted
NCT04225273GaldermaSculptra Aesthetic, Lidocaine HCL

Extension Study for 43USSA1705

Start: Dec 2019Est. completion: Jan 202138 patients
N/ACompleted
NCT03780244GaldermaSculptra Aesthetic 8ml

Safety and Effectiveness of Sculptra Aesthetic for Correction of Nasolabial Folds.

Start: Dec 2018Est. completion: Feb 202080 patients
N/ACompleted

A Post Market Evaluation After Treatment of Nasolabial Folds

Start: Jul 2014Est. completion: Jan 2016114 patients
N/ACompleted
NCT01798498Croma-PharmaPrincess® VOLUME

Study for the Evaluation of the Efficacy and Safety of the Dermal Filler Princess® VOLUME in Nasolabial Folds

Start: Apr 2013Est. completion: Jun 201448 patients
N/ACompleted
NCT00823069Q TherapeuticsPerlane and Perlane-L

Safety Study That Compares Perlane to Perlane With Lidocaine (Perlane-L) While Correcting Wrinkles in the Area Around Your Nose

Start: Jan 2009Est. completion: Apr 2009
N/ACompleted
NCT00797459Q TherapeuticsRestylane and Restylane-L

Safety & Tolerability Study That Compares Restylane to Restylane With Lidocaine While Correcting Wrinkles in the Nasolabial Folds

Start: Nov 2008Est. completion: Mar 2009
N/ACompleted

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

5 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.