NDATOPICALOINTMENT
Approved
Jan 2009
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Clinical Trials
16
Data completeness
4/8 — Partial
VECTICAL (calcitriol) by Galderma is clinical pharmacology man's natural supply of vitamin d depends mainly on exposure to the ultraviolet rays of the sun for conversion of 7-dehydrocholesterol in the skin to vitamin d 3 (cholecalciferol). First approved in 2009.
Drug data last refreshed 9h ago · AI intelligence enriched 1w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
VECTICAL is a topical ointment formulation of calcitriol, a synthetic active form of vitamin D3 (1,25-dihydroxyvitamin D3), used to treat psoriasis and other dermatological conditions. It works by binding to calcitriol receptors in skin to regulate calcium and phosphorus metabolism and modulate immune/inflammatory pathways. The drug is rapidly absorbed through skin and achieves peak serum concentrations within 3–6 hours, with a pharmacologic duration of 3–5 days.
$0.002BPart D
LOE ApproachingLimited commercial footprint with modest Part D spending and 9,000 annual claims suggests a mature, niche-market product approaching loss of exclusivity with likely consolidation of team resources.
Mechanism of Action
CLINICAL PHARMACOLOGY Man's natural supply of vitamin D depends mainly on exposure to the ultraviolet rays of the sun for conversion of 7-dehydrocholesterol in the skin to vitamin D 3 (cholecalciferol). Vitamin D 3 must be metabolically activated in the liver and the kidney before it is fully…
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.