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Photoaging

3
Pipeline Programs
5
Companies
11
Clinical Trials
2 recruiting
1
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
0
0
0
0
2
1
Early DiscoveryClinical DevelopmentMarket

On Market (1)

Approved therapies currently available

Galderma
DIFFERINApproved
adapalene
Galderma
topical2010
94K Part D

Competitive Landscape

5 companies ranked by most advanced pipeline stage

Galderma
GaldermaTX - Dallas
4 programs
2
1
AdapalenePhase 31 trial
adapalene gel, 0.3%Phase 31 trial
Restylane-LN/A1 trial
Sculptra treatmentN/A1 trial
Active Trials
NCT06195605Recruiting15Est. Nov 2026
NCT06351358Completed41Est. May 2025
NCT01406080Completed128Est. Nov 2015
+1 more trials
ReVision Therapeutics
ReVision TherapeuticsNJ - Ridgewood
4 programs
Cleansing LotionN/A1 trial
Fractional Ablative CO2 LaserN/A1 trial
Hybrid Fractional LaserN/A1 trial
Radiofrequency MicroneedlingN/A1 trial
Active Trials
NCT05514782Completed67Est. Dec 2021
NCT06366503Completed23Est. Dec 2023
NCT06436261Completed20Est. Jul 2022
+1 more trials
Bausch Health
Bausch HealthQUEBEC, Quebec, Canada
1 program
CLEAR + BRILLIANT TOUCHN/A1 trial
Active Trials
NCT05027282Completed28Est. Nov 2022
AbbVie
AbbVieNORTH CHICAGO, IL
1 program
Laser TherapyN/A1 trial
Active Trials
NCT03661697Completed14Est. Mar 2019
Eppendorf
EppendorfGermany - Hamburg
1 program
radiofrequency microneedling combined with 1927 nm thulium laserN/A1 trial
Active Trials
NCT06029725Recruiting35Est. Mar 2025

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
GaldermaAdapalene
Galdermaadapalene gel, 0.3%
GaldermaRestylane-L
GaldermaSculptra treatment
Eppendorfradiofrequency microneedling combined with 1927 nm thulium laser
ReVision TherapeuticsFractional Ablative CO2 Laser
ReVision TherapeuticsRadiofrequency Microneedling
ReVision TherapeuticsHybrid Fractional Laser
Bausch HealthCLEAR + BRILLIANT TOUCH
ReVision TherapeuticsCleansing Lotion
AbbVieLaser Therapy

Clinical Trials (11)

Total enrollment: 412 patients across 11 trials

A Comparative Study of Adapalene Gel,0.3% Versus Tretinoin Emollient Cream, 0.05% for the Treatment of Photoaging

Start: Jan 2013Est. completion: Nov 2015128 patients
Phase 3Completed
NCT00647556Galdermaadapalene gel, 0.3%

Adapalene Gel 0.3% Versus Tretinoin 0.05% Emollient Cream for Treatment of Photodamage

Start: Apr 2008Est. completion: Jan 201030 patients
Phase 3Completed

Investigating Age Dependence of Fibroblast and Extracellular Matrix Responses to Cross-linked Hyaluronic Acid Filler in Human Skin

Start: May 2024Est. completion: Nov 202615 patients
N/ARecruiting
NCT06351358GaldermaSculptra treatment

Evaluation of the Effects of a Biostimulator and Dermal Fillers for Cheek Augmentation and Contour Deficiencies

Start: Feb 2024Est. completion: May 202541 patients
N/ACompleted
NCT06029725Eppendorfradiofrequency microneedling combined with 1927 nm thulium laser

RFMN in Combination With 1927 nm Thulium Laser for Treating Photoaged Skin

Start: Dec 2023Est. completion: Mar 202535 patients
N/ARecruiting
NCT06366503ReVision TherapeuticsFractional Ablative CO2 Laser

Evaluating Procedure Pairing of a Post-Procedure Cream Versus a Comparator in Patients Treated With Fractional Ablative CO2 Laser for Facial Rejuvenation

Start: Oct 2023Est. completion: Dec 202323 patients
N/ACompleted
NCT06157853ReVision TherapeuticsRadiofrequency Microneedling

Evaluating Procedure Pairing of a Post-Procedure Cream Versus a Comparator in Patients Treated With a Radiofrequency Microneedling for Facial Rejuvenation

Start: Jul 2022Est. completion: Aug 202211 patients
N/ACompleted
NCT06436261ReVision TherapeuticsHybrid Fractional Laser

Evaluating Procedure Pairing of a Post-Procedure Cream Versus a Comparator in Patients Treated With a Hybrid-Fractional Laser for Facial Rejuvenation

Start: Dec 2021Est. completion: Jul 202220 patients
N/ACompleted
NCT05027282Bausch HealthCLEAR + BRILLIANT TOUCH

Safety and Effectiveness of the CLEAR + BRILLIANT TOUCH(R) Diode Laser 1440-nm and 1927-nm Combination Wavelength Treatment

Start: Oct 2021Est. completion: Nov 202228 patients
N/ACompleted

A Clinical Study to Evaluate the Long-Term Efficacy and Tolerability of a Daily Anti-Aging Daily Serum

Start: Sep 2021Est. completion: Dec 202167 patients
N/ACompleted
NCT03661697AbbVieLaser Therapy

Combination Versus Laser Treatment Only

Start: Oct 2018Est. completion: Mar 201914 patients
N/ACompleted

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

2 late-stage (Phase 3) programs, potential near-term approvals
2 actively recruiting trials targeting 412 patients
5 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.