NDAORALCAPSULE, EXTENDED RELEASE
Approved
May 2010
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Clinical Trials
20
Data completeness
5/8 — Partial
CONZIP (tramadol hydrochloride) by Cipher Pharmaceuticals is extended-release capsules contain tramadol, an opioid agonist, and an inhibitor of reuptake of norepinephrine and serotonin. First approved in 2010.
Drug data last refreshed Just now · AI intelligence enriched 1w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
CONZIP is an extended-release oral capsule formulation of tramadol hydrochloride, an opioid agonist approved in 2010. It treats moderate to moderately severe pain through dual mechanisms: mu-opioid receptor binding and inhibition of norepinephrine and serotonin reuptake. The active M1 metabolite is up to 6 times more potent than the parent compound in producing analgesia.
$0.042BPart D
LOE ApproachingProduct approaching loss of exclusivity with minimal current Part D claims; brand team likely focused on transition planning rather than growth expansion.
Mechanism of Action
Extended-Release Capsules contain tramadol, an opioid agonist, and an inhibitor of reuptake of norepinephrine and serotonin. Although its mode of action is not completely understood, from animal tests, at least two complementary mechanisms appear applicable: binding of parent and M1 metabolite to…
Indications
Indication data is being enriched from DailyMed and FDA labeling. Check back soon for approved therapeutic uses.
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.