Postoperative Pain

15
Pipeline Programs
9
Companies
20
Clinical Trials
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
0
0
9
0
4
2
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Small Molecule
2100%
+ 18 programs with unclassified modality

Competitive Landscape

9 companies ranked by most advanced pipeline stage

Heron Therapeutics
10 programs
7
2
1
HTX-011Phase 41 trial
HTX-011Phase 31 trial
HTX-011Phase 31 trial
HTX-011Phase 21 trial
HTX-011Phase 21 trial
+5 more programs
Active Trials
NCT03718039CompletedEst. Mar 2019
NCT03015532CompletedEst. May 2018
NCT03011333CompletedEst. Mar 2018
+7 more trials
TM
Teleflex MedicalAustralia - Mascot
1 program
1
BolusPhase 41 trial
Active Trials
NCT02662023CompletedEst. Jun 2016
M&
Merck & Co.RAHWAY, NJ
2 programs
2
MK0966, rofecoxibPhase 3Small Molecule1 trial
MK0966, rofecoxibPhase 3Small Molecule1 trial
Active Trials
NCT00092300Completed450
NCT00092313Completed271Est. Sep 2002
UP
UCB PharmaBelgium - Brussels
1 program
1
10 mg HC-ERPhase 21 trial
Active Trials
NCT02197156Completed241Est. Feb 2003
Novartis
NovartisBASEL, Switzerland
1 program
1
SAF312APhase 21 trial
Active Trials
NCT00986882Completed183Est. Mar 2011
City Therapeutics
City TherapeuticsMA - Cambridge
2 programs
Modifiye throcoabdominal nerve block through the perichondrial approachN/A1 trial
Sternotomy applicationN/A1 trial
Active Trials
NCT07403682Not Yet RecruitingEst. Sep 2026
NCT05357963UnknownEst. Aug 2024
Verona Pharma
Verona PharmaUK - London
1 program
LOSN/A1 trial
Active Trials
NCT03685370Unknown154Est. Sep 2019
Providence Therapeutics
1 program
PandaN/A1 trial
Active Trials
NCT04139590CompletedEst. Aug 2016
United Therapeutics
United TherapeuticsMD - Silver Spring
1 program
SPRINT Peripheral Nerve StimulationN/A1 trial
Active Trials
NCT04341948Completed56Est. Jun 2024

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
Heron TherapeuticsHTX-011
Teleflex MedicalBolus
Heron TherapeuticsHTX-011
Heron TherapeuticsHTX-011
Merck & Co.MK0966, rofecoxib
Merck & Co.MK0966, rofecoxib
Heron TherapeuticsHTX-011
Heron TherapeuticsHTX-011
Heron TherapeuticsHTX-011
Heron TherapeuticsHTX-011
Heron TherapeuticsHTX-011A
Heron TherapeuticsHTX-011B
Heron TherapeuticsHTX-011
NovartisSAF312A
UCB Pharma10 mg HC-ER

Showing 15 of 20 trials with date data

Clinical Trials (20)

Total enrollment: 1,355 patients across 20 trials

A Multi-surgery Assessment of ZYNRELEF (HTX-011), AMAZE.

Start: Oct 2021Est. completion: Jul 2022
Phase 4Completed

Continuous TAP Blocks: Relative Effects of a Basal Infusion vs. Repeated Bolus Doses

Start: Feb 2016Est. completion: Jun 2016
Phase 4Completed

Bunionectomy Study for Postoperative Analgesia (EPOCH 1)

Start: Oct 2017Est. completion: Mar 2018
Phase 3Completed

Phase 3 Herniorrhaphy Study for Postoperative Analgesia (EPOCH 2)

Start: Jul 2017Est. completion: Jan 2018
Phase 3Completed
NCT00092313Merck & Co.MK0966, rofecoxib

A Study of Two Approved Drugs in the Treatment of Postoperative Dental Pain (0966-182)

Start: Jun 2002Est. completion: Sep 2002271 patients
Phase 3Completed
NCT00092300Merck & Co.MK0966, rofecoxib

A Study of Two Approved Drugs in the Treatment of Postoperative Dental Pain (0966-181)(COMPLETED)

Start: May 2002450 patients
Phase 3Completed

Phase 2 Bunionectomy HTX-011 Administration Study

Start: Oct 2018Est. completion: Mar 2019
Phase 2Completed

Phase 2 Herniorrhaphy Study for Opioid Elimination

Start: Oct 2018Est. completion: Dec 2018
Phase 2Completed

Phase 2B Upper Extremity Nerve Block Study

Start: Jan 2017Est. completion: Mar 2018
Phase 2Completed

Total Knee Arthroplasty Infiltration Study for Postoperative Analgesia

Start: Jan 2017Est. completion: May 2018
Phase 2Completed

Evaluation of the Efficacy and Safety of Locally Administered HTX-011 for Postoperative Analgesia Following Bunionectomy

Start: May 2016Est. completion: Mar 2017
Phase 2Completed

Evaluation of the Efficacy and Safety of HTX-011 for Postoperative Analgesia Following Abdominoplasty Surgery

Start: Feb 2016Est. completion: Apr 2017
Phase 2Completed

Pilot Herniorrhaphy Study for Postoperative Analgesia

Start: Jul 2015Est. completion: Apr 2017
Phase 2Completed

To Evaluate the Safety, Tolerability and Analgesic Efficacy of SAF312 in Postoperative Dental Pain Patients

Start: Sep 2009Est. completion: Mar 2011183 patients
Phase 2Completed

A Multicenter Active Comparator Study of HC-ER in Adults Following Bunionectomy Surgery

Start: Aug 2002Est. completion: Feb 2003241 patients
Phase 2Completed
NCT07403682City TherapeuticsModifiye throcoabdominal nerve block through the perichondrial approach

M-TAPA vs ESPB for Postoperative Analgesia After Laparoscopic Cholecystectomy

Start: Mar 2026Est. completion: Sep 2026
N/ANot Yet Recruiting
NCT05357963City TherapeuticsSternotomy application

Incidence of Chronic Pain After Sternotomy

Start: Apr 2022Est. completion: Aug 2024
N/AUnknown
NCT04341948United TherapeuticsSPRINT Peripheral Nerve Stimulation

Treatment of Post-Operative Pain Following Orthopedic Surgery With SPRINT® Peripheral Nerve Stimulation (PNS) System

Start: Aug 2020Est. completion: Jun 202456 patients
N/ACompleted

PERiX: Comparison of Efficacy Between Placement of Epidural Catheters X-ray Guided and LOS Technique

Start: Mar 2017Est. completion: Sep 2019154 patients
N/AUnknown

Evaluation of Smartphone Versions of VAS and NRS for Use in Adults

Start: Jul 2016Est. completion: Aug 2016
N/ACompleted

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

4 late-stage (Phase 3) programs — potential near-term approvals
9 companies competing in this space