Chronic Pain

15
Pipeline Programs
15
Companies
49
Clinical Trials
3 recruiting
1
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
2
1
0
0
10
2
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Small Molecule
1100%
+ 36 programs with unclassified modality

On Market (1)

Approved therapies currently available

U
ZOHYDRO ERApproved
hydrocodone bitartrate
Unknown Company
oral2013

Competitive Landscape

15 companies ranked by most advanced pipeline stage

Flowonix Medical
Flowonix MedicalNJ - Hackettstown
2 programs
1
Prometra II Programmable Pump systemPhase 41 trial
Prometra Programmable Intrathecal Infusion PumpN/A1 trial
Active Trials
NCT01854229Completed400Est. Mar 2023
NCT03876158Withdrawn0Est. Jun 2022
Bausch Health
Bausch HealthQUEBEC, Quebec, Canada
5 programs
5
Tramadol HCl ERPhase 31 trial
Tramadol HCl ERPhase 31 trial
Tramadol HCl ERPhase 31 trial
tramadol ERPhase 31 trial
tramadol HCl ER; celecoxibPhase 3Small Molecule1 trial
Active Trials
NCT00348010CompletedEst. Jul 2001
NCT00325858CompletedEst. Dec 2003
NCT00347724CompletedEst. Nov 2001
+2 more trials
Pfizer
PfizerNEW YORK, NY
4 programs
2
1
NSAIDPhase 31 trial
PF-04531083Phase 11 trial
PF-04531083Phase 11 trial
interdisciplinary multimodal pain treatmentN/A1 trial
Active Trials
NCT05661760Unknown2,309Est. Dec 2023
NCT01103739Completed24Est. May 2010
NCT01119235Completed24Est. Jul 2010
+1 more trials
Teva
TevaIsrael - Petach Tikva
3 programs
3
Fentanyl Buccal TabletPhase 33 trials
Fentanyl Buccal Tablets Compared With Immediate-Release OxycodonePhase 31 trial
Hydrocodone ERPhase 32 trials
Active Trials
NCT04635852Completed10Est. Dec 2014
NCT00842829Terminated330Est. May 2011
NCT00813488Completed213Est. Jan 2010
+3 more trials
UP
UCB PharmaBelgium - Brussels
1 program
1
Hydrocodone BitartratePhase 31 trial
Active Trials
NCT01115569Completed424Est. Jan 2012
Providence Therapeutics
1 program
1
Ketamine InfusionPhase 1/21 trial
Active Trials
NCT07009158Not Yet RecruitingEst. Sep 2029
Abbott
AbbottABBOTT PARK, IL
11 programs
AccelerometryN/A1 trial
AwakeN/A1 trial
Burst and Tonic stimulationN/A1 trial
Burst-capable SCS systemN/A1 trial
Dorsal root ganglionN/A5 trials
+6 more programs
Active Trials
NCT02950831Completed27Est. Mar 2018
NCT02284542Completed34Est. Jan 2017
NCT02143791Completed126Est. Oct 2016
+16 more trials
Alliance Pharmaceuticals
2 programs
BraveNet Multi-Center Study on Integrative Medicine Treatment Approaches for PainN/A1 trial
Our Whole LivesN/A1 trial
Active Trials
NCT01186341Completed418Est. Jun 2011
NCT06515925Recruiting212Est. Nov 2025
T-Therapeutics
T-TherapeuticsUK - Cambridge
2 programs
Digital CBT-IN/A1 trial
Long-term Monitoring of Sleep with Ear-EEG in Patients with Chronic PainN/A1 trial
Active Trials
NCT06361914Active Not RecruitingEst. Dec 2026
NCT06368531CompletedEst. Nov 2024
Circle Pharma
Circle PharmaCA - South SF
1 program
APP-led model of care for chronic pain managementN/A1 trial
Active Trials
NCT05336903Completed45Est. Dec 2023
Connect Biopharma
Connect BiopharmaSAN DIEGO, CA
1 program
Flippin' Pain Seminar SeriesN/A1 trial
Active Trials
NCT05724667CompletedEst. Apr 2022
Verona Pharma
Verona PharmaUK - London
1 program
Internet-based interventionN/A1 trial
Active Trials
NCT07270588RecruitingEst. Apr 2026
Curonix
CuronixFL - Pompano Beach
1 program
PNSN/A1 trial
Active Trials
NCT06832449Active Not RecruitingEst. Dec 2025
Carrick Therapeutics
Carrick TherapeuticsIreland - Dublin
1 program
Posturographic evaluationN/A1 trial
Active Trials
NCT02577653WithdrawnEst. Jan 2017
Presidio Medical
Presidio MedicalCA - South SF
1 program
ULF SCSN/A1 trial
Active Trials
NCT05837234Active Not RecruitingEst. Mar 2028

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
2028
2029
Flowonix MedicalPrometra II Programmable Pump system
TevaFentanyl Buccal Tablet
PfizerNSAID
TevaHydrocodone ER
TevaHydrocodone ER
UCB PharmaHydrocodone Bitartrate
TevaFentanyl Buccal Tablet
TevaFentanyl Buccal Tablets Compared With Immediate-Release Oxycodone
Bausch Healthtramadol HCl ER; celecoxib
Bausch HealthTramadol HCl ER
Bausch HealthTramadol HCl ER
Bausch HealthTramadol HCl ER
Bausch Healthtramadol ER
TevaFentanyl Buccal Tablet
Providence TherapeuticsKetamine Infusion

Showing 15 of 49 trials with date data

Clinical Trials (49)

Total enrollment: 12,031 patients across 49 trials

NCT03876158Flowonix MedicalPrometra II Programmable Pump system

Transitioning to a Valve -Gated Intrathecal Drug Delivery System (IDDS)

Start: Oct 2019Est. completion: Jun 20220
Phase 4Withdrawn
NCT00842829TevaFentanyl Buccal Tablet

Study of Breakthrough Cancer Pain: Assessment of Fentanyl Buccal Tablets Titration and Treatment in Opioid-Tolerant Patients

Start: Jan 2009Est. completion: May 2011330 patients
Phase 4Terminated

Long Term Safety and Efficacy Study of Tanezumab in Subjects With Osteoarthritis of the Hip or Knee

Start: Jul 2015Est. completion: Feb 20193,021 patients
Phase 3Completed
NCT01240863TevaHydrocodone ER

Study to Evaluate the Efficacy and Safety of Hydrocodone Bitartrate Extended-Release Tablets (CEP-33237) for Relief of Moderate to Severe Pain in Patients With Osteoarthritis or Low Back Pain Who Require Opioid Treatment for an Extended Period of Time

Start: Nov 2010Est. completion: Aug 2011391 patients
Phase 3Completed
NCT01223365TevaHydrocodone ER

Study to Evaluate the Long-Term Safety of Hydrocodone Bitartrate Extended-Release Tablets (CEP-33237) in Patients Who Require Opioid Treatment for an Extended Period of Time

Start: Oct 2010Est. completion: Sep 2012330 patients
Phase 3Completed
NCT01115569UCB PharmaHydrocodone Bitartrate

Long-Term Study of Hydrocodone Bitartrate Controlled-release Capsules in Subjects With Chronic Pain

Start: May 2010Est. completion: Jan 2012424 patients
Phase 3Completed
NCT00813488TevaFentanyl Buccal Tablet

Fentanyl Buccal Tablets Versus Immediate Release Oxycodone for Breakthrough Pain in Patients With Chronic Pain

Start: Dec 2008Est. completion: Jan 2010213 patients
Phase 3Completed
NCT00463047TevaFentanyl Buccal Tablets Compared With Immediate-Release Oxycodone

Efficacy and Safety of Fentanyl Buccal Tablets Compared With Oxycodone for the Management of Break Through Pain

Start: Jul 2007Est. completion: Feb 2009323 patients
Phase 3Completed
NCT00348452Bausch Healthtramadol HCl ER; celecoxib

A Study Comparing the Effectiveness and Safety of Extended Release Tramadol HCl at 100 mg, 200 mg and 300 mg Doses to Placebo for the Treatment of Moderate to Severe Pain Due to Osteoarthritis (OA)

Start: Sep 2002Est. completion: Aug 2003
Phase 3Completed

A Study Comparing the Effectiveness and Safety of Varying Dose Strengths (100, 200, 300 and 400 mg) of Extended-release Tramadol HCl With Placebo for the Treatment of Osteoarthritis(OA) of the Knee and/or Hip

Start: Jan 2002Est. completion: Dec 2003
Phase 3Completed

A Study Comparing the Effectiveness and Safety of Extended Release Tramadol Versus Placebo for the Treatment of Osteoarthritis (OA) of the Knee

Start: Nov 2000Est. completion: Jul 2001
Phase 3Completed

A Study Comparing the Effectiveness and Safety of Extended-release Tramadol Versus Placebo in the Treatment of Chronic Low Back Pain

Start: Nov 2000Est. completion: Nov 2001
Phase 3Completed

A One-year, Open-label Study to Assess the Safety and Effectiveness of Extended Release Tramadol HCl in the Treatment of Chronic, Non-malignant Pain.

Start: Oct 2000Est. completion: Feb 2003
Phase 3Completed
NCT04635852TevaFentanyl Buccal Tablet

Fentanyl Buccal Tablet for the Relief of Episodic Breathlessness in Cancer Patients

Start: Mar 2013Est. completion: Dec 201410 patients
Phase 2Completed

Ketamine Assisted Psychotherapy for Treating Comorbid Chronic Pain and PTSD

Start: Oct 2025Est. completion: Sep 2029
Phase 1/2Not Yet Recruiting

A Study To Observe The Performance Of A Tablet Form Of PF-04531083 As Evidenced By The Concentration Of PF-04531083 In The Blood With Time Following Oral Administration To Healthy Volunteers.

Start: May 2010Est. completion: Jul 201024 patients
Phase 1Completed

To Explore The Potential For PF-04531083 To Effect The Blood Concentrations Of Simvastatin And Its Main Acid Metabolite Following Co-Administration Of Both Medications

Start: Mar 2010Est. completion: May 201024 patients
Phase 1Completed
NCT07270588Verona PharmaInternet-based intervention

MobACT: An Internet-Based Intervention for Chronic Pain Patients

Start: Apr 2025Est. completion: Apr 2026
N/ARecruiting

Retrospective PNS Study

Start: Dec 2024Est. completion: Dec 2025
N/AActive Not Recruiting

Our Whole Lives Gemini: Virtual Integrative Medical Group Visits for Managing Chronic Pain

Start: Aug 2024Est. completion: Nov 2025212 patients
N/ARecruiting

Digital CBT-I for Patients With Chronic Pain and Insomnia

Start: Apr 2024Est. completion: Dec 2026
N/AActive Not Recruiting
NCT06368531T-TherapeuticsLong-term Monitoring of Sleep with Ear-EEG in Patients with Chronic Pain

Long-term Monitoring of Sleep with Ear-EEG in Patients with Chronic Pain

Start: Apr 2024Est. completion: Nov 2024
N/ACompleted

Ultra Low Frequency Spinal Cord Stimulation for Chronic Low Back Pain

Start: May 2023Est. completion: Mar 2028
N/AActive Not Recruiting
NCT05336903Circle PharmaAPP-led model of care for chronic pain management

Development and Feasibility Testing of an Advanced Practice Physiotherapy Role in Chronic Pain Management

Start: Jun 2022Est. completion: Dec 202345 patients
N/ACompleted
NCT05724667Connect BiopharmaFlippin' Pain Seminar Series

An Evaluation of a Flippin' Pain Seminar Series

Start: Feb 2022Est. completion: Apr 2022
N/ACompleted
NCT05103527AbbottDorsal root ganglion

Dorsal Root Ganglion Stimulation for the Treatment of Arthritic Knee Pain

Start: Jan 2022Est. completion: May 202630 patients
N/AActive Not Recruiting
NCT03908476AbbottBurst-capable SCS system

PROLONG Prospective, Multi-center, Open-label, Post-market Study

Start: Apr 2019Est. completion: Nov 2021118 patients
N/ACompleted
NCT03876054AbbottSpinal cord stimulation

Long-Term Real-World Outcomes Study on Patients Implanted With a Neurostimulator

Start: Mar 2019Est. completion: Dec 20292,000 patients
N/ARecruiting
NCT05661760Pfizerinterdisciplinary multimodal pain treatment

Predicting Successful Outcome of Interdisciplinary Biopsychosocial Rehabilitation in Osteoarthritis

Start: Jan 2019Est. completion: Dec 20232,309 patients
N/AUnknown
NCT02986074AbbottParesthesia mapping lead evaluation first

CompaRison of Paresthesia Mapping to anatomIc Midline-based burSt Programming Strategies

Start: Nov 2016Est. completion: Aug 201960 patients
N/ACompleted
NCT02950831AbbottAccelerometry

Objective Assessment of Activity and Sleep Quality In Burst Spinal Cord Stimulation

Start: Oct 2016Est. completion: Mar 201827 patients
N/ACompleted
NCT02800863AbbottDorsal root ganglion

TARGET Post-Approval Study

Start: Aug 2016Est. completion: Sep 2021426 patients
N/ACompleted
NCT02896361AbbottReprogramming of spinal cord stimulator

Burst Optimized Stimulation Study

Start: Jul 2016Est. completion: Aug 201729 patients
N/ACompleted
NCT02587637AbbottDorsal root ganglion

Study to Evaluate the Effectiveness of DRG Stimulation for Discogenic Low Back Pain

Start: Oct 2015Est. completion: Jan 201820 patients
N/ACompleted
NCT02577653Carrick TherapeuticsPosturographic evaluation

Posturographic Characteristics of Eccentric, Isometric and Concentric Movements

Start: Oct 2015Est. completion: Jan 2017
N/AWithdrawn

NAPS: Non-awake Versus Awake Placement of Spinal Cord Stimulators

Start: Nov 2014Est. completion: Jan 201734 patients
N/ACompleted
NCT02143791AbbottBurst and Tonic stimulation

Evaluate St Jude Medical Prodigy Neuromodulation for FBSS or Chronic Pain of the Trunk and/or Limbs

Start: Jun 2014Est. completion: Oct 2016126 patients
N/ACompleted
NCT02011893AbbottTonic Stimulation

SUNBURST (Success Using Neuromodulation With BURST) Study

Start: Dec 2013Est. completion: Jan 2017173 patients
N/ACompleted
NCT02346383Abbottpreset program

Optimal Stimulation Programming for Spinal Peripheral Neuromodulation

Start: Sep 2013Est. completion: Jun 201640 patients
N/ACompleted
NCT01923285AbbottDorsal root ganglion

A Safety and Effectiveness Trial of Spinal Cord Stimulation of the Dorsal Root Ganglion for Chronic Lower Limb Pain

Start: Aug 2013Est. completion: Sep 2016152 patients
N/ACompleted
NCT01854229Flowonix MedicalPrometra Programmable Intrathecal Infusion Pump

Prometra Post-Approval Study

Start: Jun 2013Est. completion: Mar 2023400 patients
N/ACompleted
NCT02335229AbbottDorsal root ganglion

A Post Market Study to Assess the Spinal Modulation Dorsal Root Ganglion Stimulator System in Chronic Post Surgical Pain

Start: Jun 2013Est. completion: Feb 201730 patients
N/ATerminated
NCT02346656AbbottImplantation with the commercially available Axium Neurostimulator

a BavaRiAn eValuatiOn of Dorsal Root Ganglion (DRG) Stimulation for the Treatment for Chronic Post Surgical Pain of the Groin

Start: May 2013Est. completion: Sep 20157 patients
N/ATerminated
NCT02349646AbbottImplantation with the commercially available Axium Neurostimulator

A Post Market Cohort With the Spinal Modulation Neurostimulator System in Peripheral Neuropathy

Start: Apr 2013Est. completion: Oct 201633 patients
N/ATerminated
NCT02346643AbbottImplantation with the commercially available Axium Neurostimulator

A Post Market Evaluation of Chronic intractaBle paIN and the Efficacy of drG stimulatiOn in the Nordic Region

Start: Apr 2013Est. completion: Dec 201541 patients
N/ATerminated
NCT02335489AbbottImplantation with the commercially available Axium Neurostimulator

A Post Market Cohort to Assess the Performance of the Spinal Modulation Neurostimulator System for the Management of Chronic Neuropathic Pain of the Foot and/or Lower Leg

Start: Mar 2013Est. completion: Nov 201510 patients
N/ATerminated
NCT02169401AbbottImplantation with the commercially available Axium Neurostimulator

A Multi-centre Observational Study of the Axium Neurostimulator as a Treatment for Chronic Pain

Start: Nov 2012Est. completion: Jan 2017135 patients
N/ACompleted
NCT02335502AbbottImplantation with the commercially available Axium Neurostimulator

A Post Market Study to Assess the Spinal Modulation Neurostimulator System for Chronic Intractable Pain

Start: Apr 2012Est. completion: Jul 201566 patients
N/ACompleted
NCT01186341Alliance PharmaceuticalsBraveNet Multi-Center Study on Integrative Medicine Treatment Approaches for Pain

BraveNet Multi-Center Study on Integrative Medicine Treatment Approaches for Pain

Start: Jun 2009Est. completion: Jun 2011418 patients
N/ACompleted

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

10 late-stage (Phase 3) programs — potential near-term approvals
3 actively recruiting trials targeting 12,031 patients
15 companies competing in this space