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Acute Pain

21
Pipeline Programs
29
Companies
37
Clinical Trials
1
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
9
0
5
1
4
2
Early DiscoveryClinical DevelopmentMarket

On Market (1)

Approved therapies currently available

Trevena
OLINVYKApproved
oliceridine
Trevena
intravenous2020

Competitive Landscape

27 companies ranked by most advanced pipeline stage

Trevena
TrevenaPA - Chesterbrook
4 programs
1
TRV130PHASE_21 trial
OliceridinePHASE_31 trial
OLINVYK(Oliceridine)PHASE_31 trial
TRV130PHASE_31 trial
Active Trials
NCT02100748Completed333Est. Oct 2014
NCT02820324Completed407Est. Jan 2017
NCT02815709Completed418Est. Jan 2017
+1 more trials
Menarini
MenariniGermany - Dresden
2 programs
1
1
Tramadol Hydrochloride/Dexketoprofen TrometamolPhase 41 trial
Enantyum® oral solutionPhase 11 trial
Active Trials
NCT02209454Completed26Est. Jun 2014
NCT02777970Completed654Est. Feb 2017
Oregon Therapeutics
Oregon TherapeuticsFrance - Paris
2 programs
1
Supported-Self ManagementPhase 31 trial
Subacromial injectionN/A1 trial
Active Trials
NCT02971072Completed180Est. Apr 2021
NCT03581123Completed1,000Est. Jun 2024
Dompé
DompéItaly - L'Aquila
1 program
1
OKITASK®Phase 31 trial
Active Trials
NCT03836807Completed70Est. Dec 2018
Pharmbio Korea
Pharmbio KoreaKorea - Seoul
1 program
1
PBK_L1704 0.35mgPhase 31 trial
Active Trials
NCT05509868Completed182Est. Feb 2025
Apsen Farmaceutica
Apsen FarmaceuticaBrazil - São Paulo
1 program
1
etodolac and cyclobenzaprinePhase 3
Xgene Pharmaceutical
Xgene PharmaceuticalChina - Shanghai
1 program
1
XG005 tabletPhase 2/31 trial
Active Trials
NCT06017999Completed450Est. Sep 2024
EMS
EMSBrazil - Hortolândia
2 programs
2
Escócia associationPhase 21 trial
TIRADENTES ASSOCIATIONPhase 21 trial
Active Trials
NCT04666701Withdrawn0Est. Jun 2025
NCT04593329Withdrawn0Est. Dec 2023
Dr. Reddy's Laboratories
1 program
1
DFN-15Phase 21 trial
Active Trials
NCT03554772Completed120Est. Aug 2018
BioTherapeutics Inc
BioTherapeutics IncVA - Blacksburg
1 program
1
Experimental: LTG-001 High DosePhase 2
Talphera
TalpheraCA - San Mateo
1 program
1
Sufentanil NanoTab 20 mcgPhase 21 trial
Active Trials
NCT01710345Completed101Est. Feb 2013
Lotus Pharmaceuticals
Lotus PharmaceuticalsTaiwan - Taipei
1 program
1
CT-044 HClPhase 11 trial
Active Trials
NCT04175743Unknown21Est. Sep 2020
Elysium Therapeutics
1 program
1
ETR028, ETR029, [ETR028 + ETR029] or HCBTPhase 1
Charles River Laboratories
1 program
1
ETR028, ETR029, [ETR028 + ETR029] or HCBTPhase 11 trial
Active Trials
NCT05572190Unknown78Est. Mar 2024
Medpace
MedpaceCINCINNATI, OH
1 program
1
ETR028, ETR029, [ETR028 + ETR029] or HCBTPhase 1
Colorado Therapeutics
Colorado TherapeuticsCO - Louisville
1 program
1
GabapentinPhase 11 trial
Active Trials
NCT02856750Completed100Est. Oct 2018
Pfizer
PfizerNEW YORK, NY
1 program
1
PF-04457845, FAAH inhibitorPhase 11 trial
Active Trials
NCT00836082Completed41Est. Jul 2009
Sharp Therapeutics
Sharp TherapeuticsPA - Pittsburgh
1 program
1
pregabalinPhase 1
MSD
MSDIreland - Ballydine
1 program
1
pregabalinPhase 11 trial
Active Trials
NCT00601458Completed100Est. Jan 2008
Vertex Pharmaceuticals
10 programs
VX-708PHASE_11 trial
VX-150PHASE_21 trial
VX-150PHASE_21 trial
VX-548PHASE_21 trial
VX-548PHASE_21 trial
+5 more programs
Active Trials
NCT05347394Completed100Est. Apr 2023
NCT03764072Completed250Est. Jan 2019
NCT03206749Completed243Est. Dec 2017
+7 more trials
Boehringer Ingelheim
Boehringer IngelheimINGELHEIM, Germany
2 programs
Hyoscine n-butylbromideN/A1 trial
DiclofenacPHASE_31 trial
Active Trials
NCT02910167Completed360Est. Feb 2017
NCT02700815Completed746Est. Jul 2017
Spine BioPharma
Spine BioPharmaNY - New York
1 program
BiofreezeN/A1 trial
Active Trials
NCT03157349Completed59Est. Feb 2019
Human BioSciences
Human BioSciencesWV - Martinsburg
1 program
Pharmacogenetic testingN/A1 trial
Active Trials
NCT05966129Completed1,602Est. Mar 2024
Genome & Company
Genome & CompanyKorea - Suwon
1 program
Pharmacogenetic testingN/A
Eppendorf
EppendorfGermany - Hamburg
1 program
Saline injectionN/A1 trial
Active Trials
NCT03021278Completed57Est. Jul 2017
BioLineRx
BioLineRxIsrael - Modi’in
1 program
MorphinePHASE_1_21 trial
Active Trials
NCT00374881Completed9Est. Aug 2007
Latigo Biotherapeutics
Latigo BiotherapeuticsCA - Thousand Oaks
1 program
Experimental: LTG-001 High DosePHASE_21 trial
Active Trials
NCT07102459Completed343Est. Jan 2026

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
Vertex PharmaceuticalsSuzetrigine
Vertex PharmaceuticalsSuzetrigine
MenariniTramadol Hydrochloride/Dexketoprofen Trometamol
Vertex PharmaceuticalsSuzetrigine
Vertex PharmaceuticalsSUZ
Pharmbio KoreaPBK_L1704 0.35mg
Oregon TherapeuticsSupported-Self Management
DompéOKITASK®
Boehringer IngelheimDiclofenac
TrevenaOliceridine
TrevenaOliceridine
TrevenaTRV130
Xgene PharmaceuticalXG005 tablet
Latigo BiotherapeuticsExperimental: LTG-001 High Dose
Vertex PharmaceuticalsVX-993

Showing 15 of 37 trials with date data

Clinical Trials (37)

Total enrollment: 12,102 patients across 37 trials

NCT06887959Vertex PharmaceuticalsSuzetrigine

A Single-arm Study Evaluating the Effectiveness and Safety of Suzetrigine (SUZ) for Acute Pain After Selected Surgeries

Start: Mar 2025Est. completion: Nov 202547 patients
Phase 4Completed
NCT06887972Vertex PharmaceuticalsSuzetrigine

A Single-Arm Study Evaluating the Effectiveness and Safety of Suzetrigine (SUZ) for Acute Pain After Aesthetic or Reconstructive Surgeries

Start: Mar 2025Est. completion: Nov 2025100 patients
Phase 4Completed
NCT02777970MenariniTramadol Hydrochloride/Dexketoprofen Trometamol

Tramadol Hydrochloride and Dexketoprofen Trometamol for the Oral Treatment of Moderate to Severe Acute Pain Following Removal of Impacted Lower Third Molar

Start: Apr 2016Est. completion: Feb 2017654 patients
Phase 4Completed
NCT05558410Vertex PharmaceuticalsSuzetrigine

Evaluation of Efficacy and Safety of Suzetrigine for Acute Pain After an Abdominoplasty

Start: Oct 2022Est. completion: Sep 20231,118 patients
Phase 3Completed
NCT05553366Vertex PharmaceuticalsSUZ

Evaluation of Efficacy and Safety of VX-548 for Acute Pain After a Bunionectomy

Start: Oct 2022Est. completion: Dec 20231,075 patients
Phase 3Completed
NCT05509868Pharmbio KoreaPBK_L1704 0.35mg

Study of PBK_L1704 for the Treatment of Moderate to Severe Acute Pain After Bunionectomy in South Korea

Start: Jul 2022Est. completion: Feb 2025182 patients
Phase 3Completed
NCT03581123Oregon TherapeuticsSupported-Self Management

Spinal Manipulation and Patient Self-Management for Preventing Acute to Chronic Back Pain

Start: Nov 2018Est. completion: Jun 20241,000 patients
Phase 3Completed
NCT03836807DompéOKITASK®

A Study to Assess Efficacy and Tolerability of Ketoprofen 40 mg Granules vs Placebo

Start: Apr 2018Est. completion: Dec 201870 patients
Phase 3Completed
NCT02700815Boehringer IngelheimDiclofenac

Capsaicin + Diclofenac Gel in Acute Back Pain or Neck Pain

Start: May 2016Est. completion: Jul 2017746 patients
Phase 3Completed
NCT02820324TrevenaOliceridine

Study of Oliceridine (TRV130) for the Treatment of Moderate to Severe Acute Pain After Abdominoplasty

Start: May 2016Est. completion: Jan 2017407 patients
Phase 3Completed
NCT02815709TrevenaOliceridine

Study of Oliceridine (TRV130) for the Treatment of Moderate to Severe Acute Pain After Bunionectomy

Start: May 2016Est. completion: Jan 2017418 patients
Phase 3Completed
NCT02656875TrevenaTRV130

A Open-label Study to Evaluate the Safety of TRV130 in Patients With Acute Pain

Start: Dec 2015Est. completion: Aug 2017768 patients
Phase 3Completed
NCT06017999Xgene PharmaceuticalXG005 tablet

XG005 for Pain Control in Subjects Undergoing Bunionectomy

Start: Aug 2023Est. completion: Sep 2024450 patients
Phase 2/3Completed
NCT07102459Latigo BiotherapeuticsExperimental: LTG-001 High Dose

An Efficacy and Safety Study of LTG-001 Following Abdominoplasty

Start: Jul 2025Est. completion: Jan 2026343 patients
Phase 2Completed
NCT06619847Vertex PharmaceuticalsVX-993

A Study Evaluating Efficacy and Safety of VX-993 for Acute Pain After a Bunionectomy

Start: Oct 2024Est. completion: May 2025367 patients
Phase 2Completed
NCT04593329EMSTIRADENTES ASSOCIATION

Efficacy and Safety of Tiradentes Association in the Treatment of Acute Pain

Start: Mar 2023Est. completion: Dec 20230
Phase 2Withdrawn
NCT04666701EMSEscócia association

Efficacy and Safety of Escócia Association in the Treatment of Acute Pain

Start: Feb 2023Est. completion: Jun 20250
Phase 2Withdrawn
NCT05034952Vertex PharmaceuticalsVX-548

A Study Evaluating Efficacy and Safety of VX-548 for Acute Pain After an Abdominoplasty

Start: Aug 2021Est. completion: Dec 2021303 patients
Phase 2Completed
NCT04977336Vertex PharmaceuticalsVX-548

A Study Evaluating Efficacy and Safety of VX-548 for Acute Pain After a Bunionectomy

Start: Jul 2021Est. completion: Mar 2022274 patients
Phase 2Completed
NCT03764072Vertex PharmaceuticalsVX-150

A Dose-ranging Study to Evaluate Efficacy and Safety of VX-150 in Subjects With Acute Pain Following Bunionectomy

Start: Dec 2018Est. completion: Jan 2019250 patients
Phase 2Completed
NCT03554772Dr. Reddy's LaboratoriesDFN-15

Efficacy, Tolerability, Safety, and Pharmacokinetic Study of DFN-15

Start: Jun 2018Est. completion: Aug 2018120 patients
Phase 2Completed
NCT03206749Vertex PharmaceuticalsVX-150

A Study to Evaluate Efficacy and Safety of VX-150 in Subjects With Acute Pain Following Bunionectomy

Start: Jun 2017Est. completion: Dec 2017243 patients
Phase 2Completed
NCT02100748TrevenaTRV130

A Study of TRV130 for the Treatment of Pain After Bunionectomy

Start: Apr 2014Est. completion: Oct 2014333 patients
Phase 2Completed
NCT01710345TalpheraSufentanil NanoTab 20 mcg

Safety and Efficacy of Sufentanil NanoTab for Management of Acute Pain Following Bunionectomy

Start: Oct 2012Est. completion: Feb 2013101 patients
Phase 2Completed
NCT00374881BioLineRxMorphine

A Study of the Safety and Efficacy of Combination Therapy With Morphine, Phenylephrine and Sorbitol in Human Subjects

Start: Sep 2006Est. completion: Aug 20079 patients
Phase 1/2Completed
NCT05572190Charles River LaboratoriesETR028, ETR029, [ETR028 + ETR029] or HCBT

Evaluate the Safety and Pharmacokinetic Profile of ETR028 and ETR029 in Healthy Adult Subjects

Start: Sep 2022Est. completion: Mar 202478 patients
Phase 1Unknown
NCT05347394Vertex PharmaceuticalsVX-708

A Phase 1 Dose Escalation Study of Oral VX-708 in Healthy Participants

Start: Apr 2022Est. completion: Apr 2023100 patients
Phase 1Completed
NCT04175743Lotus PharmaceuticalsCT-044 HCl

Double-blind, Placebo-control, Study to Evaluate the Safety and Pharmacokinetics of CT-044 HCl, in Healthy Volunteers

Start: Dec 2019Est. completion: Sep 202021 patients
Phase 1Unknown
NCT02856750Colorado TherapeuticsGabapentin

Efficacy of Gabapentin vs. Placebo for Adjuvant Pain Control Following Acute Rib Fractures

Start: Oct 2016Est. completion: Oct 2018100 patients
Phase 1Completed
NCT02209454MenariniEnantyum® oral solution

Comparative Bioavailability of Dexketoprofen Trometamol Oral Solution vs Tablet Formulations

Start: Apr 2014Est. completion: Jun 201426 patients
Phase 1Completed
NCT00836082PfizerPF-04457845, FAAH inhibitor

A Multiple Dose Trial Evaluating the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of PF-04457845 in Healthy Volunteers

Start: Feb 2009Est. completion: Jul 200941 patients
Phase 1Completed
NCT00601458MSDpregabalin

Bunionectomy Study (0000-063)

Start: Jul 2007Est. completion: Jan 2008100 patients
Phase 1Completed
NCT05966129Human BioSciencesPharmacogenetic testing

A Depression and Opioid Pragmatic Trial in Pharmacogenetics (Acute Pain Trial)

Start: Mar 2021Est. completion: Mar 20241,602 patients
N/ACompleted
NCT03157349Spine BioPharmaBiofreeze

Effect of Biofreeze® Versus Placebo on Acute Neck Pain, Disability, and Range of Motion

Start: Mar 2017Est. completion: Feb 201959 patients
N/ACompleted
NCT03021278EppendorfSaline injection

Tactile Acuity in Experimentally Induced Acute Low Back Pain

Start: Jan 2017Est. completion: Jul 201757 patients
N/ACompleted
NCT02910167Boehringer IngelheimHyoscine n-butylbromide

Observational Prospective Study to Evaluate AEs, Risk Factors and Drug Utilization of BUSCAPINA COMPOSITUM N in Adults From Metropolitan Lima

Start: Oct 2016Est. completion: Feb 2017360 patients
N/ACompleted
NCT02971072Oregon TherapeuticsSubacromial injection

Neurophysiology of Weakness and Exercise in Rotator Cuff Tendinopathy

Start: Jul 2014Est. completion: Apr 2021180 patients
N/ACompleted

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Phase Legend

Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available

Key Insights

4 late-stage (Phase 3) programs, potential near-term approvals
29 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.