Osteoarthritis

148

Pipeline Programs

Companies

Clinical Trials

Approved Products

Pipeline by Development Stage

Preclinical

Phase 1

Phase 1/2

Phase 2

Phase 2/3

Phase 3

On Market

Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Small Molecule

2976%

Monoclonal Antibody

718%

Peptide

25%

+ 300 programs with unclassified modality

On Market (4)

Approved therapies currently available

BUTRANSApproved

buprenorphine

Purdue Pharma

Partial Opioid Agonist [EPC]transdermal2010

23M Part D

CELEBREXApproved

celecoxib

Viatris

Nonsteroidal Anti-inflammatory Drug [EPC]oral1998

16M Part D

LYRICA CRApproved

pregabalin

Viatris

oral2017

402K Part D

BEXTRAApproved

valdecoxib

Pfizer

oral2001

Competitive Landscape

81 companies ranked by most advanced pipeline stage

Pre

P1/2

P2/3

Mkt

Zimmer Biomet

66 programs

Trabecular Metal Modular Tibial Total Knee ComponentPhase 41 trial

Trilogy AB Acetabular Hip Implant SystemPhase 41 trial

Cemented Humeral StemPhase 31 trial

A Clinical Investigation of ArComXL® Polyethylene in Total Hip ReplacementN/A1 trial

A Clinical Investigation of the Comprehensive®, BioModular®, and Bi-Angular® Shoulder SystemsN/A1 trial

+61 more programs

Active Trials

NCT00698152Completed149Est. Jan 2016

NCT00699270Withdrawn0Est. Dec 2008

NCT00698750Terminated34Est. Nov 2009

+63 more trials

PfizerNEW YORK, NY

31 programs

CelecoxibPhase 4Small Molecule

VenlafaxinePhase 41 trial

celecoxibPhase 4Small Molecule1 trial

+26 more programs

Active Trials

NCT00454298Completed2Est. Mar 2008

NCT00427687CompletedEst. Jun 2007

NCT00392080Completed340Est. Feb 2008

+20 more trials

Sandoz

21 programs

lumiracoxibPhase 4Small Molecule

Diclofenac Topical Sodium Gel 1%Phase 3

Diclofenac sodium gel 1%Phase 3

Diclofenac topical sodium gel 1%Phase 3

+16 more programs

Active Trials

NCT00476034Completed1,312

Stryker

17 programs

Tritanium acetabular componentPhase 41 trial

X-3 polyethylenePhase 41 trial

Advance Biofoam porous metal backed tibial component with or without screw augmentationN/A1 trial

Aequalis Pyrocarbon Humeral HeadN/A1 trial

Blood ion levelsN/A1 trial

+12 more programs

Active Trials

NCT00657956Completed50Est. Jan 2013

NCT02525783Completed157Est. Oct 2022

NCT00380549Completed20Est. Mar 2010

+14 more trials

Prevail Therapeutics

11 programs

DuloxetinePhase 4

duloxetinePhase 4

DuloxetinePhase 3

EloralintidePhase 3Peptide

Investigational Medical ProductPhase 3

+6 more programs

Purdue Pharma

9 programs

BuprenorphinePhase 31 trial

Buprenorphine transdermal delivery systemPhase 31 trial

Buprenorphine transdermal patchPhase 31 trial

+4 more programs

Active Trials

NCT00312221Terminated418Est. Aug 2005

NCT00314652Completed260Est. Oct 1999

NCT00315848Completed225Est. Dec 1999

+6 more trials

MSD

8 programs

EtoricoxibPhase 4Small Molecule

MK0966, rofecoxibPhase 3Small Molecule

Etoricoxib, followed by placeboPhase 2

MK0686Phase 2

+3 more programs

Sharp Therapeutics

8 programs

EtoricoxibPhase 4Small Molecule

MK0966, rofecoxibPhase 3Small Molecule

Etoricoxib, followed by placeboPhase 2

MK0686Phase 2

+3 more programs

Innovation Pharmaceuticals

5 programs

LevobupivacainePhase 41 trial

Tranexamic AcidPhase 21 trial

Bandgrip Micro-Anchor Wound ClosureN/A1 trial

HemiarthroplastyN/A1 trial

Omnibond Topical Skin AdhesiveN/A1 trial

Active Trials

NCT05166642Suspended100Est. Jan 2024

NCT01288066Completed76Est. Jun 2024

NCT05173519Suspended310Est. Feb 2025

+2 more trials

ViatrisCANONSBURG, PA

5 programs

CelecoxibPhase 4Small Molecule1 trial

celecoxibPhase 3Small Molecule1 trial

pregabalinPhase 31 trial

Active Trials

NCT00163241Terminated666Est. Jan 2006

NCT00442546Completed307Est. Dec 2008

NCT00141102Completed4,484Est. May 2009

+2 more trials

FundaMental Pharma

3 programs

Comarum PalustrePhase 41 trial

Diphenhydramine 5%N/A1 trial

Epigenorm AntivirN/ASmall Molecule1 trial

Active Trials

NCT05036174Unknown30Est. Apr 2022

NCT03540186Unknown15Est. Nov 2018

NCT03530930Completed15Est. Nov 2018

Exactech

2 programs

Platelet Rich PlasmaPhase 41 trial

Total knee arthroplastyN/A1 trial

Active Trials

NCT01075230Terminated50Est. Jan 2013

NCT00826098Completed70Est. Feb 2013

Abdi Ibrahim

2 programs

Naproxen Sodium CodeinePhase 41 trial

naproxen sodium and codeine phosphatePhase 4

Active Trials

NCT02501564Completed135Est. Nov 2015

Young BioPharma

1 program

CementlessPhase 41 trial

Active Trials

NCT01335438Completed96Est. Mar 2011

Haemonetics

1 program

erythropoietin and cell saverPhase 4

Nordic PharmaFrance - Paris

6 programs

Oral Salmon CalcitoninPhase 3

SMC021 Oral CalcitoninPhase 3

SB-061Phase 1/21 trial

Oral salmon calcitoninPhase 1

+1 more programs

Active Trials

NCT03231280Completed60Est. Mar 2018

NCT02802709Completed90Est. Jun 2017

NicOx

4 programs

NaproxcinodPhase 31 trial

Naproxcinod 375 mg bidPhase 31 trial

naproxcinod 375 mg -750 mg -1125 mg bidPhase 11 trial

naproxcinod 375 mg bidPhase 11 trial

Active Trials

NCT00662610Completed120Est. Nov 2008

NCT00662896Completed300Est. Dec 2008

NCT00541489Completed800

+1 more trials

Kolon Life Science

2 programs

Invossa K Inj.Phase 31 trial

A Post Marketing Surveillance Study of INVOSSA K Inj.N/A1 trial

Active Trials

NCT03412864Unknown3,000Est. Jul 2023

NCT03383471Unknown146Est. Mar 2020

AbbottABBOTT PARK, IL

2 programs

hydrocodone / acetaminophen extended releasePhase 31 trial

ABT-981Phase 11 trial

Active Trials

NCT01668511Completed36Est. Oct 2013

NCT00298974Completed873Est. May 2007

Integrated Biosciences

1 program

DonepezilPhase 31 trial

Active Trials

NCT02927522Unknown550Est. Dec 2021

AmgenTHOUSAND OAKS, CA

1 program

HZT-501Phase 34 trials

Active Trials

NCT00984815Completed86Est. Jul 2011

NCT00613106Completed179Est. Oct 2008

NCT00450216Completed906Est. Oct 2008

+1 more trials

Handok

1 program

Ketoprofen topicalPhase 31 trial

Active Trials

NCT04421911Completed236Est. Sep 2020

Karla Therapeutics

1 program

Platelet Rich PlasmaPhase 31 trial

Active Trials

NCT03477630Completed28Est. Sep 2020

Colorado Therapeutics

6 programs

Minimally Invasive Total Knee Arthroplasty [TKA Min]Phase 21 trial

Neuromuscular Electrical StimulationPhase 21 trial

DrainN/A1 trial

Physical activity feedback with group meetingsN/A1 trial

Total Knee ArthroplastyN/A1 trial

+1 more programs

Active Trials

NCT02693457Completed29Est. Dec 2017

NCT02075931Completed45Est. Feb 2018

NCT02203045Completed28

+2 more trials

ViiV Healthcare

6 programs

GSK3196165Phase 2

GW842166Phase 2

IbuprofenPhase 1Small Molecule

RelacatibPhase 1

Osteoarthritis Initiative (OAI): A Knee Health StudyN/A

+1 more programs

Human BioSciences

4 programs

InjectionPhase 21 trial

Essential amino acidsN/A1 trial

PRT + FMN/A1 trial

Total knee replacement rehabilitationN/A1 trial

Active Trials

NCT00760383Completed60Est. Dec 2013

NCT02628795Completed80Est. Feb 2021

NCT01537328Completed185Est. Jun 2018

+1 more trials

AbbVieNORTH CHICAGO, IL

3 programs

onabotulinumtoxinAPhase 21 trial

botulinum toxin Type APhase 1/21 trial

ABT-981Phase 1

Active Trials

NCT01518257Completed121Est. Jan 2013

NCT02230956Completed176Est. Mar 2016

OliPass

2 programs

OLP-1002Phase 21 trial

A: OLP-1002Phase 11 trial

Active Trials

NCT04677933Completed30Est. Dec 2020

NCT05216341Completed134Est. Sep 2023

Centrexion Therapeutics

1 program

CNTX-4975Phase 21 trial

Active Trials

NCT02558439Completed175Est. Feb 2017

Servier

1 program

GLPG1972Phase 2

+51 more companies

Trial Timeline

Clinical trial activity over time

2021

2022

2023

2024

2025

2026

2027

Providence TherapeuticsStromal Vascular Fraction infiltration

FundaMental PharmaComarum Palustre

Novo NordiskLiraglutide 3 mg

BioventusDurolane SJ

Abdi IbrahimNaproxen Sodium Codeine

GC BiopharmaShinbaro Capsule

Eli Lilly and CompanyDuloxetine

StrykerTritanium acetabular component

Zimmer BiometTrabecular Metal Modular Tibial Total Knee Component

Zimmer BiometTrilogy AB Acetabular Hip Implant System

ExactechPlatelet Rich Plasma

Innovation PharmaceuticalsLevobupivacaine

StrykerX-3 polyethylene

Pfizercelecoxib

ViatrisCelecoxib

Showing 15 of 32 trials with date data

Clinical Trials (33)

Total enrollment: 18,187 patients across 33 trials

NCT00669123 BioibericaChondroitin sulphate

Chondroitin Sulphate Efficay/Safety in Patients With Knee Osteoarthritis and Psoriasis

126 patients

Phase 4Completed

NCT05660824 Providence TherapeuticsStromal Vascular Fraction infiltration

Effectiveness of Stromal Vascular Fraction (SVF) and Platelet -Rich Plasma (PRP) in Patients With Knee Osteoarthritis: Study Protocol for a Phase III, Prospective, Randomized, Controlled Multi-center Study.

Start: Jul 2025Est. completion: Aug 2027108 patients

Phase 4Not Yet Recruiting

NCT03530930 FundaMental PharmaComarum Palustre

Comarum Palustre in Knee Osteoarthritis and Diabetes

Start: Jun 2018Est. completion: Nov 201815 patients

Phase 4Completed

NCT02905864 Novo NordiskLiraglutide 3 mg

Liraglutide 3 mg for Knee Osteoarthritis

Start: Nov 2016Est. completion: Mar 2019150 patients

Phase 4Completed

NCT02627859 BioventusDurolane SJ

26 Week Open Label Study Evaluating Single IA Injection of DUROLANE SJ for Treatment of Osteoarthritis Pain of the Ankle

Start: Jun 2014Est. completion: Oct 201637 patients

Phase 4Unknown

NCT02501564 Abdi IbrahimNaproxen Sodium Codeine

Evaluation of NaproxenSodium and CodeinePhosphate Combination in Osteoarthritis

Start: May 2013Est. completion: Nov 2015135 patients

Phase 4Completed

NCT01604239 GC BiopharmaShinbaro Capsule

To Evaluate the Safety of 'Shinbaro Capsule'in Patients With Osteoarthritis

Start: May 2012Est. completion: Jun 2013761 patients

Phase 4Completed

NCT01558700 Eli Lilly and CompanyDuloxetine

Duloxetine in Osteoarthritis (OA) Pain

Start: Mar 2012Est. completion: Aug 201440 patients

Phase 4Completed

NCT01618084 StrykerTritanium acetabular component

RSA Study Using Two Types of Uncemented Acetabular Components and the Uncemented HA Coated Symax Stem

Start: Nov 2011Est. completion: Dec 201450 patients

Phase 4Unknown

NCT01180595 Zimmer BiometTrabecular Metal Modular Tibial Total Knee Component

Roentgen Stereophotogrammetric Analysis (RSA) Trial Comparing Trabecular Metal Monoblock and Modular Tibial Components

Start: Feb 2011Est. completion: Sep 201950 patients

Phase 4Completed

NCT00715026 Zimmer BiometTrilogy AB Acetabular Hip Implant System

Trilogy AB Acetabular Hip System Post Approval Study

Start: Apr 2009Est. completion: Jun 201231 patients

Phase 4Terminated

NCT00826098 ExactechPlatelet Rich Plasma

Platelet Rich Plasma (PRP) in Total Knee Replacement

Start: Dec 2008Est. completion: Feb 201370 patients

Phase 4Completed

NCT01106001 Innovation PharmaceuticalsLevobupivacaine

Study to Test the Efficacy of Periarticular Levo Bupivicaine Injection Following Primary Hip Arthroplasty

Start: Sep 2008Est. completion: Sep 200991 patients

Phase 4Completed

NCT00665964 StrykerX-3 polyethylene

Comparing X-3 To N2vac Polyethylene With the Triathlon Total Knee System

Start: May 2008Est. completion: May 20200

Phase 4Withdrawn

NCT00484718 Pfizercelecoxib

Measuring Gait And Self-Reported Pain In Patients With Osteoarthritis Of The Knee Using Placebo/Oxycodone/Celecoxib.

Start: Jan 2008Est. completion: Jun 20096 patients

Phase 4Terminated

NCT00359151 ViatrisCelecoxib

Celebrex Total Knee Arthroplasty Study

Start: Nov 2006Est. completion: Jul 200722 patients

Phase 4Terminated

NCT00373685 ViatrisCelecoxib

GI-Reasons- A Trial Of GI Safety Of Celecoxib Compared With Non-Selective Nonsteroidal Antiinflammatory Drugs (NSAIDS)

Start: Oct 2006Est. completion: Nov 20108,067 patients

Phase 4Completed

NCT00350155 NovartisLumiracoxib

Video Capsule Endoscopy to Investigate the Safety and Tolerability of Lumiracoxib in the Small Bowel

Start: May 2006150 patients

Phase 4Completed

NCT00348491 NovartisLumiracoxib

Efficacy of Lumiracoxib in Relieving Moderate to Severe Post-dental Surgery Pain, Compared to Both Placebo and Celecoxib

Start: Feb 2006364 patients

Phase 4Completed

NCT00830830 SanofiHyalgan

TREAD-20 Extension - Treatment of Knee Pain Due to Osteoarthritis

Start: Dec 2005Est. completion: Oct 200640 patients

Phase 4Completed

NCT00267176 NovartisLumiracoxib

Safety and Efficacy of Lumiracoxib in Patients With Osteoarthritis and With Controlled Hypertension

Start: Nov 20051,020 patients

Phase 4Completed

NCT00141102 ViatrisCelecoxib

Study Of Celecoxib Or Diclofenac And Omeprazole For Gastrointestinal (GI) Safety In High GI Risk Patients With Arthritis

Start: Oct 2005Est. completion: May 20094,484 patients

Phase 4Completed

NCT00170781 NovartisLumiracoxib

Efficacy and Safety of Lumiracoxib 400 mg Once Daily in Acute Flares of Gout

Start: Jun 2005234 patients

Phase 4Completed

NCT00170898 NovartisLumiracoxib

Safety and Efficacy of Lumiracoxib Versus Naproxen in Acute Musculoskeletal Pain

Start: Nov 2004419 patients

Phase 4Completed

NCT00130468 SanofiHyalgan

TREAD-20: Trial of Hyalgan Three Injection-Regimen for the Treatment of Knee Pain Due to Osteoarthritis

Start: Nov 2004Est. completion: May 2006150 patients

Phase 4Completed

NCT00611676 PfizerVenlafaxine

A Single-Blind Placebo Run-In Study of Venlafaxine for Activity-Limiting Osteoarthritis Pain

Start: Sep 2004Est. completion: Feb 200718 patients

Phase 4Completed

NCT02183129 Boehringer IngelheimDiclofenac

Study to Assess the Efficacy and Safety of Meloxicam vs. Diclofenac SR in Patients With Osteoarthritis of the Knee

Start: Apr 199991 patients

Phase 4Completed

NCT02197026 Boehringer IngelheimHylan G-F 20

Effectiveness and Safety of Synvisc® Versus Usual Treatments in Patients With Knee Osteoarthritis

Start: Oct 1998518 patients

Phase 4Completed

NCT02183116 Boehringer IngelheimMeloxicam

A Study to Access the Efficacy and Safety of Meloxicam in Patients With Osteoarthritis of the Knee

Start: Oct 199830 patients

Phase 4Completed

NCT01335438 Young BioPharmaCementless

Total Knee Arthroplasty Comparing Cementless to Cemented Fixation

Start: Jan 1997Est. completion: Mar 201196 patients

Phase 4Completed

NCT04421911 HandokKetoprofen topical

A Study to Assess Efficacy and Safety of the Ketoprofen vs Diclofenac

Start: Mar 2020Est. completion: Sep 2020236 patients

Phase 3Completed

NCT03477630 Karla TherapeuticsPlatelet Rich Plasma

Treatment of Osteoarthrosis of the Knee With Platelet Rich Plasma, Comparative Study With Hyaluronic Acid

Start: Feb 2019Est. completion: Sep 202028 patients

Phase 3Completed

NCT02927522 Integrated BiosciencesDonepezil

Donepezil Attenuate Postoperative Cognitive Dysfunction

Start: Sep 2018Est. completion: Dec 2021550 patients

Phase 3Unknown

Phase Legend

Preclinical— Lab & animal studies

Phase 1— Safety & dosing

Phase 2— Efficacy testing

Phase 3— Large-scale trials

On Market— Approved & available

Key Insights

56 late-stage (Phase 3) programs, potential near-term approvals

30 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.