Osteoarthritis

47
Pipeline Programs
30
Companies
50
Clinical Trials
8
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
8
0
8
1
12
18
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Small Molecule
133%
Monoclonal Antibody
133%
Peptide
133%
+ 78 programs with unclassified modality

On Market (8)

Approved therapies currently available

U
ANJESOApproved
meloxicam
Unknown Company
intravenous2020
U
DICLOFENACApproved
diclofenac
Unknown Company
oral
U
DICLOFENAC SODIUMApproved
diclofenac
Unknown Company
topical2022
U
DULOXETINE HYDROCHLORIDEApproved
duloxetine
Unknown Company
oral2015
U
MELOXICAMApproved
meloxicam
Unknown Company
Nonsteroidal Anti-inflammatory Drug [EPC]oral2006
Boehringer Ingelheim
MOBICApproved
meloxicam
Boehringer Ingelheim
oral2000
U
VIVLODEXApproved
meloxicam
Unknown Company
oral2015
U
ZORVOLEXApproved
diclofenac
Unknown Company
oral2013

Competitive Landscape

30 companies ranked by most advanced pipeline stage

Boehringer Ingelheim
Boehringer IngelheimINGELHEIM, Germany
13 programs
2
2
3
DiclofenacPhase 41 trial
Hylan G-F 20Phase 41 trial
MeloxicamPhase 41 trial
MeloxicamPhase 31 trial
Meloxicam ampoulePhase 31 trial
+8 more programs
Active Trials
NCT02184039Completed12,687
NCT02182726Completed4,760
NCT02195557Completed16
+10 more trials
Bioventus
BioventusDURHAM, NC
3 programs
1
Durolane SJPhase 41 trial
DurolaneN/A1 trial
SupartzN/A1 trial
Active Trials
NCT02610504Completed41Est. May 2017
NCT02110238Completed421Est. Feb 2015
NCT02627859Unknown37Est. Oct 2016
Eli Lilly and Company
Eli Lilly and CompanyINDIANAPOLIS, IN
2 programs
1
1
DuloxetinePhase 41 trial
Investigational Medical ProductPhase 3
Active Trials
NCT01558700Completed40Est. Aug 2014
GC Biopharma
GC BiopharmaKorea - Yongin
2 programs
1
1
Shinbaro CapsulePhase 41 trial
Shinbaro CapsulePhase 31 trial
Active Trials
NCT01535417CompletedEst. Dec 2009
NCT01604239CompletedEst. Jun 2013
Bioiberica
BioibericaSpain - Barcelona
1 program
1
Chondroitin sulphatePhase 41 trial
Active Trials
NCT00669123Completed126
Sanofi
SanofiPARIS, France
1 program
1
HyalganPhase 44 trials
Active Trials
NCT00323778Terminated40
NCT00830830Completed40Est. Oct 2006
NCT00130468Completed150Est. May 2006
+1 more trials
Novo Nordisk
Novo NordiskBAGSVAERD DENMARK, Denmark
1 program
1
Liraglutide 3 mgPhase 4Peptide1 trial
Active Trials
NCT02905864Completed150Est. Mar 2019
Providence Therapeutics
1 program
1
Stromal Vascular Fraction infiltrationPhase 41 trial
Active Trials
NCT05660824Not Yet RecruitingEst. Aug 2027
Pfizer
PfizerNEW YORK, NY
7 programs
2
4
Investigational Medical ProductPhase 31 trial
Investigational medical productPhase 31 trial
NSAIDPhase 31 trial
tanezumabPhase 3Monoclonal Antibody1 trial
AGG-523Phase 11 trial
+2 more programs
Active Trials
NCT00080171Completed4,796Est. Oct 2015
NCT00427687CompletedEst. Jun 2007
NCT00454298Completed2Est. Mar 2008
+4 more trials
Novartis
NovartisBASEL, Switzerland
5 programs
2
1
1
LumiracoxibPhase 3Small Molecule5 trials
oral salmon calcitoninPhase 21 trial
LNA043Phase 15 trials
Oral salmon calcitonin, salmon calcitonin nasal sprayPhase 12 trials
Osteoarthritis Initiative (OAI): A Knee Health StudyN/A
Active Trials
NCT04814368Terminated23Est. Jun 2024
NCT04864392Terminated582Est. May 2025
NCT04564053Completed12Est. Dec 2020
+10 more trials
Amgen
AmgenTHOUSAND OAKS, CA
2 programs
2
HZT-501Phase 31 trial
HZT-501Phase 31 trial
Active Trials
NCT00613106Completed179Est. Oct 2008
NCT00984815Completed86Est. Jul 2011
TRB Chemedica International
TRB Chemedica InternationalSwitzerland - Geneva
1 program
1
DiacereinPhase 31 trial
Active Trials
NCT02688400CompletedEst. Jun 2018
Ferring Pharmaceuticals
Ferring PharmaceuticalsArgentina - Buenos Aires
2 programs
1
sodium hyaluronatePhase 2/31 trial
EUFLEXXAN/A1 trial
Active Trials
NCT00969501Completed32Est. Aug 2010
NCT00423371Completed79Est. Sep 2007
J&
Johnson & JohnsonNEW BRUNSWICK, NJ
3 programs
1
JNJ-42160443Phase 21 trial
Cementless Total Knee ArthroplastyN/A1 trial
Hip replacementN/A3 trials
Active Trials
NCT03193034Completed81Est. Jun 2021
NCT01807104Completed87Est. Jul 2017
NCT01319227Unknown51Est. Aug 2023
+2 more trials
Galapagos
Galapagos2800 MECHELEN, Belgium
3 programs
2
1
GLPG1972Phase 21 trial
GLPG1972 600 mg oral solution fastedPhase 11 trial
GLPG1972 cohort 1Phase 11 trial
Active Trials
NCT02851485Completed12Est. Aug 2016
NCT03311009Completed30Est. Oct 2017
NCT03595618Completed932Est. Jul 2020
BT
2 programs
1
SM04690Phase 21 trial
Not applicableN/A1 trial
Active Trials
NCT02951026CompletedEst. Oct 2019
NCT02536833CompletedEst. Apr 2017
M&
Merck & Co.RAHWAY, NJ
2 programs
1
MK0686Phase 21 trial
Osteoarthritis Initiative (OAI): A Knee Health StudyN/A
Active Trials
NCT00296569Completed150Est. May 2006
Regeneron
RegeneronTARRYTOWN, NY
1 program
1
REGN475Phase 2
VP
1 program
1
VX-150Phase 21 trial
Active Trials
NCT02660424Completed124Est. Sep 2016
UP
1 program
1
lacosamidePhase 21 trial
Active Trials
NCT00485472Terminated194Est. Jan 2008
Medacta
MedactaSwitzerland - Castel San Pietro
11 programs
AMIStem Hip SystemN/A1 trial
Anterior ApproachN/A1 trial
Anterior Minimally Invasive ApproachN/A1 trial
Customized patient instrumentsN/A1 trial
Fixed Bearing or Mobile Bearing UKAN/A1 trial
+6 more programs
Active Trials
NCT01107340Active Not RecruitingEst. Jan 2028
NCT00951951CompletedEst. Dec 2014
NCT01285843CompletedEst. Sep 2012
+8 more trials
C
CorinUK - Cirencester
6 programs
CormetN/A1 trial
Cormet Hip ResurfacingN/A1 trial
Cormet Hip Resurfacing SystemN/A1 trial
Large Diameter Metal on MetalN/A1 trial
Trinity CoC Total Hip SystemN/A1 trial
+1 more programs
Active Trials
NCT01353326CompletedEst. Dec 2013
NCT00722007CompletedEst. May 2014
NCT00721994CompletedEst. Aug 2017
+3 more trials
Arthrex
ArthrexCA - Santa Barbara
2 programs
ACPN/A1 trial
Univers™N/A1 trial
Active Trials
NCT02713542CompletedEst. Aug 2018
NCT01790113TerminatedEst. Jun 2019
City Therapeutics
City TherapeuticsMA - Cambridge
2 programs
FumigationN/A1 trial
metatarsophalangeal joint endoprosthesisN/A1 trial
Active Trials
NCT03659370CompletedEst. Dec 2017
NCT05717413UnknownEst. Aug 2025
ConvaTec
ConvaTecNJ - Bridgewater
1 program
Aquacel Ag dressingN/A1 trial
Active Trials
NCT02217202WithdrawnEst. Jan 2050
Alder Therapeutics
Alder TherapeuticsSweden - Solna
1 program
Developing Allogeneic Musculoskeletal TherapiesN/A1 trial
Active Trials
NCT06167928Recruiting325Est. Sep 2037
Heidelberg Pharma
Heidelberg PharmaGermany - Ladenburg
1 program
Heidelberg Registry for Hip and Knee Joint Implants and RevisionsN/A1 trial
Active Trials
NCT06850818Recruiting10,000Est. Dec 2035
Organogenesis
OrganogenesisCANTON, MA
1 program
Knee injectionN/A1 trial
Active Trials
NCT02318511CompletedEst. Feb 2019
AstraZeneca
AstraZenecaCAMBRIDGE, United Kingdom
1 program
Magnitude of Osteoarthritis disadVantage on pEoples liveSN/A1 trial
Active Trials
NCT01423097Completed1,015Est. Nov 2011
Anika Therapeutics
Anika TherapeuticsMA - Bedford
1 program
Monovisc®N/A1 trial
Active Trials
NCT00653432CompletedEst. Feb 2010

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
Providence TherapeuticsStromal Vascular Fraction infiltration
Novo NordiskLiraglutide 3 mg
BioventusDurolane SJ
GC BiopharmaShinbaro Capsule
Eli Lilly and CompanyDuloxetine
NovartisLumiracoxib
SanofiHyalgan
NovartisLumiracoxib
NovartisLumiracoxib
NovartisLumiracoxib
SanofiHyalgan
Boehringer IngelheimDiclofenac
Boehringer IngelheimHylan G-F 20
Boehringer IngelheimMeloxicam
PfizerInvestigational medical product

Showing 15 of 49 trials with date data

Clinical Trials (50)

Total enrollment: 23,520 patients across 50 trials

NCT00669123BioibericaChondroitin sulphate

Chondroitin Sulphate Efficay/Safety in Patients With Knee Osteoarthritis and Psoriasis

126 patients
Phase 4Completed
NCT05660824Providence TherapeuticsStromal Vascular Fraction infiltration

Effectiveness of Stromal Vascular Fraction (SVF) and Platelet -Rich Plasma (PRP) in Patients With Knee Osteoarthritis: Study Protocol for a Phase III, Prospective, Randomized, Controlled Multi-center Study.

Start: Jul 2025Est. completion: Aug 2027
Phase 4Not Yet Recruiting
NCT02905864Novo NordiskLiraglutide 3 mg

Liraglutide 3 mg for Knee Osteoarthritis

Start: Nov 2016Est. completion: Mar 2019150 patients
Phase 4Completed

26 Week Open Label Study Evaluating Single IA Injection of DUROLANE SJ for Treatment of Osteoarthritis Pain of the Ankle

Start: Jun 2014Est. completion: Oct 201637 patients
Phase 4Unknown
NCT01604239GC BiopharmaShinbaro Capsule

To Evaluate the Safety of 'Shinbaro Capsule'in Patients With Osteoarthritis

Start: May 2012Est. completion: Jun 2013
Phase 4Completed

Duloxetine in Osteoarthritis (OA) Pain

Start: Mar 2012Est. completion: Aug 201440 patients
Phase 4Completed

Video Capsule Endoscopy to Investigate the Safety and Tolerability of Lumiracoxib in the Small Bowel

Start: May 2006150 patients
Phase 4Completed

TREAD-20 Extension - Treatment of Knee Pain Due to Osteoarthritis

Start: Dec 2005Est. completion: Oct 200640 patients
Phase 4Completed

Safety and Efficacy of Lumiracoxib in Patients With Osteoarthritis and With Controlled Hypertension

Start: Nov 20051,020 patients
Phase 4Completed

Efficacy and Safety of Lumiracoxib 400 mg Once Daily in Acute Flares of Gout

Start: Jun 2005234 patients
Phase 4Completed

Safety and Efficacy of Lumiracoxib Versus Naproxen in Acute Musculoskeletal Pain

Start: Nov 2004419 patients
Phase 4Completed

TREAD-20: Trial of Hyalgan Three Injection-Regimen for the Treatment of Knee Pain Due to Osteoarthritis

Start: Nov 2004Est. completion: May 2006150 patients
Phase 4Completed

Study to Assess the Efficacy and Safety of Meloxicam vs. Diclofenac SR in Patients With Osteoarthritis of the Knee

Start: Apr 199991 patients
Phase 4Completed

Effectiveness and Safety of Synvisc® Versus Usual Treatments in Patients With Knee Osteoarthritis

Start: Oct 1998518 patients
Phase 4Completed

A Study to Access the Efficacy and Safety of Meloxicam in Patients With Osteoarthritis of the Knee

Start: Oct 199830 patients
Phase 4Completed
NCT03031938PfizerInvestigational medical product

Protocol to Monitor the Neurological Development of Infants With Exposure in Utero From Birth to 15 Months in Tanezumab Clinical Studies

Start: Nov 2017Est. completion: Jun 20204 patients
Phase 3Completed
NCT02674386PfizerInvestigational Medical Product

Long-term Observational Study of Subjects From Tanezumab Studies Who Undergo a Total Knee, Hip or Shoulder Replacement

Start: Aug 2016Est. completion: Jul 2019154 patients
Phase 3Completed

Effect of Diacerein vs Celecoxib on Symptoms and Structural Changes in Symptomatic Knee Osteoarthritis

Start: May 2016Est. completion: Jun 2018
Phase 3Completed

Safety Study of HZT-501 in Patients Who Require Long-Term Daily Non-steroidal Anti-inflammatory Drug Treatment

Start: Sep 2009Est. completion: Jul 201186 patients
Phase 3Completed
NCT01535417GC BiopharmaShinbaro Capsule

Efficacy and Safety of Shinbaro Capsule

Start: May 2009Est. completion: Dec 2009
Phase 3Completed

Long-Term Analgesic Efficacy And Safety Of Tanezumab Alone Or In Combination With Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) Versus NSAIDs Alone In Patients With Osteoarthritis Of The Knee Or Hip

Start: Feb 2009Est. completion: Jan 20112,720 patients
Phase 3Terminated

Extension Study Of Tanezumab In Osteoarthritis

Start: Feb 2009Est. completion: Jun 20112,147 patients
Phase 3Terminated

Double-Blind Follow-on Safety Study of HZT-501 (Ibuprofen 800 mg/Famotidine 26.6 mg) in Subjects Who Have Completed Participation in HZ-CA-301 (NCT00450658) or HZ-CA-303 (NCT00450216)

Start: Sep 2007Est. completion: Oct 2008179 patients
Phase 3Completed

Prospective Assessment of the Efficacy of Hyaluronate Knee Injections in Patients With Osteoarthritis

Start: May 200640 patients
Phase 3Terminated

6 Week Open-label Trial With Lumiracoxib 200mg o.d. in Primary Knee Osteoarthritis or Rheumatoid Arthritis

Start: Nov 2004135 patients
Phase 3Completed

Efficacy and Safety Study of Lumiracoxib in Patients With Primary Hip Osteoarthritis

Start: Nov 20041,200 patients
Phase 3Completed

52 Week, International, Multi-center, Randomized, Double-blind, Double-dummy, Parallel-group Clinical Trial to Compare Retention on Treatment, Safety, Tolerability & Efficacy of Lumiracoxib 100 mg od, Lumiracoxib 100 mg Bid & Celecoxib 200 mg od in Pts With Primary OA of Hip, Knee, Hand or Spine

Start: Sep 20043,036 patients
Phase 3Completed

A Study to Compare Meloxicam IM Once Daily and Meloxicam Administered Orally Once Daily in Patients With Osteoarthritis

Start: Jul 2004Est. completion: Dec 2004168 patients
Phase 3Completed

Efficacy and Safety of Lumiracoxib in Patients With Primary Knee Osteoarthritis(OA)

Start: Jan 2004833 patients
Phase 3Completed

Efficacy and Safety of Lumiracoxib in Patients With Primary Knee Osteoarthritis (OA)

Start: Dec 20031,312 patients
Phase 3Completed

Efficacy and Safety of Lumiracoxib in Patients With Primary Knee Osteoarthritis (OA)

Start: Sep 20031,684 patients
Phase 3Completed

Efficacy and Safety of Lumiracoxib in Patients With Knee Osteoarthritis (OA).

Start: Sep 20031,464 patients
Phase 3Completed

HUPS: Hyalgan Use in Painful Shoulder

Start: Jan 2002Est. completion: Sep 2004602 patients
Phase 3Completed

Safety of Lumiracoxib in Patients With Osteoarthritis

Start: Dec 2000Est. completion: Mar 2001309 patients
Phase 3Completed

Efficacy and Safety of Lumiracoxib

Start: Nov 2000330 patients
Phase 3Completed

Study to Compare Prescription Non-Steroidal Anti-Inflammatory Drug (NSAID) Changes, Health Care Utilization, Efficacy and Safety of Meloxicam 7.5 mg Versus Usual Care Administration of Prescription NSAIDs in a Managed Healthcare Setting in Patients With Osteoarthritis

Start: Oct 19981,309 patients
Phase 3Completed

Double-Blind,Randomized,Placebo-Controlled Efficacy & Safety Study of EUFLEXXA™ for Treatment of OA of the First CMC

Start: Dec 2006Est. completion: Sep 200779 patients
Phase 2/3Completed

A Safety and Efficacy Study of Anti-inflammatory (Canakinumab) and Cartilage Stimulating (LNA043) Drugs Injected Into the Knee Joint of Participants With Knee Osteoarthritis (OA)

Start: Aug 2021Est. completion: Jun 202423 patients
Phase 2Terminated

Study of Efficacy, Safety, and Tolerability of LNA043 in Patients With Knee Osteoarthritis

Start: May 2021Est. completion: May 2025582 patients
Phase 2Terminated

A Study to Assess Efficacy and Safety of GLPG1972/S201086 in Participants With Knee Osteoarthritis

Start: Aug 2018Est. completion: Jul 2020932 patients
Phase 2Completed

Study on Safety, Tolerability and Prelimenary Efficacy of LNA043 in Patients Undergoing Autologous Chondrocyte Implantation

Start: Oct 2017Est. completion: Apr 201914 patients
Phase 2Terminated

Study of Safety, Tolerability, Preliminary Efficacy of Intra-articular LNA043 Injections in Patients With Articular Cartilage Lesions and Knee Osteoarthritis.

Start: Sep 2017Est. completion: Sep 2022142 patients
Phase 2Completed

A Study of the Efficacy and Safety of VX-150 in Subjects With Osteoarthritis of the Knee

Start: Dec 2015Est. completion: Sep 2016124 patients
Phase 2Completed

A Study Evaluating the Safety, Tolerability, and Efficacy of SM04690 Injected in the Target Knee Joint of Moderately to Severely Symptomatic Osteoarthritis Subjects

Start: Sep 2015Est. completion: Apr 2017
Phase 2Completed

A Dose-ranging Study of the Safety and Effectiveness of JNJ-42160443 as add-on Treatment in Patients With Osteoarthritis-related Pain

Start: Sep 2009Est. completion: Jun 2011467 patients
Phase 2Terminated

Trial to Assess Efficacy and Safety of Lacosamide in Subjects With Osteoarthritis of the Knee

Start: Mar 2007Est. completion: Jan 2008194 patients
Phase 2Terminated

A Study to Assess the Safety and Efficacy of an Investigational Drug (MK-686) in Patients With Osteoarthritis (0686-006)

Start: Sep 2005Est. completion: May 2006150 patients
Phase 2Completed
NCT00376311Novartisoral salmon calcitonin

Effects of Oral Salmon Calcitonin in Human Osteoarthritis

Start: Sep 2002Est. completion: May 200454 patients
Phase 2Terminated

Study of Safety, Tolerability and Pharmacokinetics of LNA043 in Japanese Osteoarthritis Participants

Start: Sep 2020Est. completion: Dec 202012 patients
Phase 1Completed
NCT03311009GalapagosGLPG1972 cohort 1

A Study With GLPG1972 in Osteoarthritis Subjects

Start: May 2017Est. completion: Oct 201730 patients
Phase 1Completed

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

12 late-stage (Phase 3) programs — potential near-term approvals
30 companies competing in this space