Skip to main content

Osteoarthritis

140
Pipeline Programs
30
Companies
36
Clinical Trials
2 recruiting
2
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
25
4
34
0
54
23
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Small Molecule
2574%
Monoclonal Antibody
721%
Peptide
26%
+ 298 programs with unclassified modality

On Market (2)

Approved therapies currently available

Purdue Pharma
BUTRANSApproved
buprenorphine
Purdue Pharma
Partial Opioid Agonist [EPC]transdermal2010
23M Part D
Pfizer
BEXTRAApproved
valdecoxib
Pfizer
oral2001

Competitive Landscape

79 companies ranked by most advanced pipeline stage

Zimmer Biomet
66 programs
1
2
Trabecular Metal Modular Tibial Total Knee ComponentPhase 41 trial
Trilogy AB Acetabular Hip Implant SystemPhase 41 trial
Cemented Humeral StemPhase 31 trial
A Clinical Investigation of ArComXL® Polyethylene in Total Hip ReplacementN/A1 trial
A Clinical Investigation of the Comprehensive®, BioModular®, and Bi-Angular® Shoulder SystemsN/A1 trial
+61 more programs
Active Trials
NCT00698152Completed149Est. Jan 2016
NCT00699270Withdrawn0Est. Dec 2008
NCT00698750Terminated34Est. Nov 2009
+63 more trials
Pfizer
PfizerNEW YORK, NY
31 programs
5
7
13
5
CelecoxibPhase 4Small Molecule1 trial
CelecoxibPhase 4Small Molecule1 trial
CelecoxibPhase 4Small Molecule1 trial
VenlafaxinePhase 41 trial
celecoxibPhase 4Small Molecule1 trial
+26 more programs
Active Trials
NCT00427687CompletedEst. Jun 2007
NCT00454298Completed2Est. Mar 2008
NCT00392080Completed340Est. Feb 2008
+25 more trials
Sandoz
21 programs
3
4
12
1
lumiracoxibPhase 4Small Molecule1 trial
Diclofenac Topical Sodium Gel 1%Phase 31 trial
Diclofenac Topical Sodium Gel 1%Phase 31 trial
Diclofenac sodium gel 1%Phase 31 trial
Diclofenac topical sodium gel 1%Phase 31 trial
+16 more programs
Active Trials
NCT00080171Completed4,796Est. Oct 2015
NCT04564053Completed12Est. Dec 2020
NCT00486369Completed
+18 more trials
Stryker
17 programs
2
Tritanium acetabular componentPhase 41 trial
X-3 polyethylenePhase 41 trial
Advance Biofoam porous metal backed tibial component with or without screw augmentationN/A1 trial
Aequalis Pyrocarbon Humeral HeadN/A1 trial
Blood ion levelsN/A1 trial
+12 more programs
Active Trials
NCT00657956Completed50Est. Jan 2013
NCT02525783Completed157Est. Oct 2022
NCT00380549Completed20Est. Mar 2010
+13 more trials
Prevail Therapeutics
4
5
2
DuloxetinePhase 41 trial
duloxetinePhase 41 trial
DuloxetinePhase 31 trial
EloralintidePhase 3Peptide1 trial
Investigational Medical ProductPhase 31 trial
+6 more programs
Active Trials
NCT04456686Completed117Est. Aug 2021
NCT05080660Completed160Est. Jun 2022
NCT04627038Completed202Est. Oct 2021
+8 more trials
Purdue Pharma
9 programs
9
1
BuprenorphinePhase 31 trial
Buprenorphine transdermal delivery systemPhase 31 trial
Buprenorphine transdermal delivery systemPhase 31 trial
Buprenorphine transdermal patchPhase 31 trial
Buprenorphine transdermal patchPhase 31 trial
+4 more programs
Active Trials
NCT00312221Terminated418Est. Aug 2005
NCT00315848Completed225Est. Dec 1999
NCT00314652Completed260Est. Oct 1999
+6 more trials
MSD
8 programs
1
3
2
1
EtoricoxibPhase 4Small Molecule1 trial
MK0966, rofecoxibPhase 3Small Molecule1 trial
MK0966, rofecoxibPhase 3Small Molecule1 trial
Etoricoxib, followed by placeboPhase 21 trial
MK0686Phase 21 trial
+3 more programs
Active Trials
NCT00772967Completed22Est. Nov 2008
NCT01619150Completed39Est. Jul 2013
NCT00296569Completed150Est. May 2006
+4 more trials
Sharp Therapeutics
1
3
2
1
EtoricoxibPhase 4Small Molecule
MK0966, rofecoxibPhase 3Small Molecule
MK0966, rofecoxibPhase 3Small Molecule
Etoricoxib, followed by placeboPhase 2
MK0686Phase 2
+3 more programs
Innovation Pharmaceuticals
1
1
LevobupivacainePhase 41 trial
Tranexamic AcidPhase 21 trial
Bandgrip Micro-Anchor Wound ClosureN/A1 trial
HemiarthroplastyN/A1 trial
Omnibond Topical Skin AdhesiveN/A1 trial
Active Trials
NCT05166642Suspended100Est. Jan 2024
NCT01288066Completed76Est. Jun 2024
NCT05173519Suspended310Est. Feb 2025
+2 more trials
FundaMental Pharma
1
Comarum PalustrePhase 41 trial
Diphenhydramine 5%N/A1 trial
Epigenorm AntivirN/ASmall Molecule1 trial
Active Trials
NCT05036174Unknown30Est. Apr 2022
NCT03540186Unknown15Est. Nov 2018
NCT03530930Completed15Est. Nov 2018
Exactech
2 programs
1
Platelet Rich PlasmaPhase 41 trial
Total knee arthroplastyN/A1 trial
Active Trials
NCT01075230Terminated50Est. Jan 2013
NCT00826098Completed70Est. Feb 2013
Abdi Ibrahim
2 programs
2
Naproxen Sodium CodeinePhase 41 trial
naproxen sodium and codeine phosphatePhase 4
Active Trials
NCT02501564Completed135Est. Nov 2015
Young BioPharma
1
CementlessPhase 41 trial
Active Trials
NCT01335438Completed96Est. Mar 2011
Haemonetics
1 program
1
erythropoietin and cell saverPhase 41 trial
Active Trials
NCT00998088Completed2,598Est. Sep 2009
Nordic Pharma
6 programs
2
2
2
Oral Salmon CalcitoninPhase 3
SMC021 Oral CalcitoninPhase 3
SB-061Phase 1/21 trial
SB-061Phase 1/21 trial
Oral salmon calcitoninPhase 1
+1 more programs
Active Trials
NCT03231280Completed60Est. Mar 2018
NCT02802709Completed90Est. Jun 2017
NicOx
4 programs
2
2
NaproxcinodPhase 31 trial
Naproxcinod 375 mg bidPhase 31 trial
naproxcinod 375 mg -750 mg -1125 mg bidPhase 11 trial
naproxcinod 375 mg bidPhase 11 trial
Active Trials
NCT00662610Completed120Est. Nov 2008
NCT00662896Completed300Est. Dec 2008
NCT00541489Completed800
+1 more trials
Kolon Life Science
1
Invossa K Inj.Phase 31 trial
A Post Marketing Surveillance Study of INVOSSA K Inj.N/A1 trial
Active Trials
NCT03412864Unknown3,000Est. Jul 2023
NCT03383471Unknown146Est. Mar 2020
Abbott
AbbottABBOTT PARK, IL
2 programs
1
1
hydrocodone / acetaminophen extended releasePhase 31 trial
ABT-981Phase 11 trial
Active Trials
NCT01668511Completed36Est. Oct 2013
NCT00298974Completed873Est. May 2007
Integrated Biosciences
1
DonepezilPhase 31 trial
Active Trials
NCT02927522Unknown550Est. Dec 2021
Amgen
AmgenTHOUSAND OAKS, CA
1 program
1
HZT-501Phase 34 trials
Active Trials
NCT00984815Completed86Est. Jul 2011
NCT00613106Completed179Est. Oct 2008
NCT00450658Completed627Est. Oct 2008
+1 more trials
Handok
1 program
1
Ketoprofen topicalPhase 31 trial
Active Trials
NCT04421911Completed236Est. Sep 2020
Karla Therapeutics
1
Platelet Rich PlasmaPhase 31 trial
Active Trials
NCT03477630Completed28Est. Sep 2020
Colorado Therapeutics
2
Minimally Invasive Total Knee Arthroplasty [TKA Min]Phase 21 trial
Neuromuscular Electrical StimulationPhase 21 trial
DrainN/A1 trial
Physical activity feedback with group meetingsN/A1 trial
Total Knee ArthroplastyN/A1 trial
+1 more programs
Active Trials
NCT02693457Completed29Est. Dec 2017
NCT02075931Completed45Est. Feb 2018
NCT02203045Completed28
+3 more trials
ViiV Healthcare
6 programs
2
2
GSK3196165Phase 2
GW842166Phase 2
IbuprofenPhase 1Small Molecule
RelacatibPhase 1
Osteoarthritis Initiative (OAI): A Knee Health StudyN/A
+1 more programs
Human BioSciences
1
InjectionPhase 21 trial
Essential amino acidsN/A1 trial
PRT + FMN/A1 trial
Total knee replacement rehabilitationN/A
Active Trials
NCT00760383Completed60Est. Dec 2013
NCT02628795Completed80Est. Feb 2021
NCT02838069Completed100Est. Mar 2024
AbbVie
AbbVieNORTH CHICAGO, IL
3 programs
1
1
1
onabotulinumtoxinAPhase 21 trial
botulinum toxin Type APhase 1/21 trial
ABT-981Phase 1
Active Trials
NCT01518257Completed121Est. Jan 2013
NCT02230956Completed176Est. Mar 2016
OliPass
2 programs
1
1
OLP-1002Phase 21 trial
A: OLP-1002Phase 11 trial
Active Trials
NCT04677933Completed30Est. Dec 2020
NCT05216341Completed134Est. Sep 2023
Centrexion Therapeutics
1
CNTX-4975Phase 21 trial
Active Trials
NCT02558439Completed175Est. Feb 2017
Servier
1 program
1
GLPG1972Phase 21 trial
Active Trials
NCT03595618Completed932Est. Jul 2020
Cytopeutics
1 program
1
Hyaluronic AcidPhase 21 trial
Active Trials
NCT01459640Unknown50Est. Mar 2014

+49 more companies

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
2028
Providence TherapeuticsStromal Vascular Fraction infiltration
FundaMental PharmaComarum Palustre
Novo NordiskLiraglutide 3 mg
BioventusDurolane SJ
Abdi IbrahimNaproxen Sodium Codeine
GC BiopharmaShinbaro Capsule
Prevail TherapeuticsDuloxetine
StrykerTritanium acetabular component
Zimmer BiometTrabecular Metal Modular Tibial Total Knee Component
MSDEtoricoxib
Zimmer BiometTrilogy AB Acetabular Hip Implant System
ExactechPlatelet Rich Plasma
Innovation PharmaceuticalsLevobupivacaine
StrykerX-3 polyethylene
Pfizercelecoxib

Showing 15 of 35 trials with date data

Clinical Trials (36)

Total enrollment: 21,573 patients across 36 trials

NCT00669123BioibericaChondroitin sulphate

Chondroitin Sulphate Efficay/Safety in Patients With Knee Osteoarthritis and Psoriasis

126 patients
Phase 4Completed
NCT05660824Providence TherapeuticsStromal Vascular Fraction infiltration

Effectiveness of Stromal Vascular Fraction (SVF) and Platelet -Rich Plasma (PRP) in Patients With Knee Osteoarthritis: Study Protocol for a Phase III, Prospective, Randomized, Controlled Multi-center Study.

Start: Jul 2025Est. completion: Aug 2027108 patients
Phase 4Not Yet Recruiting

Comarum Palustre in Knee Osteoarthritis and Diabetes

Start: Jun 2018Est. completion: Nov 201815 patients
Phase 4Completed
NCT02905864Novo NordiskLiraglutide 3 mg

Liraglutide 3 mg for Knee Osteoarthritis

Start: Nov 2016Est. completion: Mar 2019150 patients
Phase 4Completed

26 Week Open Label Study Evaluating Single IA Injection of DUROLANE SJ for Treatment of Osteoarthritis Pain of the Ankle

Start: Jun 2014Est. completion: Oct 201637 patients
Phase 4Unknown
NCT02501564Abdi IbrahimNaproxen Sodium Codeine

Evaluation of NaproxenSodium and CodeinePhosphate Combination in Osteoarthritis

Start: May 2013Est. completion: Nov 2015135 patients
Phase 4Completed
NCT01604239GC BiopharmaShinbaro Capsule

To Evaluate the Safety of 'Shinbaro Capsule'in Patients With Osteoarthritis

Start: May 2012Est. completion: Jun 2013761 patients
Phase 4Completed

Duloxetine in Osteoarthritis (OA) Pain

Start: Mar 2012Est. completion: Aug 201440 patients
Phase 4Completed
NCT01618084StrykerTritanium acetabular component

RSA Study Using Two Types of Uncemented Acetabular Components and the Uncemented HA Coated Symax Stem

Start: Nov 2011Est. completion: Dec 201450 patients
Phase 4Unknown
NCT01180595Zimmer BiometTrabecular Metal Modular Tibial Total Knee Component

Roentgen Stereophotogrammetric Analysis (RSA) Trial Comparing Trabecular Metal Monoblock and Modular Tibial Components

Start: Feb 2011Est. completion: Sep 201950 patients
Phase 4Completed
NCT00927004MSDEtoricoxib

Efficacy of Etoricoxib 60 mg in Modifying Pain Hypersensitivity in People With Knee Osteoarthritis

Start: Aug 2010Est. completion: Dec 201180 patients
Phase 4Completed
NCT00715026Zimmer BiometTrilogy AB Acetabular Hip Implant System

Trilogy AB Acetabular Hip System Post Approval Study

Start: Apr 2009Est. completion: Jun 201231 patients
Phase 4Terminated
NCT00826098ExactechPlatelet Rich Plasma

Platelet Rich Plasma (PRP) in Total Knee Replacement

Start: Dec 2008Est. completion: Feb 201370 patients
Phase 4Completed

Study to Test the Efficacy of Periarticular Levo Bupivicaine Injection Following Primary Hip Arthroplasty

Start: Sep 2008Est. completion: Sep 200991 patients
Phase 4Completed
NCT00665964StrykerX-3 polyethylene

Comparing X-3 To N2vac Polyethylene With the Triathlon Total Knee System

Start: May 2008Est. completion: May 20200
Phase 4Withdrawn

Measuring Gait And Self-Reported Pain In Patients With Osteoarthritis Of The Knee Using Placebo/Oxycodone/Celecoxib.

Start: Jan 2008Est. completion: Jun 20096 patients
Phase 4Terminated

Celebrex Total Knee Arthroplasty Study

Start: Nov 2006Est. completion: Jul 200722 patients
Phase 4Terminated

GI-Reasons- A Trial Of GI Safety Of Celecoxib Compared With Non-Selective Nonsteroidal Antiinflammatory Drugs (NSAIDS)

Start: Oct 2006Est. completion: Nov 20108,067 patients
Phase 4Completed

TREAD-20 Extension - Treatment of Knee Pain Due to Osteoarthritis

Start: Dec 2005Est. completion: Oct 200640 patients
Phase 4Completed

Safety and Efficacy of Lumiracoxib in Patients With Osteoarthritis and With Controlled Hypertension

Start: Nov 20051,020 patients
Phase 4Completed

Study Of Celecoxib Or Diclofenac And Omeprazole For Gastrointestinal (GI) Safety In High GI Risk Patients With Arthritis

Start: Oct 2005Est. completion: May 20094,484 patients
Phase 4Completed

TREAD-20: Trial of Hyalgan Three Injection-Regimen for the Treatment of Knee Pain Due to Osteoarthritis

Start: Nov 2004Est. completion: May 2006150 patients
Phase 4Completed

A Single-Blind Placebo Run-In Study of Venlafaxine for Activity-Limiting Osteoarthritis Pain

Start: Sep 2004Est. completion: Feb 200718 patients
Phase 4Completed

A Single-Blind Placebo Run-in Study of Duloxetine for Activity-Limiting Osteoarthritis Pain

Start: Sep 2004Est. completion: Feb 200725 patients
Phase 4Completed
NCT00998088Haemoneticserythropoietin and cell saver

Blood Management in Orthopedic Surgery

Start: May 2004Est. completion: Sep 20092,598 patients
Phase 4Completed

Study to Assess the Efficacy and Safety of Meloxicam vs. Diclofenac SR in Patients With Osteoarthritis of the Knee

Start: Apr 199991 patients
Phase 4Completed

Effectiveness and Safety of Synvisc® Versus Usual Treatments in Patients With Knee Osteoarthritis

Start: Oct 1998518 patients
Phase 4Completed

A Study to Access the Efficacy and Safety of Meloxicam in Patients With Osteoarthritis of the Knee

Start: Oct 199830 patients
Phase 4Completed

Total Knee Arthroplasty Comparing Cementless to Cemented Fixation

Start: Jan 1997Est. completion: Mar 201196 patients
Phase 4Completed

Efficacy and Safety of Eloralintide (LY3841136) in Participants With Osteoarthritis Knee Pain and Obesity or Overweight

Start: Feb 2026Est. completion: May 2028900 patients
Phase 3Recruiting

A Study of Orforglipron (LY3502970) in Participants With Obesity or Overweight and Osteoarthritis (OA) of the Knee

Start: Sep 2025Est. completion: May 2028800 patients
Phase 3Recruiting
NCT04421911HandokKetoprofen topical

A Study to Assess Efficacy and Safety of the Ketoprofen vs Diclofenac

Start: Mar 2020Est. completion: Sep 2020236 patients
Phase 3Completed
NCT03477630Karla TherapeuticsPlatelet Rich Plasma

Treatment of Osteoarthrosis of the Knee With Platelet Rich Plasma, Comparative Study With Hyaluronic Acid

Start: Feb 2019Est. completion: Sep 202028 patients
Phase 3Completed

Donepezil Attenuate Postoperative Cognitive Dysfunction

Start: Sep 2018Est. completion: Dec 2021550 patients
Phase 3Unknown

The Efficacy and Safety of Invossa K Injection in Patients Diagnosed With Knee Osteoarthritis

Start: Feb 2018Est. completion: Mar 2020146 patients
Phase 3Unknown
NCT03031938Prevail TherapeuticsInvestigational medical product

Protocol to Monitor the Neurological Development of Infants With Exposure in Utero From Birth to 15 Months in Tanezumab Clinical Studies

Start: Nov 2017Est. completion: Jun 20204 patients
Phase 3Completed

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

54 late-stage (Phase 3) programs, potential near-term approvals
2 actively recruiting trials targeting 21,573 patients
30 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.