Tumors

Oncology
30
Pipeline Programs
17
Companies
50
Clinical Trials
1 recruiting
2
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
21
6
0
0
0
3
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Small Molecule
686%
Monoclonal Antibody
114%
+ 21 programs with unclassified modality

On Market (2)

Approved therapies currently available

Sanofi
ELITEKApproved
rasburicase
Sanofi
intravenous2002
Amgen
VECTIBIXApproved
panitumumab
Amgen
Epidermal Growth Factor Receptor Antagonist [EPC]iv (infusion)2006

Competitive Landscape

17 companies ranked by most advanced pipeline stage

Amgen
AmgenTHOUSAND OAKS, CA
2 programs
2
1
Anti-angiogenesisPhase 11 trial
VECTIBIX(panitumumab)Phase 1Monoclonal Antibody5 trials
Active Trials
NCT00093873Completed71Est. Dec 2006
NCT07094113Recruiting434Est. Apr 2031
NCT06252649Recruiting450Est. Aug 2031
+3 more trials
Sanofi
SanofiPARIS, France
1 program
1
RasburicasePhase 41 trial
Active Trials
NCT00230217Completed94Est. Jul 2006
E
EisaiChina - Liaoning
5 programs
3
2
LenvatinibPhase 1/2Small Molecule1 trial
LenvatinibPhase 1/2Small Molecule1 trial
E7046Phase 11 trial
E7090Phase 11 trial
LenvatinibPhase 1Small Molecule1 trial
Active Trials
NCT02540291Terminated31Est. Feb 2018
NCT02275910Completed40Est. Sep 2021
NCT02686164Completed51Est. Aug 2018
+2 more trials
Bristol Myers Squibb
3 programs
2
1
BMS-663513Phase 1/21 trial
BMS-275183Phase 11 trial
DasatinibPhase 1Small Molecule1 trial
Active Trials
NCT00207025Terminated60
NCT00339144Completed16Est. Sep 2008
NCT00309023Terminated115Est. Sep 2009
Bayer
BayerLEVERKUSEN, Germany
2 programs
1
1
PTK787/ZK 222584Phase 1/21 trial
SH U04722Phase 11 trial
Active Trials
NCT00375453Terminated10Est. Oct 2007
NCT00171587Completed22Est. Mar 2007
H
HutchmedChina - Hong Kong
2 programs
1
1
surufatinibPhase 1/2Small Molecule1 trial
VolitinibPhase 1Small Molecule1 trial
Active Trials
NCT01985555Completed85Est. Apr 2019
NCT02549937Completed130Est. Jun 2023
Novartis
NovartisBASEL, Switzerland
1 program
1
PTK787/ZK 222584Phase 1/2
Boehringer Ingelheim
Boehringer IngelheimINGELHEIM, Germany
2 programs
2
BIBF 1120Phase 11 trial
BIBF 1120Phase 11 trial
Active Trials
NCT02182128Completed24
NCT02182206Completed50
Biogen
BiogenCAMBRIDGE, MA
2 programs
2
CNF2024Phase 11 trial
hCBE-11Phase 11 trial
Active Trials
NCT00345189Completed70Est. Apr 2009
NCT00105170Terminated13Est. Aug 2006
Astellas
AstellasChina - Shenyang
1 program
1
AGS-22M6EPhase 1
AstraZeneca
AstraZenecaCAMBRIDGE, United Kingdom
1 program
1
AZD1152 part APhase 11 trial
Active Trials
NCT00338182Completed43Est. Mar 2017
M&
Merck & Co.RAHWAY, NJ
1 program
1
Biomarker sample collection before and after dosing with cytotoxic agentPhase 11 trial
Active Trials
NCT00800865Completed36Est. Oct 2009
Curis
CurisMA - Lexington
1 program
1
CUDC-101Phase 11 trial
Active Trials
NCT00728793CompletedEst. Apr 2010
Astex Pharmaceuticals
Astex PharmaceuticalsUK - Cambridge
1 program
1
RubitecanPhase 11 trial
Active Trials
NCT00113113Completed
Taiho Oncology
Taiho OncologyNJ - Princeton
1 program
1
S-1Phase 11 trial
Active Trials
NCT00400023CompletedEst. May 2007
Pfizer
PfizerNEW YORK, NY
1 program
1
TTI-237Phase 11 trial
Active Trials
NCT00195325Terminated45
Zentalis Pharmaceuticals
1 program
1
ZN-c3Phase 11 trial
Active Trials
NCT05431582WithdrawnEst. Dec 2022

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
2028
2029
2030
2031
Amgenpanitumumab
SanofiRasburicase
Amgenpanitumumab
Amgenpanitumumab
Amgenpanitumumab
Amgenpanitumumab
Amgenpanitumumab
Amgenpanitumumab
Amgenpanitumumab
Amgenpanitumumab
Amgenpanitumumab
Amgenpanitumumab
Amgenpanitumumab
Amgenpanitumumab
Amgenpanitumumab

Showing 15 of 50 trials with date data

Clinical Trials (50)

Total enrollment: 8,547 patients across 50 trials

NCT02301962Amgenpanitumumab

Phase IV Panitumumab Study in Indian Subjects With Metastatic Colorectal Cancer

Start: Jul 2015Est. completion: Jan 202258 patients
Phase 4Unknown

Study of Rasburicase as Treatment or Prevention of Hyperuricemia Associated With Tumor Lysis Syndrome in Patients With Relapsed or Refractory Lymphoma, Leukemia, or Solid Tumor Malignancy

Start: Mar 2004Est. completion: Jul 200694 patients
Phase 4Completed
NCT06252649Amgenpanitumumab

Study of Sotorasib, Panitumumab and FOLFIRI Versus FOLFIRI With or Without Bevacizumab-awwb in Treatment-naïve Participants With Metastatic Colorectal Cancer With KRAS p.G12C Mutation

Start: Jul 2024Est. completion: Aug 2031450 patients
Phase 3Recruiting
NCT05198934Amgenpanitumumab

Sotorasib and Panitumumab Versus Investigator's Choice for Participants With Kirsten Rat Sarcoma (KRAS) p.G12C Mutation

Start: Apr 2022Est. completion: May 2026160 patients
Phase 3Active Not Recruiting
NCT03635021Amgenpanitumumab

Study to Evaluate the Efficacy of FOLFOX + Panitumumab Followed by FOLFIRI + Bevacizumab (Sequence 1) Versus FOLFOX + Bevacizumab Followed by FOLFIRI + Panitumumab (Sequence 2) in Untreated Patients With Wild-type RAS Metastatic, Primary Left-sided, Unresectable Colorectal Cancer

Start: Oct 2018Est. completion: Jun 2025419 patients
Phase 3Active Not Recruiting
NCT03300609Amgenpanitumumab

5-FU Based Maintenance Therapy in RAS Wild Type Metastatic Colorectal Cancer After Induction With FOLFOX Plus Panitumumab

Start: Feb 2018Est. completion: Oct 20194 patients
Phase 3Terminated
NCT01412957Amgenpanitumumab

Comparison of Survival Benefit of Panitumumab With Supportive Care to Best Supportive Care Alone in Patients With Metastatic Colorectal Cancer

Start: Nov 2011Est. completion: Nov 2016377 patients
Phase 3Completed
NCT00460265Amgenpanitumumab

Study of Panitumumab Efficacy in Patients With Recurrent and/or Metastatic Head and Neck Cancer

Start: May 2007Est. completion: May 2012658 patients
Phase 3Completed
NCT00364013Amgenpanitumumab

PRIME: Panitumumab Randomized Trial In Combination With Chemotherapy for Metastatic Colorectal Cancer to Determine Efficacy

Start: Aug 2006Est. completion: Mar 20131,183 patients
Phase 3Completed
NCT00339183Amgenpanitumumab

Comparison of Treatment Effect of Chemotherapy With Panitumumab to Chemotherapy Alone

Start: Jun 2006Est. completion: Nov 20101,186 patients
Phase 3Completed
NCT00115765Amgenpanitumumab

PACCE: Panitumumab Advanced Colorectal Cancer Evaluation Study

Start: Jun 2005Est. completion: May 20091,053 patients
Phase 3Completed
NCT00113763Amgenpanitumumab

Evaluating Panitumumab (ABX-EGF) Plus Best Supportive Care Versus Best Supportive Care in Patients With Metastatic Colorectal Cancer

Start: Jan 2004Est. completion: Jun 2009463 patients
Phase 3Completed
NCT04787341Amgenpanitumumab

PAnitumumab REchallenge Followed by REgorafenib Versus the Reverse Sequence

Start: Dec 2020Est. completion: Mar 2026214 patients
Phase 2Active Not Recruiting
NCT04169347Amgenpanitumumab

FOLFOXIRI Plus Panitumumab in Metastatic RAS Wild-type, Left-sided Colorectal Cancer

Start: Dec 2019Est. completion: Jan 202527 patients
Phase 2Unknown
NCT03584711Amgenpanitumumab

FOLFOX + Panitumumab According to a "Stop and go" Strategy With a Reintroduction Loop After Progression on Fluoropyrimidine as Maintenance Treatment, as the First Line in Patients With Metastatic Colorectal Adenocarcinoma Without a RAS Mutation

Start: Apr 2018Est. completion: Mar 2025118 patients
Phase 2Completed
NCT03142516Amgenpanitumumab

FOLFIRI + Panitumumab First-line Treatment in Elderly Patients With Unresectable Metastatic Colorectal Cancer, RAS/BRAF Wild-type and Good Performance Status

Start: Oct 2017Est. completion: Jan 202120 patients
Phase 2Completed
NCT03000374Amgenpanitumumab

Induction Therapy With Panitumumab + mFOLFOX-6 in Rectal Cancer and Quadruple Wild-type Mutation Before Surgery

Start: May 2017Est. completion: Dec 202134 patients
Phase 2Completed
NCT01916109Amgenpanitumumab

Study of Gemcitabine, Carboplatin, and Panitumumab (GCaP) as Neoadjuvant Chemotherapy in Patients With Muscle-Invasive Bladder Cancer

Start: Aug 20134 patients
Phase 2Terminated
NCT01508000Amgenpanitumumab

Efficacy of FOLFOX Alone, FOLFOX Plus Bevacizumab and FOLFOX Plus Panitumumab in Patients With Resectable Liver Metastases

Start: Jun 2013Est. completion: Sep 201644 patients
Phase 2Terminated
NCT01814501Amgenpanitumumab

Panitumumab and Chemotherapy in Patients With Advanced Colorectal Cancer After Prior Therapy With Bevacizumab

Start: Feb 2013Est. completion: Aug 201816 patients
Phase 2Completed
NCT01312493Amgenpanitumumab

Selective IMRT for Locally Advanced Head and Neck Carcinoma With Concurrent Panitumumab

Start: Dec 2011Est. completion: Dec 20180
Phase 2Withdrawn
NCT00984217Amgenpanitumumab

Trial of Radiotherapy and Panitumumab in Salivary Gland Malignancies

Start: Aug 2011Est. completion: Aug 20110
Phase 2Withdrawn
NCT01182610Amgenpanitumumab

Panitumumab, Paclitaxel, Carboplatin and 5FU in the Treatment of Potentially Resectable Gastroesophageal Adenocarcinoma

Start: Apr 2011Est. completion: Mar 20121 patients
Phase 2Terminated
NCT01328171Amgenpanitumumab

FOLFOXIRI With or Without Panitumumab in Metastatic Colorectal Cancer (VOLFI)

Start: Apr 2011Est. completion: Jan 202293 patients
Phase 2Completed
NCT01264328Amgenpanitumumab

Study of the Combination of Panitumumab With Paclitaxel as First-line Treatment of Subjects With Head and Neck Cancer

Start: Mar 2011Est. completion: Sep 201440 patients
Phase 2Completed
NCT01312857Amgenpanitumumab

Study of Hepatic Arterial Infusion With Intravenous Irinotecan, 5FU and Leucovorin With or Without Panitumumab, in Patients With Wild Type RAS Who Have Resected Hepatic Metastases From Colorectal Cancer

Start: Mar 2011Est. completion: Jul 202475 patients
Phase 2Completed
NCT01296035Amgenpanitumumab

Panitumumab and Gemcitabine in Relapsed Ovarian Cancer

Start: Feb 2011Est. completion: Nov 20138 patients
Phase 2Terminated
NCT01305772Amgenpanitumumab

Identification of Gene Expression Signature for Panitumumab Sensitivity in Untreated Locally Advanced SCCHN

Start: Jan 2011Est. completion: May 20126 patients
Phase 2Terminated
NCT01308840Amgenpanitumumab

Gemcitabine, Oxaliplatin and Panitumumab in Kras/B-raf Wild-Type Biliary Track and Gallbladder Cancer

Start: Dec 2010Est. completion: Jan 201331 patients
Phase 2Completed
NCT01226719Amgenpanitumumab

FOLFOXIRI Plus Panitumumab Patients With Metastatic KRAS Wild-Type Colorectal Cancer With Liver Metastases Only

Start: Dec 2010Est. completion: Mar 201415 patients
Phase 2Completed
NCT01379807Amgenpanitumumab

Efficacy and Safety of Panitumumab Combined With Docetaxel and Cisplatin as a First-line Treatment of Advanced Gastric or Gastroesophageal Junction Adenocarcinoma

Start: Dec 2010Est. completion: Dec 201555 patients
Phase 2Unknown
NCT01288339Amgenpanitumumab

Study Assessing Potential Predictive Tumor Markers in Metastatic Colorectal Cancer

Start: Nov 2010Est. completion: Feb 201578 patients
Phase 2Completed
NCT01202409Amgenpanitumumab

CAPOX in KRAS Wild-Type Advanced Adenocarcinoma of the Small Bowel or Ampulla of Vater

Start: Nov 2010Est. completion: Jul 201819 patients
Phase 2Completed
NCT01285778Amgenpanitumumab

Vectibix for the Treatment of Anal Cancer

Start: Oct 2010Est. completion: Mar 201758 patients
Phase 2Completed
NCT01234324Amgenpanitumumab

ECX + Panitumumab vs. ECX Alone in Locally Advanced Gastric Cancer or Cancer of the Gastroesophageal Junction

Start: Oct 2010Est. completion: Aug 2017171 patients
Phase 2Completed
NCT01042288Amgenpanitumumab

Carboplatin, Pemetrexed, and Panitumumab in Patients With Advanced Non-Squamous K-ras Wild Type NSCLC

Start: Jun 2010Est. completion: Jul 201570 patients
Phase 2Completed
NCT01126112Amgenpanitumumab

Study of First-line Single-agent Panitumumab in Frail Elderly Patients With Advanced Wild Type K-RAS Colorectal Cancer

Start: May 2010Est. completion: Jul 201433 patients
Phase 2Completed
NCT00894504Amgenpanitumumab

Panitumumab, Gemcitabine and Carboplatin in Triple-Negative Metastatic Breast Cancer

Start: Feb 2010Est. completion: Sep 201471 patients
Phase 2Completed
NCT01017653Amgenpanitumumab

Panitumumab and Irinotecan for Malignant Gliomas

Start: Feb 2010Est. completion: Oct 201116 patients
Phase 2Terminated
NCT01144195Amgenpanitumumab

A Clinical Trial of Panitumumab in Combination With FOLFIRI Chemotherapy as Second Line Treatment in Subjects With Metastatic Colorectal Cancer Expressing Wild-type KRAS and Who Had Progressed ≥ 6 Months After the Last Dose of the First Line Chemotherapy

Start: Sep 200980 patients
Phase 2Unknown
NCT00958386Amgenpanitumumab

Safety and Efficacy Study of Panitumumab+Irinotecan in Patients Wild-Type (WT) KRAS Metastatic Colorectal Cancer Refractory to Irinotecan Based Chemotherapy (SPECTRA)

Start: Aug 2009Est. completion: Jul 201461 patients
Phase 2Completed
NCT00836277Amgenpanitumumab

Phase II Study of Irinotecan and Panitumumab

Start: May 2009Est. completion: Aug 201524 patients
Phase 2Completed
NCT00885885Amgenpanitumumab

Safety and Efficacy Study of FOLFOX4+Panitumumab vs.FOLFIRI+Panitumumab in Subjects WT KRAS Colorectal Cancer and Liver-only Metastases

Start: May 2009Est. completion: Mar 201580 patients
Phase 2Completed
NCT00756444Amgenpanitumumab

A Randomized Phase 2 Pharmacokinetic Trial of Chemotherapy With or Without Panitumumab in Patients With Metastatic and/or Recurrent Squamous Cell Carcinoma of the Head and Neck

Start: Oct 2008Est. completion: Mar 201267 patients
Phase 2Completed
NCT00547157Amgenpanitumumab

Radiotherapy Plus Panitumumab Compared to Chemoradiotherapy With Unresected, Locally Advanced Squamous Cell Carcinoma of the Head and Neck

Start: Nov 2007Est. completion: Mar 2012152 patients
Phase 2Completed
NCT00500760Amgenpanitumumab

Study of Addition of Panitumumab to Chemoradiation Therapy in Patients With Locally Advanced Head and Neck Cancer

Start: Oct 2007Est. completion: Apr 2011153 patients
Phase 2Completed
NCT00508404Amgenpanitumumab

Panitumumab Plus FOLFIRI in First-line Treatment of Metastatic Colorectal Cancer

Start: May 2007Est. completion: Jun 2012154 patients
Phase 2Completed
NCT00475293Amgenpanitumumab

Panitumumab in Combination With Irinotecan Chemotherapy as 2nd-line Therapy in Subjects With mCRC

Start: May 2007Est. completion: Mar 201085 patients
Phase 2Completed
NCT00613730Amgenpanitumumab

Adenocarcinoma of the Pancreas Treated With Panitumumab and Gemcitabine Regimen to Investigate Overall Survival as Primary Endpoint

Start: Jan 2007Est. completion: Apr 20093 patients
Phase 2Terminated
NCT00418938Amgenpanitumumab

SPIRITT - Second-Line Panitumumab Irinotecan Treatment Trial

Start: Nov 2006Est. completion: Apr 2013266 patients
Phase 2Completed

Related Jobs in Oncology

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

1 actively recruiting trials targeting 8,547 patients
17 companies competing in this space