Renal Insufficiency, Chronic

Nephrology
8
Pipeline Programs
8
Companies
9
Clinical Trials
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
3
1
2
0
1
1
Early DiscoveryClinical DevelopmentMarket

Competitive Landscape

8 companies ranked by most advanced pipeline stage

Amgen
AmgenTHOUSAND OAKS, CA
1 program
1
Epoetin alfaPhase 41 trial
Active Trials
NCT02253654Completed216Est. May 2016
Abbott
AbbottABBOTT PARK, IL
1 program
1
paricalcitol capsulePhase 31 trial
Active Trials
NCT00048516Completed68
Biogen
BiogenCAMBRIDGE, MA
2 programs
1
1
Bardoxolone methylPhase 21 trial
Bardoxolone MethylPhase 11 trial
Active Trials
NCT01551446Withdrawn0Est. Nov 2012
NCT01053936Completed129Est. Feb 2011
HM
Huadong MedicineChina - Hangzhou
1 program
1
Yougui granulesPhase 21 trial
Active Trials
NCT01665651WithdrawnEst. May 2017
Fresenius Kabi
Fresenius KabiGermany - Bad Homburg
1 program
1
Ketosteril®Phase 1/21 trial
Active Trials
NCT03077048Completed23Est. May 2018
Boehringer Ingelheim
Boehringer IngelheimINGELHEIM, Germany
1 program
1
Dabigatran EtexilatePhase 11 trial
Active Trials
NCT01711853Completed19Est. Dec 2013
Pfizer
PfizerNEW YORK, NY
1 program
1
PF-00734200Phase 11 trial
Active Trials
NCT00596518Completed30Est. Jul 2008
AstraZeneca
AstraZenecaCAMBRIDGE, United Kingdom
1 program
Bringing Knowledge About Chronic Kidney Disease in Brazil: Filling the GapN/A1 trial
Active Trials
NCT07103629Completed8,428Est. Sep 2025

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
AmgenEpoetin alfa
Abbottparicalcitol capsule
Huadong MedicineYougui granules
BiogenBardoxolone methyl
Fresenius KabiKetosteril®
Boehringer IngelheimDabigatran Etexilate
BiogenBardoxolone Methyl
PfizerPF-00734200
AstraZenecaBringing Knowledge About Chronic Kidney Disease in Brazil: Filling the Gap

Clinical Trials (9)

Total enrollment: 8,913 patients across 9 trials

NCT02253654AmgenEpoetin alfa

Evaluation of Two Epoetin Alfa Dosing Strategies in Subjects With Chronic Kidney Disease Receiving Hemodialysis

Start: Apr 2015Est. completion: May 2016216 patients
Phase 4Completed
NCT00048516Abbottparicalcitol capsule

Safety and Efficacy of Zemplar Capsule in Reducing Serum iPTH Levels in Chronic Kidney Disease Subjects (Daily Dosing)

Start: Feb 200268 patients
Phase 3Completed
NCT01665651Huadong MedicineYougui granules

Kidney Yin/Yang Replenishment on Patients With Renal Osteodystrophy

Start: Aug 2012Est. completion: May 2017
Phase 2Withdrawn
NCT01053936BiogenBardoxolone methyl

Phase II Pharmacodynamic Trial to Determine the Effects of Bardoxolone Methyl on eGFR in Patients With Type 2 Diabetes and Chronic Kidney Disease

Start: Jan 2010Est. completion: Feb 2011129 patients
Phase 2Completed
NCT03077048Fresenius KabiKetosteril®

Short-term Metabolic Effects of Ketosteril® Supplemented Low Protein Diet in Pre-dialysis Chronic Kidney Disease (CKD) Patients

Start: Mar 2017Est. completion: May 201823 patients
Phase 1/2Completed
NCT01711853Boehringer IngelheimDabigatran Etexilate

Study to Evaluate the Pharmacokinetics and Pharmacodynamics of Dabigatran Etexilate in Patients With Stable Severe Renal Disease.

Start: Oct 2012Est. completion: Dec 201319 patients
Phase 1Completed
NCT01551446BiogenBardoxolone Methyl

Pilot Assessment of the Effects of Bardoxolone Methyl on Renal Perfusion, Systemic Haemodynamics and Cardiac Function in Patients With Chronic Kidney Disease and Type 2 Diabetes

Start: Apr 2012Est. completion: Nov 20120
Phase 1Withdrawn
NCT00596518PfizerPF-00734200

A Study to Evaluate the Blood Levels, Safety, and Tolerability of PF-00734200 in Subjects With Impaired Kidney Function and Normal Kidney Function

Start: Oct 2007Est. completion: Jul 200830 patients
Phase 1Completed
NCT07103629AstraZenecaBringing Knowledge About Chronic Kidney Disease in Brazil: Filling the Gap

Bringing Knowledge About Chronic Kidney Disease in Brazil: Filling the Gap

Start: May 2025Est. completion: Sep 20258,428 patients
N/ACompleted

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Phase Legend

Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available

Key Insights

1 late-stage (Phase 3) programs — potential near-term approvals
8 companies competing in this space

Related Indications

Chronic Kidney Disease(86)Renal Impairment(67)End Stage Renal Disease(56)Kidney Transplantation(49)Renal Insufficiency(27)Chronic Kidney Diseases(25)Kidney Transplant(19)Diabetic Nephropathies(18)Kidney Diseases(17)Kidney Transplant Rejection(16)