Rectal Neoplasms

Oncology
3
Pipeline Programs
4
Companies
4
Clinical Trials
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
0
0
2
0
1
0
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Monoclonal Antibody
1100%
+ 3 programs with unclassified modality

Competitive Landscape

3 companies ranked by most advanced pipeline stage

Sanofi
SanofiPARIS, France
2 programs
1
1
local rectal excisionPhase 31 trial
Oxaliplatin, capecitabine, radiotherapyPhase 21 trial
Active Trials
NCT00174616Completed87Est. Nov 2007
NCT00427375Completed148Est. Feb 2018
Roche
RocheSTAVANGER NORWAY, Norway
1 program
1
bevacizumabPhase 2Monoclonal Antibody1 trial
Active Trials
NCT00557713Unknown44Est. Oct 2013
Heidelberg Pharma
Heidelberg PharmaGermany - Ladenburg
1 program
endoscopic posterior mesorectal resectionN/A1 trial
Active Trials
NCT00531297Terminated18Est. Aug 2018

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
Sanofilocal rectal excision
Rochebevacizumab
SanofiOxaliplatin, capecitabine, radiotherapy
Heidelberg Pharmaendoscopic posterior mesorectal resection

Clinical Trials (4)

Total enrollment: 297 patients across 4 trials

NCT00427375Sanofilocal rectal excision

Local Excision in Downstaged Rectal Cancer

Start: Mar 2007Est. completion: Feb 2018148 patients
Phase 3Completed
NCT00557713Rochebevacizumab

XELOX+Bevacizumab Followed by Capecitabine+Bevacizumab+Radiotherapy as Neoadjuvant Treatment of Locally Advanced Rectal Adenocarcinoma

Start: Feb 2007Est. completion: Oct 201344 patients
Phase 2Unknown
NCT00174616SanofiOxaliplatin, capecitabine, radiotherapy

CORE: Capecitabine, Oxaliplatin, Radiotherapy and Excision

Start: Jul 2003Est. completion: Nov 200787 patients
Phase 2Completed
NCT00531297Heidelberg Pharmaendoscopic posterior mesorectal resection

Endoscopic Posterior Mesorectal Resection in T1 Rectal Cancer

Start: Dec 2005Est. completion: Aug 201818 patients
N/ATerminated

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Phase Legend

Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available

Key Insights

1 late-stage (Phase 3) programs — potential near-term approvals
4 companies competing in this space

Related Indications

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