Proteinuric Kidney Disease

Nephrology
3
Pipeline Programs
2
Companies
3
Clinical Trials
3 recruiting
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
0
0
2
1
0
0
Early DiscoveryClinical DevelopmentMarket

Competitive Landscape

2 companies ranked by most advanced pipeline stage

VP
2 programs
1
1
VX-147Phase 2/31 trial
InaxaplinPhase 21 trial
Active Trials
NCT06794996Recruiting45Est. Dec 2026
NCT05312879Recruiting466Est. Jun 2026
Maze Therapeutics
Maze TherapeuticsCA - South SF
1 program
1
MZE829Phase 21 trial
Active Trials
NCT06830629Recruiting56Est. Sep 2026

Trial Timeline

Clinical trial activity over time

2022
2023
2024
2025
2026
Vertex PharmaceuticalsVX-147
Maze TherapeuticsMZE829
Vertex PharmaceuticalsInaxaplin

Clinical Trials (3)

Total enrollment: 567 patients across 3 trials

NCT05312879Vertex PharmaceuticalsVX-147

Phase 2/3 Adaptive Study of VX-147 in Adult and Pediatric Participants With APOL1- Mediated Proteinuric Kidney Disease

Start: Mar 2022Est. completion: Jun 2026466 patients
Phase 2/3Recruiting
NCT06830629Maze TherapeuticsMZE829

A Phase 2 Study of MZE829 in Adults With APOL1 Kidney Disease

Start: Feb 2025Est. completion: Sep 202656 patients
Phase 2Recruiting
NCT06794996Vertex PharmaceuticalsInaxaplin

Inaxaplin in Participants With Proteinuric APOL1 Mediated Kidney Disease With or Without Comorbidities

Start: Feb 2025Est. completion: Dec 202645 patients
Phase 2Recruiting

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Phase Legend

Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available

Key Insights

3 actively recruiting trials targeting 567 patients
2 companies competing in this space

Related Indications

Chronic Kidney Disease(86)Renal Impairment(67)End Stage Renal Disease(56)Kidney Transplantation(49)Renal Insufficiency(27)Chronic Kidney Diseases(25)Kidney Transplant(19)Diabetic Nephropathies(18)Kidney Diseases(17)Kidney Transplant Rejection(16)