Prostate Cancer Metastatic

Oncology
9
Pipeline Programs
8
Companies
10
Clinical Trials
2 recruiting
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
2
3
2
0
2
0
Early DiscoveryClinical DevelopmentMarket

Competitive Landscape

8 companies ranked by most advanced pipeline stage

Novartis
NovartisBASEL, Switzerland
2 programs
1
1
177Lu-PMSA-617Phase 31 trial
ARV-766 Part A&BPhase 1/21 trial
Active Trials
NCT05067140Active Not Recruiting152Est. May 2027
NCT06496581Recruiting500Est. Aug 2039
Bavarian Nordic
Bavarian NordicDenmark - Kvistgard
1 program
1
PROSTVAC-VPhase 31 trial
Active Trials
NCT01322490Completed1,297Est. Dec 2017
DS
Daiichi SankyoChina - Shanghai
1 program
1
EnhertuPhase 21 trial
Active Trials
NCT06610825Recruiting60Est. Oct 2028
Regeneron
RegeneronTARRYTOWN, NY
1 program
1
REGN2810Phase 21 trial
Active Trials
NCT03951831Active Not Recruiting26Est. Apr 2028
Arvinas
ArvinasCT - New Haven
2 programs
1
1
ARV-110Phase 1/21 trial
ARV-110 in Combination with AbirateronePhase 11 trial
Active Trials
NCT05177042CompletedEst. Apr 2025
NCT03888612CompletedEst. Jan 2025
Laekna Therapeutics
Laekna TherapeuticsChina - Shanghai
1 program
1
LAE001Phase 1/21 trial
Active Trials
NCT03843918TerminatedEst. Oct 2023
Genentech
GenentechCA - Oceanside
1 program
1
Atezolizumab1200 mg IVPhase 11 trial
Active Trials
NCT03024216Completed37Est. Dec 2020
Bayer
BayerLEVERKUSEN, Germany
1 program
Blood testsN/A1 trial
Active Trials
NCT03223727Completed100Est. Feb 2023

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
2028
2029
2030
2031
Novartis177Lu-PMSA-617
Bavarian NordicPROSTVAC-V
Daiichi SankyoEnhertu
RegeneronREGN2810
NovartisARV-766 Part A&B
Laekna TherapeuticsLAE001
ArvinasARV-110
ArvinasARV-110 in Combination with Abiraterone
GenentechAtezolizumab1200 mg IV
BayerBlood tests

Clinical Trials (10)

Total enrollment: 2,172 patients across 10 trials

NCT06496581Novartis177Lu-PMSA-617

Standard of Care +/- 177Lu-PSMA-617 In de Novo mHSPC Patients With Poor PSA Response (PEACE6-Poor Responders)

Start: Sep 2024Est. completion: Aug 2039500 patients
Phase 3Recruiting
NCT01322490Bavarian NordicPROSTVAC-V

A Randomized, Double-blind, Phase 3 Efficacy Trial of PROSTVAC-V/F +/- GM-CSF in Men With Asymptomatic or Minimally Symptomatic Metastatic Castrate-Resistant Prostate Cancer

Start: Nov 2011Est. completion: Dec 20171,297 patients
Phase 3Completed
NCT06610825Daiichi SankyoEnhertu

Castrate Resistant Prostate Cancer Enhertu Therapy

Start: Mar 2025Est. completion: Oct 202860 patients
Phase 2Recruiting
NCT03951831RegeneronREGN2810

REGN2810 Followed by Chemoimmunotherapy for Newly Metastatic Hormone-sensitive Prostate Cancer

Start: May 2019Est. completion: Apr 202826 patients
Phase 2Active Not Recruiting
NCT05067140NovartisARV-766 Part A&B

A Study of ARV-766 Given by Mouth in Men With Metastatic Prostate Cancer

Start: Sep 2021Est. completion: May 2027152 patients
Phase 1/2Active Not Recruiting
NCT03843918Laekna TherapeuticsLAE001

A Study on the Safety and Efficacy of LAE001 in the Treatment of Metastatic Prostate Cancer

Start: Apr 2019Est. completion: Oct 2023
Phase 1/2Terminated
NCT03888612ArvinasARV-110

Trial of ARV-110 in Patients With Metastatic Castration Resistant Prostate Cancer

Start: Mar 2019Est. completion: Jan 2025
Phase 1/2Completed
NCT05177042ArvinasARV-110 in Combination with Abiraterone

Trial of ARV-110 and Abiraterone in Patients With Metastatic Castration Resistant Prostate Cancer (mCRPC)

Start: Feb 2022Est. completion: Apr 2025
Phase 1Completed
NCT03024216GenentechAtezolizumab1200 mg IV

Clinical Study of Atezolizumab (Anti-PD-L1) and Sipuleucel-T in Patients With Asymptomatic or Minimally Symptomatic Metastatic Castrate Resistant Prostate Cancer

Start: Feb 2017Est. completion: Dec 202037 patients
Phase 1Completed
NCT03223727BayerBlood tests

Treatment Outcomes in a Non-study Population of Symptomatic mCRPC Patients Treated With Radium-223

Start: Oct 2015Est. completion: Feb 2023100 patients
N/ACompleted

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Phase Legend

Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available

Key Insights

2 late-stage (Phase 3) programs — potential near-term approvals
2 actively recruiting trials targeting 2,172 patients
8 companies competing in this space

Related Indications

Breast Cancer(530)Non-small Cell Lung Cancer(373)Prostate Cancer(371)Multiple Myeloma(244)Advanced Solid Tumors(221)Acute Myeloid Leukemia(204)Cancer(187)Neoplasms(173)Colorectal Cancer(166)Advanced Solid Tumor(165)