Pneumonia

Infectious Diseases
31
Pipeline Programs
15
Companies
50
Clinical Trials
9
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
0
0
4
3
11
13
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Small Molecule
5100%
+ 28 programs with unclassified modality

On Market (9)

Approved therapies currently available

Bayer
AVELOX IN SODIUM CHLORIDE 0.8% IN PLASTIC CONTAINERApproved
moxifloxacin hydrochloride
Bayer
intravenous2001
Sanofi
KETEKApproved
telithromycin
Sanofi
oral2004
J&
LEVAQUINApproved
levofloxacin
Johnson & Johnson
injection1996
J&
LEVAQUIN IN DEXTROSE 5% IN PLASTIC CONTAINERApproved
levofloxacin
Johnson & Johnson
injection1996
U
LEVOFLOXACINApproved
levofloxacin
Unknown Company
injection2011
U
LEVOFLOXACIN IN DEXTROSE 5% IN PLASTIC CONTAINERApproved
levofloxacin
Unknown Company
Fluoroquinolone Antibacterial [EPC]injection2011
U
LINEZOLIDApproved
linezolid
Unknown Company
Oxazolidinone Antibacterial [EPC]oral2015
Pfizer
LINEZOLID IN SODIUM CHLORIDE 0.9% IN PLASTIC CONTAINERApproved
linezolid
Pfizer
Oxazolidinone Antibacterial [EPC]intravenous2015
Pfizer
ZYVOXApproved
linezolid
Pfizer
Oxazolidinone Antibacterial [EPC]oral2000

Competitive Landscape

14 companies ranked by most advanced pipeline stage

Pfizer
PfizerNEW YORK, NY
8 programs
2
1
LinezolidPhase 41 trial
MERREM I.V. 2g as a 3 hour infusion every 8 hoursPhase 31 trial
clarithromycin extended releasePhase 31 trial
Costs, Health Status and Outcomes of CAP (Community-Acquired Pneumonia)N/A1 trial
Pneumonia and Empyema in Emergency Departments in ChildrenN/A1 trial
+3 more programs
Active Trials
NCT00812084Completed48,634Est. Oct 2014
NCT05274607Unknown20,000Est. Jun 2025
NCT07251465Not Yet Recruiting846,279Est. Mar 2026
+5 more trials
M&
Merck & Co.RAHWAY, NJ
3 programs
1
Ceftolozane / Tazobactam InjectionPhase 41 trial
Microbiology and Clinical Outcome of PneumoniaN/A1 trial
Surveillance of Non-invasive Streptococcus Pneumoniae Infections in BelgiumN/A
Active Trials
NCT00873522Unknown2,600Est. Mar 2010
NCT04673175Terminated17Est. Mar 2025
Bayer
BayerLEVERKUSEN, Germany
3 programs
1
1
AVELOX IN SODIUM CHLORIDE 0.8% IN PLASTIC CONTAINER(Avelox)Phase 45 trials
Amikacin inhalation solutionPhase 21 trial
MoxifloxacinN/ASmall Molecule5 trials
Active Trials
NCT05481528Completed51Est. Apr 2023
NCT04423744Completed42Est. Jan 2021
NCT00987792Completed2,595Est. Oct 2012
+8 more trials
J&
Johnson & JohnsonNEW BRUNSWICK, NJ
3 programs
1
2
1
doripenemPhase 31 trial
doripenemPhase 35 trials
levofloxacinPhase 2/3Small Molecule5 trials
Active Trials
NCT00002249Completed
NCT00402688Completed242Est. Sep 2008
NCT00821782Completed143Est. Sep 2006
+8 more trials
Sanofi
SanofiPARIS, France
2 programs
2
1
LevofloxacinPhase 3Small Molecule1 trial
TelithromycinPhase 35 trials
Active Trials
NCT00253955Completed460Est. Nov 2007
NCT00315549Terminated233Est. Sep 2006
NCT00315003Terminated1,500Est. Jul 2006
+3 more trials
Roche
RocheSTAVANGER NORWAY, Norway
1 program
1
ceftriaxonePhase 41 trial
Active Trials
NCT00374959Completed80Est. Oct 2003
BP
Basilea PharmaceuticaSwitzerland - Allschwil
3 programs
3
Ceftobiprole medocarilPhase 31 trial
ceftobiprole plus placeboPhase 31 trial
ceftobiprole plus placeboPhase 31 trial
Active Trials
NCT00326287CompletedEst. Jul 2007
NCT00210964CompletedEst. May 2007
NCT00229008CompletedEst. May 2007
OD
2 programs
1
1
levofloxacinPhase 3Small Molecule
levofloxacinPhase 2/3Small Molecule
Takeda
TakedaTOKYO, Japan
1 program
1
VenticutePhase 31 trial
Active Trials
NCT00074906Completed1,200Est. Jun 2008
PTC Therapeutics
1 program
1
PTC299Phase 2/31 trial
Active Trials
NCT04439071Terminated189Est. Jul 2022
Nektar Therapeutics
Nektar TherapeuticsSAN FRANCISCO, CA
2 programs
2
AmikacinPhase 2
Amikacin inhalation solutionPhase 2
Allergy Therapeutics
Allergy TherapeuticsUK - West Sussex
1 program
1
Interferon GammaPhase 21 trial
Active Trials
NCT00001407CompletedEst. May 2003
City Therapeutics
City TherapeuticsMA - Cambridge
2 programs
LactateN/A1 trial
Osteopathic Manipulative TreatmentN/A1 trial
Active Trials
NCT04826848CompletedEst. Dec 2019
NCT00258661CompletedEst. Apr 2007
Connect Biopharma
Connect BiopharmaSAN DIEGO, CA
1 program
Home hospitalizationN/A1 trial
Active Trials
NCT02864420CompletedEst. Dec 2016

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
Merck & Co.Ceftolozane / Tazobactam Injection
PfizerLinezolid
Johnson & Johnsondoripenem
Johnson & Johnsondoripenem
Johnson & Johnsondoripenem
BayerAvelox
BayerMoxifloxacin
BayerAvelox
BayerAvelox
SanofiTelithromycin
SanofiTelithromycin
SanofiTelithromycin
SanofiTelithromycin
SanofiTelithromycin
SanofiTelithromycin

Showing 15 of 50 trials with date data

Clinical Trials (50)

Total enrollment: 22,257 patients across 50 trials

NCT04673175Merck & Co.Ceftolozane / Tazobactam Injection

Ceftolozane-Tazobactam for Directed Treatment of Pseudomonas Aeruginosa Bacteremia and Pneumonia in Patients With Hematological Malignancies and Hematopoietic Stem Cell Transplantation

Start: Jan 2023Est. completion: Mar 202517 patients
Phase 4Terminated
NCT01805284PfizerLinezolid

Pharmacokinetic and Pharmacodynamic Evaluation of Linezolid Administered Intravenously in MRSA-positive, Morbidly Obese Patients With Pneumonia

Start: Feb 2013Est. completion: Sep 201615 patients
Phase 4Completed
NCT01027897Johnson & Johnsondoripenem

Pharmacokinetic and Pharmacodynamic Evaluation of Doripenem in Critically Ill Trauma Patients

Start: Apr 2010Est. completion: Dec 201130 patients
Phase 4Completed
NCT00986102Johnson & Johnsondoripenem

PROUD Study: A Prospective Study on the Usage Patterns of Doripenem in the Asia Pacific Region

Start: Jul 2009Est. completion: Sep 2011216 patients
Phase 4Completed
NCT00965848Johnson & Johnsondoripenem

A Safety and Efficacy Study of Doripenem in Participants With Nosocomial Pneumonia, Complicated Intra-Abdominal Infections and Urinary Tract Infections

Start: Jun 2009Est. completion: Jul 2010270 patients
Phase 4Completed
NCT00895089BayerAvelox

Moxifloxacin Versus Ceftriaxone in the Treatment of Primary Pyogenic Liver Abscess

Start: May 2009Est. completion: Dec 201124 patients
Phase 4Completed
NCT01302951BayerMoxifloxacin

Penetration of Moxifloxacin Into Liver Tissue of Patients Undergoing Liver Resection.

Start: Jul 2008Est. completion: Jul 201034 patients
Phase 4Completed
NCT00656747BayerAvelox

Moxifloxacin Versus Amoxicillin Clavulanic Acid in Treatment of Acute Exacerbation of Chronic Bronchitis

Start: Mar 2008Est. completion: Dec 20101,372 patients
Phase 4Completed
NCT00493038BayerAvelox

Study to Evaluate the Efficacy and Safety of Moxifloxacin Versus Amoxicillin/Clavulanate in the Treatment of Acute Bacterial Rhinosinusitis

Start: Feb 2006Est. completion: Jan 2008293 patients
Phase 4Terminated
NCT00288223SanofiTelithromycin

Telithromycin in Acute Exacerbation of Chronic Bronchitis

Start: Jan 2006Est. completion: Jan 200754 patients
Phase 4Terminated
NCT00315601SanofiTelithromycin

Intrapulmonary Pharmacokinetics of Antibiotics

Start: Jan 2006Est. completion: Nov 200635 patients
Phase 4Terminated
NCT00245440SanofiTelithromycin

Study to Measure the Impact of Antibiotics on Bacterial Flora in Adults With Acute Sinusitis

Start: Dec 2005Est. completion: Jul 2006192 patients
Phase 4Terminated
NCT00237445SanofiTelithromycin

Study Comparing the Clinical Efficacy and Health Outcomes of Outpatients With Mild to Moderate Community-Acquired Pneumonia (CAP) Treated With Either Telithromycin Once Daily for 7 Days, or Azithromycin Once Daily for 5 Days

Start: Nov 2005Est. completion: Sep 2006110 patients
Phase 4Terminated
NCT00245453SanofiTelithromycin

Outpatient Registry Trial of Respiratory Tract Infections in Adults

Start: Oct 2005Est. completion: Jul 20060
Phase 4Withdrawn
NCT00261105SanofiTelithromycin

Telithromycin in Respiratory Tract Infections

Start: Feb 2005Est. completion: Dec 2005
Phase 4Completed
NCT00174694SanofiTelithromycin

CHOOSE : Telithromycin, Acute Bacterial Sinusitis

Start: Nov 2004298 patients
Phase 4Completed
NCT00239161Johnson & Johnsonlevofloxacin

Safety and Efficacy Study of the Treatment of Kidney Infections With Short Course Levofloxacin

Start: Sep 2004Est. completion: Jul 200530 patients
Phase 4Terminated
NCT00668304BayerAvelox

Trial to Evaluate Time to Symptom Relief and Elimination of Infecting Bacteria in Treating Sinusitis With Avelox

Start: Jun 2004Est. completion: Jan 2005192 patients
Phase 4Completed
NCT00546676SanofiTelithromycin

Ketek in CAP / AECB in Ambulatory Adult Patients

Start: May 2004Est. completion: Dec 2004174 patients
Phase 4Completed
NCT00132938SanofiTelithromycin

PERSPECTIVE: Telithromycin - Acute Exacerbation of Chronic Bronchitis

Start: Jan 2004Est. completion: May 20065,660 patients
Phase 4Completed
NCT00236912Johnson & Johnsonlevofloxacin

A Study Comparing Safety and Efficacy of Levofloxacin and Metronidazole Versus Piperacillin/Tazobactam in Treating Complicated Appendicitis

Start: Jul 2003Est. completion: Sep 2004139 patients
Phase 4Terminated
NCT00538018SanofiTelithromycin

Telithromycin, Treating Adult Outpatients With Mild to Moderate Community-acquired Pneumonia (CAP) in High Bacterial Resistance Areas

Start: Jan 2003Est. completion: Jun 2004978 patients
Phase 4Completed
NCT00538148SanofiTelithromycin

Telithromycin: in the Treatment of Acute Exacerbation of Chronic Bronchitis in Adult Outpatients With COPD

Start: Nov 2002Est. completion: Sep 2004668 patients
Phase 4Completed
NCT00665327BayerAvelox

Avelox for Treatment of Elderly Patients With Community Acquired Pneumonia

Start: Nov 2002Est. completion: Apr 2004401 patients
Phase 4Completed
NCT00374959Rocheceftriaxone

Prevention of Pneumonia Comparing Ceftriaxone With Subglottic Aspiration

Start: Oct 2000Est. completion: Oct 200380 patients
Phase 4Completed
NCT00828971BayerAvelox

A Study to Assess Efficacy and Safety of IV/PO Moxifloxacin in the Treatment of cSSSIs

Start: Nov 2008Est. completion: Oct 200916 patients
Phase 3Completed
NCT00717561BayerAvelox

A Study to Assess the Efficacy and Safety of IV/PO Moxifloxacin in Subjects With Community-acquired Pneumonia

Start: Feb 2008Est. completion: Jun 200960 patients
Phase 3Completed
NCT00453349BayerAvelox

A Trial Comparing Moxifloxacin Versus Levofloxacin Plus Metronidazole In Uncomplicated Pelvic Inflammatory Disease

Start: Jan 2007Est. completion: May 2008460 patients
Phase 3Completed
NCT00402688Johnson & Johnsonlevofloxacin

An Effectiveness and Safety Study for Levofloxacin in Chronic Prostatitis

Start: Nov 2006Est. completion: Sep 2008242 patients
Phase 3Completed
NCT00402727BayerAvelox

Comparison of Sequential IV/PO Moxifloxacin With IV Piperacillin/Tazobactam Followed by PO Amoxicillin/Clavulanic Acid in Patients With a Complicated Skin and Skin Structure Infection

Start: Sep 2006Est. completion: Jun 2008813 patients
Phase 3Completed
NCT00492726BayerAvelox

Therapy of Complicated Intra-Abdominal Infections With Moxifloxacin or Ertapenem

Start: Jul 2006Est. completion: Feb 2009804 patients
Phase 3Completed
NCT00326287Basilea PharmaceuticaCeftobiprole medocaril

Ceftobiprole in the Treatment of Patients With Community-Acquired Pneumonia

Start: Jun 2006Est. completion: Jul 2007
Phase 3Completed
NCT00315549SanofiTelithromycin

TELI TAD - Telithromycin in Tonsillitis in Adolescents and Adults

Start: Feb 2006Est. completion: Sep 2006233 patients
Phase 3Terminated
NCT00315003SanofiTelithromycin

TELI COM - Telithromycin in Children With Otitis Media

Start: Jan 2006Est. completion: Jul 20061,500 patients
Phase 3Terminated
NCT00629135BayerMoxifloxacin

Moxifloxacin Plus Metronidazole Versus Piperacillin/Tazobactam for the Treatment of Patients With Intra-abdominal Abscesses

Start: Nov 2005Est. completion: Aug 2011180 patients
Phase 3Completed
NCT00229008Basilea Pharmaceuticaceftobiprole plus placebo

Ceftobiprole in Hospital Acquired Pneumonia

Start: Nov 2005Est. completion: May 2007
Phase 3Completed
NCT00174811SanofiTelithromycin

Comparative Study to Evaluate the Efficacy and Safety of Telithromycin Given Once Daily Versus Cefuroxime Axetil Given Twice Daily in Children With Middle Ear Infections

Start: Jun 2005Est. completion: Jun 2006639 patients
Phase 3Terminated
NCT00210964Basilea Pharmaceuticaceftobiprole plus placebo

Ceftobiprole in Hospital Acquired Pneumonia

Start: Apr 2005Est. completion: May 2007
Phase 3Completed
NCT00492024BayerAvelox

BAY12-8039: 5 Days for Sinusitis vs Placebo

Start: Jan 2005Est. completion: Mar 2008374 patients
Phase 3Completed
NCT00210886Johnson & Johnsonlevofloxacin

A Comparison of the Effectiveness and Safety of Levofloxacin to That of Ciprofloxacin in Treating Complicated Urinary Tract Infection and Acute Pyelonephritis.

Start: Oct 2004Est. completion: Apr 20061,109 patients
Phase 3Completed
NCT00473460BayerAvelox

Intermittent Moxifloxacin Therapy For The Prevention Of Acute Exacerbations In Patients With Chronic Bronchitis

Start: Oct 2004Est. completion: Jan 20071,404 patients
Phase 3Completed
NCT00211016Johnson & Johnsondoripenem

Doripenem in the Treatment of Ventilator-Associated Pneumonia

Start: Aug 2004Est. completion: Oct 2006318 patients
Phase 3Completed
NCT00408135SanofiTelithromycin

Japanese Study Evaluating Safety, Efficacy and Acceptability of Telithromycin in Children With Infections

Start: Aug 2004Est. completion: May 2005111 patients
Phase 3Completed
NCT00211003Johnson & Johnsondoripenem

Doripenem in the Treatment of Hospital-Acquired Pneumonia

Start: May 2004Est. completion: Oct 2006240 patients
Phase 3Completed
NCT00210938Johnson & Johnsondoripenem

Doripenem in the Treatment of Complicated Intra-Abdominal Infections

Start: Mar 2004Est. completion: Jan 2006478 patients
Phase 3Completed
NCT00210990Johnson & Johnsondoripenem

Doripenem in the Treatment of Complicated Lower Urinary Tract Infection or Pyelonephritis

Start: Mar 2004Est. completion: Apr 2006403 patients
Phase 3Completed
NCT00638859SanofiTelithromycin

Japanese Study Evaluating the Effects of Telithromycin in Children With Community-Acquired Pneumonia

Start: Mar 2004Est. completion: Oct 200456 patients
Phase 3Completed
NCT00638534SanofiTelithromycin

Japanese Study Evaluating the Effects of Telithromycin in Children With Acute Otitis Media

Start: Feb 2004Est. completion: Oct 200456 patients
Phase 3Completed
NCT00431678BayerAvelox

Efficacy and Safety of Sequential IV/PO Moxifloxacin in Comparison to IV Levofloxacin Plus IV Ceftriaxone Followed by PO Levofloxacin, in the Treatment of Patients With Community-acquired Pneumonia

Start: Jan 2004Est. completion: Jul 2005738 patients
Phase 3Completed
NCT00229021Johnson & Johnsondoripenem

Doripenem in the Treatment of Complicated Lower Urinary Tract Infection or Pyelonephritis

Start: Dec 2003Est. completion: Mar 2006741 patients
Phase 3Completed

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Phase Legend

Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available

Key Insights

11 late-stage (Phase 3) programs — potential near-term approvals
15 companies competing in this space

Related Indications

HIV Infections(449)COVID-19(223)Hepatitis C(191)Influenza(173)HIV(138)HIV-1-infection(115)Hepatitis C, Chronic(94)Chronic Hepatitis B(93)Chronic Hepatitis C(91)Covid19(79)