Persistent Atrial Fibrillation

Cardiovascular
3
Pipeline Programs
4
Companies
40
Clinical Trials
2
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
0
0
0
0
0
3
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Small Molecule
1100%
+ 3 programs with unclassified modality

On Market (2)

Approved therapies currently available

Sanofi
AVAPROApproved
irbesartan
Sanofi
Angiotensin 2 Receptor Blocker [EPC]oral1997
U
IRBESARTANApproved
irbesartan
Unknown Company
Angiotensin 2 Receptor Blocker [EPC]oral2018

Competitive Landscape

4 companies ranked by most advanced pipeline stage

Sanofi
SanofiPARIS, France
1 program
1
AVAPRO(irbesartan)Phase 4Small Molecule5 trials
Active Trials
NCT00317915Completed
NCT02842359Completed11Est. Apr 2018
NCT01625494Completed158Est. Jan 2013
+2 more trials
Rhythm Pharmaceuticals
1 program
CryoballoonN/A1 trial
Active Trials
NCT03706677Completed69Est. Apr 2023
Biotronik
BiotronikGermany - Berlin
1 program
Insertable Cardiac MonitorN/A1 trial
Active Trials
NCT04190186Completed55Est. Feb 2024
Abbott
AbbottABBOTT PARK, IL
1 program
Substrate+mCPVAN/A1 trial
Active Trials
NCT02571218Completed81Est. Feb 2017

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
Sanofiirbesartan
Sanofiirbesartan
Sanofiirbesartan
Sanofiirbesartan
Sanofiirbesartan
Sanofiirbesartan
Sanofiirbesartan
Sanofiirbesartan
Sanofiirbesartan
Sanofiirbesartan
Sanofiirbesartan
Sanofiirbesartan
Sanofiirbesartan
Sanofiirbesartan
Sanofiirbesartan

Showing 15 of 39 trials with date data

Clinical Trials (40)

Total enrollment: 40,231 patients across 40 trials

Evaluation of the Fixed-dose Combination of Irbesartan/Atorvastatin in Type 2 Diabetic Patients Diagnosed With Hyperlipidemia and Hypertension

Start: Aug 2016Est. completion: Apr 201811 patients
Phase 4Completed

Irbesartan and Adhesion Molecules in AF

Start: May 2009Est. completion: May 201060 patients
Phase 4Unknown

ACTUAL: Efficacy and Safety of Irbesartan/Hydrochlorothiazide Combination

Start: Jun 2008Est. completion: Jul 2009832 patients
Phase 4Completed

Irbesartan/Hydrochlorothiazide to Control Elevated Blood Pressure to Target in Moderate to Severe Hypertensive Patients

Start: Apr 2008503 patients
Phase 4Completed

Efficacy of Irbesartan/Hydrochlorothiazide Versus Valsartan/Hydrochlorothiazide in Mild to Moderate Hypertension

Start: Jul 2007Est. completion: Jan 20101,617 patients
Phase 4Completed

Irbesartan/Hydrochlorothiazide National Taiwan University Hospital Listing

Start: Sep 200660 patients
Phase 4Completed

Irbesartan in Chinese Hypertensive Diabetics With Microalbuminuria

Start: May 2006Est. completion: Jun 2008192 patients
Phase 4Completed

I SELECT - Irbesartan In Hypertensive Patients With Left Ventricular Hypertrophy

Start: Mar 2006Est. completion: Jun 2008281 patients
Phase 4Completed

I SAVE - Irbesartan in Mild to Moderate Hypertensive Patients

Start: Feb 2006Est. completion: Nov 20061,630 patients
Phase 4Completed

Irbesartan in the Treatment of Hypertensive Patients With Metabolic Syndrome

Start: Nov 2005Est. completion: Feb 2007400 patients
Phase 4Completed

Irbesartan in Hypertension

Start: Sep 200588 patients
Phase 4Completed

APROVE : Irbesartan in Hypertension

Start: Apr 2005200 patients
Phase 4Completed

Irbesartan, Ciprofibrate and Their Combination Onto the Endothelial Functions

Start: Feb 2005Est. completion: Aug 200760 patients
Phase 4Completed

Irbesartan Versus Placebo in Combination With Ramipril for Treatment of Albuminuria

Start: Sep 2004Est. completion: Nov 2005400 patients
Phase 4Completed

AMISH : Aprovel for Management of Isolated Systolic Hypertension

Start: Aug 2004436 patients
Phase 4Completed

Irbesartan-Hydrochlorothiazide Phase IV Study: Treatment of Hypertension in Chinese Population

Start: Dec 2003968 patients
Phase 4Completed

Irbesartan Effects on Endothelial Dysfunction in Hypertensive Type II Diabetic Patients Comparing Atenolol

Start: Oct 2003Est. completion: Apr 200544 patients
Phase 4Completed

The Efficacy and Safety of Irbesartan 150/12.5 mg and 300/25 mg in Patients With Mild Hypertension

Start: Jul 2003Est. completion: Aug 20041,005 patients
Phase 4Completed

Evaluation of Efficacy and Safety of the Dosage Adjustment of Aprovel® (Irbesartan) in Hypertensive Outpatients in Current Clinical Practice

Start: Feb 2003Est. completion: Dec 2004115 patients
Phase 4Completed

Effect of the Angiotensin II Receptor Antagonist Irbesartan on Biochemical and Functional Markers of Endothelial Dysfunction in Patients With Hypertension

Start: Jul 2002Est. completion: Jan 2005108 patients
Phase 4Completed

Irbesartan in Type 2 Diabetes

Phase 3Completed

Study of Efficacy and Safety of Irbesartan/Amlodipine 4 Fixed Combination Therapy in Hypertensive Patients Uncontrolled on Irbesartan or Amlodipine Monotherapy

Start: May 2012Est. completion: Jan 2013158 patients
Phase 3Completed

Irbesartan/Amlodipine in Hypertensive Patients Uncontrolled on Amlodipine 5 mg Monotherapy

Start: Jul 2009Est. completion: Aug 2010406 patients
Phase 3Completed

Irbesartan/Amlodipine in Hypertensive Patients Uncontrolled on Irbesartan 150 mg Monotherapy

Start: Jul 2009Est. completion: Sep 2010435 patients
Phase 3Completed

Evaluation of Irbesartan on Hepatic Fibrosis in Chronic Hepatitis C

Start: Oct 2006Est. completion: Nov 2013166 patients
Phase 3Completed

ARCHIPELAGO: Irbesartan in Patients With Acute Coronary Syndrome Without ST Segment Elevation

Start: Feb 2006440 patients
Phase 3Completed

Irbesartan for the Prevention of Atrial Arrhythmias and Cardiac Electrical Remodeling in Patients With Hypertension and Permanent Pacemakers

Start: Dec 2005Est. completion: Jul 2007200 patients
Phase 3Unknown

Irbesartan/Hydrochlorothiazide and Irbesartan in the Treatment of Mild to Moderate Hypertension

Start: Jun 200540 patients
Phase 3Completed

Irbesartan/Hydrochlorothiazide (HCTZ) Combination Therapy for Patients With Moderate Hypertension

Start: Oct 2004Est. completion: Jun 2005496 patients
Phase 3Completed

Irbesartan/Hydrochlorothiazide (HCTZ) Combination Therapy as First Line Treatment for Severe Hypertension

Start: Sep 2004Est. completion: May 2005645 patients
Phase 3Completed

Randomized, Parallel, Comparison, Double-Blind Efficacy & Safety Study of APROVEL Versus Placebo in Chinese Patients With Hypertensive Type II Diabetic Patients With Microalbuminuria

Start: Jan 2004Est. completion: Jul 2005241 patients
Phase 3Completed

Atrial Fibrillation Clopidogrel Trial With Irbesartan for Prevention of Vascular Events (ACTIVE W)

Start: Jul 2003Est. completion: Sep 20056,706 patients
Phase 3Terminated

Atrial Fibrillation Clopidogrel Trial With Irbesartan for Prevention of Vascular Events (ACTIVE I)

Start: Jun 2003Est. completion: Aug 20099,016 patients
Phase 3Completed

Atrial Fibrillation Clopidogrel Trial With Irbesartan for Prevention of Vascular Events (ACTIVE A)

Start: Jun 2003Est. completion: Mar 20097,554 patients
Phase 3Completed

Irbesartan in Heart Failure With Preserved Systolic Function (I-Preserve)

Start: Jun 2002Est. completion: Jul 20084,128 patients
Phase 3Completed

Irbesartan and Atenolol in Hypertensive Heart Disease

Start: Apr 1995Est. completion: Apr 1997115 patients
Phase 2/3Completed

Irbesartan and Amlodipine Combination in Controlling Blood Pressure

Start: Jul 2009Est. completion: Jan 2010270 patients
Phase 2Completed
NCT04190186BiotronikInsertable Cardiac Monitor

Hybrid Ablation Plus Medical Therapy for Persistent Atrial Fibrillation

Start: Jun 2020Est. completion: Feb 202455 patients
N/ACompleted

FIRE AND ICE II Trial Pilot

Start: Apr 2019Est. completion: Apr 202369 patients
N/ACompleted
NCT02571218AbbottSubstrate+mCPVA

AF Substrate Mapping and Guided Ablation

Start: Jul 2015Est. completion: Feb 201781 patients
N/ACompleted

Related Jobs in Cardiovascular

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

4 companies competing in this space