Pancreatic Neoplasms

Oncology
15
Pipeline Programs
15
Companies
23
Clinical Trials
1 recruiting
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
3
3
8
0
1
0
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Monoclonal Antibody
1100%
+ 18 programs with unclassified modality

Competitive Landscape

14 companies ranked by most advanced pipeline stage

Sanofi
SanofiPARIS, France
2 programs
1
1
LeucovorinPhase 33 trials
oxaliplatinPhase 1/21 trial
Active Trials
NCT00242190Completed40Est. Feb 2010
NCT01121848Completed108Est. Oct 2013
NCT00210184Completed42Est. Apr 2010
+1 more trials
Boehringer Ingelheim
Boehringer IngelheimINGELHEIM, Germany
3 programs
1
2
BI 2536Phase 21 trial
brigimadlinPhase 21 trial
BI 2536, intravenousPhase 11 trial
Active Trials
NCT02215044Terminated12
NCT00710710Completed89Est. Oct 2008
NCT05512377Completed99Est. Sep 2025
CT
2 programs
2
PenpulimabPhase 2Monoclonal Antibody1 trial
TQB2868 injectionPhase 21 trial
Active Trials
NCT05493995CompletedEst. May 2024
NCT06767813RecruitingEst. Nov 2026
M&
Merck & Co.RAHWAY, NJ
1 program
1
ARQ 197Phase 21 trial
Active Trials
NCT00558207Completed43Est. Apr 2008
Eli Lilly and Company
Eli Lilly and CompanyINDIANAPOLIS, IN
1 program
1
GemcitabinePhase 21 trial
Active Trials
NCT00191568Completed45Est. May 2007
Pfizer
PfizerNEW YORK, NY
1 program
1
PX-12Phase 2
Genomics
GenomicsUK - Oxford
1 program
1
PX-12Phase 21 trial
Active Trials
NCT00417287Terminated17Est. Apr 2009
Heidelberg Pharma
Heidelberg PharmaGermany - Ladenburg
2 programs
1
neoadjuvant short course IMRTPhase 1/21 trial
strength trainingN/A1 trial
Active Trials
NCT01395563Withdrawn0Est. Dec 2011
NCT01372735Unknown46Est. Aug 2017
Bayer
BayerLEVERKUSEN, Germany
1 program
1
BAY86-9766+GemcitabinePhase 1/21 trial
Active Trials
NCT01251640Completed90Est. Aug 2013
Biogen
BiogenCAMBRIDGE, MA
1 program
1
Bardoxolone methylPhase 14 trials
Active Trials
NCT01598363Completed32Est. Jul 2012
NCT01549769Terminated24Est. Oct 2013
NCT00664027Completed80Est. May 2009
+1 more trials
Genentech
GenentechCA - Oceanside
1 program
1
DMUC4064APhase 11 trial
Active Trials
NCT02146313Completed35Est. Jun 2018
AstraZeneca
AstraZenecaCAMBRIDGE, United Kingdom
1 program
LYNPARZA Pancreas Cancer Japan Post-Marketing Surveillance (PMS)N/A1 trial
Active Trials
NCT04889404Completed130Est. Feb 2025
Verona Pharma
Verona PharmaUK - London
1 program
Pancreaticoduodenectomy with portal vein resectionN/A1 trial
Active Trials
NCT04053998CompletedEst. Feb 2020
RenovoRx
RenovoRxMOUNTAIN VIEW, CA
1 program
RenovoCath™ R120 CatheterN/A1 trial
Active Trials
NCT02591082CompletedEst. Feb 2021

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
SanofiLeucovorin
Chia Tai TianQing Pharmaceutical GroupTQB2868 injection
Boehringer Ingelheimbrigimadlin
Chia Tai TianQing Pharmaceutical GroupPenpulimab
BiogenBardoxolone methyl
Merck & Co.ARQ 197
GenomicsPX-12
Boehringer IngelheimBI 2536
SanofiLeucovorin
Eli Lilly and CompanyGemcitabine
SanofiLeucovorin
Heidelberg Pharmaneoadjuvant short course IMRT
BayerBAY86-9766+Gemcitabine
Sanofioxaliplatin
GenentechDMUC4064A

Showing 15 of 23 trials with date data

Clinical Trials (23)

Total enrollment: 1,040 patients across 23 trials

NCT01121848SanofiLeucovorin

Randomized Study With Oxaliplatin in 2nd Line Pancreatic Cancer

Start: Jul 2010Est. completion: Oct 2013108 patients
Phase 3Completed
NCT06767813Chia Tai TianQing Pharmaceutical GroupTQB2868 injection

Clinical Study of TQB2868 Injection Combined With Anlotinib Capsule and Chemotherapy in the First-line Treatment of Metastatic Pancreatic Neoplasms

Start: Mar 2024Est. completion: Nov 2026
Phase 2Recruiting
NCT05512377Boehringer Ingelheimbrigimadlin

Brightline-2: A Study to Test Whether Brigimadlin (BI 907828) Helps People With Cancer in the Biliary Tract, Pancreas, Lung or Bladder

Start: Dec 2022Est. completion: Sep 202599 patients
Phase 2Completed
NCT05493995Chia Tai TianQing Pharmaceutical GroupPenpulimab

A Study of Penpulimab and Anlotinib Plus Nab-paclitaxel and Gemcitabine for Metastatic Pancreatic Cancer.

Start: Jul 2022Est. completion: May 2024
Phase 2Completed
NCT00664027BiogenBardoxolone methyl

Phase IIa Trial to Determine the Effects of Bardoxolone Methyl on Renal Function in Patients With Diabetic Nephropathy

Start: Apr 2008Est. completion: May 200980 patients
Phase 2Completed
NCT00558207Merck & Co.ARQ 197

A Randomized Phase 2 Study of ARQ 197 Versus Gemcitabine in Treatment-Naïve Patients With Unresectable Locally Advanced or Metastatic Pancreatic Adenocarcinoma

Start: Nov 2007Est. completion: Apr 200843 patients
Phase 2Completed
NCT00417287GenomicsPX-12

Phase II Study of PX-12 in Patients With Advanced Pancreatic Cancer

Start: Dec 2006Est. completion: Apr 200917 patients
Phase 2Terminated
NCT00710710Boehringer IngelheimBI 2536

Open, Randomized Phase II Trial to Investigate the Efficacy and Safety of the PLK-1 Inhibitor BI 2536 in Patients With Advanced, Unresectable Pancreatic Cancer

Start: Aug 2006Est. completion: Oct 200889 patients
Phase 2Completed
NCT00210184SanofiLeucovorin

Evaluation of Efficacy and Safety of FOLFIRI Association Treatment in Patients 70 Years of Age and Older With Gastric Cancer

Start: Jul 2004Est. completion: Apr 201042 patients
Phase 2Completed
NCT00191568Eli Lilly and CompanyGemcitabine

Gemcitabine, Oxaliplatin and Radiotherapy in Treating Patients With Completely Resected Pancreatic Cancer

Start: Oct 2002Est. completion: May 200745 patients
Phase 2Completed
NCT00003305SanofiLeucovorin

Aminopterin in Treating Patients With Refractory Leukemia

Start: Jul 1997Est. completion: Sep 200775 patients
Phase 2Completed
NCT01372735Heidelberg Pharmaneoadjuvant short course IMRT

Trial of Neoadjuvant Short Course IMRT Followed by Surgery and IORT for Resectable Pancreatic Cancer

Start: Aug 2011Est. completion: Aug 201746 patients
Phase 1/2Unknown
NCT01251640BayerBAY86-9766+Gemcitabine

Combination With Gemcitabine in Advanced Pancreatic Cancer

Start: Jan 2011Est. completion: Aug 201390 patients
Phase 1/2Completed
NCT00242190Sanofioxaliplatin

Gemcitabine, Oxaliplatin and Radiation Therapy in Pancreatic Cancer

Start: Jun 2004Est. completion: Feb 201040 patients
Phase 1/2Completed
NCT02146313GenentechDMUC4064A

A Study Evaluating the Safety and Pharmacokinetics of DMUC4064A in Participants With Platinum-Resistant Ovarian Cancer or Unresectable Pancreatic Cancer

Start: Jun 2014Est. completion: Jun 201835 patients
Phase 1Completed
NCT01598363BiogenBardoxolone methyl

An Open-Label Study of the Effect of Bardoxolone Methyl on the Single Dose Pharmacokinetics of Digoxin and Rosuvastatin in Healthy Volunteers

Start: Jun 2012Est. completion: Jul 201232 patients
Phase 1Completed
NCT01549769BiogenBardoxolone methyl

Pharmacokinetic and Pharmacodynamic Study of Bardoxolone Methyl in Patients With Chronic Kidney Disease and Type 2 Diabetes

Start: Apr 2012Est. completion: Oct 201324 patients
Phase 1Terminated
NCT00529113BiogenBardoxolone methyl

Study With Gemcitabine and RTA 402 for Patients With Unresectable Pancreatic Cancer

Start: Sep 2007Est. completion: Nov 200933 patients
Phase 1Terminated
NCT02215044Boehringer IngelheimBI 2536, intravenous

Dose-finding Study of BI 2536 Administered in Combination With Gemcitabine in Patients With Locally Advanced or Metastatic Pancreatic Cancer

Start: Jun 200712 patients
Phase 1Terminated
NCT04889404AstraZenecaLYNPARZA Pancreas Cancer Japan Post-Marketing Surveillance (PMS)

LYNPARZA Pancreas Cancer Japan Post-Marketing Surveillance (PMS)

Start: May 2021Est. completion: Feb 2025130 patients
N/ACompleted
NCT04053998Verona PharmaPancreaticoduodenectomy with portal vein resection

Benchmarking Outcomes in Pancreatic Surgery - WhippleBenchmarks.Org

Start: Aug 2019Est. completion: Feb 2020
N/ACompleted
NCT02591082RenovoRxRenovoCath™ R120 Catheter

Intra-Arterial Treatment of Pancreatic Cancer Using the RenovoCath™ RC120 Catheter

Start: Dec 2015Est. completion: Feb 2021
N/ACompleted
NCT01395563Heidelberg Pharmastrength training

Strength Training on Pancreatic Cancer

Start: Jan 2009Est. completion: Dec 20110
N/AWithdrawn

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Phase Legend

Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available

Key Insights

1 late-stage (Phase 3) programs — potential near-term approvals
1 actively recruiting trials targeting 1,040 patients
15 companies competing in this space

Related Indications

Breast Cancer(530)Non-small Cell Lung Cancer(373)Prostate Cancer(371)Multiple Myeloma(244)Advanced Solid Tumors(221)Acute Myeloid Leukemia(204)Cancer(187)Neoplasms(173)Colorectal Cancer(166)Advanced Solid Tumor(165)