Non-Small Cell Lung Cancer (NSCLC)

Oncology
32
Pipeline Programs
18
Companies
50
Clinical Trials
8 recruiting
2
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
10
7
9
0
4
2
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Monoclonal Antibody
770%
Small Molecule
220%
ADC
110%
+ 27 programs with unclassified modality

On Market (2)

Approved therapies currently available

DS
DATROWAYApproved
datopotamab deruxtecan
Daiichi Sankyo
iv (infusion)2025
Bristol Myers Squibb
OPDIVOApproved
nivolumab
Bristol Myers Squibb
injection2015

Competitive Landscape

18 companies ranked by most advanced pipeline stage

Bristol Myers Squibb
6 programs
1
1
2
1
PumitamigPhase 31 trial
nivolumabPhase 3Monoclonal Antibody1 trial
PaclitaxelPhase 25 trials
IpilimumabPhase 1/2Monoclonal Antibody1 trial
Approved Non-small Cell Lung CancerN/A1 trial
+1 more programs
Active Trials
NCT06448793Recruiting55Est. Jun 2026
NCT07215962Active Not Recruiting300Est. Mar 2026
NCT02221739Completed39Est. Oct 2015
+7 more trials
DS
Daiichi SankyoChina - Shanghai
5 programs
3
1
1
Datopotamab deruxtecanPhase 3ADC1 trial
DS-1205cPhase 12 trials
HER3-DXdPhase 11 trial
HER3-DXdPhase 11 trial
No drugN/A1 trial
Active Trials
NCT06617390Completed1,041Est. Jul 2025
NCT03255083Terminated13Est. Sep 2020
NCT03599518Terminated20Est. Jun 2020
+3 more trials
E
EisaiChina - Liaoning
1 program
1
EribulinPhase 31 trial
Active Trials
NCT01454934Completed540Est. May 2016
Regeneron
RegeneronTARRYTOWN, NY
3 programs
1
1
Alirocumab and CemiplimabPhase 2Monoclonal Antibody1 trial
S095018Phase 1/21 trial
CemiplimabN/AMonoclonal Antibody1 trial
Active Trials
NCT06132191Approved For Marketing
NCT06162572Active Not Recruiting100Est. Jul 2027
NCT05553834Active Not Recruiting60Est. Mar 2026
Genentech
GenentechCA - Oceanside
3 programs
1
2
ABT-869 .25 mg/kgPhase 2
BevacizumabPhase 2Monoclonal Antibody
AlectinibPhase 1/2Small Molecule1 trial
Active Trials
NCT02521051Terminated11Est. Apr 2022
Takeda
TakedaTOKYO, Japan
2 programs
1
TAK-788Phase 21 trial
A Chart Review Study of Adults With Advanced NSCLCN/A1 trial
Active Trials
NCT05207423Completed179Est. Feb 2023
NCT04576208Withdrawn0Est. Jul 2022
M&
Merck & Co.RAHWAY, NJ
2 programs
1
1
PembrolizumabPhase 2Monoclonal Antibody1 trial
HER3-DXdPhase 1
Active Trials
NCT03197467Completed30Est. May 2023
Abbott
AbbottABBOTT PARK, IL
1 program
1
ABT-869 .25 mg/kgPhase 21 trial
Active Trials
NCT00517790Completed140Est. Jun 2012
Celldex Therapeutics
1 program
1
FLT3 Ligand TherapyPhase 21 trial
Active Trials
NCT02839265Completed33Est. Nov 2024
Corcept Therapeutics
Corcept TherapeuticsCA - Redwood City
1 program
1
MifepristonePhase 21 trial
Active Trials
NCT02642939Terminated3Est. Oct 2020
REVOLUTION Medicines
REVOLUTION MedicinesREDWOOD CITY, CA
5 programs
3
2
ElironrasibPhase 1/21 trial
RMC-6236Phase 1/21 trial
RMC-5127Phase 11 trial
RMC-6291Phase 11 trial
RMC-9805Phase 11 trial
Active Trials
NCT07349537Recruiting574Est. Oct 2028
NCT05462717Active Not Recruiting222Est. Dec 2025
NCT06040541Recruiting604Est. Apr 2027
+2 more trials
Philogen
PhilogenItaly - Monteriggioni
1 program
1
F16IL2Phase 1/21 trial
Active Trials
NCT05468294Unknown3Est. Jul 2022
Pierre Fabre
Pierre FabreFrance - Aignan
1 program
1
STX-241Phase 1/21 trial
Active Trials
NCT06567015Recruiting171Est. Jul 2030
Bavarian Nordic
Bavarian NordicDenmark - Kvistgard
1 program
1
CV301Phase 11 trial
Active Trials
NCT02840994Completed24Est. Jan 2020
Sanofi
SanofiPARIS, France
1 program
1
ZD6474Phase 11 trial
Active Trials
NCT00807170Terminated5Est. Aug 2010
Astellas
AstellasChina - Shenyang
1 program
1
gilteritinibPhase 1Small Molecule1 trial
Active Trials
NCT07140016Recruiting40Est. Dec 2029
Roche
RocheSTAVANGER NORWAY, Norway
1 program
Actigraphy deviceN/A1 trial
Active Trials
NCT04751162Completed71Est. May 2023
Varian Medical Systems
1 program
Calypso Beacon ImplantationN/A1 trial
Active Trials
NCT02111681CompletedEst. Jul 2024

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
2028
2029
2030
2031
Bristol Myers SquibbPumitamig
Daiichi SankyoDatopotamab deruxtecan
Bristol Myers Squibbnivolumab
Bristol Myers SquibbPaclitaxel
EisaiEribulin
Bristol Myers SquibbPaclitaxel
Bristol Myers SquibbPaclitaxel
Bristol Myers SquibbPaclitaxel
Bristol Myers SquibbPaclitaxel
Bristol Myers SquibbPaclitaxel
RegeneronAlirocumab and Cemiplimab
TakedaTAK-788
Merck & Co.Pembrolizumab
Celldex TherapeuticsFLT3 Ligand Therapy
Corcept TherapeuticsMifepristone

Showing 15 of 49 trials with date data

Clinical Trials (50)

Total enrollment: 9,589 patients across 50 trials

A Study to Evaluate the Efficacy of Pumitamig Versus Pembrolizumab in Participants With Previously Untreated Advanced Non-Small Cell Lung Cancer and PD-L1 ≥ 50%. (ROSETTA Lung-202)

Start: Apr 2026Est. completion: Oct 2031750 patients
Phase 3Not Yet Recruiting
NCT07291037Daiichi SankyoDatopotamab deruxtecan

Phase III Study of Datopotamab Deruxtecan Versus Docetaxel in Previously Treated TROP2-positive Advanced or Metastatic Non-squamous NSCLC Without Actionable Genomic Alterations

Start: Oct 2025Est. completion: Jan 2029400 patients
Phase 3Recruiting

A Study of Nivolumab and Ipilimumab in Untreated Participants With Stage 3 Non-small Cell Lung Cancer (NSCLC) That is Unable or Not Planned to be Removed by Surgery

Start: Oct 2019Est. completion: Nov 2024925 patients
Phase 3Completed

A Study to Compare BMS-936558 to the Physician's Choice of Either Dacarbazine or Carboplatin and Paclitaxel in Advanced Melanoma Patients That Have Progressed Following Anti-CTLA-4 Therapy (CheckMate 037)

Start: Dec 2012Est. completion: Dec 2020405 patients
Phase 3Completed

A Randomized, Open-label, Multicenter, Phase 3 Study to Compare the Efficacy and Safety of Eribulin With Treatment of Physician's Choice in Subjects With Advanced Non-Small Cell Lung Cancer

Start: Dec 2011Est. completion: May 2016540 patients
Phase 3Completed

Study Comparing Weekly Taxol and Carboplatin vs Standard Taxol and Carboplatin Regimen for Stage IIIB or IV Non-Small-Cell Lung Cancer

Start: Jun 2000Est. completion: Dec 2004444 patients
Phase 3Completed

Maintenance Chemotherapy in Metastatic Breast Cancer

Start: Apr 1998Est. completion: Oct 2003524 patients
Phase 3Unknown

A Study of Izalontamab Brengitecan Versus Chemotherapy in Participants With Previously Untreated, Locally Advanced, Recurrent Inoperable, or Metastatic Triple-negative Breast Cancer Ineligible for Anti-PD(L)1 Drugs (IZABRIGHT-Breast01)

Start: Sep 2025Est. completion: May 2030500 patients
Phase 2/3Recruiting

A Phase II Trial Neoadjuvant Paclitaxel and Cisplatin in Patients With Locally Advanced Head and Neck Cancer

Start: May 2005Est. completion: Jun 200750 patients
Phase 2/3Completed

A Phase II Study of Paclitaxel, UFT, and Leucovorin in Patients With Metastatic Esophageal Cancer

Phase 2Unknown

Safety and Preliminary Effectiveness of BNT327, an Investigational Therapy for Breast Cancer, When Given in Combination With Chemotherapy

Start: Aug 2024Est. completion: Jun 202983 patients
Phase 2Active Not Recruiting
NCT05553834RegeneronAlirocumab and Cemiplimab

PCSK9 Inhibitor and PD-1 Inhibitor in Patients With Metastatic, Refractory To Prior Anti PD-1 Non-small Cell Lung

Start: May 2023Est. completion: Mar 202660 patients
Phase 2Active Not Recruiting

A Study to Evaluate the Impact of Management Strategies on Gastrointestinal-Related Adverse Events in Participants With Non-Small Cell Lung Cancer Harboring Epidermal Growth Factor Receptor (EGFR) Exon 20 Insertion Mutations Receiving TAK-788

Start: Nov 2020Est. completion: Jul 20220
Phase 2Withdrawn

Neoadjuvant Anti PD-1 Immunotherapy in Resectable Non-small Cell Lung Cancer

Start: Jun 2018Est. completion: May 202330 patients
Phase 2Completed

FLT3 Ligand Immunotherapy and Stereotactic Radiotherapy for Advanced Non-small Cell Lung Cancer

Start: Jul 2016Est. completion: Nov 202433 patients
Phase 2Completed

Study of Oral Mifepristone as Salvage Therapy in Patients With Advanced or Metastatic Non-Small Cell Lung Cancer

Start: Dec 2015Est. completion: Oct 20203 patients
Phase 2Terminated

Ph II of a Novel Anti-angiogenic Agent in Combination With Chemotherapy for the Treatment of Non-Small Cell Lung Cancer

Start: Jun 2009Est. completion: Aug 2013255 patients
Phase 2Terminated

Rollover Study of Weekly Paclitaxel (BMS-181339) in Patients With Advanced or Recurrent Esophageal Cancer

Start: Mar 2008Est. completion: Apr 20121 patients
Phase 2Completed
NCT00517790AbbottABT-869 .25 mg/kg

Study of ABT-869 in Subjects With Advanced Non-small Cell Lung Cancer (NSCLC)

Start: Aug 2007Est. completion: Jun 2012140 patients
Phase 2Completed

Rollover Study of Weekly Paclitaxel (BMS-181339) in Patients With Head and Neck Cancer

Start: Aug 2006Est. completion: Nov 200811 patients
Phase 2Completed

Phase II Study of Weekly Paclitaxel (BMS-181339)in Patients With Advanced or Recurrent Esophageal Cancer

Start: Jun 2006Est. completion: Mar 200853 patients
Phase 2Completed

Late Phase II Study of Weekly Paclitaxel (BMS-181339) in Patients With Advanced or Recurrent Head and Neck Cancer

Start: Oct 2005Est. completion: Oct 200636 patients
Phase 2Completed

Rollover Study of Weekly Paclitaxel (BMS-181339) in Patients With Advanced Breast Cancer

Start: Jun 2005Est. completion: Mar 20086 patients
Phase 2Completed

Early Phase II Study of Weekly Paclitaxel (BMS-181339) in Patient With Advanced or Recurrent Head and Neck Cancer

Start: Jan 2004Est. completion: Dec 200536 patients
Phase 2Completed

Phase II Study of Weekly Paclitaxel (BMS-181339) in Patient With Non-Small Cell Lung Cancer (NSCLC)

Start: Dec 2002Est. completion: Mar 200560 patients
Phase 2Completed

Paclitaxel and Carboplatin in Treating Patients With Metastatic Prostate Cancer That Has Not Responded to Hormone Therapy

Start: Oct 2002Est. completion: Mar 200958 patients
Phase 2Completed

Study for Patients With Non Small Cell Lung Cancer (NSCLC)

Start: Oct 2002Est. completion: Dec 200680 patients
Phase 2Unknown

Phase II Study of Weekly Paclitaxel (BMS-181339) in Patient With Breast Cancer

Start: Oct 2002Est. completion: Jul 200568 patients
Phase 2Completed

Paclitaxel, Carboplatin And Low Dose Radiation As Induction Therapy In Locally Advanced Head And Neck Cancer

Start: Sep 2002Est. completion: Jan 201726 patients
Phase 2Completed

Chemoradiotherapy of NSCLC Stage IIIB

Start: Mar 2002Est. completion: Dec 2006130 patients
Phase 2Completed

Weekly Paclitaxel and Trastuzumab in Metastatic Breast Cancer

Start: Feb 2001Est. completion: Dec 2009121 patients
Phase 2Completed

Weekly Paclitaxel, Low-Dose Estramustine, and Carboplatin in the Treatment of Hormone Refractory Prostate Carcinoma

Start: Aug 2000Est. completion: Feb 2007100 patients
Phase 2Completed

Paclitaxel, Carboplatin and Radiotherapy as Induction Therapy in Locally Advanced Head and Neck Cancer

Start: May 2000Est. completion: Oct 201240 patients
Phase 2Completed

Chemotherapy With or Without Surgical Resection in Locally Advanced Esophageal Cancer

Start: Oct 1999Est. completion: Jul 2007200 patients
Phase 2Completed

Study of FIH of STX-241 in Locally Advanced or Metastatic NSCLC Resistant to EGFR TKIs

Start: Sep 2024Est. completion: Jul 2030171 patients
Phase 1/2Recruiting

Phase 1b/2 Platform Study of Select Immunotherapy Combinations in Participants With Advanced Non-small Cell Lung Cancer (NSCLC)

Start: Aug 2024Est. completion: Jul 2027100 patients
Phase 1/2Active Not Recruiting

Study of Elironrasib and Daraxonrasib as Monotherapies and Combination Therapy in Participants With Advanced KRAS G12C Mutant Solid Tumors

Start: Nov 2023Est. completion: Jun 2029534 patients
Phase 1/2Recruiting

Study of RMC-6236 in Patients With Advanced Solid Tumors Harboring Specific Mutations in RAS

Start: May 2022Est. completion: Jul 2027754 patients
Phase 1/2Recruiting

Ultrasound-based Blood-brain Barrier Opening and Albumin-bound Paclitaxel and Carboplatin for Recurrent Glioblastoma

Start: Oct 2020Est. completion: Nov 202557 patients
Phase 1/2Active Not Recruiting

F16IL2 in Combination With Nivolumab in Patients With Non-small Cell Lung Cancer

Start: Mar 2017Est. completion: Jul 20223 patients
Phase 1/2Unknown

Phase I/II Trial of Alectinib and Bevacizumab in Patients With Advanced, Anaplastic Lymphoma Kinase (ALK)-Positive, Non-Small Cell Lung Cancer

Start: Sep 2015Est. completion: Apr 202211 patients
Phase 1/2Terminated

Study of Combined Ionizing Radiation and Ipilimumab in Metastatic Non-small Cell Lung Cancer (NSCLC)

Start: Jul 2014Est. completion: Oct 201539 patients
Phase 1/2Completed

A Study of Paclitaxel and Carboplatin in Combination With Bexarotene Oral Capsules in Patients With Advanced Lung Cancer

Start: Aug 2001Est. completion: Mar 200933 patients
Phase 1/2Terminated

Study of RMC-5127 in Patients With Advanced KRAS G12V-Mutant Solid Tumors

Start: Jan 2026Est. completion: Oct 2028574 patients
Phase 1Recruiting

A Study of Gilteritinib in Adults With Advanced ALK-positive Non-small Cell Lung Cancer (NSCLC)

Start: Sep 2025Est. completion: Dec 202940 patients
Phase 1Recruiting

Study of RMC-9805 in Participants With KRAS G12D-Mutant Solid Tumors

Start: Sep 2023Est. completion: Apr 2027604 patients
Phase 1Recruiting

Dose Escalation and Dose Expansion Study of RMC-6291 Monotherapy in Subjects With Advanced KRASG12C Mutant Solid Tumors

Start: Sep 2022Est. completion: Dec 2025222 patients
Phase 1Active Not Recruiting

HER3-DXd (Patritumab Deruxtecan; U3-1402) in Combination With Osimertinib in Subjects With Locally Advanced or Metastatic EGFR-mutated Non-Small Cell Lung Cancer

Start: Jun 2021Est. completion: Apr 2027246 patients
Phase 1Active Not Recruiting

DS-1205c With Osimertinib for Metastatic or Unresectable Epidermal Growth Factor Receptor (EGFR)-Mutant Non-Small Cell Lung Cancer

Start: Apr 2019Est. completion: Sep 202013 patients
Phase 1Terminated

DS-1205c With Gefitinib for Metastatic or Unresectable Epidermal Growth Factor Receptor (EGFR)-Mutant Non-Small Cell Lung Cancer

Start: Sep 2018Est. completion: Jun 202020 patients
Phase 1Terminated

Related Jobs in Oncology

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

4 late-stage (Phase 3) programs — potential near-term approvals
8 actively recruiting trials targeting 9,589 patients
18 companies competing in this space