Non-small Cell Lung Cancer Metastatic

Oncology
7
Pipeline Programs
7
Companies
7
Clinical Trials
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
2
1
2
0
2
0
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

ADC
150%
Small Molecule
150%
+ 5 programs with unclassified modality

Competitive Landscape

7 companies ranked by most advanced pipeline stage

Amgen
AmgenTHOUSAND OAKS, CA
1 program
1
CarboplatinPhase 31 trial
Active Trials
NCT01966003Completed642Est. Jul 2015
H
HutchmedChina - Hong Kong
1 program
1
SavolitinibPhase 3Small Molecule1 trial
Active Trials
NCT04923945Completed203Est. Nov 2024
DS
Daiichi SankyoChina - Shanghai
1 program
1
Patritumab DeruxtecanPhase 2ADC1 trial
Active Trials
NCT04619004Active Not Recruiting277Est. Jan 2026
Sanofi
SanofiPARIS, France
1 program
1
SAR408701Phase 21 trial
Active Trials
NCT04394624Terminated31Est. Oct 2024
Highlight Therapeutics
Highlight TherapeuticsSpain - Valencia
1 program
1
BO-112 in combination with ablative radiotherapyPhase 1/21 trial
Active Trials
NCT05265650Unknown30Est. Jun 2024
AstraZeneca
AstraZenecaCAMBRIDGE, United Kingdom
1 program
1
CTCPhase 11 trial
Active Trials
NCT01380795Terminated30Est. Jun 2019
BeyondSpring Pharmaceuticals
1 program
1
Nivolumab + PlinabulinPhase 11 trial
Active Trials
NCT02812667CompletedEst. Oct 2025

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
HutchmedSavolitinib
AmgenCarboplatin
Daiichi SankyoPatritumab Deruxtecan
SanofiSAR408701
Highlight TherapeuticsBO-112 in combination with ablative radiotherapy
BeyondSpring PharmaceuticalsNivolumab + Plinabulin
AstraZenecaCTC

Clinical Trials (7)

Total enrollment: 1,213 patients across 7 trials

NCT04923945HutchmedSavolitinib

Savolitinib for Treating Locally Advanced or Metastatic Non-small Cell Lung Cancer (NSCLC) Patients

Start: Aug 2021Est. completion: Nov 2024203 patients
Phase 3Completed
NCT01966003AmgenCarboplatin

Efficacy and Safety Study of ABP 215 Compared With Bevacizumab in Patients With Advanced Non-Small Cell Lung Cancer

Start: Nov 2013Est. completion: Jul 2015642 patients
Phase 3Completed
NCT04619004Daiichi SankyoPatritumab Deruxtecan

HERTHENA-Lung01: Patritumab Deruxtecan in Subjects With Metastatic or Locally Advanced EGFR-mutated Non-Small Cell Lung Cancer

Start: Feb 2021Est. completion: Jan 2026277 patients
Phase 2Active Not Recruiting
NCT04394624SanofiSAR408701

Tusamitamab Ravtansine (SAR408701) in Combination With Ramucirumab or Ramucirumab and Pembrolizumab in Pretreated Patients With NSQ NSCLC (CARMEN-LC04)

Start: Aug 2020Est. completion: Oct 202431 patients
Phase 2Terminated
NCT05265650Highlight TherapeuticsBO-112 in combination with ablative radiotherapy

Study of BO-112 With Radiotherapy and Nivolumab for Metastatic Refractory NSCLC

Start: Jun 2022Est. completion: Jun 202430 patients
Phase 1/2Unknown
NCT02812667BeyondSpring PharmaceuticalsNivolumab + Plinabulin

Nivolumab in Combination With Plinabulin in Patients With Metastatic Non-Small Cell Lung Cancer (NSCLC)

Start: Aug 2016Est. completion: Oct 2025
Phase 1Completed
NCT01380795AstraZenecaCTC

Feasibility of the Research for Mutation of K-ras and EGFR in CTCs From Metastatic Non Small Cells Bronchial Carcinomas

Start: Mar 2011Est. completion: Jun 201930 patients
Phase 1Terminated

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Phase Legend

Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available

Key Insights

2 late-stage (Phase 3) programs — potential near-term approvals
7 companies competing in this space

Related Indications

Breast Cancer(530)Non-small Cell Lung Cancer(373)Prostate Cancer(371)Multiple Myeloma(244)Advanced Solid Tumors(221)Acute Myeloid Leukemia(204)Cancer(187)Neoplasms(173)Colorectal Cancer(166)Advanced Solid Tumor(165)