Neuroblastoma

Oncology
12
Pipeline Programs
10
Companies
20
Clinical Trials
3 recruiting
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
6
2
4
0
0
0
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Monoclonal Antibody
267%
Small Molecule
133%
+ 13 programs with unclassified modality

Competitive Landscape

10 companies ranked by most advanced pipeline stage

United Therapeutics
United TherapeuticsMD - Silver Spring
7 programs
3
1
2
Radiation: 131I-MIBGPhase 21 trial
Universal DonorPhase 21 trial
ch14.18 -NCIPhase 1/21 trial
131I-MIBGPhase 11 trial
DinutuximabPhase 1Monoclonal Antibody1 trial
+2 more programs
Active Trials
NCT02693171Terminated13Est. Dec 2016
NCT03332667Completed45Est. Feb 2024
NCT02573896Active Not Recruiting13Est. Sep 2025
+4 more trials
Bayer
BayerLEVERKUSEN, Germany
1 program
1
NifurtimoxPhase 25 trials
Active Trials
NCT05477953Not Yet Recruiting50Est. Jan 2032
NCT03334838Completed36Est. Jan 2020
NCT03708133Completed24Est. Jun 2019
+2 more trials
Genentech
GenentechCA - Oceanside
1 program
1
anti-CD20Phase 21 trial
Active Trials
NCT00202930Terminated4Est. Feb 2009
Alder Therapeutics
Alder TherapeuticsSweden - Solna
1 program
1
ch14.18/CHOPhase 1/21 trial
Active Trials
NCT01701479Unknown288Est. Dec 2020
Novartis
NovartisBASEL, Switzerland
1 program
1
PRRT with 177Lu-DOTATATEPhase 11 trial
Active Trials
NCT03966651Recruiting18Est. Sep 2026
Cook Medical
Cook MedicalIN - Bloomington
1 program
1
SorafenibPhase 1Small Molecule1 trial
Active Trials
NCT02298348Active Not RecruitingEst. Dec 2025
AstraZeneca
AstraZenecaCAMBRIDGE, United Kingdom
1 program
1
ZD6474Phase 11 trial
Active Trials
NCT00533169Terminated10Est. Feb 2011
Recordati
RecordatiFrance - Saint-Victor
1 program
Data-collectionN/A1 trial
Active Trials
NCT04253015Recruiting125Est. Jun 2032
ProgenaBiome
ProgenaBiomeCA - Ventura
1 program
Fecal Microbial TransplantationN/A1 trial
Active Trials
NCT07223606No Longer Available
Genomics
GenomicsUK - Oxford
1 program
Guided TherapyN/A1 trial
Active Trials
NCT02162732Completed186Est. Jan 2024

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
2028
2029
2030
2031
United TherapeuticsRadiation: 131I-MIBG
United TherapeuticsUniversal Donor
BayerNifurtimox
Genentechanti-CD20
United Therapeuticsch14.18 -NCI
Alder Therapeuticsch14.18/CHO
NovartisPRRT with 177Lu-DOTATATE
United TherapeuticsDinutuximab with Chemotherapy
BayerNifurtimox
United TherapeuticsDinutuximab
BayerNifurtimox
United Therapeutics131I-MIBG
Cook MedicalSorafenib
BayerNifurtimox
AstraZenecaZD6474

Showing 15 of 19 trials with date data

Clinical Trials (20)

Total enrollment: 1,180 patients across 20 trials

NCT07261241United TherapeuticsRadiation: 131I-MIBG

NANT 2021-02: Randomized MIBG With Vorinostat/Dinutuximab/Vorinostat + Dinutuximab

Start: Jul 2026Est. completion: Jul 2031118 patients
Phase 2Not Yet Recruiting

NANT 2021-01 Phase II STING (Sequential Temozolomide, Irinotecan, NK Cells and GD2 mAb) Trial

Start: Dec 2024Est. completion: Dec 203862 patients
Phase 2Recruiting

Study of Nifurtimox to Treat Refractory or Relapsed Neuroblastoma or Medulloblastoma

Start: Jan 2008Est. completion: Oct 2022112 patients
Phase 2Completed

Use of Rituximab in Opsoclonus-Myoclonus in Children With Neuroblastoma

Start: Jul 2005Est. completion: Feb 20094 patients
Phase 2Terminated

ch14.18 Pharmacokinetic Study in High-risk Neuroblastoma

Start: Aug 2012Est. completion: Jun 201428 patients
Phase 1/2Completed

Long Term Continuous Infusion ch14.18/CHO Plus s.c. Aldesleukin (IL-2)

Start: Jan 2012Est. completion: Dec 2020288 patients
Phase 1/2Unknown
NCT03966651NovartisPRRT with 177Lu-DOTATATE

A Clinical Study Evaluating the Safety of Peptide Receptor Radionuclide Therapy (PRRT) With 177Lu-DOTA0-Tyr3-Octreotate in Children With Refractory or Recurrent Neuroblastoma Expressing Somatostatin Receptors.

Start: Apr 2023Est. completion: Sep 202618 patients
Phase 1Recruiting
NCT05421897United TherapeuticsDinutuximab with Chemotherapy

Rapid Administration Pilot for Infusing Dinutuximab

Start: Nov 2022Est. completion: Jan 202611 patients
Phase 1Active Not Recruiting

Study to Assess the Food Effect on the Pharmacokinetics of Nifurtimox Tablets in Chronic Chagas' Patients - Dietary Habits Study

Start: Jun 2019Est. completion: Jan 202036 patients
Phase 1Completed

Immunotherapy of Relapsed Refractory Neuroblastoma With Expanded NK Cells

Start: Jan 2019Est. completion: Sep 202513 patients
Phase 1Active Not Recruiting

Study to Assess Bioequivalence of a New Nifurtimox Oral Tablet Formulation

Start: Dec 2018Est. completion: Jun 201924 patients
Phase 1Completed

MIBG With Dinutuximab +/- Vorinostat

Start: Sep 2018Est. completion: Feb 202445 patients
Phase 1Completed

Sorafenib and Cyclophosphamide/Topotecan in Patients With Relapsed and Refractory Neuroblastoma

Start: Oct 2015Est. completion: Dec 2025
Phase 1Active Not Recruiting

Study to Assess Bioequivalence of 30 and 120 mg Nifurtimox Tablets in Chronic Chagas' Patients

Start: Nov 2013Est. completion: Sep 201437 patients
Phase 1Completed

ZD6474 Alone and in Combination With Retinoic Acid in Pediatric Neuroblastoma

Start: Sep 2007Est. completion: Feb 201110 patients
Phase 1Terminated
NCT07223606ProgenaBiomeFecal Microbial Transplantation

Fecal Microbiota Transplant for Neuroblastoma in a Single Patient

N/ANo Longer Available

An Observational Pregnancy Safety Study in Women Who Were Exposed to the Drug Nifurtimox During Pregnancy to Learn About the Risk of Pregnancy Complications and About the Mother's and Baby's Health

Start: Jun 2026Est. completion: Jan 203250 patients
N/ANot Yet Recruiting
NCT04253015RecordatiData-collection

A Post-Authorisation Safety Study Patient Registry of Patients With Neuroblastoma Being Treated With Dinutuximab Beta

Start: Sep 2019Est. completion: Jun 2032125 patients
N/ARecruiting

Post-Marketing Assessment of Immunogenicity and Safety of Unituxin® in High-Risk Neuroblastoma Patients

Start: Mar 2016Est. completion: Dec 201613 patients
N/ATerminated
NCT02162732GenomicsGuided Therapy

Molecular-Guided Therapy for Childhood Cancer

Start: Jul 2014Est. completion: Jan 2024186 patients
N/ACompleted

Related Jobs in Oncology

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

3 actively recruiting trials targeting 1,180 patients
10 companies competing in this space