Lung Diseases, Interstitial

Respiratory
8
Pipeline Programs
1
Companies
17
Clinical Trials
1 recruiting
1
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
0
0
0
0
7
1
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Small Molecule
12100%
+ 5 programs with unclassified modality

On Market (1)

Approved therapies currently available

Boehringer Ingelheim
OFEVApproved
nintedanib
Boehringer Ingelheim
oral2014

Competitive Landscape

1 companies ranked by most advanced pipeline stage

Boehringer Ingelheim
Boehringer IngelheimINGELHEIM, Germany
17 programs
7
1
BI 1015550Phase 31 trial
NintedanibPhase 3Small Molecule1 trial
NintedanibPhase 3Small Molecule1 trial
NintedanibPhase 3Small Molecule1 trial
NintedanibPhase 3Small Molecule1 trial
+12 more programs
Active Trials
NCT04559581Completed425Est. Jan 2025
NCT05503030Terminated88Est. Sep 2025
NCT04702893Completed108Est. Apr 2024
+14 more trials

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
2028
2029
Boehringer IngelheimBI 1015550
Boehringer IngelheimNintedanib
Boehringer IngelheimNintedanib
Boehringer IngelheimNintedanib
Boehringer IngelheimNintedanib
Boehringer IngelheimNintedanib
Boehringer IngelheimNintedanib
Boehringer IngelheimOxygen Therapy Use in Patients With Fibrotic Interstitial Lung Disease
Boehringer IngelheimNintedanib
Boehringer IngelheimNintedanib
Boehringer IngelheimSpirometry
Boehringer IngelheimNintedanib
Boehringer Ingelheimchest CT
Boehringer IngelheimNintedanib
Boehringer IngelheimNintedanib

Clinical Trials (17)

Total enrollment: 119,623 patients across 17 trials

A Study to Find Out Whether BI 1015550 Improves Lung Function in People With Progressive Fibrosing Interstitial Lung Diseases (PF-ILDs)

Start: Nov 2022Est. completion: Apr 20251,178 patients
Phase 3Completed

A Study to Evaluate Long-term Safety of Nintedanib in Children and Adolescents With Interstitial Lung Disease (InPedILD®-ON)

Start: Apr 2022Est. completion: Aug 202554 patients
Phase 3Completed

A Study to Test How Well a Medicine Called Nintedanib Helps People in China With Progressive Lung Fibrosis

Start: Nov 2021Est. completion: May 202481 patients
Phase 3Completed

A Study to Find Out How Nintedanib is Taken up in the Body and How Well it is Tolerated in Children and Adolescents With Interstitial Lung Disease (ILD)

Start: Dec 2019Est. completion: May 202239 patients
Phase 3Completed

A Follow-up Study Investigating Long Term Treatment With Nintedanib in Patients With Progressive Fibrosing Interstitial Lung Disease (PF-ILD)

Start: Apr 2019Est. completion: Aug 2022435 patients
Phase 3Completed

A Trial to Evaluate the Safety of Long Term Treatment With Nintedanib in Patients With Scleroderma Related Lung Fibrosis

Start: Nov 2017Est. completion: Jan 2023444 patients
Phase 3Completed

Efficacy and Safety of Nintedanib in Patients With Progressive Fibrosing Interstitial Lung Disease (PF-ILD)

Start: Jan 2017Est. completion: Aug 2019663 patients
Phase 3Completed

An Expanded Access Program to Provide Nintedanib to Patients With Non-IPF ILD Who Have no Alternative Treatment Possibilities

N/AApproved For Marketing

An Expanded Access Program in Belgium to Provide Nintedanib to People With Lung Diseases Called Non-IPF ILDs Who Have no Alternative Treatment Options

N/ANo Longer Available
NCT05957198Boehringer IngelheimOxygen Therapy Use in Patients With Fibrotic Interstitial Lung Disease

Oxygen Therapy Use in Patients With Fibrotic Interstitial Lung Disease

Start: Jul 2023Est. completion: Sep 2023114,921 patients
N/ACompleted

INCHANGE - Nintedanib for Changes in Cough and Dyspnea in Patients Suffering From Chronic Fibrosing Interstitial Lung Disease With a Progressive Phenotype in Everyday Clinical Practice: a Real-world Evaluation

Start: Feb 2023Est. completion: Sep 2025158 patients
N/ACompleted

Correlation Between Changes in Lung Function and Changes in Cough and Dyspnoea in Nintedanib-treated Connective Tissue Disease Interstitial Lung Disease (CTD-ILD) Patients

Start: Dec 2022Est. completion: Sep 202588 patients
N/ATerminated

A Study to Test Different Imaging Techniques in Patients With Different Types of Interstitial Lung Disease

Start: Dec 2022Est. completion: Jun 202631 patients
N/AActive Not Recruiting

INREAL - Nintedanib for Changes in Dyspnea and Cough in Patients Suffering From Chronic Fibrosing Interstitial Lung Disease (ILD) With a Progressive Phenotype in Everyday Clinical Practice: a Real-world Evaluation

Start: May 2021Est. completion: Apr 2024108 patients
N/ACompleted

Database for Interstitial Lung Disease

Start: May 2021Est. completion: Jan 2029412 patients
N/ARecruiting

Post-marketing Surveillance of Ofev Capsules in Chronic Fibrosing Interstitial Lung Diseases With a Progressive Phenotype in Japan

Start: Oct 2020Est. completion: Jan 2025425 patients
N/ACompleted

Post-marketing Surveillance on Long Term Use of Ofev Capsules in Systemic Scleroderma Associated Interstitial Lung Disease (SSc-ILD) in Japan

Start: May 2020Est. completion: Jun 2026586 patients
N/AActive Not Recruiting

Related Jobs in Respiratory

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

7 late-stage (Phase 3) programs — potential near-term approvals
1 actively recruiting trials targeting 119,623 patients
Small Molecule is the dominant modality (100% of programs)
1 companies competing in this space