COPD

Respiratory
27
Pipeline Programs
14
Companies
50
Clinical Trials
4 recruiting
2
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
3
3
10
0
4
7
Early DiscoveryClinical DevelopmentMarket

On Market (2)

Approved therapies currently available

Boehringer Ingelheim
SPIRIVAApproved
tiotropium bromide
Boehringer Ingelheim
inhalation2004
U
TIOTROPIUM BROMIDEApproved
tiotropium bromide
Unknown Company
inhalation2023

Competitive Landscape

14 companies ranked by most advanced pipeline stage

Boehringer Ingelheim
Boehringer IngelheimINGELHEIM, Germany
14 programs
1
2
Tiotropium BromidePhase 41 trial
tiotropium bromidePhase 41 trial
Handihaler-Tiotropium 18 mcg untrainedPhase 31 trial
Continuous Monitoring of Patients With Chronic Obstructive Pulmonary DiseaseN/A1 trial
Desktop helperN/A1 trial
+9 more programs
Active Trials
NCT01741935Completed25Est. Aug 2013
NCT04539457Completed24Est. Dec 2022
NCT02352220Unknown310Est. Dec 2020
+11 more trials
Novartis
NovartisBASEL, Switzerland
10 programs
1
3
1
2
Automated telehealth systemPhase 41 trial
Ultibro®Phase 41 trial
indacaterol and glycopyrronium bromidePhase 31 trial
AD 237Phase 21 trial
QAB149Phase 21 trial
+5 more programs
Active Trials
NCT01786720Unknown20,154Est. Apr 2014
NCT05562466Recruiting200Est. May 2028
NCT04589663Completed24Est. Apr 2022
+9 more trials
E
EisaiChina - Liaoning
1 program
1
Lysozyme hydrochloridePhase 41 trial
Active Trials
NCT01645800Completed408Est. Mar 2015
AstraZeneca
AstraZenecaCAMBRIDGE, United Kingdom
15 programs
2
1
1
1
Aclidinium bromide/formoterol Fixed-Dose CombinationPhase 32 trials
AZD2115Phase 24 trials
TRIXEO AEROSPHEREPhase 1/21 trial
AZD7624Phase 11 trial
AZD8683Phase 11 trial
+10 more programs
Active Trials
NCT06659666Completed100Est. Jul 2025
NCT01921127Completed3,000Est. Mar 2014
NCT02413359Completed1,016Est. Jul 2015
+16 more trials
Verona Pharma
Verona PharmaUK - London
8 programs
5
1
Ensifentrine 3 mg twice dailyPhase 31 trial
EnsifentrinePhase 21 trial
EnsifentrinePhase 21 trial
Part A: RPL554Phase 21 trial
RPL554 SuspensionPhase 21 trial
+3 more programs
Active Trials
NCT04201548CompletedEst. Jun 2024
NCT06652776Enrolling By InvitationEst. Dec 2035
NCT03937479Completed416Est. Nov 2019
+5 more trials
One Biosciences
One BiosciencesFrance - Paris
1 program
1
Biological: Solrikitug low dosePhase 21 trial
Active Trials
NCT06496620RecruitingEst. Oct 2026
Teva
TevaIsrael - Petach Tikva
2 programs
1
Tiotropium HFA BAI 4.5 mcgPhase 1/21 trial
ProAir DigihalerN/A1 trial
Active Trials
NCT04821869Completed27Est. Jun 2022
NCT01785433Completed36Est. Aug 2013
Roche
RocheSTAVANGER NORWAY, Norway
2 programs
1
R7103Phase 11 trial
voice samplingN/A1 trial
Active Trials
NCT05825261Recruiting200Est. May 2026
NCT01009424Withdrawn0Est. Dec 2009
Pfizer
PfizerNEW YORK, NY
4 programs
Evaluation of Airway Gene Expression in COPD and Controlled PopulationsN/A1 trial
MISSION ABC Integrated Care clinicN/A1 trial
PCV13N/A1 trial
The Canadian Cohort Obstructive Lung DiseaseN/A
Active Trials
NCT00571792Terminated42Est. Feb 2011
NCT03096509Completed342Est. Mar 2018
NCT03046134Unknown384Est. Feb 2019
GS
Gilead SciencesFOSTER CITY, CA
2 programs
Clinical Impact of Fungal Domestic Environmental Exposure on COPD PatientsN/A1 trial
Clinical Impact of Fungal Domestic Environmental Exposure on COPD PatientsN/A
Active Trials
NCT02318524Completed65Est. Oct 2017
Senti Biosciences
Senti BiosciencesCA - South SF
1 program
Senti Wear device system with Senti-AI subsystemN/A1 trial
Active Trials
NCT05745155CompletedEst. Apr 2024
M&
Merck & Co.RAHWAY, NJ
1 program
The Canadian Cohort Obstructive Lung DiseaseN/A
Takeda
TakedaTOKYO, Japan
1 program
The Canadian Cohort Obstructive Lung DiseaseN/A
Heidelberg Pharma
Heidelberg PharmaGermany - Ladenburg
1 program
Whole Body VibrationN/A1 trial
Active Trials
NCT02679677Completed42Est. Aug 2016

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
2028
Boehringer IngelheimTiotropium Bromide
NovartisUltibro®
NovartisIndacaterol
NovartisIndacaterol
NovartisIndacaterol
NovartisAutomated telehealth system
NovartisIndacaterol
NovartisIndacaterol
NovartisIndacaterol
NovartisIndacaterol
NovartisIndacaterol
EisaiLysozyme hydrochloride
NovartisIndacaterol
NovartisIndacaterol
NovartisIndacaterol

Showing 15 of 50 trials with date data

Clinical Trials (50)

Total enrollment: 25,400 patients across 50 trials

Anti-inflammatory Effects of Tiotropium in Patients with Stable COPD

Start: Aug 2019Est. completion: Dec 202337 patients
Phase 4Completed

Ultibro® Versus Spiriva® Alone to Reduce Exertional Dyspnea in Patients With Moderate to Severe COPD

Start: Jun 2016Est. completion: Nov 201850 patients
Phase 4Completed

Assessment of Switching From Salmeterol/Fluticasone to Indacaterol/Glycopyrronium in a symtomaticCOPD Patient Cohort

Start: Oct 2015Est. completion: May 2017500 patients
Phase 4Completed

Prospective Cohort Study for the Real - Life Effectiveness Evaluation of GlycOpyrronium With IndacatERol Combination in the Management of COPD in Canada (POWER Study)

Start: Aug 2014Est. completion: Apr 2017401 patients
Phase 4Completed

Study to Evaluate Efficacy/Safety of Combination Budesonide/Indacaterol vs Fluticasone/Salmeterol in Patients With COPD

Start: May 2014Est. completion: Jan 2016222 patients
Phase 4Completed
NCT01992081NovartisAutomated telehealth system

Study to Evaluate the Impact of the "PROactive Telecoaching Program" on Physical Activity in Patients With COPD.

Start: May 2014Est. completion: Jun 20150
Phase 4Withdrawn

Study to Evaluate the Efficacy and Safety of Glycopyrronium or Indacaterol Maleate and Glycopyrronium Bromide Fixed-dose Combination Regarding Symptoms and Health Status in Patients With Moderate COPD Switching From Treatment With Any Standard COPD Regimen

Start: Feb 2014Est. completion: Apr 20164,389 patients
Phase 4Completed

Study Evaluating Preference, Satisfaction And Correct Use Of Inhalers In COPD Patients

Start: Apr 2013Est. completion: Nov 2015140 patients
Phase 4Completed

A Randomized, Multicenter, Open-label, Parallel-group, 12-week Study to Assess the Efficacy and Safety of Switching From Tiotropium to QVA149 (Indacaterol Maleate/Glycopyrronium Bromide) in Symptomatic Mild to Moderate COPD Patients

Start: Mar 2013Est. completion: Jun 2018379 patients
Phase 4Completed

Indacaterol Versus Tiotropium on Dynamic Hyperinflation in COPD

Start: Mar 2013Est. completion: Oct 201320 patients
Phase 4Completed

A 1-year Multi-center, Prospective, Cohort Study in Patients With Chronic Obstructive Pulmonary Disease Treated With Long-acting Bronchodilator

Start: Feb 2013Est. completion: May 20152,229 patients
Phase 4Completed
NCT01645800EisaiLysozyme hydrochloride

Effects of Lysozyme on Acute Exacerbation of Chronic Obstructive Pulmonary Disease : A Randomised Placebo-Controlled Study

Start: Aug 2012Est. completion: Mar 2015408 patients
Phase 4Completed

Comparison of Indacaterol 150 mcg Once Daily (o.d.) With Salmeterol/Fluticasone Propionate 50 mcg/500 mcg Twice Daily (b.i.d.)

Start: Feb 2012Est. completion: Feb 2014581 patients
Phase 4Completed

Efficacy of Indacaterol 150 µg Versus Formoterol

Start: Sep 2011Est. completion: Feb 20120
Phase 4Withdrawn

To Determine the Relationship Between Baseline Reversibility and the Efficacy of Indacaterol

Start: Apr 2010Est. completion: May 2012625 patients
Phase 4Completed

Study to Evaluate the Effects of Tiotropium Bromide on Chronic Obstructive Pulmonary Disease (COPD) During Exercise

Start: Jun 2006Est. completion: Apr 200920 patients
Phase 4Completed
NCT06460493Verona PharmaEnsifentrine 3 mg twice daily

Effect of Ensifentrine Treatment on CAT Score

Start: Jun 2024Est. completion: Dec 202420 patients
Phase 3Completed

A Study to Evaluate the Efficacy and Safety of QMF149 (Indacaterol Acetate/Mometasone Furoate) Versus Budesonide in Children From 6 to Less Than 12 Years of Age With Asthma

Start: May 2023Est. completion: May 2028200 patients
Phase 3Recruiting
NCT03022097AstraZenecaAclidinium bromide/formoterol Fixed-Dose Combination

Study to Assess Efficacy and Safety of Aclidinium Bromide and Aclidinium Bromide/Formoterol Fumarate in Stabile COPD Patients

Start: Feb 2017Est. completion: Apr 20221,625 patients
Phase 3Completed
NCT02683668Boehringer IngelheimHandihaler-Tiotropium 18 mcg untrained

Airway Effects of Tiotropium in Patients With COPD

Start: Feb 2016Est. completion: Jan 201844 patients
Phase 3Completed

A Multicenter Randomized 52 Week Treatment Double-blind, Triple Dummy Parallel Group Study to Assess the Efficacy and Safety of QMF149 Compared to Mometasone Furoate in Participants With Asthma

Start: Dec 2015Est. completion: Jun 20192,216 patients
Phase 3Completed

QVA vs. Salmeterol/Fluticasone, 52-week Exacerbation Study, FLAME (EFfect of Indacaterol Glycopyronium Vs Fluticasone Salmeterol on COPD Exacerbations)

Start: Jul 2013Est. completion: Sep 20153,362 patients
Phase 3Completed

Indacaterol EfectIveness In COPD Patients With Tuberculosis History

Start: Feb 2013Est. completion: Sep 2014136 patients
Phase 3Completed
NCT01572792AstraZenecaAclidinium bromide/formoterol Fixed-Dose Combination

Efficacy, Safety and Tolerability of Two Fixed Dose Combinations of Aclidinium Bromide/Formoterol Fumarate, Aclidinium Bromide, Formoterol Fumarate and Placebo for 28-Weeks Treatment in Patients With Moderate to Severe, Stable Chronic Obstructive Pulmonary Disease (COPD)

Start: Apr 2012Est. completion: Jun 2013921 patients
Phase 3Completed

12-week Open-label Evaluation of Efficacy and Safety of Indacaterol

Start: Mar 2011Est. completion: May 201290 patients
Phase 3Completed
NCT01294787Novartisindacaterol and glycopyrronium bromide

Effect of QVA149 on Exercise Tolerance in Patients With Chronic Obstructive Pulmonary Disease (COPD)

Start: Feb 2011Est. completion: Nov 201185 patients
Phase 3Completed

Exacerbation Study

Start: Mar 2009Est. completion: Jul 20123,439 patients
Phase 3Completed

Confirmatory Study of Indacaterol in Patients With Chronic Obstructive Pulmonary Disease (COPD)

Start: Mar 2009Est. completion: Oct 2010186 patients
Phase 3Completed

Indacaterol Delivered Via a Single Dose Dry Powder Inhaler (SDDPI) in Chronic Obstructive Pulmonary Disease (COPD)

Start: Oct 2006Est. completion: Jan 200751 patients
Phase 2/3Completed
NCT06496620One BiosciencesBiological: Solrikitug low dose

A Study to Evaluate Solrikitug in Participants With COPD (ZION)

Start: Aug 2024Est. completion: Oct 2026
Phase 2Recruiting

Effect of Ensifentrine on Sputum Markers of Inflammation in COPD

Start: May 2022Est. completion: Jun 202756 patients
Phase 2Recruiting

Study to Compare the Pharmacokinetics of Mometasone Furoate Alone and in Combination With Indacaterol in Patients ≥ 6 to < 12 Years Old With Asthma

Start: Jun 2021Est. completion: Apr 202224 patients
Phase 2Completed

Study Investigating the Effect of 4 Doses of RPL554 Given in Addition to Tiotropium to Patients With COPD

Start: May 2019Est. completion: Nov 2019416 patients
Phase 2Completed

A Study of RPL554 Drug Administered by Metered Dose Inhaler to Treat Chronic Obstructive Pulmonary Disease

Start: Apr 2019Est. completion: Jan 202140 patients
Phase 2Completed
NCT03673670Verona PharmaRPL554 Suspension

Bronchodilator Effect of RPL554 Administered in Addition to Tiotropium/Olodaterol in Patients With COPD

Start: Jul 2018Est. completion: Nov 201879 patients
Phase 2Completed
NCT03443414Verona PharmaRPL554 suspension

Dose Ranging Study of RPL554 in Chronic Obstructive Pulmonary Disease (COPD) Patients

Start: Jun 2017Est. completion: Feb 2018405 patients
Phase 2Completed

Efficacy and Safety of QMF149 vs. Salmeterol Xinafoate/Fluticasone Propionate in Patients With Chronic Obstructive Pulmonary Disease (COPD)

Start: Nov 2012Est. completion: Sep 2013629 patients
Phase 2Completed

A Single-dose Study to Investigate the Effects of 3 Different Doses of Inhaled AZD2115 in COPD Patients

Start: Mar 2012Est. completion: Oct 201239 patients
Phase 2Completed

A Study to Assess the Safety and Efficacy of Different AD 237 Doses in Adults With COPD

Start: Oct 2005300 patients
Phase 2Completed

Dose-Ranging Study in Patients With Chronic Obstructive Pulmonary Disease (COPD)

Start: Jul 2004Est. completion: Dec 2004686 patients
Phase 2Completed
NCT06110403AstraZenecaTRIXEO AEROSPHERE

Impact of Long-acting Bronchodilator- -Corticoid Inhaled Therapy on Ventilation, Lung Function and Breathlessness

Start: Sep 2023Est. completion: Sep 202635 patients
Phase 1/2Recruiting
NCT01785433TevaTiotropium HFA BAI 4.5 mcg

To Compare the Pharmacokinetics of Tiotropium in Subjects With Chronic Obstructive Pulmonary Disease (COPD)

Start: Jan 2013Est. completion: Aug 201336 patients
Phase 1/2Completed

Effect of Indacaterol on Inspiratory Capacity and Lung Function in Patients With COPD Versus Placebo and Formoterol

Start: Sep 200630 patients
Phase 1/2Completed

PET Study to Determine Muscarinic Receptor Occupancy in Lungs After Inhalation of AZD2115 and Tiotropium

Start: Apr 2017Est. completion: Dec 201719 patients
Phase 1Completed

To Assess the Safety, Tolerability, and Pharmacokinetics of AZD7624 in Healthy Volunteers and COPD Patients

Start: Sep 2013Est. completion: Oct 201452 patients
Phase 1Completed

AZD8683 Multiple Dose Study in Healthy Volunteers and Chronic Obstructive Pulmonary Disease (COPD) Patients

Start: Jun 2012Est. completion: Nov 201230 patients
Phase 1Terminated

AZD2115 Multiple Ascending Dose Study

Start: Oct 2011Est. completion: Jul 201232 patients
Phase 1Completed

AZD2115 Single Ascending Dose Study

Start: Jan 2011Est. completion: Aug 201196 patients
Phase 1Completed

A Multi-center Study to Investigate the Safety, Tolerability, Pharmacodynamics and Pharmacokinetics of R7103 Following Repeated Inhalation in Patients With Moderate-to-severe Chronic Obstructive Pulmonary Disease

Start: Oct 2009Est. completion: Dec 20090
Phase 1Withdrawn

Evaluation of Pharmacokinetic Interaction of Indacaterol With Ketoconazole in Healthy Adult Subjects

Start: Dec 200620 patients
Phase 1Completed

Related Jobs in Respiratory

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

4 late-stage (Phase 3) programs — potential near-term approvals
4 actively recruiting trials targeting 25,400 patients
14 companies competing in this space