Idiopathic Pulmonary Fibrosis

Respiratory
60
Pipeline Programs
19
Companies
50
Clinical Trials
6 recruiting
3
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
10
1
28
0
13
8
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Small Molecule
1789%
Peptide
15%
Monoclonal Antibody
15%
+ 62 programs with unclassified modality

On Market (3)

Approved therapies currently available

Boehringer Ingelheim
JASCAYDApproved
nerandomilast
Boehringer Ingelheim
oral2025
GS
LETAIRISApproved
ambrisentan
Gilead Sciences
Endothelin Receptor Antagonist [EPC]oral2007
Boehringer Ingelheim
OFEVApproved
nintedanib
Boehringer Ingelheim
oral2014

Competitive Landscape

19 companies ranked by most advanced pipeline stage

Boehringer Ingelheim
Boehringer IngelheimINGELHEIM, Germany
41 programs
2
8
5
5
Littmann ®Phase 41 trial
NintedanibPhase 4Small Molecule1 trial
NintedanibPhase 4Small Molecule1 trial
nintedanibPhase 4Small Molecule1 trial
nintedanibPhase 4Small Molecule1 trial
+36 more programs
Active Trials
NCT02551068Recruiting88Est. Dec 2026
NCT03074149Completed301Est. Mar 2021
NCT01695408Completed1,232Est. Dec 2021
+38 more trials
GS
Gilead SciencesFOSTER CITY, CA
5 programs
2
3
1
AmbrisentanPhase 31 trial
AmbrisentanPhase 3
AmbrisentanPhase 31 trial
GS-6624Phase 1
GS-6624Phase 11 trial
Active Trials
NCT01362231Completed48Est. Dec 2012
NCT00879229Terminated40Est. Feb 2011
NCT00768300Terminated494Est. Feb 2011
Galapagos
Galapagos2800 MECHELEN, Belgium
4 programs
2
2
GLPG1690Phase 31 trial
GLPG1690Phase 31 trial
GLPG1205Phase 21 trial
GLPG1690 600 mg QDPhase 21 trial
Active Trials
NCT03725852Completed68Est. Aug 2020
NCT02738801Completed23Est. May 2017
NCT03733444Terminated781Est. Mar 2021
+1 more trials
Genentech
GenentechCA - Oceanside
3 programs
1
2
PirfenidonePhase 31 trial
pirfenidonePhase 3
PirfenidonePhase 21 trial
Active Trials
NCT00080223Completed83Est. Apr 2015
NCT00287729Completed344Est. Nov 2008
United Therapeutics
United TherapeuticsMD - Silver Spring
1 program
1
Inhaled TreprostinilPhase 31 trial
Active Trials
NCT04905693Enrolling By Invitation1,850Est. Jun 2026
Pliant Therapeutics
Pliant TherapeuticsCA - South SF
5 programs
1
4
PLN-74809Phase 21 trial
PLN-74809Phase 21 trial
PLN-74809Phase 21 trial
PLN-74809Phase 21 trial
[18F]FP-R01-MG-F2Phase 11 trial
Active Trials
NCT03183570Completed21Est. Jan 2025
NCT04072315Completed9Est. Jul 2022
NCT05621252Completed10Est. Jan 2024
+2 more trials
Roche
RocheSTAVANGER NORWAY, Norway
4 programs
1
Matching PlaceboPhase 21 trial
PirfenidoneN/A5 trials
PirfenidoneN/A1 trial
SpirometryN/A1 trial
Active Trials
NCT03208933Completed60Est. Nov 2019
NCT02598193Completed89Est. May 2017
NCT02525484Completed44Est. Aug 2015
+5 more trials
Endeavor BioMedicines
Endeavor BioMedicinesCA - San Diego
4 programs
2
2
ENV-101Phase 21 trial
taladegibPhase 21 trial
taladegibPhase 11 trial
taladegibPhase 11 trial
Active Trials
NCT07454291Not Yet Recruiting57Est. Oct 2026
NCT05817240Completed21Est. Jun 2023
NCT06422884Active Not Recruiting213Est. Oct 2026
+1 more trials
Trevi Therapeutics
Trevi TherapeuticsNEW HAVEN, CT
3 programs
1
2
NAL ERPhase 21 trial
NAL ERPhase 21 trial
NAL ERPhase 11 trial
Active Trials
NCT07036029RecruitingEst. Apr 2026
NCT04030026CompletedEst. May 2022
NCT05964335CompletedEst. Apr 2025
AbbVie
AbbVieNORTH CHICAGO, IL
1 program
1
ABBV-142Phase 21 trial
Active Trials
NCT07230288Recruiting165Est. Sep 2029
Biogen
BiogenCAMBRIDGE, MA
1 program
1
BG00011Phase 21 trial
Active Trials
NCT03573505Terminated109Est. Nov 2019
Vicore Pharma
Vicore PharmaSweden - Stockholm
1 program
1
C21Phase 21 trial
Active Trials
NCT04533022Completed52Est. Mar 2024
CSL Behring
CSL BehringIL - Bradley
1 program
1
GaradacimabPhase 2Monoclonal Antibody1 trial
Active Trials
NCT05130970Completed81Est. Jan 2024
MediciNova
MediciNovaLA JOLLA, CA
1 program
1
MN-001Phase 21 trial
Active Trials
NCT02503657Completed15Est. Mar 2022
Contineum Therapeutics
1 program
1
PIPE-791 Dose APhase 21 trial
Active Trials
NCT07284459Recruiting324Est. Jun 2028
Novartis
NovartisBASEL, Switzerland
1 program
1
QAX576Phase 21 trial
Active Trials
NCT01266135Terminated40Est. Apr 2013
BT
1 program
1
SM04646Phase 21 trial
Active Trials
NCT03591926WithdrawnEst. Jan 1900
Arrowhead Pharmaceuticals
1 program
1
ARO-MMP7 Inhalation SolutionPhase 1/21 trial
Active Trials
NCT05537025Completed105Est. Sep 2025
Rein Therapeutics
2 programs
2
Caveolin-1-Scaffolding-Protein-Derived PeptidePhase 1Peptide1 trial
LTI-03Phase 11 trial
Active Trials
NCT04233814CompletedEst. Dec 2021
NCT05954988CompletedEst. Sep 2024

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
2028
2029
Boehringer IngelheimNintedanib
Boehringer IngelheimLittmann ®
Boehringer Ingelheimnintedanib
Boehringer Ingelheimnintedanib
RochePirfenidone
Boehringer IngelheimNintedanib
Boehringer IngelheimNerandomilast
Boehringer IngelheimBI 1015550
United TherapeuticsInhaled Treprostinil
GalapagosGLPG1690
GalapagosGLPG1690
RochePirfenidone
Boehringer IngelheimNintedanib
Boehringer IngelheimMatching Placebo
Boehringer IngelheimNintedanib

Showing 15 of 50 trials with date data

Clinical Trials (50)

Total enrollment: 12,703 patients across 50 trials

Study of Pulmonary Rehabilitation in Patients With Idiopathic Pulmonary Fibrosis (IPF)

Start: Nov 2018Est. completion: Jun 202019 patients
Phase 4Terminated

Digital Auscultation Test - IPF Data Collection

Start: Mar 2018Est. completion: Jan 2019274 patients
Phase 4Completed

Effect of Nintedanib on Biomarkers of Extracellular Matrix Turnover in Patients With Idiopathic Pulmonary Fibrosis and Limited Forced Vital Capacity Impairment

Start: Jun 2016Est. completion: Jun 2018347 patients
Phase 4Completed

A Study to Compare the Amount of Nintedanib and Pirfenidone in the Blood When Nintedanib and Pirfenidone Are Given Separately or in Combination

Start: Apr 2016Est. completion: Mar 201737 patients
Phase 4Completed
NCT02598193RochePirfenidone

Safety and Tolerability Study of Pirfenidone in Combination With Nintedanib in Participants With Idiopathic Pulmonary Fibrosis (IPF)

Start: Jan 2016Est. completion: May 201789 patients
Phase 4Completed

Safety, Tolerability and PK of Nintedanib in Combination With Pirfenidone in IPF

Start: Oct 2015Est. completion: Jan 2017105 patients
Phase 4Completed

A Follow-up Study to Test Long-term Treatment With Nerandomilast in People With Pulmonary Fibrosis Who Took Part in a Previous Study With Nerandomilast

Start: May 2024Est. completion: May 20271,700 patients
Phase 3Recruiting

A Study to Find Out Whether BI 1015550 Improves Lung Function in People With Idiopathic Pulmonary Fibrosis (IPF)

Start: Oct 2022Est. completion: Dec 20241,177 patients
Phase 3Completed
NCT04905693United TherapeuticsInhaled Treprostinil

Extension Study of Inhaled Treprostinil in Subjects With Fibrotic Lung Disease

Start: Sep 2022Est. completion: Jun 20261,850 patients
Phase 3Enrolling By Invitation

A Clinical Study to Test How Effective and Safe GLPG1690 is for Subjects With Idiopathic Pulmonary Fibrosis (IPF) When Used Together With Standard of Care

Start: Nov 2018Est. completion: Mar 2021525 patients
Phase 3Terminated

A Clinical Study to Test How Effective and Safe GLPG1690 is for Participants With Idiopathic Pulmonary Fibrosis (IPF) When Used Together With Standard of Care

Start: Nov 2018Est. completion: Mar 2021781 patients
Phase 3Terminated
NCT03208933RochePirfenidone

Open-label Study to Assess the Effectiveness of Pirfenidone in Participants With Idiopathic Pulmonary Fibrosis (IPF).

Start: Oct 2017Est. completion: Nov 201960 patients
Phase 3Completed

Efficacy and Safety of Nintedanib Co-administered With Sildenafil in Idiopathic Pulmonary Fibrosis Patients With Advanced Lung Function Impairment

Start: Jun 2016Est. completion: Apr 2018274 patients
Phase 3Completed

Nintedanib Twice Daily vs Placebo in Patients Diagnosed With Idiopathic Pulmonary Fibrosis (IPF)

Start: Nov 2013Est. completion: Oct 2016113 patients
Phase 3Completed

Extension Trial of the Long Term Safety of BIBF 1120 in Patients With Idiopathic Pulmonary Fibrosis

Start: Jun 2012Est. completion: Feb 2021752 patients
Phase 3Completed

ARTEMIS-PH - Study of Ambrisentan in Subjects With Pulmonary Hypertension Associated With Idiopathic Pulmonary Fibrosis

Start: Jul 2009Est. completion: Feb 201140 patients
Phase 3Terminated

(ARTEMIS-IPF) Randomized, Placebo-Controlled Study to Evaluate Safety and Effectiveness of Ambrisentan in IPF

Start: Dec 2008Est. completion: Feb 2011494 patients
Phase 3Terminated
NCT00662038RochePirfenidone

Open-Label Study of the Long Term Safety of Pirfenidone in Patients With Idiopathic Pulmonary Fibrosis (IPF)

Start: Aug 2008Est. completion: Feb 20161,058 patients
Phase 3Completed

Safety and Efficacy of Pirfenidone in Patients With Idiopathic Pulmonary Fibrosis

Start: Apr 2006Est. completion: Nov 2008344 patients
Phase 3Completed

A Study in People With Idiopathic Pulmonary Fibrosis to Test Whether Pirfenidone Influences the Amount of BI 1015550 in the Blood

Start: Mar 2026Est. completion: Aug 202620 patients
Phase 2Recruiting

Study of ABBV-142 to Assess Adverse Events and Change in Disease Activity in Adult Participants With Idiopathic Pulmonary Fibrosis

Start: Jan 2026Est. completion: Sep 2029165 patients
Phase 2Recruiting

Study to Evaluate the Efficacy, Safety, and Tolerability of PIPE 791 in Subjects With Idiopathic Pulmonary Fibrosis

Start: Jan 2026Est. completion: Jun 2028324 patients
Phase 2Recruiting

A Study to Find Out Whether BI 765423 Has an Effect on Lung Function in People With Idiopathic Pulmonary Fibrosis (IPF) With or Without Standard Treatment

Start: Nov 2025Est. completion: Sep 202771 patients
Phase 2Recruiting

A Phase 2 Trial of ENV-101 in Patients With Lung Fibrosis (WHISTLE-PF Trial)

Start: Nov 2024Est. completion: Oct 2026213 patients
Phase 2Active Not Recruiting

A Study to Test Whether BI 1819479 Improves Lung Function in People With Idiopathic Pulmonary Fibrosis (IPF)

Start: Sep 2024Est. completion: Jan 2026322 patients
Phase 2Completed

A Study to Test Whether BI 1839100 Improves Cough in People With Idiopathic Pulmonary Fibrosis or Progressive Pulmonary Fibrosis

Start: Aug 2024Est. completion: Sep 202585 patients
Phase 2Terminated

Cough Reduction in IPF With Nalbuphine ER

Start: Feb 2024Est. completion: Apr 2025
Phase 2Completed

Randomized, Double-blind Study of Efficacy and Safety of Bexotegrast (PLN-74809) for Idiopathic Pulmonary Fibrosis

Start: Nov 2023Est. completion: Apr 2025320 patients
Phase 2Terminated
NCT05241275Boehringer IngelheimHyperpolarized 129 Xenon Gas Comparing Progressive Pulmonary Fibrosis Treatment

Xenon MRI and Progressive ILD

Start: Jul 2022Est. completion: Aug 202660 patients
Phase 2Active Not Recruiting

Imaging Evaluation of PLN-74809 in Participants With IPF (PLN-74809)

Start: Jul 2022Est. completion: Jan 202410 patients
Phase 2Completed

129Xe Gas Exchange Imaging in IPF and cHP: A Reliability Study

Start: May 2022Est. completion: Aug 20220
Phase 2Withdrawn

Garadacimab Safety, Pharmacokinetics, and Pharmacodynamics in Idiopathic Pulmonary Fibrosis

Start: Feb 2022Est. completion: Jan 202481 patients
Phase 2Completed

A Study Evaluating the Safety and Efficacy of ENV-101 in Subjects With Idiopathic Pulmonary Fibrosis (IPF)

Start: Aug 2021Est. completion: Nov 202341 patients
Phase 2Completed

Safety, Efficacy and Pharmacokinetics of C21 in Subjects With IPF

Start: Nov 2020Est. completion: Mar 202452 patients
Phase 2Completed

A Study to Test How Taking BI 1015550 for 12 Weeks Affects Lung Function in People With Idiopathic Pulmonary Fibrosis (IPF)

Start: Jul 2020Est. completion: Oct 2021147 patients
Phase 2Completed

Evaluation of Efficacy and Safety of PLN-74809 in Patients With Idiopathic Pulmonary Fibrosis

Start: Mar 2020Est. completion: Feb 2023120 patients
Phase 2Completed

Phase 2a Evaluation of PLN-74809 on αvβ6 Receptor Occupancy Using PET Imaging in Participants With IPF/

Start: Feb 2020Est. completion: Jul 20229 patients
Phase 2Completed

A Study of Nalbuphine (Extended Release) ER in Idiopathic Pulmonary Fibrosis (IPF) for Treatment of Cough

Start: Oct 2019Est. completion: May 2022
Phase 2Completed

Continuation of Nintedanib After Single Lung Transplantation in IPF Subjects

Start: Jul 2019Est. completion: Dec 20211 patients
Phase 2Terminated

A Clinical Study to Test How Effective and Safe GLPG1205 is for Participants With Idiopathic Pulmonary Fibrosis (IPF)

Start: Sep 2018Est. completion: Aug 202068 patients
Phase 2Completed

An Efficacy and Safety Study of BG00011 in Participants With Idiopathic Pulmonary Fibrosis

Start: Sep 2018Est. completion: Nov 2019109 patients
Phase 2Terminated

Safety, Tolerability, and Efficacy of MN-001 (Tipelukast) in Patients With Idiopathic Pulmonary Fibrosis

Start: Mar 2016Est. completion: Mar 202215 patients
Phase 2Completed
NCT02738801GalapagosGLPG1690 600 mg QD

Study to Assess Safety, Tolerability, Pharmacokinetic and Pharmacodynamic Properties of GLPG1690 in Subjects With Idiopathic Pulmonary Fibrosis (IPF)

Start: Mar 2016Est. completion: May 201723 patients
Phase 2Completed
NCT02707640RocheMatching Placebo

A Study to Assess the Safety and Tolerability of N-Acetylcysteine When Administered With Pirfenidone to Participants With Idiopathic Pulmonary Fibrosis (IPF)

Start: Aug 2013Est. completion: Feb 2015123 patients
Phase 2Completed

Safety and Efficacy of QAX576 in Patients With Idiopathic Pulmonary Fibrosis (IPF)

Start: Dec 2010Est. completion: Apr 201340 patients
Phase 2Terminated

Safety Study of Oral Pirfenidone in Patients With Pulmonary Fibrosis/Idiopathic Pulmonary Fibrosis

Start: Aug 2003Est. completion: Apr 201583 patients
Phase 2Completed

A Study Evaluating the Safety, Pharmacokinetics, Pharmacodynamics, and Efficacy of SM04646 Inhalation Solution in Subjects With Idiopathic Pulmonary Fibrosis (IPF)

Start: Jan 1900Est. completion: Jan 1900
Phase 2Withdrawn
NCT05537025Arrowhead PharmaceuticalsARO-MMP7 Inhalation Solution

Study of ARO-MMP7 Inhalation Solution in Healthy Subjects and Patients With Idiopathic Pulmonary Fibrosis

Start: Jan 2023Est. completion: Sep 2025105 patients
Phase 1/2Completed

A Phase 1, Open-Label Study to Evaluate Pharmacokinetics and Drug-drug Interactions of ENV-101 (Taladegib) in Healthy Participants

Start: Mar 2026Est. completion: Oct 202657 patients
Phase 1Not Yet Recruiting

NAL ER IPF Respiratory Function and Safety Study

Start: Aug 2025Est. completion: Apr 2026
Phase 1Recruiting

Related Jobs in Respiratory

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

13 late-stage (Phase 3) programs — potential near-term approvals
6 actively recruiting trials targeting 12,703 patients
19 companies competing in this space