Pulmonary Embolism

Respiratory
8
Pipeline Programs
18
Companies
19
Clinical Trials
3 recruiting
1
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
0
1
1
0
3
3
Early DiscoveryClinical DevelopmentMarket

On Market (1)

Approved therapies currently available

J&
XARELTOApproved
rivaroxaban
Johnson & Johnson
Factor Xa Inhibitor [EPC]oral2021

Competitive Landscape

14 companies ranked by most advanced pipeline stage

C
CordisFL - Miami Lakes
2 programs
1
OPTEASE Vena Cava FilterPhase 41 trial
IVC FilterN/A1 trial
Active Trials
NCT02381509Completed1,428Est. Sep 2021
NCT00233740Completed150Est. May 2005
J&
Johnson & JohnsonNEW BRUNSWICK, NJ
1 program
1
1
RivaroxabanPhase 31 trial
Active Trials
NCT00439777Completed4,833Est. Dec 2011
E
EisaiChina - Liaoning
1 program
1
MonteplasePhase 41 trial
Active Trials
NCT00442234Completed5Est. Apr 2008
Sanofi
SanofiPARIS, France
3 programs
1
SR34006Phase 31 trial
AlertN/A1 trial
Human AlertN/A1 trial
Active Trials
NCT00853463Completed2,515Est. May 2011
NCT00409136Completed2,496Est. Aug 2008
NCT00062803CompletedEst. Oct 2005
Boehringer Ingelheim
Boehringer IngelheimINGELHEIM, Germany
1 program
1
AlteplasePhase 31 trial
Active Trials
NCT04430569Recruiting800Est. Aug 2028
DS
Daiichi SankyoChina - Shanghai
2 programs
1
1
DS-9231Phase 21 trial
DS-1040bPhase 1/21 trial
Active Trials
NCT02923115Completed134Est. Aug 2019
NCT03316729Withdrawn0Est. Feb 2020
Argon Medical Devices
2 programs
Cleaner Pro Thrombectomy SystemN/A1 trial
IVC FilterN/A
Active Trials
NCT06189313RecruitingEst. Sep 2027
IS
Interventional SystemsAustria - Kitzbühel
2 programs
IVC FilterN/A
VenaTech Convertible Vena Cava FilterN/A1 trial
Active Trials
NCT01112917CompletedEst. Sep 2015
Penumbra
PenumbraALAMEDA, CA
2 programs
Indigo Aspiration SystemN/A1 trial
Indigo Aspiration SystemN/A1 trial
Active Trials
NCT04798261Recruiting1,500Est. Feb 2028
NCT03218566Completed119Est. Apr 2019
Magneto Thrombectomy Solutions
2 programs
Magneto PE KitN/A1 trial
eTrieve PE KitN/A1 trial
Active Trials
NCT04949048Completed15Est. Dec 2023
NCT05821426Not Yet Recruiting130Est. Oct 2027
Cook Medical
Cook MedicalIN - Bloomington
1 program
IVC FilterN/A
Bayer
BayerLEVERKUSEN, Germany
1 program
Optimizing Protocols for the Individual Patient in CT Pulmonary Angiography.N/A1 trial
Active Trials
NCT02611115Completed235Est. Dec 2016
Intrinsic Therapeutics
1 program
The Angel® CatheterN/A1 trial
Active Trials
NCT02186223Completed172Est. Dec 2015
Inquis Medical
Inquis MedicalCA - Menlo Park
1 program
ThrombectomyN/A1 trial
Active Trials
NCT05907564Active Not RecruitingEst. Oct 2026

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
2028
EisaiMonteplase
CordisOPTEASE Vena Cava Filter
Boehringer IngelheimAlteplase
Johnson & JohnsonRivaroxaban
SanofiSR34006
Daiichi SankyoDS-9231
Daiichi SankyoDS-1040b
Magneto Thrombectomy SolutionseTrieve PE Kit
Argon Medical DevicesCleaner Pro Thrombectomy System
Inquis MedicalThrombectomy
Magneto Thrombectomy SolutionsMagneto PE Kit
PenumbraIndigo Aspiration System
PenumbraIndigo Aspiration System
CordisIVC Filter
BayerOptimizing Protocols for the Individual Patient in CT Pulmonary Angiography.

Showing 15 of 19 trials with date data

Clinical Trials (19)

Total enrollment: 14,532 patients across 19 trials

NCT00442234EisaiMonteplase

Post-marketing Study of Monteplase ("Cleactor") in Patients With Acute Pulmonary Embolism

Start: May 2007Est. completion: Apr 20085 patients
Phase 4Completed
NCT00233740CordisOPTEASE Vena Cava Filter

Protection From Pulmonary Embolism With the Permanent OptEase™ Filter (PROOF)

Start: Sep 2003Est. completion: May 2005150 patients
Phase 4Completed
NCT04430569Boehringer IngelheimAlteplase

Pulmonary Embolism International THrOmbolysis Study-3

Start: Aug 2021Est. completion: Aug 2028800 patients
Phase 3Recruiting
NCT00439777Johnson & JohnsonRivaroxaban

Oral Direct Factor Xa Inhibitor Rivaroxaban in Patients With Acute Symptomatic Pulmonary Embolism - The EINSTEIN PE Study

Start: Mar 2007Est. completion: Dec 20114,833 patients
Phase 3Completed
NCT00062803SanofiSR34006

SR34006 Compared to Vitamin K Antagonist (VKA) in the Treatment of Pulmonary Embolism

Start: Jun 2003Est. completion: Oct 2005
Phase 3Completed
NCT03316729Daiichi SankyoDS-9231

DS-9231 in Intermediate-risk (Sub-massive) Acute Pulmonary Embolism (PE)

Start: Jan 2018Est. completion: Feb 20200
Phase 2Withdrawn
NCT02923115Daiichi SankyoDS-1040b

Study to Assess the Safety, Pharmacokinetics/Dynamics of DS-1040b in Subjects With Acute Submassive Pulmonary Embolism

Start: Jun 2016Est. completion: Aug 2019134 patients
Phase 1/2Completed
NCT05821426Magneto Thrombectomy SolutionseTrieve PE Kit

Evaluation of the Magneto eTrieve™ PE Kit for Endovascular Thrombectomy in Subjects With Acute Pulmonary Embolism

Start: Jul 2026Est. completion: Oct 2027130 patients
N/ANot Yet Recruiting
NCT06189313Argon Medical DevicesCleaner Pro Thrombectomy System

CLEANer Aspiration for Pulmonary Embolism

Start: Jan 2025Est. completion: Sep 2027
N/ARecruiting
NCT05907564Inquis MedicalThrombectomy

Aventus Thrombectomy System Pulmonary Embolism Clinical Study

Start: Sep 2023Est. completion: Oct 2026
N/AActive Not Recruiting
NCT04949048Magneto Thrombectomy SolutionsMagneto PE Kit

Evaluation of the Safety and Performance of Magneto PE Kit

Start: Aug 2021Est. completion: Dec 202315 patients
N/ACompleted
NCT04798261PenumbraIndigo Aspiration System

Study of the Long-Term Safety and Outcomes of Treating Pulmonary Embolism With the Indigo Aspiration System

Start: Jun 2021Est. completion: Feb 20281,500 patients
N/ARecruiting
NCT03218566PenumbraIndigo Aspiration System

Evaluating the Safety and Efficacy of the Indigo® Aspiration System in Acute Pulmonary Embolism

Start: Nov 2017Est. completion: Apr 2019119 patients
N/ACompleted
NCT02381509CordisIVC Filter

Predicting the Safety and Effectiveness of Inferior Vena Cava Filters

Start: Oct 2015Est. completion: Sep 20211,428 patients
N/ACompleted
NCT02611115BayerOptimizing Protocols for the Individual Patient in CT Pulmonary Angiography.

Optimizing Protocols for the Individual Patient in CT Pulmonary Angiography.

Start: Sep 2015Est. completion: Dec 2016235 patients
N/ACompleted
NCT02186223Intrinsic TherapeuticsThe Angel® Catheter

The Angel® Catheter Pivotal Clinical Trial

Start: Jan 2015Est. completion: Dec 2015172 patients
N/ACompleted
NCT01112917Interventional SystemsVenaTech Convertible Vena Cava Filter

VenaTech Convertible Vena Cava Filter U.S. Multi-Center Clinical Trial

Start: Dec 2011Est. completion: Sep 2015
N/ACompleted
NCT00853463SanofiAlert

Discharge ALERT: Quality Improvement Initiative

Start: Apr 2009Est. completion: May 20112,515 patients
N/ACompleted
NCT00409136SanofiHuman Alert

Multi-Center Human Alert Trial to Prevent DVT and PE

Start: Mar 2006Est. completion: Aug 20082,496 patients
N/ACompleted

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Phase Legend

Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available

Key Insights

3 late-stage (Phase 3) programs — potential near-term approvals
3 actively recruiting trials targeting 14,532 patients
18 companies competing in this space

Related Indications

Asthma(378)Pulmonary Disease, Chronic Obstructive(263)Chronic Obstructive Pulmonary Disease(123)Idiopathic Pulmonary Fibrosis(90)COPD(74)Chronic Obstructive Pulmonary Disease (COPD)(38)Respiratory Syncytial Virus Infections(26)Severe Asthma(21)Lung Diseases, Interstitial(19)Pulmonary Fibrosis(15)