Leukemia

Oncology
92
Pipeline Programs
30
Companies
50
Clinical Trials
1 recruiting
10
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
16
20
37
1
7
11
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Small Molecule
1040%
Monoclonal Antibody
832%
Cell Therapy
520%
Vaccine
14%
ADC
14%
+ 64 programs with unclassified modality

On Market (10)

Approved therapies currently available

U
ARSENIC TRIOXIDEApproved
arsenic trioxide
Unknown Company
injection2023
U
CYCLOSPORINEApproved
cyclosporine
Unknown Company
oral2025
U
DASATINIBApproved
dasatinib
Unknown Company
oral2025
U
HYDROXYUREAApproved
hydroxyurea
Unknown Company
Antimetabolite [EPC]oral2024
U
PHYRAGOApproved
dasatinib
Unknown Company
oral2023
Roche
RITUXANApproved
rituximab
Roche
CD20-directed Cytolytic Antibody [EPC]intravenous1997
Bristol Myers Squibb
SPRYCELApproved
dasatinib
Bristol Myers Squibb
oral2006
DS
VANFLYTAApproved
quizartinib
Daiichi Sankyo
oral2023
U
VERKAZIAApproved
cyclosporine
Unknown Company
Calcineurin Inhibitor Immunosuppressant [EPC]ophthalmic2021
U
XROMIApproved
hydroxyurea
Unknown Company
Antimetabolite [EPC]oral2024

Competitive Landscape

31 companies ranked by most advanced pipeline stage

Bristol Myers Squibb
9 programs
1
3
4
1
1
DasatinibPhase 3Small Molecule1 trial
DasatinibPhase 2Small Molecule1 trial
DasatinibPhase 2Small Molecule1 trial
LirilumabPhase 2Monoclonal Antibody1 trial
RituximabPhase 2Monoclonal Antibody1 trial
+4 more programs
Active Trials
NCT00454753No Longer Available
NCT04115059Terminated3Est. Dec 2021
NCT04150471Unknown79Est. Dec 2023
+10 more trials
Pfizer
PfizerNEW YORK, NY
5 programs
3
1
1
inotuzumab ozogamicin-dose level 2Phase 4ADC1 trial
MylotargPhase 2/31 trial
chemotherapyPhase 21 trial
chemotherapyPhase 21 trial
lintuzumabPhase 2Monoclonal Antibody1 trial
Active Trials
NCT00003131Completed55Est. Feb 2002
NCT00003673Completed55Est. Mar 1999
NCT00997243Terminated7Est. May 2011
+2 more trials
DS
Daiichi SankyoChina - Shanghai
1 program
1
1
VANFLYTA(Quizartinib)Phase 3Small Molecule5 trials
Active Trials
NCT06578247Recruiting700Est. Jun 2030
NCT04459585Completed20Est. Oct 2020
NCT02984995Completed37Est. Sep 2018
+2 more trials
Roche
RocheSTAVANGER NORWAY, Norway
1 program
1
1
RituximabPhase 3Monoclonal Antibody1 trial
Active Trials
NCT00645606Completed542Est. Jul 2017
Alliance Pharmaceuticals
18 programs
1
9
2
arsenic trioxidePhase 31 trial
hydroxyureaPhase 31 trial
G-CSFPhase 22 trials
alemtuzumabPhase 2Monoclonal Antibody2 trials
anti-thymocyte globulinPhase 21 trial
+13 more programs
Active Trials
NCT01284010Completed200Est. Sep 2014
NCT01004640Unknown60
NCT00896701Completed451Est. Apr 2014
+18 more trials
Takeda
TakedaTOKYO, Japan
4 programs
1
2
1
cyclosporinePhase 31 trial
IxazomibPhase 21 trial
troxacitabinePhase 21 trial
GDX012Phase 1/21 trial
Active Trials
NCT05886491Active Not Recruiting16Est. May 2026
NCT02302846Terminated5Est. May 2017
NCT00012259Completed31Est. Mar 2002
+1 more trials
Novo Nordisk
Novo NordiskBAGSVAERD DENMARK, Denmark
1 program
1
Insulin GlarginePhase 31 trial
Active Trials
NCT00500240Terminated52Est. Apr 2012
Knight Therapeutics
Knight TherapeuticsQC - Montréal
8 programs
2
5
CampathPhase 21 trial
bcr-abl peptide vaccinePhase 2Vaccine1 trial
cyclophosphamidePhase 21 trial
cytarabinePhase 21 trial
recombinant interferon alfaPhase 21 trial
+3 more programs
Active Trials
NCT00899795Completed35Est. Oct 2010
NCT00053248Completed16Est. Jun 2005
NCT00253513Completed60Est. Oct 2009
+5 more trials
Bayer
BayerLEVERKUSEN, Germany
6 programs
2
4
AzacytidinePhase 21 trial
CyclophosphamidePhase 25 trials
GM-CSFPhase 21 trial
alemtuzumabPhase 2Monoclonal Antibody5 trials
Atuveciclib, BAY1143572Phase 11 trial
+1 more programs
Active Trials
NCT02345382Completed42Est. Jul 2017
NCT03404726Terminated40Est. Jan 2021
NCT02196857Completed16Est. Nov 2018
+11 more trials
E
4 programs
2
1
1
E7070Phase 21 trial
DecitabinePhase 1/21 trial
DecitabinePhase 11 trial
E5564Phase 11 trial
Active Trials
NCT01378416Completed16Est. Jun 2007
NCT00756912Terminated30
NCT00075010Completed54Est. Nov 2006
+1 more trials
Swedish Orphan Biovitrum
3 programs
2
1
PaliferminPhase 21 trial
PaliferminPhase 11 trial
Palifermin 6 x 60 μg/kg/dayPhase 1
Active Trials
NCT00460421CompletedEst. May 2011
NCT01746849Active Not RecruitingEst. Dec 2026
Novartis
NovartisBASEL, Switzerland
3 programs
1
2
CLAG RegimenPhase 21 trial
Imatinib MesylatePhase 21 trial
5-azacytidinePhase 1/21 trial
Active Trials
NCT01202877Completed54Est. Jul 2015
NCT00955916Completed38Est. May 2014
NCT00038610Completed54Est. Jul 2014
M&
Merck & Co.RAHWAY, NJ
2 programs
1
1
MK0457Phase 21 trial
Farnesyl Protein Transferase InhibitorPhase 1/21 trial
Active Trials
NCT00034684Completed132Est. Oct 2003
NCT00405054Terminated52Est. Jun 2009
Astex Pharmaceuticals
Astex PharmaceuticalsUK - Cambridge
2 programs
1
1
rituximabPhase 2Monoclonal Antibody1 trial
PentostatinPhase 1/2Small Molecule1 trial
Active Trials
NCT00506922CompletedEst. Nov 2009
NCT00541034CompletedEst. Jan 2016
BeOne Medicines
BeOne MedicinesCA - San Carlos
1 program
1
BGB-11417Phase 21 trial
Active Trials
NCT05479994Active Not RecruitingEst. Aug 2027
Jazz Pharmaceuticals
Jazz PharmaceuticalsCA - Palo Alto
1 program
1
CytarabinePhase 21 trial
Active Trials
NCT02419469Terminated1Est. Jun 2017
BioCryst Pharmaceuticals
1 program
1
Forodesine Hydrochloride Sterile Solution, 5 mg/mLPhase 21 trial
Active Trials
NCT00419081Terminated100Est. Mar 2007
Cellectar Biosciences
Cellectar BiosciencesFLORHAM PARK, NJ
1 program
1
NOV-002Phase 21 trial
Active Trials
NCT00960726Withdrawn
Precision BioSciences
4 programs
4
CD123 CAR-T cellsPhase 1/2Cell Therapy1 trial
CD123 CAR-T cellsPhase 1/2Cell Therapy1 trial
CD19 CAR-T cellsPhase 1/2Cell Therapy1 trial
CD19 CAR-T cellsPhase 1/2Cell Therapy1 trial
Active Trials
NCT04265963Unknown45Est. Jul 2024
NCT04272125Unknown40Est. Jul 2024
NCT04271410Unknown80Est. Jul 2024
+1 more trials
Teva
TevaIsrael - Petach Tikva
2 programs
1
1
BendamustinePhase 1/21 trial
OmacetaxinePhase 11 trial
Active Trials
NCT02141477Terminated2Est. Jun 2017
NCT01088984Completed43Est. Aug 2011
Karyopharm Therapeutics
2 programs
1
1
SelinexorPhase 1/21 trial
SelinexorPhase 11 trial
Active Trials
NCT02403310CompletedEst. Feb 2021
NCT02530476CompletedEst. Apr 2019
Molecular Partners
Molecular PartnersSchlieren-Zurich, Switzerland
1 program
1
MP0533Phase 1/21 trial
Active Trials
NCT05673057Recruiting249Est. Dec 2029
Genentech
GenentechCA - Oceanside
1 program
1
MosunetuzumabPhase 1/2Monoclonal Antibody1 trial
Active Trials
NCT07052695Recruiting40Est. Dec 2032
AbbVie
AbbVieNORTH CHICAGO, IL
1 program
1
VenetoclaxPhase 1/21 trial
Active Trials
NCT03319901Recruiting82Est. Apr 2027
City Therapeutics
City TherapeuticsMA - Cambridge
1 program
1
cyclophosphamidePhase 1/21 trial
Active Trials
NCT00576979Active Not RecruitingEst. Feb 2026
AstraZeneca
AstraZenecaCAMBRIDGE, United Kingdom
1 program
1
AZD6738Phase 11 trial
Active Trials
NCT03770429Active Not Recruiting52Est. May 2026
BlossomHill Therapeutics
1 program
1
BH-30236Phase 11 trial
Active Trials
NCT06501196RecruitingEst. Jun 2027
Celularity
CelularityFLORHAM PARK, NJ
1 program
1
CYNK-001Phase 11 trial
Active Trials
NCT04310592TerminatedEst. Apr 2023
Ipsen
IpsenChina - Tianjin
1 program
1
EPZ-5676Phase 11 trial
Active Trials
NCT02141828Completed18Est. Jun 2016
Eureka Therapeutics
Eureka TherapeuticsCA - Emeryville
1 program
1
ET019003-T CellsPhase 11 trial
Active Trials
NCT04014894UnknownEst. Jul 2022

+1 more companies

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
2028
2029
2030
Pfizerinotuzumab ozogamicin-dose level 2
Bristol Myers SquibbDasatinib
Bayeralemtuzumab
Daiichi SankyoQuizartinib
BayerCyclophosphamide
RocheRituximab
Bayeralemtuzumab
Bristol Myers SquibbDasatinib
Bayeralemtuzumab
Alliance Pharmaceuticalsarsenic trioxide
Bristol Myers SquibbDasatinib
Bristol Myers SquibbDasatinib
Bristol Myers SquibbDasatinib
Novo NordiskInsulin Glargine
Alliance Pharmaceuticalshydroxyurea

Showing 15 of 49 trials with date data

Clinical Trials (50)

Total enrollment: 7,072 patients across 50 trials

NCT03677596Pfizerinotuzumab ozogamicin-dose level 2

A Study Of Two Inotuzumab Ozogamicin Doses in Relapsed/ Refractory Acute Lymphoblastic Leukemia Transplant Eligible Patients

Start: Jul 2019Est. completion: May 2023102 patients
Phase 4Completed

Phase IV, Open-label, Multicenter Study of Dasatinib in Chronic-Phase Chronic Myeloid Leukemia (CP-CML) Patients With Chronic, Low-grade Non-Hematologic Toxicity to Imatinib

Start: Dec 2012Est. completion: Oct 201539 patients
Phase 4Completed
NCT00177138Bayeralemtuzumab

Use of Campath for Induction and Maintenance Therapy in Pancreas After Kidney Transplantation

Start: Jul 2004Est. completion: Nov 20069 patients
Phase 4Terminated

Quizartinib or Placebo Plus Chemotherapy in Newly Diagnosed Patients With FLT3-ITD Negative AML

Start: Nov 2024Est. completion: Jun 2030700 patients
Phase 3Recruiting
NCT02626455BayerCyclophosphamide

Study of Copanlisib in Combination With Standard Immunochemotherapy in Relapsed Indolent Non-Hodgkin's Lymphoma (iNHL)

Start: Jan 2016Est. completion: Nov 2023551 patients
Phase 3Terminated

Rituximab Maintenance Versus Observation After First-line Immunochemotherapy by FCR in Older Patients With Chronic Lymphocytic Leukemia

Start: Dec 2007Est. completion: Jul 2017542 patients
Phase 3Completed
NCT00548405Bayeralemtuzumab

Comparison of Alemtuzumab and Rebif® Efficacy in Multiple Sclerosis, Study Two

Start: Oct 2007Est. completion: Sep 2011840 patients
Phase 3Completed

A Phase III Study of Dasatinib vs Imatinib in Patients With Newly Diagnosed Chronic Phase Chronic Myeloid Leukemia

Start: Sep 2007Est. completion: Dec 2015547 patients
Phase 3Completed
NCT00530348Bayeralemtuzumab

Comparison of Alemtuzumab and Rebif® Efficacy in Multiple Sclerosis, Study One

Start: Aug 2007Est. completion: Apr 2011581 patients
Phase 3Completed

Phase III Trial in Acute Promyelocytic Leukemia Patients

Start: Aug 2007Est. completion: Oct 2019276 patients
Phase 3Completed

A Study of Dasatinib vs. High-Dose Imatinib (600 mg) in Patients With Chronic Phase Chronic Myeloid Leukemia (CML) Who Failed to Achieve Complete Cytogenetic Response After 3-18 Months of Imatinib Therapy

Start: Apr 2007Est. completion: Jun 20083 patients
Phase 3Terminated

Chronic Myelogenous Leukemia (CML) - Follow on: Study of BMS-354825 in Subjects With CML

Start: Jul 2005Est. completion: Jul 2014724 patients
Phase 3Completed

Advanced Chronic Myelogenous Leukemia (CML) - Follow On: Study of BMS-354825 in Subjects With CML

Start: Jun 2005Est. completion: Jun 2013638 patients
Phase 3Completed
NCT00500240Novo NordiskInsulin Glargine

Effect of Tight Control of Blood Glucose During Hyper-CVAD Chemotherapy For Acute Lymphocytic Leukemia (ALL)

Start: Apr 2004Est. completion: Apr 201252 patients
Phase 3Terminated

Homoharringtonine Compared With Hydroxyurea for Chronic Myelogenous Leukemia That Has Not Responded to Interferon Alfa

Start: Jan 2000Est. completion: May 20015 patients
Phase 3Terminated
NCT00003056Takedacyclosporine

Prevention of Graft-Versus-Host Disease in Patients With Advanced Leukemia or Lymphoma Who Are Eligible for Peripheral Stem Cell Transplantation

Start: Apr 1997Est. completion: Jun 2003105 patients
Phase 3Terminated

Study of Dasatinib in Imatinib Resistant or Intolerant Subjects With Chronic or Advanced Phase CML or Philadelphia Chromosome Positive ALL

Start: Dec 20060
Phase 2/3Withdrawn

Nonmyeloablative Preparative Regimen Using Mylotarg for Patients With High Risk Acute Myeloid Leukemia (AML), Acute Lymphocytic Leukemia (ALL), Chronic Myeloid Leukemia (CML) and Myelodysplastic Syndrome (MDS)

Start: May 2001Est. completion: Nov 20043 patients
Phase 2/3Terminated

NOV-002 in Myelodysplastic Syndrome (MDS)

Phase 2Withdrawn

Study of BGB-11417 in Participants With Relapsed or Refractory Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma

Start: Oct 2022Est. completion: Aug 2027
Phase 2Active Not Recruiting

Phase 2 Study of Quizartinib in Participants With Acute Myeloid Leukemia (AML) FLT3 Internal Tandem Duplication (FLT3/ITD) Mutation

Start: Dec 2016Est. completion: Sep 201837 patients
Phase 2Completed

An Investigational Immuno-therapy Study to Test Combination Treatments in Patients With Advanced Non-Small Cell Lung Cancer

Start: May 2016Est. completion: Jan 2020295 patients
Phase 2Terminated

Augmented Berlin-Frankfurt-Munster Therapy Plus Ofatumumab for Young Adults With Acute Lymphoblastic Leukemia or Lymphoblastic Lymphoma

Start: Nov 2015Est. completion: Jun 20171 patients
Phase 2Terminated

Continuing Treatment for Subjects Who Have Participated on a Prior Protocol Investigating Dasatinib

Start: Jul 2015Est. completion: May 202217 patients
Phase 2Completed

Urelumab (CD137 mAb) With Rituximab for Relapsed, Refractory or High-risk Untreated Chronic Lymphocytic Leukemia (CLL) Patients

Start: Jul 20150
Phase 2Withdrawn

Lirilumab With Rituximab for Relapsed, Refractory or High-risk Untreated Chronic Lymphocytic Leukemia (CLL) Patients

Start: Jun 2015Est. completion: Aug 20197 patients
Phase 2Completed

Phase II Trial of Dasatinib in Patients With Isocitrate Dehydrogenase (IDH)-Mutant Advanced Intrahepatic Cholangiocarcinoma

Start: Apr 2015Est. completion: Feb 20188 patients
Phase 2Completed

Study of MLN9708 as Maintenance Therapy for Patients With Acute Myeloid Leukemia (AML) and High Risk Myelodysplastic Syndrome (MDS) in Remission

Start: Mar 2015Est. completion: May 20175 patients
Phase 2Terminated
NCT02196857BayerAzacytidine

Sorafenib Plus 5-Azacitidine Initial Therapy of Patients With Acute Myeloid Leukemia (AML) and High Risk Myelodysplastic Syndrome (MS) With FLT3-ITD Mutation

Start: Feb 2015Est. completion: Nov 201816 patients
Phase 2Completed

Open-Label Study Evaluating Dasatinib Therapy Discontinuation in Patients With Chronic Phase Chronic Myeloid Leukemia With Stable Complete Molecular Response

Start: Jan 2014Est. completion: Oct 202184 patients
Phase 2Completed

Phase II Short-term Adjuvant Therapy and Biomarker Studies With Targeted Agents in Women With Estrogen Receptor Negative Breast Cancer

Start: Jan 2014Est. completion: May 202426 patients
Phase 2Completed

Dasatinib in Patients With Chronic Myeloid Leukemia in Chronic Phase

Start: Mar 2013Est. completion: Dec 201618 patients
Phase 2Unknown

E7070, Idarubicin and Cytarabine in Relapsed AML and High-Risk Myelodysplastic Syndromes

Start: Feb 2013Est. completion: Jun 201743 patients
Phase 2Completed

Palifermin With Leuprolide Acetate for the Promotion of Immune Recovery Following Total Body Irradiation Based T-Cell Depleted Allogeneic Hematopoietic Stem Cell Transplantation

Start: Dec 2012Est. completion: Dec 2026
Phase 2Active Not Recruiting

Study of Dasatinib vs Imatinib in Patients With Chronic Myeloid Leukemia (CML) Who Did Not Have Favorable Response to Imatinib

Start: Sep 2012Est. completion: Apr 2022262 patients
Phase 2Completed

Phase II Study of 5-FU, Oxaliplatin Plus Dasatinib in Metastatic Pancreatic Adenocarcinoma

Start: Jul 2012Est. completion: Jul 202044 patients
Phase 2Completed

Trial of Dasatinib in Patients With Advanced Cancers Harboring DDR2 Mutation or Inactivating B-RAF Mutation

Start: May 2012Est. completion: Jul 201419 patients
Phase 2Terminated

Pediatric Philadelphia Positive Acute Lymphoblastic Leukemia

Start: Apr 2012Est. completion: Jun 2021106 patients
Phase 2Completed

Open Label Study to Evaluate Safety and Efficacy of 2 Doses of Quizartinib in Patients With Relapsed or Refractory Acute Myeloid Leukemia

Start: Apr 2012Est. completion: Mar 201576 patients
Phase 2Completed

Phase 2 Dasatinib Combo With Smoothened (SMO) Antagonist (BMS-833923)

Start: Sep 2011Est. completion: Jan 201670 patients
Phase 2Terminated

Cetuximab and Dasatinib in Recurrent Squamous Cell Carcinoma

Start: Sep 2011Est. completion: Aug 201621 patients
Phase 2Terminated

Treatment With Dasatinib in Patients With Acral Lentiginous, Mucosal, or Chronic Sun-damaged Melanoma

Start: Mar 2011Est. completion: Aug 201419 patients
Phase 2Terminated

Donor Stem Cell Transplant in Treating Patients With Relapsed Hematologic Malignancies or Secondary Myelodysplasia Previously Treated With High-Dose Chemotherapy and Autologous Stem Cell Transplant

Start: Dec 2010Est. completion: Aug 20136 patients
Phase 2Terminated

Dasatinib With Fludarabine and Rituximab in Relapsed and Refractory CLL and SLL

Start: Jul 2010Est. completion: Jan 201510 patients
Phase 2Terminated

Efficacy and Safety Study of Dasatinib in Patients With Chronic Myeloid Leukemia

Start: Feb 2010Est. completion: Nov 201150 patients
Phase 2Terminated

Azacitidine and Lintuzumab in Treating Patients With Previously Untreated Myelodysplastic Syndromes

Start: Nov 2009Est. completion: May 20117 patients
Phase 2Terminated

CLAG Gleevec in Relapsed or Refractory Acute Myeloid Leukemia (AML)

Start: Aug 2009Est. completion: May 201438 patients
Phase 2Completed

A Study to Evaluate the Safety and Efficacy of Dasatinib (Sprycel) in Subjects With Relapsed or Refractory Diffuse Large B-Cell Lymphoma (DLBCL)

Start: Jun 2009Est. completion: May 20112 patients
Phase 2Terminated

Pegaspargase and Combination Chemotherapy in Treating Patients With Newly Diagnosed Acute Lymphoblastic Leukemia

Start: Jun 2009Est. completion: May 201411 patients
Phase 2Terminated

Genomic Guided Therapy With Dasatinib or Nilutamide in Metastatic Castration-Resistant Prostate Cancer

Start: May 2009Est. completion: Aug 201357 patients
Phase 2Terminated

Related Jobs in Oncology

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

7 late-stage (Phase 3) programs — potential near-term approvals
1 actively recruiting trials targeting 7,072 patients
30 companies competing in this space